second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  270 DYADAALVFTADGSNDYLrqdsgTSEYGFRPKIELPCHKAILSARSPFFRNLIARRTRNMDEyveRSLHVPTRIVLDETV 349
Cdd:cd18284     1 DYGDAVLVFASDKETVES-----SSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGED---RTLSTPTRIVLDESI 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665391661  350 IPKRYARVLLQAIYLDSVDLSLILRGVGSGTSAGSlgevHALTNTGRVRPTTLEEAMELYQIGRFLELDILAQGCEDL 427
Cdd:cd18284    73 IPRRYARVLLHAMYTDSVDLSLILRSSPSESSLSE----VQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  166 LCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHD-PNIDITL 244
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDsRSQNLDV 80

                          90
                  ....*....|..
gi 665391661  245 LRQLGKDFGTPN 256
Cdd:cd18283    81 LIQLSEEFGTPN 92

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  270 DYADAALVFTADGSNDYLrqdsgTSEYGFRPKIELPCHKAILSARSPFFRNLIARRTRNMDEyveRSLHVPTRIVLDETV 349
Cdd:cd18284     1 DYGDAVLVFASDKETVES-----SSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGED---RTLSTPTRIVLDESI 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665391661  350 IPKRYARVLLQAIYLDSVDLSLILRGVGSGTSAGSlgevHALTNTGRVRPTTLEEAMELYQIGRFLELDILAQGCEDL 427
Cdd:cd18284    73 IPRRYARVLLHAMYTDSVDLSLILRSSPSESSLSE----VQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  166 LCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHD-PNIDITL 244
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDsRSQNLDV 80

                          90
                  ....*....|..
gi 665391661  245 LRQLGKDFGTPN 256
Cdd:cd18283    81 LIQLSEEFGTPN 92

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665391661    169 DCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPtsPIDVQLFSSLLRYLYTGDLCPHDPNIDITL 244
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD--DVSPEDFRALLNFLYTGKLDLPEENVEELL 74

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661   456 QACQYLREEFAAVSSSPVLHQLDKSQLIHILHSNFLQ-ASELEVLQAVLKWGEQELIRRMEDRePNLLSH 524
Cdd:pfam07707   19 AALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERRKKHL-PELLSA 87

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10
                   ....*....|....*....
gi 665391661   303 ELPCHKAILSARSPFFRNL 321
Cdd:pfam00651   21 EFRAHKAVLAACSPYFKAL 39

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  270 DYADAALVFTADGSNDYLrqdsgTSEYGFRPKIELPCHKAILSARSPFFRNLIARRTRNMDEyveRSLHVPTRIVLDETV 349
Cdd:cd18284     1 DYGDAVLVFASDKETVES-----SSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGED---RTLSTPTRIVLDESI 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665391661  350 IPKRYARVLLQAIYLDSVDLSLILRGVGSGTSAGSlgevHALTNTGRVRPTTLEEAMELYQIGRFLELDILAQGCEDL 427
Cdd:cd18284    73 IPRRYARVLLHAMYTDSVDLSLILRSSPSESSLSE----VQAIVAGKGPETRLEEAMELYHIARFLEFDILAQGCEDI 146

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  166 LCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHD-PNIDITL 244
Cdd:cd18283     1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDsRSQNLDV 80

                          90
                  ....*....|..
gi 665391661  245 LRQLGKDFGTPN 256
Cdd:cd18283    81 LIQLSEEFGTPN 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661   163 EKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPtsPIDVQLFSSLLRYLYTGDLCPHDpNIDI 242
Cdd:pfam00651    6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD--DVSPEDFEALLEFMYTGKLISEE-NVDD 82

                           90       100
                   ....*....|....*....|....*.
gi 665391661   243 TLlrQLGKDFGTPNPLEHDLRYLLET 268
Cdd:pfam00651   83 LL--AAADKLQIPSLVDKCEEFLIKS 106

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665391661    169 DCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPtsPIDVQLFSSLLRYLYTGDLCPHDPNIDITL 244
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD--DVSPEDFRALLNFLYTGKLDLPEENVEELL 74

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  162 YEKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLagCPGFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHDPNid 241
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSML--TGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEEN-- 76

                          90
                  ....*....|....*....
gi 665391661  242 ITLLRQLGKDFGTPNPLEH 260
Cdd:cd18314    77 VLDLLMLASKYQVPDLEKL 95

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  156 QDLAAIYEKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPTspIDVQLFSSLLRYLYtGDLCP 235
Cdd:cd18286     6 KDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTG--VSHAAVSFVLLFIY-GGVLD 82

                  ....*...
gi 665391661  236 HDPNIDIT 243
Cdd:cd18286    83 LPDDVNLG 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  150 PAATFKQDLAAIYEKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELptSPIDVQLFSSLLRYLY 229
Cdd:cd18344     6 PRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEI--HDLDPQVFKEMMGFIY 83

                  ....*..
gi 665391661  230 TGDlCPH 236
Cdd:cd18344    84 TGK-APH 89

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665391661  156 QDLAAIYEKNLCTDCDLVFRGTI-FSVHRAILSARCVYFRDLlagcpgFGARICLELpTSPIDVQLFSSLLRYLYTGDL 233
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADL------FLMMTVVTL-DSDITPEAFRRVLEFLYTGVL 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665391661  164 KNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLlagcpgFGARIC--LELPTSpIDVQLFSSLLRYLYTGDL 233
Cdd:cd18290    24 QGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDL------FNSSRSavVELPAA-VQPQSFQQILSFCYTGRL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665391661  170 CDLVFRGTIFSVHRAILSARCVYFRDLLAGcpGFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHDPNIDITLL 245
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRG--GFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLE 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  150 PAATFKQDLAAIYEKNLCTDCDLVFRGTIFSVHRAILSARcvyfrdllagCPGFGARICLELPTSP--------IDVQLF 221
Cdd:cd18343     4 PECRLAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAAR----------SPVFNAMFEHEMEESKknrveindVDPEVF 73

                          90       100
                  ....*....|....*....|
gi 665391661  222 SSLLRYLYTGDLcphdPNID 241
Cdd:cd18343    74 KEMMRFIYTGKA----PNLD 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665391661  168 TDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCP-GFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHDPNIDITL 244
Cdd:cd18258    18 TDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSrDSGGGEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLL 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665391661  170 CDLVF----RGTIFSVHRAILSARCVYFRDLLAgcPGFGAriclELPTSPIDVQ-----LFSSLLRYLYTG 231
Cdd:cd18294    15 SDVKFlvgpERQEIFAHKCILAARCEVFRAMFL--TGPQK----ESTQSPLVLSdiepeVFRAVLEFIYTN 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665391661  171 DLVFR--GTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPTSPIDVqlFSSLLRYLYTG--DLCPHD 237
Cdd:cd18298    14 DLKFRvdGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPV--YYAFLRYLYTDqvDLPPED 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665391661  171 DLVFR--GTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPTSPIDVqlFSSLLRYLYTGDL-CPHDPNIDI 242
Cdd:cd18297    14 DVTFLveGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDI--FQLMMQYLYTGGVeSLDVAQDDA 86

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665391661  171 DLVFR--GTIFSVHRAILSARCVYFRDLLAGcpGFGARIC-------LELPTSPIDVqlFSSLLRYLYTGD 232
Cdd:cd18296    19 DVCFQveGHRFPCHKAFFCGRSDYFKALLRD--HFAESEEnngsipvVTLHDVSPEV--FAIVLYYIYTDD 85

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 665391661  455 RQAC-QYLREEFAAVSSSPVLHQLDKSQLIHILHSNFLQ-ASELEVLQAVLKW 505
Cdd:cd18493    21 AEAClEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVvEDEYTLFQAVEKW 73

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20
                  ....*....|....*....|
gi 665391661  305 PCHKAILSARSPFFRNLIAR 324
Cdd:cd18283    15 PVHRAILSARCPFFRDLLSS 34

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  156 QDLAAIYEKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLagCPGF--GARICLELPT-SPIDVQLfssLLRYLYTGD 232
Cdd:cd18263     2 QSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMF--TSGMkeSTQSVVQLPTiPAKDLRL---LISFAYSGI 76

                  .
gi 665391661  233 L 233
Cdd:cd18263    77 L 77

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665391661  452 WVFRQACQYLREEFAAVSSSPVLHQLDKSQLIHILHSNFLQA-SELEVLQAVLKWGEQELIRR---MEDREPNLLSHTA 526
Cdd:cd18455    19 HVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVgNEEYIFEAVLRWVRHDPEERkvhLKDLMSSCWRSGL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665391661  163 EKNLCtDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARICLELPTSPIDVQLFSSLLRYLYTG 231
Cdd:cd18245    11 EPHLC-DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTG 78

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  154 FKQDLAAIYEKNLCTDCDLVFR-GTIFSVHRAILSARCVYFRDLLAGCPGFGAriCLELPtSPIDVQLFSSLLRYLYTGD 232
Cdd:cd18311     1 FLQRLQNLFNKTEYCDLTLQFRdNEQLKVHRLVLSACTDYFNVLEQTCEIVDD--TLIMP-NELQADAVVPVINFMYTGQ 77

                  .
gi 665391661  233 L 233
Cdd:cd18311    78 L 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  156 QDLAAIYEKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAgcpgFGARICLELPTSPIDVQLFSSLLRYLYTGDLCP 235
Cdd:cd18193    10 QQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFV----HQTSECVRLKPTDIQPDIFSYLLHLMYTGKMAP 85

                  ....*
gi 665391661  236 H--DP 238
Cdd:cd18193    86 QliDP 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665391661  163 EKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLagCPGFGARICLELPTSPIDVQLFSSLLRYLYTGDLCPHDPNI 240
Cdd:cd18253    14 DSRLFTDVIICVEGREFPCHRAILSACSSYFRAMF--CNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENV 89

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665391661  171 DLVF--RGTIFSVHRAILSARCVYFRDLLAGcPGFGARICLeLPTSPIDVQLFSSLLRYLYTGDLCP 235
Cdd:cd18360    12 DVVFkiQGTTVPAHRAVLVARCEVMAAMFNG-NYAEAKSFL-VPIYGVSKDTFLSFLEYLYTDSCCP 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665391661  164 KNLCTDCDLVFRGTIFSVHRAILSARCVYFRDLLAGcpgfGARICLELPTSPIDV---QLFSSLLRYLYTGDL 233
Cdd:cd18199    15 QDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSH----YIQDTGRPSTASFDVfssDAFSIILDFVYSGKL 83

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391661  168 TDCDLVFRGTIFSVHRAILSARCVYFRDLLAGCPGFGARIcLELP-TSPIDVQLfssLLRYLYTGDLC-PHDpniDITLL 245
Cdd:cd18315     2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPV-IILPdVPYSELKA---LLDFIYTGEVNvSQE---QLESL 74

                  ....*...
gi 665391661  246 RQLGKDFG 253
Cdd:cd18315    75 LKLAELLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665391661  153 TFKQDLAAIYEKNLCTDCDLVFRGTIFSVHRAILSARCVYFRDL-------LAGCPGFGARICLE 210
Cdd:cd18243    18 NLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLfsinnlvLQGCSSIGLRLVLE 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665391661  170 CD--LVFRGTIFSVHRAILSARCVYFRDLLAGcpGFGARICLELPTSPIDVQLFSSLLRYLYTGDL 233
Cdd:cd18256    21 CDvqLQVGMELFSVHRLVLAASSPYFAALFAG--GMSESSKDVVQIHGVEPDIFHILLDFIYTGVV 84

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665391661  446 QPHGSAWVFRQACQYLREEFAAVSSSPVLHQLDKSQLIHILHSNFLQA-SELEVLQAVLKWGEQELIRR 513
Cdd:cd18458    15 EQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVrCESEVYNAVIRWVKYDEENR 83