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Conserved domains on  [gi|740922492|ref|NP_001290330|]
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centrosomal protein of 97 kDa isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-242 1.00e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 1.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI----N 121
Cdd:cd21340   34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLtfdpR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 122 SCTA----LQHLDLSDNNISQIGDLSKLVSLKTLLlhgniitslrmapaylprslailsLAENEIRDLNEIS-FLASLTE 196
Cdd:cd21340  114 SLAAlsnsLRVLNISGNNIDSLEPLAPLRNLEQLD------------------------ASNNQISDLEELLdLLSSWPS 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 740922492 197 LEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340  170 LRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 496-516 1.85e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.85e-04
                         10        20
                 ....*....|....*....|.
gi 740922492 496 LQKLNDAATKLQACWRGFYAR 516
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-242 1.00e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 1.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI----N 121
Cdd:cd21340   34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLtfdpR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 122 SCTA----LQHLDLSDNNISQIGDLSKLVSLKTLLlhgniitslrmapaylprslailsLAENEIRDLNEIS-FLASLTE 196
Cdd:cd21340  114 SLAAlsnsLRVLNISGNNIDSLEPLAPLRNLEQLD------------------------ASNNQISDLEELLdLLSSWPS 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 740922492 197 LEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340  170 LRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-205 6.52e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 6.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  40 TLILDKNQIIKLENLEKCKRLIQLSVANNRlvrmmGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAM- 117
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 118 EQINSCTALQHLDLSDNNISQIGD-LSKLVSLKTLLLHGNIITSLRMAPAYLPrSLAILSLAENEIRDLNEisFLASLTE 196
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLT-NLEELDLSGNQLTDLPE--PLANLTN 229


                 ....*....
gi 740922492 197 LEQLSIMNN 205
Cdd:COG4886  230 LETLDLSNN 238
LRR_9 pfam14580
Leucine-rich repeat;
107-256 1.41e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.63  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  107 LNLAGNNLKAMEQIN-SCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIItsLRMAPA---YLPrSLAILSLAENEI 182
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRI--CRIGEGlgeALP-NLTELILTNNNL 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740922492  183 RDLNEISFLASLTELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGR 256
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGK 168
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-198 4.24e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  38 IHTLILDKNQIIKL-ENLEKckRLIQLSVANNRLVRM-------MGVAKLTLLRVLNLP-------------HNSIGCV- 95
Cdd:PRK15370 201 ITTLILDNNELKSLpENLQG--NIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsalqsldlfHNKISCLp 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  96 EGLKElvHLEWLNLAGNNLKAM-EQINSctALQHLDLSDNNISQIGDLSKLvSLKTLLLHGNIITSLrmaPAYLPRSLAI 174
Cdd:PRK15370 279 ENLPE--ELRYLSVYDNSIRTLpAHLPS--GITHLNVQSNSLTALPETLPP-GLKTLEAGENALTSL---PASLPPELQV 350

                        170       180
                 ....*....|....*....|....
gi 740922492 175 LSLAENEIRDLNEiSFLASLTELE 198
Cdd:PRK15370 351 LDVSKNQITVLPE-TLPPTITTLD 373
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 496-516 1.85e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.85e-04
                         10        20
                 ....*....|....*....|.
gi 740922492 496 LQKLNDAATKLQACWRGFYAR 516
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-242 1.00e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 1.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI----N 121
Cdd:cd21340   34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLtfdpR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 122 SCTA----LQHLDLSDNNISQIGDLSKLVSLKTLLlhgniitslrmapaylprslailsLAENEIRDLNEIS-FLASLTE 196
Cdd:cd21340  114 SLAAlsnsLRVLNISGNNIDSLEPLAPLRNLEQLD------------------------ASNNQISDLEELLdLLSSWPS 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 740922492 197 LEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340  170 LRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-205 6.52e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 6.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  40 TLILDKNQIIKLENLEKCKRLIQLSVANNRlvrmmGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAM- 117
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 118 EQINSCTALQHLDLSDNNISQIGD-LSKLVSLKTLLLHGNIITSLRMAPAYLPrSLAILSLAENEIRDLNEisFLASLTE 196
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLT-NLEELDLSGNQLTDLPE--PLANLTN 229


                 ....*....
gi 740922492 197 LEQLSIMNN 205
Cdd:COG4886  230 LETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-206 1.46e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 1.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  40 TLILDKNQIIKL-ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKA 116
Cdd:COG4886  163 SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 117 MEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTE 196
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                        170
                 ....*....|
gi 740922492 197 LEQLSIMNNP 206
Cdd:COG4886  323 LLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-206 2.50e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  40 TLILDKNQIIKL-ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAM 117
Cdd:COG4886  186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 118 EQINSCTALQHLDLSDNNIS--QIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLT 195
Cdd:COG4886  266 PPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                        170
                 ....*....|.
gi 740922492 196 ELEQLSIMNNP 206
Cdd:COG4886  346 LLALLTLLLLL 356
LRR_9 pfam14580
Leucine-rich repeat;
107-256 1.41e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.63  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  107 LNLAGNNLKAMEQIN-SCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIItsLRMAPA---YLPrSLAILSLAENEI 182
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRI--CRIGEGlgeALP-NLTELILTNNNL 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740922492  183 RDLNEISFLASLTELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGR 256
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGK 168
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-205 3.86e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 3.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  38 IHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAM 117
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 118 EQINSCTALQHLDLSDNNisqigDLSKLVSLKTLLLHGNIITSLrmaPAYLPR--SLAILSLAENEIRDLNEisFLASLT 195
Cdd:COG4886   90 TDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDL---PEELANltNLKELDLSNNQLTDLPE--PLGNLT 159

                        170
                 ....*....|
gi 740922492 196 ELEQLSIMNN 205
Cdd:COG4886  160 NLKSLDLSNN 169
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-198 4.24e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  38 IHTLILDKNQIIKL-ENLEKckRLIQLSVANNRLVRM-------MGVAKLTLLRVLNLP-------------HNSIGCV- 95
Cdd:PRK15370 201 ITTLILDNNELKSLpENLQG--NIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsalqsldlfHNKISCLp 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  96 EGLKElvHLEWLNLAGNNLKAM-EQINSctALQHLDLSDNNISQIGDLSKLvSLKTLLLHGNIITSLrmaPAYLPRSLAI 174
Cdd:PRK15370 279 ENLPE--ELRYLSVYDNSIRTLpAHLPS--GITHLNVQSNSLTALPETLPP-GLKTLEAGENALTSL---PASLPPELQV 350

                        170       180
                 ....*....|....*....|....
gi 740922492 175 LSLAENEIRDLNEiSFLASLTELE 198
Cdd:PRK15370 351 LDVSKNQITVLPE-TLPPTITTLD 373
LRR_8 pfam13855
Leucine rich repeat;
103-156 1.06e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 740922492  103 HLEWLNLAGNNLKAMEQ--INSCTALQHLDLSDNNISQI--GDLSKLVSLKTLLLHGN 156
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 103-144 1.37e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.62  E-value: 1.37e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 740922492  103 HLEWLNLAGNNLKAMEQINSCTALQHLDLSDNN-ISQIGDLSK 144
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-159 1.56e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  23 QGLQKLGPNLPCEADIHTLILDKNQI-----IKL-ENLEKCKRLIQLSVANNRL----VRMM--GVAKLTLLRVLNLPHN 90
Cdd:COG5238  251 EGVIALAEALKNNTTVETLYLSGNQIgaegaIALaKALQGNTTLTSLDLSVNRIgdegAIALaeGLQGNKTLHTLNLAYN 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  91 SIG------CVEGLKELVHLEWLNLAGNNLKA------MEQINSCTALQHLDLSDNNISQIG-----DLSKLVSLKTLLL 153
Cdd:COG5238  331 GIGaqgaiaLAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIGKQGaealiDALQTNRLHTLIL 410


                 ....*.
gi 740922492 154 HGNIIT 159
Cdd:COG5238  411 DGNLIG 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 128-205 1.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 1.79e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740922492 128 HLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYlpRSLAILSLAENEIRdlnEISFLASLTELEQLSIMNN 205
Cdd:cd21340    6 HLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIE---KIENLENLVNLKKLYLGGN 78
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 78-200 2.04e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  78 KLTLLRVLNLPHNSIG------CVEGLKELVHLEWLNLAGNNL-----KAM-EQINSCTALQHLDLSDNNISQIGdlskL 145
Cdd:cd00116  163 ANRDLKELNLANNGIGdagiraLAEGLKANCNLEVLDLNNNGLtdegaSALaETLASLKSLEVLNLGDNNLTDAG----A 238

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 740922492 146 VSLKTLLLHGNIitslrmapaylprSLAILSLAENEIRDLNEISFLASLTELEQL 200
Cdd:cd00116  239 AALASALLSPNI-------------SLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
LRR_8 pfam13855
Leucine rich repeat;
147-206 3.88e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.88e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  147 SLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFlASLTELEQLSIMNNP 206
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-205 5.84e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 5.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  23 QGLQKLGPNLPCEADIHTLILDKNQI------IKLENLEKCKRLIQLSVANNRLVR--MMGVAKL----TLLRVLNLPHN 90
Cdd:COG5238  195 EGIEELAEALTQNTTVTTLWLKRNPIgdegaeILAEALKGNKSLTTLDLSNNQIGDegVIALAEAlknnTTVETLYLSGN 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  91 SIGC------VEGLKELVHLEWLNLAGNNLKAMEQINSCTALQH------LDLSDNNISQIG------DLSKLVSLKTLL 152
Cdd:COG5238  275 QIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIGAQGaialakALQENTTLHSLD 354

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 153 LHGNIIT-----SLRMAPAYLPrSLAILSLAENEIRDLNEISFLASL--TELEQLSIMNN 205
Cdd:COG5238  355 LSDNQIGdegaiALAKYLEGNT-TLRELNLGKNNIGKQGAEALIDALqtNRLHTLILDGN 413
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 124-161 6.26e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 6.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 740922492  124 TALQHLDLSDNNISQIGDLSKLVSLKTL-LLHGNIITSL 161
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDL 39
LRR_8 pfam13855
Leucine rich repeat;
82-136 1.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 740922492   82 LRVLNLPHNSIGCVEG--LKELVHLEWLNLAGNNLKAMEQ--INSCTALQHLDLSDNNI 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-201 1.74e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  38 IHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEgLKELVHLEWLNLAGNNLKAM 117
Cdd:COG4886  230 LETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 118 EQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTEL 197
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388


                 ....
gi 740922492 198 EQLS 201
Cdd:COG4886  389 LLLL 392
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 496-516 1.85e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.85e-04
                         10        20
                 ....*....|....*....|.
gi 740922492 496 LQKLNDAATKLQACWRGFYAR 516
Cdd:cd23767    5 LQRMNRAATLIQALWRGYKVR 25
PLN03150 PLN03150
hypothetical protein; Provisional
 101-156 5.31e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 101 LVHLEWLNLAGNNLKAM--EQINSCTALQHLDLSDN--NISQIGDLSKLVSLKTLLLHGN 156
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNsfNGSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
63-114 1.22e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 740922492   63 LSVANNRLVRMMGVA--KLTLLRVLNLPHNSIGCVEG--LKELVHLEWLNLAGNNL 114
Cdd:pfam13855   6 LDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-205 1.47e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492  76 VAKLTLLRVLNLPHNSI--GCVEGLKELVHLEWLNLAGNNLKAM--EQINSCTALQHLDLSDNNI-----SQIGDLSKlv 146
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLvgQIPRELGQMKSLKWIYLGYNNLSGEipYEIGGLTSLNHLDLVYNNLtgpipSSLGNLKN-- 261

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740922492 147 sLKTLLLHGNIITSLRMAPAYLPRSLAILSLAEN----EIRDLneisfLASLTELEQLSIMNN 205
Cdd:PLN00113 262 -LQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNslsgEIPEL-----VIQLQNLEILHLFSN 318
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 104-182 6.55e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 6.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740922492 104 LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNIS-----QIGDLSklvSLKTLLLHGNIITSlrMAPAYLPR--SLAILS 176
Cdd:PLN00113 120 LRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgeipnDIGSFS---SLKVLDLGGNVLVG--KIPNSLTNltSLEFLT 194


                 ....*.
gi 740922492 177 LAENEI 182
Cdd:PLN00113 195 LASNQL 200
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 82-114 8.27e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 8.27e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 740922492   82 LRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNL 114
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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