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Conserved domains on  [gi|749502286|ref|NP_001291348|]
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IQ and AAA domain-containing protein 1-like [Homo sapiens]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 535-694 1.65e-77

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19506:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 160  Bit Score: 247.44  E-value: 1.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 535 DIRQNVALYAVLRLGSPDIHIMAPLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVF 614
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 615 KVARLLQPSVIWIGNAEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQLAEMRGLCRVYERILFM 694
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
SpoVK super family cl33891
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 411-744 1.02e-16

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0464:

Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 83.04  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 411 SIHPSQNYDSETLREEKRKEVELEIRIQVDELMRQELRKLRLAVDKEEERPLRAPKKTPGKKTGKKKEKDLTSDRSVESL 490
Cdd:COG0464   59 LLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTY 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 491 YEELVISGLLRKSESVALKDYIGdflylgstLSLVKKLPMPSLFDIRQNVALYAVLRLGSPdihimapliRSILLVGPSG 570
Cdd:COG0464  139 EDIGGLEEELLELREAILDDLGG--------LEEVKEELRELVALPLKRPELREEYGLPPP---------RGLLLYGPPG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 571 MGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKED-------- 642
Cdd:COG0464  202 TGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKN--LREVFDKARGLAPCVLFIDEADALAGKRGEVGDgvgrrvvn 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 643 ---KEMDPKRikkdltkalrlltpgDRVMLIGTTSRPQL--AEMRglcRVYERILFMPRPDYASRYVLWKRMIEARGIqp 717
Cdd:COG0464  280 tllTEMEELR---------------SDVVVIAATNRPDLldPALL---RRFDEIIFFPLPDAEERLEIFRIHLRKRPL-- 339

                        330       340
                 ....*....|....*....|....*..
gi 749502286 718 TQHLDISALAKVSDGYTPGHILQAIQS 744
Cdd:COG0464  340 DEDVDLEELAEATEGLSGADIRNVVRR 366
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 535-694 1.65e-77

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 247.44  E-value: 1.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 535 DIRQNVALYAVLRLGSPDIHIMAPLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVF 614
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 615 KVARLLQPSVIWIGNAEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQLAEMRGLCRVYERILFM 694
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 411-744 1.02e-16

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 83.04  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 411 SIHPSQNYDSETLREEKRKEVELEIRIQVDELMRQELRKLRLAVDKEEERPLRAPKKTPGKKTGKKKEKDLTSDRSVESL 490
Cdd:COG0464   59 LLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTY 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 491 YEELVISGLLRKSESVALKDYIGdflylgstLSLVKKLPMPSLFDIRQNVALYAVLRLGSPdihimapliRSILLVGPSG 570
Cdd:COG0464  139 EDIGGLEEELLELREAILDDLGG--------LEEVKEELRELVALPLKRPELREEYGLPPP---------RGLLLYGPPG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 571 MGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKED-------- 642
Cdd:COG0464  202 TGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKN--LREVFDKARGLAPCVLFIDEADALAGKRGEVGDgvgrrvvn 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 643 ---KEMDPKRikkdltkalrlltpgDRVMLIGTTSRPQL--AEMRglcRVYERILFMPRPDYASRYVLWKRMIEARGIqp 717
Cdd:COG0464  280 tllTEMEELR---------------SDVVVIAATNRPDLldPALL---RRFDEIIFFPLPDAEERLEIFRIHLRKRPL-- 339

                        330       340
                 ....*....|....*....|....*..
gi 749502286 718 TQHLDISALAKVSDGYTPGHILQAIQS 744
Cdd:COG0464  340 DEDVDLEELAEATEGLSGADIRNVVRR 366
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 561-742 8.36e-16

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 79.28  E-value: 8.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRnGAQmMVHIVFKVARLLQPSVIWIgnaeknfykktpk 640
Cdd:COG1222  113 KGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGE-GAR-NVREVFELAREKAPSIIFI------------- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 641 eDkEMD---PKRIKKDLTKALR-----LLT------PGDRVMLIGTTSRPQL---AemrgLCRV--YERILFMPRPDYAS 701
Cdd:COG1222  178 -D-EIDaiaARRTDDGTSGEVQrtvnqLLAeldgfeSRGDVLIIAATNRPDLldpA----LLRPgrFDRVIEVPLPDEEA 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 749502286 702 RYVLWKRMIEARGIQPTqhLDISALAKVSDGYTpGHILQAI 742
Cdd:COG1222  252 REEILKIHLRDMPLADD--VDLDKLAKLTEGFS-GADLKAI 289
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 563-696 4.40e-15

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 72.63  E-value: 4.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  563 ILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWIgnaeKNFYKKTPKED 642
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKR--LRELFEAAKKLAPCVIFI----DEIDALAGSRG 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 749502286  643 KEMDP--KRIKKDLTKAL-RLLTPGDRVMLIGTTSRPQL--AEMRGLCrvyERILFMPR 696
Cdd:pfam00004  75 SGGDSesRRVVNQLLTELdGFTSSNSKVIVIAATNRPDKldPALLGRF---DRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 561-804 1.00e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 74.94  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPK 640
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGE--SEKAIREIFRKARQAAPAIIFFDEIDAIAPARGAR 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  641 EDKEMDPKRIKKDLTKALRLLTPGDrVMLIGTTSRPQLAEmRGLCRV--YERILFMPRPDYASRYVLWKrmIEARGIQPT 718
Cdd:TIGR01243 566 FDTSVTDRIVNQLLTEMDGIQELSN-VVVIAATNRPDILD-PALLRPgrFDRLILVPPPDEEARKEIFK--IHTRSMPLA 641

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  719 QHLDISALAKVSDGYTPGHilqaIQSVLSERRFLQLskRPLVASeflgqlVKLDPVYREEEESLKDWyfktplgKKSMKH 798
Cdd:TIGR01243 642 EDVDLEELAEMTEGYTGAD----IEAVCREAAMAAL--RESIGS------PAKEKLEVGEEEFLKDL-------KVEMRH 702


                  ....*.
gi 749502286  799 RMDQLE 804
Cdd:TIGR01243 703 FLEALK 708
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 563-742 1.27e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 54.84  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 563 ILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRnGAQmMVHIVFKVARLLQPSVIWIgnaeknfykktpked 642
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKAPSIIFI--------------- 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 643 KEMDP---KRIkKDLTKALR--------LLT------PGDRVMLIGTTSRPQLAEmRGLCRV--YERILFMPRPDYASRY 703
Cdd:PRK03992 231 DEIDAiaaKRT-DSGTSGDRevqrtlmqLLAemdgfdPRGNVKIIAATNRIDILD-PAILRPgrFDRIIEVPLPDEEGRL 308

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 749502286 704 VLWKrmIEARGIQPTQHLDISALAKVSDGYTpGHILQAI 742
Cdd:PRK03992 309 EILK--IHTRKMNLADDVDLEELAELTEGAS-GADLKAI 344
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 561-698 3.30e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 3.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286   561 RSILLVGPSGMGKKMLVKAVCTE-----------TGANLFDLSPENLLGKYPGRNGAQ----MMVHIVFKVARLLQPSVI 625
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARElgppgggviyiDGEDILEEVLDQLLLIIVGGKKASgsgeLRLRLALALARKLKPDVL 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749502286   626 WIGNAEKNFykktpkeDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQL---AEMRglcRVYERILFMPRPD 698
Cdd:smart00382  83 ILDEITSLL-------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDlgpALLR---RRFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 535-694 1.65e-77

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 247.44  E-value: 1.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 535 DIRQNVALYAVLRLGSPDIHIMAPLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVF 614
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 615 KVARLLQPSVIWIGNAEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQLAEMRGLCRVYERILFM 694
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 558-678 1.16e-17

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 80.79  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 558 PLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGrnGAQMMVHIVFKVARLLQPSVIWIGNAEKNFYKK 637
Cdd:cd19481   24 GLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVG--ESEKNLRKIFERARRLAPCILFIDEIDAIGRKR 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 749502286 638 tpkeDKEMDPKRIKKDLTKALRLLTPG---DRVMLIGTTSRPQL 678
Cdd:cd19481  102 ----DSSGESGELRRVLNQLLTELDGVnsrSKVLVIAATNRPDL 141
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 535-677 8.75e-17

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 78.55  E-value: 8.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 535 DIRQNVaLYAVLRlgsPDI--HIMAPlIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHI 612
Cdd:cd19509   10 ALKEAV-ILPSLR---PDLfpGLRGP-PRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGE--SEKIVRA 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749502286 613 VFKVARLLQPSVIWIGNAEKNFYKKTPKEDKEmdPKRIKKDLTKALRLLT--PGDRVMLIGTTSRPQ 677
Cdd:cd19509   83 LFALARELQPSIIFIDEIDSLLSERGSGEHEA--SRRVKTEFLVQMDGVLnkPEDRVLVLGATNRPW 147
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 411-744 1.02e-16

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 83.04  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 411 SIHPSQNYDSETLREEKRKEVELEIRIQVDELMRQELRKLRLAVDKEEERPLRAPKKTPGKKTGKKKEKDLTSDRSVESL 490
Cdd:COG0464   59 LLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTY 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 491 YEELVISGLLRKSESVALKDYIGdflylgstLSLVKKLPMPSLFDIRQNVALYAVLRLGSPdihimapliRSILLVGPSG 570
Cdd:COG0464  139 EDIGGLEEELLELREAILDDLGG--------LEEVKEELRELVALPLKRPELREEYGLPPP---------RGLLLYGPPG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 571 MGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKED-------- 642
Cdd:COG0464  202 TGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKN--LREVFDKARGLAPCVLFIDEADALAGKRGEVGDgvgrrvvn 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 643 ---KEMDPKRikkdltkalrlltpgDRVMLIGTTSRPQL--AEMRglcRVYERILFMPRPDYASRYVLWKRMIEARGIqp 717
Cdd:COG0464  280 tllTEMEELR---------------SDVVVIAATNRPDLldPALL---RRFDEIIFFPLPDAEERLEIFRIHLRKRPL-- 339

                        330       340
                 ....*....|....*....|....*..
gi 749502286 718 TQHLDISALAKVSDGYTPGHILQAIQS 744
Cdd:COG0464  340 DEDVDLEELAEATEGLSGADIRNVVRR 366
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 545-677 6.71e-16

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 76.57  E-value: 6.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 545 VLRLGSPDIH--IMAPlIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQP 622
Cdd:cd19525   39 VWPMLRPDIFtgLRGP-PKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGE--GEKMVRALFSVARCKQP 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 749502286 623 SVIWIGNAEKNFYKKTPKEDKEmdPKRIKKDLTKALRLLT--PGDRVMLIGTTSRPQ 677
Cdd:cd19525  116 AVIFIDEIDSLLSQRGEGEHES--SRRIKTEFLVQLDGATtsSEDRILVVGATNRPQ 170
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 561-742 8.36e-16

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 79.28  E-value: 8.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRnGAQmMVHIVFKVARLLQPSVIWIgnaeknfykktpk 640
Cdd:COG1222  113 KGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGE-GAR-NVREVFELAREKAPSIIFI------------- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 641 eDkEMD---PKRIKKDLTKALR-----LLT------PGDRVMLIGTTSRPQL---AemrgLCRV--YERILFMPRPDYAS 701
Cdd:COG1222  178 -D-EIDaiaARRTDDGTSGEVQrtvnqLLAeldgfeSRGDVLIIAATNRPDLldpA----LLRPgrFDRVIEVPLPDEEA 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 749502286 702 RYVLWKRMIEARGIQPTqhLDISALAKVSDGYTpGHILQAI 742
Cdd:COG1222  252 REEILKIHLRDMPLADD--VDLDKLAKLTEGFS-GADLKAI 289
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 561-691 1.05e-15

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 75.27  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPK 640
Cdd:cd19524   34 RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGE--GEKLVRALFAVARELQPSIIFIDEVDSLLSERSEG 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 749502286 641 EDKEmdPKRIKKDLTKALRLLT--PGDRVMLIGTTSRPQLAEMRGLCRVYERI 691
Cdd:cd19524  112 EHEA--SRRLKTEFLIEFDGVQsnGDDRVLVMGATNRPQELDDAVLRRFTKRV 162
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 563-696 4.40e-15

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 72.63  E-value: 4.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  563 ILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWIgnaeKNFYKKTPKED 642
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKR--LRELFEAAKKLAPCVIFI----DEIDALAGSRG 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 749502286  643 KEMDP--KRIKKDLTKAL-RLLTPGDRVMLIGTTSRPQL--AEMRGLCrvyERILFMPR 696
Cdd:pfam00004  75 SGGDSesRRVVNQLLTELdGFTSSNSKVIVIAATNRPDKldPALLGRF---DRIIEFPL 130
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 561-677 3.60e-14

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 70.92  E-value: 3.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEkNFYKKTPK 640
Cdd:cd19520   36 KGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGE--SQKLVAAVFSLASKLQPSIIFIDEID-SFLRQRSS 112

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 749502286 641 EDKEMDPKRIKKDLTKALRLLT-PGDRVMLIGTTSRPQ 677
Cdd:cd19520  113 TDHEATAMMKAEFMSLWDGLSTdGNCRVIVMGATNRPQ 150
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 542-677 5.38e-14

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 70.30  E-value: 5.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 542 LYAVLRlgSPDIHIMAPLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQ 621
Cdd:cd19523   17 LWPLLR--PDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGE--GEKILQASFLAARCRQ 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 749502286 622 PSVIWIGNAEKNFykktPKEDKEMDP-KRIKKDLTKALR--LLTPGDRVMLIGTTSRPQ 677
Cdd:cd19523   93 PSVLFISDLDALL----SSQDDEASPvGRLQVELLAQLDgvLGSGEDGVLVVCTTSKPE 147
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 561-804 1.00e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 74.94  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPK 640
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGE--SEKAIREIFRKARQAAPAIIFFDEIDAIAPARGAR 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  641 EDKEMDPKRIKKDLTKALRLLTPGDrVMLIGTTSRPQLAEmRGLCRV--YERILFMPRPDYASRYVLWKrmIEARGIQPT 718
Cdd:TIGR01243 566 FDTSVTDRIVNQLLTEMDGIQELSN-VVVIAATNRPDILD-PALLRPgrFDRLILVPPPDEEARKEIFK--IHTRSMPLA 641

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  719 QHLDISALAKVSDGYTPGHilqaIQSVLSERRFLQLskRPLVASeflgqlVKLDPVYREEEESLKDWyfktplgKKSMKH 798
Cdd:TIGR01243 642 EDVDLEELAEMTEGYTGAD----IEAVCREAAMAAL--RESIGS------PAKEKLEVGEEEFLKDL-------KVEMRH 702


                  ....*.
gi 749502286  799 RMDQLE 804
Cdd:TIGR01243 703 FLEALK 708
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 561-676 5.63e-13

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 67.70  E-value: 5.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPK 640
Cdd:cd19522   34 KGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGE--SEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 749502286 641 EDKEMDpKRIKKDL-------TKALRLLTPGDRVMLIGTTSRP 676
Cdd:cd19522  112 EEHEAS-RRVKSELlvqmdgvGGASENDDPSKMVMVLAATNFP 153
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 560-676 1.28e-12

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 66.55  E-value: 1.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 560 IRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEknfyKKTP 639
Cdd:cd19503   34 PRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGE--SEKNLREIFEEARSHAPSIIFIDEID----ALAP 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 749502286 640 KEDK---EMDpKRIKKDLTKALRLLTPGDRVMLIGTTSRP 676
Cdd:cd19503  108 KREEdqrEVE-RRVVAQLLTLMDGMSSRGKVVVIAATNRP 146
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 561-678 4.84e-10

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 59.05  E-value: 4.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEknfyKKTPK 640
Cdd:cd19529   28 KGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGE--SEKAIREIFRKARQVAPCVIFFDEID----SIAPR 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 749502286 641 EDKEMD---PKRIKKDLTKALRLLTPGDRVMLIGTTSRPQL 678
Cdd:cd19529  102 RGTTGDsgvTERVVNQLLTELDGLEEMNGVVVIAATNRPDI 142
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 533-676 6.39e-10

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 58.65  E-value: 6.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 533 LFDIRQNVALYAVLRLGSPDIH----IMAPliRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQM 608
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYkalgIDLP--TGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGE--SER 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 609 MVHIVFKVARLLQPSVIWIgnaeKNFYKKTPKEDKEMD--PKRIKKDLTKALRLLTPGDRVMLIGTTSRP 676
Cdd:cd19530   77 AVRQVFQRARASAPCVIFF----DEVDALVPKRGDGGSwaSERVVNQLLTEMDGLEERSNVFVIAATNRP 142
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 561-784 6.68e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 62.62  E-value: 6.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEknfyKKTPK 640
Cdd:TIGR01243 213 KGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGE--SEERLREIFKEAEENAPSIIFIDEID----AIAPK 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286  641 EDK---EMDpKRIKKDLTKALRLLTPGDRVMLIGTTSRPQLAE--MRGLCRvYERILFMPRPDYASRYVLWKrmIEARGI 715
Cdd:TIGR01243 287 REEvtgEVE-KRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDpaLRRPGR-FDREIVIRVPDKRARKEILK--VHTRNM 362

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 749502286  716 QPTQHLDISALAKVSDGYTpGHILQAI---QSVLSERRFLQLSKRPLVASEFLGQLVK-LDPVYREEEESLKD 784
Cdd:TIGR01243 363 PLAEDVDLDKLAEVTHGFV-GADLAALakeAAMAALRRFIREGKINFEAEEIPAEVLKeLKVTMKDFMEALKM 434
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 561-676 2.10e-09

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 57.56  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGnaEKNFYKKTPK 640
Cdd:cd19521   41 SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGE--SEKLVKQLFAMARENKPSIIFID--EVDSLCGTRG 116

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 749502286 641 EDKEMDPKRIKKDLTKALR-LLTPGDRVMLIGTTSRP 676
Cdd:cd19521  117 EGESEASRRIKTELLVQMNgVGNDSQGVLVLGATNIP 153
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 561-682 1.53e-08

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 54.60  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIGNAEknfyKKTPK 640
Cdd:cd19511   28 KGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGE--SERAVREIFQKARQAAPCIIFFDEID----SLAPR 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 749502286 641 EDKEMD---PKRIKKDLTKALRLLTPGDRVMLIGTTSRPQL---AEMR 682
Cdd:cd19511  102 RGQSDSsgvTDRVVSQLLTELDGIESLKGVVVIAATNRPDMidpALLR 149
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 561-627 8.68e-08

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 52.72  E-value: 8.68e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGrNGAQmMVHIVFKVARLLQPSVIWI 627
Cdd:cd19502   38 KGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIG-EGAR-LVRELFEMAREKAPSIIFI 102
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 563-742 1.27e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 54.84  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 563 ILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRnGAQmMVHIVFKVARLLQPSVIWIgnaeknfykktpked 642
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKAPSIIFI--------------- 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 643 KEMDP---KRIkKDLTKALR--------LLT------PGDRVMLIGTTSRPQLAEmRGLCRV--YERILFMPRPDYASRY 703
Cdd:PRK03992 231 DEIDAiaaKRT-DSGTSGDRevqrtlmqLLAemdgfdPRGNVKIIAATNRIDILD-PAILRPgrFDRIIEVPLPDEEGRL 308

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 749502286 704 VLWKrmIEARGIQPTQHLDISALAKVSDGYTpGHILQAI 742
Cdd:PRK03992 309 EILK--IHTRKMNLADDVDLEELAELTEGAS-GADLKAI 344
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 561-676 1.79e-07

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 51.64  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWIGNAEknfyKKTPK 640
Cdd:cd19518   35 RGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEK--IRELFDQAISNAPCIVFIDEID----AITPK 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 749502286 641 ED---KEMDpKRIKKDLTKALRLL----TPGDRVMLIGTTSRP 676
Cdd:cd19518  109 REsaqREME-RRIVSQLLTCMDELnnekTAGGPVLVIGATNRP 150
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 561-676 1.92e-07

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 51.67  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMmvHIVFKVARLLQPSVIWIGNAEknfyKKTPK 640
Cdd:cd19519   35 RGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNL--RKAFEEAEKNAPAIIFIDEID----AIAPK 108

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 749502286 641 EDK---EMDpKRIKKDLTKALRLLTPGDRVMLIGTTSRP 676
Cdd:cd19519  109 REKthgEVE-RRIVSQLLTLMDGLKQRAHVIVMAATNRP 146
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 563-678 3.37e-07

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 50.59  E-value: 3.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 563 ILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKED 642
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEAN--VREVFQKARDAKPCVIFFDELDSLAPSRGNSGD 106

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 749502286 643 KEMDPKRIKKDLTKALR-LLTPGDRVMLIGTTSRPQL 678
Cdd:cd19527  107 SGGVMDRVVSQLLAELDgMSSSGQDVFVIGATNRPDL 143
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 561-627 1.06e-05

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 48.61  E-value: 1.06e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWI 627
Cdd:PTZ00454 180 RGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGE--GPRMVRDVFRLARENAPSIIFI 244
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 561-682 1.22e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 45.99  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTET---GANLFDLSPENLLGKYPGRNGAQM-MVHIVFKVARLLQPSVIWIGNAEKNFYK 636
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHfLVRLLFELAEKAKPGVLFIDEIDSLSRG 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 749502286 637 KTPKEDKEMDpkrikkdltKALRLLTPGDRVMLIGTTSRPQLAEMR 682
Cdd:cd00009  100 AQNALLRVLE---------TLNDLRIDRENVRVIGATNRPLLGDLD 136
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 558-678 2.83e-05

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 45.11  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 558 PLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRngAQMMVHIVFKVARLLQPSVIWIgnaeKNFYKK 637
Cdd:cd19526   25 RLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGA--SEQNVRDLFSRAQSAKPCILFF----DEFDSI 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 749502286 638 TPK--EDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQL 678
Cdd:cd19526   99 APKrgHDSTGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDL 141
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 561-627 3.52e-05

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 44.92  E-value: 3.52e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRnGAQmMVHIVFKVARLLQPSVIWI 627
Cdd:cd19501   38 KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGV-GAS-RVRDLFEQAKKNAPCIVFI 102
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 557-634 6.50e-05

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 43.90  E-value: 6.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 749502286 557 APLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMmvHIVFKVARLLQPSVIWIGNAEKNF 634
Cdd:cd19507   28 LPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRL--RQMIQTAEAIAPCVLWIDEIEKGF 103
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 561-627 1.44e-04

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 43.27  E-value: 1.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749502286 561 RSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQmmVHIVFKVARLLQPSVIWI 627
Cdd:cd19528   28 KGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEAN--VRDIFDKARAAAPCVLFF 92
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 546-629 1.73e-03

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 40.05  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286 546 LRLGSPdihimapLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYP------GRNGAQMM------VHIV 613
Cdd:cd19505    5 LRLGLS-------PSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKPdfgnddWIDGMLILkeslhrLNLQ 77

                         90
                 ....*....|....*.
gi 749502286 614 FKVARLLQPSVIWIGN 629
Cdd:cd19505   78 FELAKAMSPCIIWIPN 93
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 561-698 3.30e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 3.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749502286   561 RSILLVGPSGMGKKMLVKAVCTE-----------TGANLFDLSPENLLGKYPGRNGAQ----MMVHIVFKVARLLQPSVI 625
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARElgppgggviyiDGEDILEEVLDQLLLIIVGGKKASgsgeLRLRLALALARKLKPDVL 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749502286   626 WIGNAEKNFykktpkeDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQL---AEMRglcRVYERILFMPRPD 698
Cdd:smart00382  83 ILDEITSLL-------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDlgpALLR---RRFDRRIVLLLIL 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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