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Conserved domains on  [gi|922580850|ref|NP_001299995|]
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Pry-1 Interacting and CABIN1 Domain containing [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tolA super family cl35847
cell envelope integrity inner membrane protein TolA; Provisional
 1798-1851 1.32e-03

cell envelope integrity inner membrane protein TolA; Provisional


The actual alignment was detected with superfamily member PRK09510:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 1.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580850 1798 AAQLIQALQ------AAKDAQTAKLVAQEKAKKEAQEKARREAEAKKEAQLAQLMKIAEE 1851
Cdd:PRK09510  123 AAKQAALKQkqaeeaAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAE 182
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1798-1851 1.32e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 1.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580850 1798 AAQLIQALQ------AAKDAQTAKLVAQEKAKKEAQEKARREAEAKKEAQLAQLMKIAEE 1851
Cdd:PRK09510  123 AAKQAALKQkqaeeaAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAE 182
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1799-1854 8.77e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 8.77e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922580850  1799 AQLIQALQAAKDAQTAKLVAQEKAKKEAQEKARREAEAKKEAQ-------LAQLMKIAEERSK 1854
Cdd:TIGR02794   95 EQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEaeaerkaKEEAAKQAEEEAK 157
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1798-1851 1.32e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 1.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580850 1798 AAQLIQALQ------AAKDAQTAKLVAQEKAKKEAQEKARREAEAKKEAQLAQLMKIAEE 1851
Cdd:PRK09510  123 AAKQAALKQkqaeeaAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAE 182
PRK07353 PRK07353
F0F1 ATP synthase subunit B'; Validated
 1753-1853 6.26e-03

F0F1 ATP synthase subunit B'; Validated


Pssm-ID: 235999 [Multi-domain]  Cd Length: 140  Bit Score: 39.22  E-value: 6.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580850 1753 DNVSKFILANANSAD---SQKQRLALQLLahaqasapaaptasstNQIAAQLIQALQAAKDAQT-AKLVAQEK---AKKE 1825
Cdd:PRK07353   35 EEREDYIRTNRAEAKerlAEAEKLEAQYE----------------QQLASARKQAQAVIAEAEAeADKLAAEAlaeAQAE 98

                          90       100       110
                  ....*....|....*....|....*....|.
gi 922580850 1826 AQ---EKARREAEAKKEAQLAQLMKIAEERS 1853
Cdd:PRK07353   99 AQaskEKARREIEQQKQAALAQLEQQVDALS 129
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1803-1851 6.45e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 41.33  E-value: 6.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 922580850 1803 QALQAAKDAQTAKLVAQEKAKKEAQEKArrEAEAKKEAQLAQLMKIAEE 1851
Cdd:PRK09510  152 EAKRAAAAAKKAAAEAKKKAEAEAAKKA--AAEAKKKAEAEAAAKAAAE 198
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1799-1854 8.77e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 8.77e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922580850  1799 AQLIQALQAAKDAQTAKLVAQEKAKKEAQEKARREAEAKKEAQ-------LAQLMKIAEERSK 1854
Cdd:TIGR02794   95 EQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEaeaerkaKEEAAKQAEEEAK 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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