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Conserved domains on  [gi|665391156|ref|NP_001285211|]
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neuropilin and tolloid-like, isoform B [Drosophila melanogaster]

Protein Classification

neuropilin and tolloid-like protein( domain architecture ID 10035862)

neuropilin and tolloid-like protein is a CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to Homo sapiens neuropilin and tolloid-like protein 1 involved in the development and/or maintenance of neuronal circuitry

Gene Ontology:  GO:0045202|GO:0098696

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 151-252 9.07e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 131.00  E-value: 9.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156 151 ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRnSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSKER 230
Cdd:cd00041   12 TISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFE-DFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGN 90

                         90       100
                 ....*....|....*....|..
gi 665391156 231 YLWLHFHSDETIEYTGFSAVYE 252
Cdd:cd00041   91 SLTVRFRSDSSVTGRGFKATYS 112
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 298-384 2.66e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.45  E-value: 2.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156 298 LDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGS-AGESITAESNILHLRFYADQTAINS 376
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGStLPPPIISSGNSLTVRFRSDSSVTGR 105


                 ....*...
gi 665391156 377 TFGILFTA 384
Cdd:cd00041  106 GFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 392-426 3.66e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.12  E-value: 3.66e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 665391156 392 CTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC 426
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 151-252 9.07e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 131.00  E-value: 9.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156 151 ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRnSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSKER 230
Cdd:cd00041   12 TISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFE-DFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGN 90

                         90       100
                 ....*....|....*....|..
gi 665391156 231 YLWLHFHSDETIEYTGFSAVYE 252
Cdd:cd00041   91 SLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 151-251 8.38e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.42  E-value: 8.38e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156   151 ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFrNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPE-ITSKE 229
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSS 80

                           90       100
                   ....*....|....*....|..
gi 665391156   230 RYLWLHFHSDETIEYTGFSAVY 251
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
151-251 2.70e-29

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 112.39  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156  151 ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFrNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSKER 230
Cdd:pfam00431  11 SISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSSN 89

                          90       100
                  ....*....|....*....|.
gi 665391156  231 YLWLHFHSDETIEYTGFSAVY 251
Cdd:pfam00431  90 QMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 298-384 2.66e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.45  E-value: 2.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156 298 LDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGS-AGESITAESNILHLRFYADQTAINS 376
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGStLPPPIISSGNSLTVRFRSDSSVTGR 105


                 ....*...
gi 665391156 377 TFGILFTA 384
Cdd:cd00041  106 GFKATYSA 113
CUB pfam00431
CUB domain;
299-382 5.86e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 60.00  E-value: 5.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156  299 DCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGS-AGESITAESNILHLRFYADQTAINST 377
Cdd:pfam00431  26 DCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSgIPEDIVSSSNQMTIKFVSDASVQKRG 105


                  ....*
gi 665391156  378 FGILF 382
Cdd:pfam00431 106 FKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 298-370 2.27e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 55.47  E-value: 2.27e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665391156   298 LDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGSAG--ESITAESNILHLRFYAD 370
Cdd:smart00042  16 LDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAppPVISSSSNSLTLTFVSD 90
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 392-426 3.66e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.12  E-value: 3.66e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 665391156 392 CTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC 426
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 151-252 9.07e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 131.00  E-value: 9.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156 151 ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRnSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSKER 230
Cdd:cd00041   12 TISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFE-DFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGN 90

                         90       100
                 ....*....|....*....|..
gi 665391156 231 YLWLHFHSDETIEYTGFSAVYE 252
Cdd:cd00041   91 SLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 151-251 8.38e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.42  E-value: 8.38e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156   151 ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFrNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPE-ITSKE 229
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSS 80

                           90       100
                   ....*....|....*....|..
gi 665391156   230 RYLWLHFHSDETIEYTGFSAVY 251
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
151-251 2.70e-29

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 112.39  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156  151 ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFrNSFNIEAKEGCKFDFLEIRDGQYGFSTLIGKFCGTDFPPEITSKER 230
Cdd:pfam00431  11 SISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSSN 89

                          90       100
                  ....*....|....*....|.
gi 665391156  231 YLWLHFHSDETIEYTGFSAVY 251
Cdd:pfam00431  90 QMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 298-384 2.66e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.45  E-value: 2.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156 298 LDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGS-AGESITAESNILHLRFYADQTAINS 376
Cdd:cd00041   26 LNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGStLPPPIISSGNSLTVRFRSDSSVTGR 105


                 ....*...
gi 665391156 377 TFGILFTA 384
Cdd:cd00041  106 GFKATYSA 113
CUB pfam00431
CUB domain;
299-382 5.86e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 60.00  E-value: 5.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391156  299 DCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGS-AGESITAESNILHLRFYADQTAINST 377
Cdd:pfam00431  26 DCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSgIPEDIVSSSNQMTIKFVSDASVQKRG 105


                  ....*
gi 665391156  378 FGILF 382
Cdd:pfam00431 106 FKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 298-370 2.27e-09

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 55.47  E-value: 2.27e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665391156   298 LDCIWRIQVKENWKIFLKFLDFKLSKPNDCQTNFLDIFPEQTVMPLRVKNFCGSAG--ESITAESNILHLRFYAD 370
Cdd:smart00042  16 LDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAppPVISSSSNSLTLTFVSD 90
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 392-426 3.66e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.12  E-value: 3.66e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 665391156 392 CTEDEYDCEDATCISKDLKCNNLDNCKFRWDEEGC 426
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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