F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

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gi 665410334   6 IEELYNDCLYHIFDFLTT-EDRIIFAQVCHRFRQL 39
Cdd:cd22163    1 INDLDDDCLMHIFSFLTPlPDRFNAARVCKRWRAL 35

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 665410334   6 IEELYNDCLYHIFDFLTT-EDRIIFAQVCHRFRQL 39
Cdd:cd22163    1 INDLDDDCLMHIFSFLTPlPDRFNAARVCKRWRAL 35

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 665410334    6 IEELYNDCLYHIFDFLTTEDRIIFAQVCHRFRQLF 40
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLV 35

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 665410334   6 IEELYNDCLYHIFDFLTT-EDRIIFAQVCHRFRQL 39
Cdd:cd22163    1 INDLDDDCLMHIFSFLTPlPDRFNAARVCKRWRAL 35

F-box domain found in F-box/LRR-repeat protein 22 (FBXL22) and similar proteins; FBXL22, also called F-box and leucine-rich repeat protein 22, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC). It acts as a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 665410334   6 IEELYNDCLYHIFDFLTTEDRIIFAQVCHRFRQLFIN 42
Cdd:cd22129    1 ITELNRECLLHLFSFLDKDSRRSLSLTCHRLRDVFLD 37

F-box domain found in F-box/LRR-repeat protein 3 (FBXL3) and similar proteins; FBXL3, also called F-box and leucine-rich repeat protein 3A, or F-box/LRR-repeat protein 3A, is the substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex that mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2, and thus, is involved in circadian rhythm function. It plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 665410334   8 ELYNDCLYHIFDFLTTEDRIIFAQVCHRFRQLF 40
Cdd:cd22178    5 NLLQDIILQIFQYLPLLDRAHASQVCRNWNQVF 37

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 665410334   6 IEELYNDCLYHIFDFLTTEDRIIFAQVCHRFRQL 39
Cdd:cd22123    1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWRRL 34

F-box-like; This is an F-box-like family.

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gi 665410334    6 IEELYNDCLYHIFDFLTTEDRIIFAQVCHRFRQL 39
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWREL 34