BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356664  135 IFSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIYPPHLppkqwIKESDLVEq 211
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvseITLDDVSPEDFEALLEFMYTGKL-----ISEENVDD- 82

                          90
                  ....*....|....*.
gi 808356664  212 fehiqrILRIGKSLQI 227
Cdd:pfam00651  83 ------LLAAADKLQI 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356664  135 IFSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIYPPHLppkqwIKESDLVEq 211
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvseITLDDVSPEDFEALLEFMYTGKL-----ISEENVDD- 82

                          90
                  ....*....|....*.
gi 808356664  212 fehiqrILRIGKSLQI 227
Cdd:pfam00651  83 ------LLAAADKLQI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356664 136 FSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIY 193
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSsseIELDDVSPEAFEALLDYIY 61

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356664  135 IFSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIYPPHLppkqwIKESDLVEq 211
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvseITLDDVSPEDFEALLEFMYTGKL-----ISEENVDD- 82

                          90
                  ....*....|....*.
gi 808356664  212 fehiqrILRIGKSLQI 227
Cdd:pfam00651  83 ------LLAAADKLQI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356664 136 FSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIY 193
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSsseIELDDVSPEAFEALLDYIY 61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808356664 135 IFSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDE---RSLELCNISAPDFRRILNIIY 193
Cdd:cd18272   31 LFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEarnRVIELKDVSESVFQLLVDYIY 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 808356664 139 TIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIYP 194
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGqaeINLRDISPEDFRALLEFLYG 59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356664 134 PIFSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDER---SLELCNISAPDFRRILNIIYP---PHL 197
Cdd:cd18344   21 SLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERlknPIEIHDLDPQVFKEMMGFIYTgkaPHL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356664 138 DTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIYpphlppkqwikESDLVEQFEH 214
Cdd:cd18255   20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSqdeIELKGVSAKGLKHILDFAY-----------TSELTLDLDC 88

                         90       100
                 ....*....|....*....|....*.
gi 808356664 215 IQRILRIGKSLQISIVLEVADKWLVK 240
Cdd:cd18255   89 IQDVLGAAVHLQMLPVVELCEEFLKS 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356664 136 FSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERSLELCNISAPD---FRRILNIIY 193
Cdd:cd18345   18 FSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDhevMREMLRFIY 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356664 137 SDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIYPPHLPPKQWIKESDLVEQFE 213
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENegeIVIEDVEPPVFKALLHFIYKDELPDDVEPAGSDSSSLDT 94

                 ....*..
gi 808356664 214 H-IQRIL 219
Cdd:cd18280   95 TmAQHLL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356664 135 IFSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERSL---ELCNISAPDFRRILNIIYpphlppkqwikESDLVEQ 211
Cdd:cd18265   22 TFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQavvEIQKVSAAAMEVLLDYMY-----------GGGLRIQ 90

                         90       100
                 ....*....|....*....|....*..
gi 808356664 212 FEHIQRILRIGKSLQISIVLEVADKWL 238
Cdd:cd18265   91 EDNVESVLEASDLLQVSKLREACVRFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808356664 136 FSDTIVLVDGVKFHVNRMILSMASPIFLEAFVTNFDERS---LELCNISAPDFRRILNIIY---PPHL 197
Cdd:cd18279   18 FTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKknrVEINDVDPEVFKEMMRFIYtgkAPNL 85