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Conserved domains on  [gi|665394841|ref|NP_001287480|]
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secretory 13, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-288 3.35e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 3.35e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWAHPkfGNILASCSYDRKVIVWKSTT 89
Cdd:COG2319  117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLW-DLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PRdwtKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVsvltcnteyGVWDAK-----KIPNAHTIGVNAISWcpaqA 164
Cdd:COG2319  194 GK---LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTV---------RLWDLAtgkllRTLTGHSGSVRSVAF----S 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 PDPafdqrvtsrsaavKRLVSGGCDNLVKIWreDNDRWVEEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWs 244
Cdd:COG2319  256 PDG-------------RLLASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPD----GKLLASGSDDGTVRLW- 315

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 665394841 245 snaDLSewTSTVLHTFD---DAVWSISWSTTGNILAVTGGDNNVTLW 288
Cdd:COG2319  316 ---DLA--TGKLLRTLTghtGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-288 3.35e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 3.35e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWAHPkfGNILASCSYDRKVIVWKSTT 89
Cdd:COG2319  117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLW-DLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PRdwtKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVsvltcnteyGVWDAK-----KIPNAHTIGVNAISWcpaqA 164
Cdd:COG2319  194 GK---LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTV---------RLWDLAtgkllRTLTGHSGSVRSVAF----S 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 PDPafdqrvtsrsaavKRLVSGGCDNLVKIWreDNDRWVEEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWs 244
Cdd:COG2319  256 PDG-------------RLLASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPD----GKLLASGSDDGTVRLW- 315

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 665394841 245 snaDLSewTSTVLHTFD---DAVWSISWSTTGNILAVTGGDNNVTLW 288
Cdd:COG2319  316 ---DLA--TGKLLRTLTghtGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 1.27e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 1.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWaHPKfGNILASCSYDRKVIVWKSTT 89
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDKTIRLW-DLETGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PrdwTKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVsvltcnteyGVWDAKKIP-----NAHTIGVNAISWCPAQa 164
Cdd:cd00200  125 G---KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTI---------KLWDLRTGKcvatlTGHTGEVNSVAFSPDG- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 pdpafdqrvtsrsaavKRLVSGGCDNLVKIWREDNDRWVeeHRLEAHSDWVRDVAWAPSIGLprsqIATASQDRHVIVWS 244
Cdd:cd00200  190 ----------------EKLLSSSSDGTIKLWDLSTGKCL--GTLRGHENGVNSVAFSPDGYL----LASGSEDGTIRVWD 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 665394841 245 SnadlseWTSTVLHTF---DDAVWSISWSTTGNILAVTGGDNNVTLWK 289
Cdd:cd00200  248 L------RTGECVQTLsghTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-86 2.37e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.37e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665394841    45 NNKALAELKGHQGPVWQVAWAHpkFGNILASCSYDRKVIVWK 86
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
46-85 3.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 665394841   46 NKALAELKGHQGPVWQVAWahPKFGNILASCSYDRKVIVW 85
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 24-85 1.64e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665394841  24 YGLLLATCSSDGSVRIFHSRKNNKALAE-------LKGHQGPVWQVAWaHPKFGNILASCSYDRKVIVW 85
Cdd:PTZ00420  86 FSEILASGSEDLTIRVWEIPHNDESVKEikdpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFVNIW 153
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-288 3.35e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 3.35e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWAHPkfGNILASCSYDRKVIVWKSTT 89
Cdd:COG2319  117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLW-DLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PRdwtKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVsvltcnteyGVWDAK-----KIPNAHTIGVNAISWcpaqA 164
Cdd:COG2319  194 GK---LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTV---------RLWDLAtgkllRTLTGHSGSVRSVAF----S 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 PDPafdqrvtsrsaavKRLVSGGCDNLVKIWreDNDRWVEEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWs 244
Cdd:COG2319  256 PDG-------------RLLASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPD----GKLLASGSDDGTVRLW- 315

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 665394841 245 snaDLSewTSTVLHTFD---DAVWSISWSTTGNILAVTGGDNNVTLW 288
Cdd:COG2319  316 ---DLA--TGKLLRTLTghtGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
10-288 6.88e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 6.88e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAAL--DfyGLLLATCSSDGSVRIFHSRkNNKALAELKGHQGPVWQVAWAHPkfGNILASCSYDRKVIVWKS 87
Cdd:COG2319  159 TGHSGAVTSVAFspD--GKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  88 TTPRdwtKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVSVltcnteygvWDAK-----KIPNAHTIGVNAISWcpa 162
Cdd:COG2319  234 ATGK---LLRTLTGHSGSVRSVAFSPD--GRLLASGSADGTVRL---------WDLAtgellRTLTGHSGGVNSVAF--- 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 163 qAPDPafdqrvtsrsaavKRLVSGGCDNLVKIWREDNDRWVeeHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIV 242
Cdd:COG2319  297 -SPDG-------------KLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRL 356

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 665394841 243 WSSNadlsewTSTVLHTF---DDAVWSISWSTTGNILAVTGGDNNVTLW 288
Cdd:COG2319  357 WDLA------TGELLRTLtghTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 1.27e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 1.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWaHPKfGNILASCSYDRKVIVWKSTT 89
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDKTIRLW-DLETGECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVET 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PrdwTKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVsvltcnteyGVWDAKKIP-----NAHTIGVNAISWCPAQa 164
Cdd:cd00200  125 G---KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTI---------KLWDLRTGKcvatlTGHTGEVNSVAFSPDG- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 pdpafdqrvtsrsaavKRLVSGGCDNLVKIWREDNDRWVeeHRLEAHSDWVRDVAWAPSIGLprsqIATASQDRHVIVWS 244
Cdd:cd00200  190 ----------------EKLLSSSSDGTIKLWDLSTGKCL--GTLRGHENGVNSVAFSPDGYL----LASGSEDGTIRVWD 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 665394841 245 SnadlseWTSTVLHTF---DDAVWSISWSTTGNILAVTGGDNNVTLWK 289
Cdd:cd00200  248 L------RTGECVQTLsghTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-288 1.79e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 1.79e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWAHPkfGNILASCSYDRKVIVWKSTT 89
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLW-DLATGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PRdwtKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVSVltcnteygvWDAK-----KIPNAHTIGVNAISWcpaqA 164
Cdd:COG2319  152 GK---LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRL---------WDLAtgkllRTLTGHTGAVRSVAF----S 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 PDPafdqrvtsrsaavKRLVSGGCDNLVKIWREDNDRWVeeHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWS 244
Cdd:COG2319  214 PDG-------------KLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPD----GRLLASGSADGTVRLWD 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 665394841 245 SNADLSEWTstvLHTFDDAVWSISWSTTGNILAVTGGDNNVTLW 288
Cdd:COG2319  275 LATGELLRT---LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-293 7.72e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 7.72e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWAHpkFGNILASCSYDRKVIVWKSTT 89
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-DLETGELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PRdwtKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVsvltcnteyGVWD-----AKKIPNAHTIGVNAISWCPAQa 164
Cdd:cd00200   83 GE---CVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTI---------KVWDvetgkCLTTLRGHTDWVNSVAFSPDG- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 pdpafdqrvtsrsaavKRLVSGGCDNLVKIWreDNDRWVEEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWs 244
Cdd:cd00200  148 ----------------TFVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW- 204

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 665394841 245 snaDLSEWTST-VLHTFDDAVWSISWSTTGNILAVTGGDNNVTLWKENTE 293
Cdd:cd00200  205 ---DLSTGKCLgTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
10-244 5.24e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 5.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFhSRKNNKALAELKGHQGPVWQVAWaHPKfGNILASCSYDRKVIVWKSTT 89
Cdd:COG2319  201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW-DLATGKLLRTLTGHSGSVRSVAF-SPD-GRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PRdwtKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVSVltcnteygvWDAK-----KIPNAHTIGVNAISWcpaqA 164
Cdd:COG2319  278 GE---LLRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRL---------WDLAtgkllRTLTGHTGAVRSVAF----S 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 PDPafdqrvtsrsaavKRLVSGGCDNLVKIWreDNDRWVEEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWS 244
Cdd:COG2319  340 PDG-------------KTLASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSPD----GRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
10-288 5.48e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.00  E-value: 5.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFHSRkNNKALAELKGHQGPVWQVAWAHPkfGNILASCSYDRKVIVWKSTT 89
Cdd:COG2319   33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA-AGALLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  90 PRDWTKLyeySNHDSSVNSVDFAPSeyGLVLACASSDGSVSVltcnteygvWDAK-----KIPNAHTIGVNAISWcpaqA 164
Cdd:COG2319  110 GLLLRTL---TGHTGAVRSVAFSPD--GKTLASGSADGTVRL---------WDLAtgkllRTLTGHSGAVTSVAF----S 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 165 PDPafdqrvtsrsaavKRLVSGGCDNLVKIWREDNDRWVeeHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWS 244
Cdd:COG2319  172 PDG-------------KLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRLWD 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 665394841 245 SNadlSEWTSTVLHTFDDAVWSISWSTTGNILAVTGGDNNVTLW 288
Cdd:COG2319  233 LA---TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-297 2.36e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 2.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  49 LAELKGHQGPVWQVAWaHPKfGNILASCSYDRKVIVWKSTTPrdwTKLYEYSNHDSSVNSVDFapSEYGLVLACASSDGS 128
Cdd:cd00200    2 RRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAA--SADGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 129 VSVltcnteygvWDAKKIP-----NAHTIGVNAISWCPaqapdpafDQRVtsrsaavkrLVSGGCDNLVKIWreDNDRWV 203
Cdd:cd00200   75 IRL---------WDLETGEcvrtlTGHTSYVSSVAFSP--------DGRI---------LSSSSRDKTIKVW--DVETGK 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 204 EEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWssnaDLSEWTS-TVLHTFDDAVWSISWSTTGNILAVTGGD 282
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPD----GTFVASSSQDGTIKLW----DLRTGKCvATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                        250
                 ....*....|....*
gi 665394841 283 NNVTLWkENTEGQWI 297
Cdd:cd00200  199 GTIKLW-DLSTGKCL 212
WD40 COG2319
WD40 repeat [General function prediction only];
10-89 1.89e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  10 TEHEDMVHHAALDFYGLLLATCSSDGSVRIFHsRKNNKALAELKGHQGPVWQVAWAHPkfGNILASCSYDRKVIVWKSTT 89
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-293 1.68e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841 204 EEHRLEAHSDWVRDVAWAPSIGLprsqIATASQDRHVIVWSSNADLSEWTSTVlHTfdDAVWSISWSTTGNILAVTGGDN 283
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL----LATGSGDGTIKVWDLETGELLRTLKG-HT--GPVRDVAASADGTYLASGSSDK 73

                         90
                 ....*....|
gi 665394841 284 NVTLWKENTE 293
Cdd:cd00200   74 TIRLWDLETG 83
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-86 2.37e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.37e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665394841    45 NNKALAELKGHQGPVWQVAWAHpkFGNILASCSYDRKVIVWK 86
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
46-85 3.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 665394841   46 NKALAELKGHQGPVWQVAWahPKFGNILASCSYDRKVIVW 85
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-244 8.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 8.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 665394841   202 WVEEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWS 244
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 24-85 1.64e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665394841  24 YGLLLATCSSDGSVRIFHSRKNNKALAE-------LKGHQGPVWQVAWaHPKFGNILASCSYDRKVIVW 85
Cdd:PTZ00420  86 FSEILASGSEDLTIRVWEIPHNDESVKEikdpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFVNIW 153
PTZ00420 PTZ00420
coronin; Provisional
 35-131 3.35e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.16  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394841  35 GSVRIfHSRKNNKALAELKGHQGPVWQVAWaHPKFGNILASCSYDRKVIVWKstTPRDWTKLYEYSN-------HDSSVN 107
Cdd:PTZ00420  54 GAIRL-ENQMRKPPVIKLKGHTSSILDLQF-NPCFSEILASGSEDLTIRVWE--IPHNDESVKEIKDpqcilkgHKKKIS 129

                         90       100
                 ....*....|....*....|....
gi 665394841 108 SVDFAPSEYgLVLACASSDGSVSV 131
Cdd:PTZ00420 130 IIDWNPMNY-YIMCSSGFDSFVNI 152
WD40 pfam00400
WD domain, G-beta repeat;
202-244 3.96e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 665394841  202 WVEEHRLEAHSDWVRDVAWAPSiglpRSQIATASQDRHVIVWS 244
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 7.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 665394841    92 DWTKLYEYSNHDSSVNSVDFAPSeyGLVLACASSDGSVSV 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-289 8.43e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665394841   256 VLHTFDDAVWSISWSTTGNILAVTGGDNNVTLWK 289
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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