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Conserved domains on  [gi|665409853|ref|NP_001286929|]
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uncharacterized protein Dmel_CG12012, isoform C [Drosophila melanogaster]

Protein Classification

brain protein I3( domain architecture ID 10562754)

brain protein I3 is a DUF2367 domain-containing protein that participates in tumor necrosis factor-alpha (TNF)-induced cell death

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRI3 pfam10164
Brain protein I3; This is a highly conserved family of proteins which contains three pairs of ...
 20-122 2.72e-34

Brain protein I3; This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.


:

Pssm-ID: 431102  Cd Length: 104  Bit Score: 114.62  E-value: 2.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409853   20 PSQDSRLIVGVHQGAPSAPPPNMHMPTYGAFETTPVSVVIQPapvamPTEIIVIGGCPACRIGYLEDTFSACGLCCAIFF 99
Cdd:pfam10164   7 TAPPQYLITYVVTQAPPPYQYPDGPAVSQQPQQTTYTIVVQP-----TQSVVVVGGCPACRVGVLEDDFTCLGILCAIFF 81

                          90       100
                  ....*....|....*....|...
gi 665409853  100 FPLGILCCLAMREKRCSNCGTVF 122
Cdd:pfam10164  82 FPIGILCCLAMRQRRCPNCGATF 104
 
Name Accession Description Interval E-value
BRI3 pfam10164
Brain protein I3; This is a highly conserved family of proteins which contains three pairs of ...
 20-122 2.72e-34

Brain protein I3; This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.


Pssm-ID: 431102  Cd Length: 104  Bit Score: 114.62  E-value: 2.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409853   20 PSQDSRLIVGVHQGAPSAPPPNMHMPTYGAFETTPVSVVIQPapvamPTEIIVIGGCPACRIGYLEDTFSACGLCCAIFF 99
Cdd:pfam10164   7 TAPPQYLITYVVTQAPPPYQYPDGPAVSQQPQQTTYTIVVQP-----TQSVVVVGGCPACRVGVLEDDFTCLGILCAIFF 81

                          90       100
                  ....*....|....*....|...
gi 665409853  100 FPLGILCCLAMREKRCSNCGTVF 122
Cdd:pfam10164  82 FPIGILCCLAMRQRRCPNCGATF 104
 
Name Accession Description Interval E-value
BRI3 pfam10164
Brain protein I3; This is a highly conserved family of proteins which contains three pairs of ...
 20-122 2.72e-34

Brain protein I3; This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.


Pssm-ID: 431102  Cd Length: 104  Bit Score: 114.62  E-value: 2.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409853   20 PSQDSRLIVGVHQGAPSAPPPNMHMPTYGAFETTPVSVVIQPapvamPTEIIVIGGCPACRIGYLEDTFSACGLCCAIFF 99
Cdd:pfam10164   7 TAPPQYLITYVVTQAPPPYQYPDGPAVSQQPQQTTYTIVVQP-----TQSVVVVGGCPACRVGVLEDDFTCLGILCAIFF 81

                          90       100
                  ....*....|....*....|...
gi 665409853  100 FPLGILCCLAMREKRCSNCGTVF 122
Cdd:pfam10164  82 FPIGILCCLAMRQRRCPNCGATF 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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