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Conserved domains on  [gi|665393550|ref|NP_001287232|]
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uncharacterized protein Dmel_CG7443, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
kgd super family cl39092
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 22-109 6.21e-07

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


The actual alignment was detected with superfamily member PRK12270:

Pssm-ID: 476867 [Multi-domain]  Cd Length: 1228  Bit Score: 46.81  E-value: 6.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393550   22 DTDWWTILEDilYDNDSDsddagdenvfvqAAPNATANGSTVAPQAGGAAPGSSPGAPATPPgsTPAVPATVAPETPAPS 101
Cdd:PRK12270   26 DPSWREFFAD--YGPGST------------AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPA--PPAAAAPAAPPKPAAA 89


                  ....*...
gi 665393550  102 APATSPQP 109
Cdd:PRK12270   90 AAAAAAPA 97
 
Name Accession Description Interval E-value
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 22-109 6.21e-07

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.81  E-value: 6.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393550   22 DTDWWTILEDilYDNDSDsddagdenvfvqAAPNATANGSTVAPQAGGAAPGSSPGAPATPPgsTPAVPATVAPETPAPS 101
Cdd:PRK12270   26 DPSWREFFAD--YGPGST------------AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPA--PPAAAAPAAPPKPAAA 89


                  ....*...
gi 665393550  102 APATSPQP 109
Cdd:PRK12270   90 AAAAAAPA 97
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 42-110 7.56e-05

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 7.56e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665393550   42 DAGDENVFVQAAPNATANGSTVAPQAGGAAPGSSPGAPATP-PGSTPAVPATVAPETPAP-SAPATSPQPV 110
Cdd:TIGR00601  65 KEKDFVVVMVSKPKTGTGKVAPPAATPTSAPTPTPSPPASPaSGMSAAPASAVEEKSPSEeSATATAPESP 135
 
Name Accession Description Interval E-value
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 22-109 6.21e-07

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.81  E-value: 6.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393550   22 DTDWWTILEDilYDNDSDsddagdenvfvqAAPNATANGSTVAPQAGGAAPGSSPGAPATPPgsTPAVPATVAPETPAPS 101
Cdd:PRK12270   26 DPSWREFFAD--YGPGST------------AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPA--PPAAAAPAAPPKPAAA 89


                  ....*...
gi 665393550  102 APATSPQP 109
Cdd:PRK12270   90 AAAAAAPA 97
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 57-110 2.67e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.18  E-value: 2.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 665393550   57 TANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPV 110
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPA 87
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 34-109 2.97e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.18  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665393550   34 YDNDSDSDDAGDENVFVQAAPNATANGSTVAPQAGGAAPGSSPgAPATPPGSTPAVPATVAPETPAPSAPATSPQP 109
Cdd:PRK12270   18 YLADPNSVDPSWREFFADYGPGSTAAPTAAAAAAAAAASAPAA-APAAKAPAAPAPAPPAAAAPAAPPKPAAAAAA 92
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 42-110 7.56e-05

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 7.56e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665393550   42 DAGDENVFVQAAPNATANGSTVAPQAGGAAPGSSPGAPATP-PGSTPAVPATVAPETPAP-SAPATSPQPV 110
Cdd:TIGR00601  65 KEKDFVVVMVSKPKTGTGKVAPPAATPTSAPTPTPSPPASPaSGMSAAPASAVEEKSPSEeSATATAPESP 135
PRK10856 PRK10856
cytoskeleton protein RodZ;
35-111 1.73e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 39.62  E-value: 1.73e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393550  35 DNDSDSDDAGDENVFVQAAPNATANGSTVAP--QAGGAAPGSSPGAPATPPGSTPAVPATVApetpAPSAPATSPQPVV 111
Cdd:PRK10856 181 PVDTTPTNSQTPAVATAPAPAVDPQQNAVVApsQANVDTAATPAPAAPATPDGAAPLPTDQA----GVSTPAADPNALV 255
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 50-110 2.14e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 2.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665393550  50 VQAAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPV 110
Cdd:PRK14951 385 EAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV 445
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
47-110 4.05e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 38.60  E-value: 4.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665393550  47 NVFVQAAPNATANGST---VAPQAGGAAPGSSPGAPATPPGSTPAVPATVAP-ETPAPSAPATSPQPV 110
Cdd:PRK14971 393 SAAAAASPSPSQSSAAaqpSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPqAVRPAQFKEEKKIPV 460
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 52-109 1.63e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 37.00  E-value: 1.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665393550  52 AAPNATANGSTVAPQAGGAAPGSSPGAPATPPGStpAVPATVAPETPAPSAPATSPQP 109
Cdd:PRK14951 427 AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV--AIPVRVAPEPAVASAAPAPAAA 482
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 50-111 2.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 36.38  E-value: 2.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665393550  50 VQAAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPVV 111
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLL 423
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 36-111 3.18e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 36.22  E-value: 3.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665393550  36 NDSDSDDAGDENVFVQAAPNATANGSTVAPQAGGAAPGSSPgaPATPPGSTPAVPATVAPETPAPSAPATSPQPVV 111
Cdd:PLN02217 581 NTTFSSDSPSTVVAPSTSPPAGHLGSPPATPSKIVSPSTSP--PASHLGSPSTTPSSPESSIKVASTETASPESSI 654
PRK10856 PRK10856
cytoskeleton protein RodZ;
52-110 6.06e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 35.39  E-value: 6.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 665393550  52 AAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQPV 110
Cdd:PRK10856 168 TTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPA 226
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
47-109 6.78e-03

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 35.21  E-value: 6.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665393550  47 NVFVQAAPNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPaVPATVAPETPAPSAPATSPQP 109
Cdd:PRK11907  22 NPKLAQAEEIVTTTPATSTEAEQTTPVESDATEEADNTETP-VAATTAAEAPSSSETAETSDP 83
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
54-110 7.15e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 35.14  E-value: 7.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665393550  54 PNATANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSaPATSPQPV 110
Cdd:PRK14971 392 PSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNP-PSTAPQAV 447
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 67-131 8.46e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 35.08  E-value: 8.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665393550  67 AGGAAPGSSPGAPATPPGSTPA---VPATVAPETPAPSAPATSPQPVVTALPTAAPPTAAPPTAAPGG 131
Cdd:PRK14951 369 AAEAAAPAEKKTPARPEAAAPAaapVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAA 436
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 57-109 8.56e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 34.96  E-value: 8.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665393550  57 TANGSTVAPQAGGAAPGSSPGAPATPPGSTPAVPATVAPETPAPSAPATSPQP 109
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAP 439
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 52-110 9.76e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 34.69  E-value: 9.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665393550  52 AAPNATANGSTVAPQAGGAAPGSSPGAPATPPG---STPAVPATVAPETPAPSAPATSPQPV 110
Cdd:PRK14951 376 AEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAaaaSAPAAPPAAAPPAPVAAPAAAAPAAA 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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