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Conserved domains on  [gi|665390429|ref|NP_001285049|]
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aladin, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
152-336 1.14e-14

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 152 LAVAGVDDVVRIYTKSSSATTATVlkSPSQTQITCMAWRPlCASEIVIGCRQG-LCFWEVDSTLHLGRTNAPSEifkypn 230
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGKLLRTLTGHSG------ 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 231 nlPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRLGPPGSL---LKWSPDNDWLFAATVDRVFRVWNCHQQWT 307
Cdd:COG2319  248 --SVRSVAFSPDGRLLASGS-ADGTVRLWDLATG--ELLRTLTGHSGGvnsVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                        170       180
                 ....*....|....*....|....*....
gi 665390429 308 TeRWVCGPGGYVQTACWSPCGRFLLFVSS 336
Cdd:COG2319  323 L-RTLTGHTGAVRSVAFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
152-336 1.14e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 152 LAVAGVDDVVRIYTKSSSATTATVlkSPSQTQITCMAWRPlCASEIVIGCRQG-LCFWEVDSTLHLGRTNAPSEifkypn 230
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGKLLRTLTGHSG------ 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 231 nlPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRLGPPGSL---LKWSPDNDWLFAATVDRVFRVWNCHQQWT 307
Cdd:COG2319  248 --SVRSVAFSPDGRLLASGS-ADGTVRLWDLATG--ELLRTLTGHSGGvnsVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                        170       180
                 ....*....|....*....|....*....
gi 665390429 308 TeRWVCGPGGYVQTACWSPCGRFLLFVSS 336
Cdd:COG2319  323 L-RTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-398 5.45e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 5.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 140 VRYLAWNQHFFCLAVAGVDDVVRIYTKSSSATTATVLKSPSqtQITCMAWRPlcASEIVIGCRQG--LCFWEVDSTLHLG 217
Cdd:cd00200   54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTS--YVSSVAFSP--DGRILSSSSRDktIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 218 RTNAPSEifkypnnlPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRL-GPPGSL--LKWSPDNDWLFAATVD 294
Cdd:cd00200  130 TLRGHTD--------WVNSVAFSPDGTFVASSS-QDGTIKLWDLRTG--KCVATLtGHTGEVnsVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 295 RVFRVWNChqqwTTERWVC---GPGGYVQTACWSPCGRFLlfvssaepilyrlqfvqqsllsSSADEKEILPIADLNACS 371
Cdd:cd00200  199 GTIKLWDL----STGKCLGtlrGHENGVNSVAFSPDGYLL----------------------ASGSEDGTIRVWDLRTGE 252

                        250       260
                 ....*....|....*....|....*....
gi 665390429 372 IDanRTLVG--GPAQQLAWDPHGNYLVVT 398
Cdd:cd00200  253 CV--QTLSGhtNSVTSLAWSPDGKRLASG 279
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-259 2.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.07e-03
                           10        20
                   ....*....|....*....|....*..
gi 665390429   233 PITSMQWNKDGTQLATASiGDRSIIIW 259
Cdd:smart00320  14 PVTSVAFSPDGKYLASGS-DDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 279-331 8.98e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 665390429  279 LKWSPDNDWLFAATVD---RVFRVwNCHQQWTTErwVCGPGGYVQTACWSPCGRFL 331
Cdd:pfam12894   1 MSWCPTMDLIALATEDgelLLHRL-NWQRVWTLS--PDKEDLEVTSLAWRPDGKLL 53
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
152-336 1.14e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 152 LAVAGVDDVVRIYTKSSSATTATVlkSPSQTQITCMAWRPlCASEIVIGCRQG-LCFWEVDSTLHLGRTNAPSEifkypn 230
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSP-DGKLLASGSADGtVRLWDLATGKLLRTLTGHSG------ 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 231 nlPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRLGPPGSL---LKWSPDNDWLFAATVDRVFRVWNCHQQWT 307
Cdd:COG2319  248 --SVRSVAFSPDGRLLASGS-ADGTVRLWDLATG--ELLRTLTGHSGGvnsVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                        170       180
                 ....*....|....*....|....*....
gi 665390429 308 TeRWVCGPGGYVQTACWSPCGRFLLFVSS 336
Cdd:COG2319  323 L-RTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
152-336 3.42e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 3.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 152 LAVAGVDDVVRIYtkssSATTATVLKSPS--QTQITCMAWRP---LCASeiviGCRQG-LCFWEVDSTLHLGRTNAPSEi 225
Cdd:COG2319  219 LASGSADGTVRLW----DLATGKLLRTLTghSGSVRSVAFSPdgrLLAS----GSADGtVRLWDLATGELLRTLTGHSG- 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 226 fkypnnlPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRLGPPGSL---LKWSPDNDWLFAATVDRVFRVWNC 302
Cdd:COG2319  290 -------GVNSVAFSPDGKLLASGS-DDGTVRLWDLATG--KLLRTLTGHTGAvrsVAFSPDGKTLASGSDDGTVRLWDL 359

                        170       180       190
                 ....*....|....*....|....*....|....
gi 665390429 303 HQQWTTERWVcGPGGYVQTACWSPCGRFLLFVSS 336
Cdd:COG2319  360 ATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
103-336 1.23e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 103 AQFLGLATGLRILPHTQQLSAERIAQFVETRDWLNSDVRYLAWNQHFFCLAVAGVDDVVRIYTKSSSATTATVLksPSQT 182
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL--GHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 183 QITCMAWRPLCASEIVIGCRQGLCFWEVDSTLHLGRTNAPSEifkypnnlPITSMQWNKDGTQLATASiGDRSIIIWQPD 262
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG--------AVRSVAFSPDGKTLASGS-ADGTVRLWDLA 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665390429 263 TGmmQPLKRL-GPPGSL--LKWSPDNDWLFAATVDRVFRVWNChQQWTTERWVCGPGGYVQTACWSPCGRFLLFVSS 336
Cdd:COG2319  151 TG--KLLRTLtGHSGAVtsVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-398 5.45e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 5.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 140 VRYLAWNQHFFCLAVAGVDDVVRIYTKSSSATTATVLKSPSqtQITCMAWRPlcASEIVIGCRQG--LCFWEVDSTLHLG 217
Cdd:cd00200   54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTS--YVSSVAFSP--DGRILSSSSRDktIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 218 RTNAPSEifkypnnlPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRL-GPPGSL--LKWSPDNDWLFAATVD 294
Cdd:cd00200  130 TLRGHTD--------WVNSVAFSPDGTFVASSS-QDGTIKLWDLRTG--KCVATLtGHTGEVnsVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 295 RVFRVWNChqqwTTERWVC---GPGGYVQTACWSPCGRFLlfvssaepilyrlqfvqqsllsSSADEKEILPIADLNACS 371
Cdd:cd00200  199 GTIKLWDL----STGKCLGtlrGHENGVNSVAFSPDGYLL----------------------ASGSEDGTIRVWDLRTGE 252

                        250       260
                 ....*....|....*....|....*....
gi 665390429 372 IDanRTLVG--GPAQQLAWDPHGNYLVVT 398
Cdd:cd00200  253 CV--QTLSGhtNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-331 1.10e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 137 NSDVRYLAWNQHFFCLAVAGVDDVVRIYtKSSSATTATVLKSPSQTqITCMAWRPlcASEIVIGCRQglcfwevDSTLHL 216
Cdd:cd00200   93 TSYVSSVAFSPDGRILSSSSRDKTIKVW-DVETGKCLTTLRGHTDW-VNSVAFSP--DGTFVASSSQ-------DGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 217 --GRTNAPSEIFKyPNNLPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRL-GPPGSL--LKWSPDNDWLFAA 291
Cdd:cd00200  162 wdLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLSTG--KCLGTLrGHENGVnsVAFSPDGYLLASG 237

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 665390429 292 TVDRVFRVWNchqqwtTERWVC-----GPGGYVQTACWSPCGRFL 331
Cdd:cd00200  238 SEDGTIRVWD------LRTGECvqtlsGHTNSVTSLAWSPDGKRL 276
WD40 COG2319
WD40 repeat [General function prediction only];
152-301 4.08e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 4.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 152 LAVAGVDDVVRIYtkssSATTATVLKSPSQTQ--ITCMAWRP-----LCASEivigcrqglcfwevDSTLHLGRTNAPSE 224
Cdd:COG2319  261 LASGSADGTVRLW----DLATGELLRTLTGHSggVNSVAFSPdgkllASGSD--------------DGTVRLWDLATGKL 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 225 IFKYP-NNLPITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRL-GPPGSL--LKWSPDNDWLFAATVDRVFRVW 300
Cdd:COG2319  323 LRTLTgHTGAVRSVAFSPDGKTLASGS-DDGTVRLWDLATG--ELLRTLtGHTGAVtsVAFSPDGRTLASGSADGTVRLW 399


                 .
gi 665390429 301 N 301
Cdd:COG2319  400 D 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-332 2.84e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 2.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 233 PITSMQWNKDGTQLATASiGDRSIIIWqpDTGMMQPLKRL-GPPGSLLK--WSPDNDWLFAATVDRVFRVWN-----CHQ 304
Cdd:cd00200   11 GVTCVAFSPDGKLLATGS-GDGTIKVW--DLETGELLRTLkGHTGPVRDvaASADGTYLASGSSDKTIRLWDletgeCVR 87

                         90       100
                 ....*....|....*....|....*...
gi 665390429 305 QWTTERwvcgpgGYVQTACWSPCGRFLL 332
Cdd:cd00200   88 TLTGHT------SYVSSVAFSPDGRILS 109
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-301 3.90e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 3.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 137 NSDVRYLAWNQHFFCLAVAGVDDVVRIYtKSSSATTATVLKSPSQtQITCMAWRPLcASEIVIGCRQGLC-FWEVDSTLH 215
Cdd:cd00200  135 TDWVNSVAFSPDGTFVASSSQDGTIKLW-DLRTGKCVATLTGHTG-EVNSVAFSPD-GEKLLSSSSDGTIkLWDLSTGKC 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 216 LGrtnapseIFKYPNNlPITSMQWNKDGtQLATASIGDRSIIIWQPDTG-MMQPLKRLGPPGSLLKWSPDNDWLFAATVD 294
Cdd:cd00200  212 LG-------TLRGHEN-GVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGeCVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*..
gi 665390429 295 RVFRVWN 301
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
233-397 1.11e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 233 PITSMQWNKDGTQLATASiGDRSIIIWQPDTGmmQPLKRLGPPGSL---LKWSPDNDWLFAATVDRVFRVWNcHQQWTTE 309
Cdd:COG2319   80 AVLSVAFSPDGRLLASAS-ADGTVRLWDLATG--LLLRTLTGHTGAvrsVAFSPDGKTLASGSADGTVRLWD-LATGKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 310 RWVCGPGGYVQTACWSPCGRFLLfvssaepilyrlqfvqqsllSSSADEKeilpIADLNACSIDANRTLVG--GPAQQLA 387
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLA--------------------SGSDDGT----VRLWDLATGKLLRTLTGhtGAVRSVA 211

                        170
                 ....*....|
gi 665390429 388 WDPHGNYLVV 397
Cdd:COG2319  212 FSPDGKLLAS 221
WD40 COG2319
WD40 repeat [General function prediction only];
152-263 3.58e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 3.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 152 LAVAGVDDVVRIYTKSSSATTATVlkSPSQTQITCMAWRPLcASEIVIGCRQG-LCFWEVDSTLHLGRTNAPSEifkypn 230
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPD-GKTLASGSDDGtVRLWDLATGELLRTLTGHTG------ 373

                         90       100       110
                 ....*....|....*....|....*....|...
gi 665390429 231 nlPITSMQWNKDGTQLATASiGDRSIIIWQPDT 263
Cdd:COG2319  374 --AVTSVAFSPDGRTLASGS-ADGTVRLWDLAT 403
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 235-346 1.88e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.97  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390429 235 TSMQWNKDGTQLATASIGDRSIIIWQ--PDTGMMQPLKRLGPPGSLLKWSPDNDWL-FAATVDRVFRVWNCHQQWTTERW 311
Cdd:COG0823   34 TSPAWSPDGRRIAFTSDRGGGPQIYVvdADGGEPRRLTFGGGYNASPSWSPDGKRLaFVSRSDGRFDIYVLDLDGGAPRR 113

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 665390429 312 VCGPGGyvqTACWSPCGRFLLFVS--SAEPILYRLQF 346
Cdd:COG0823  114 LTDGPG---SPSWSPDGRRIVFSSdrGGRPDLYVVDL 147
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-259 2.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.07e-03
                           10        20
                   ....*....|....*....|....*..
gi 665390429   233 PITSMQWNKDGTQLATASiGDRSIIIW 259
Cdd:smart00320  14 PVTSVAFSPDGKYLASGS-DDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 279-331 8.98e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 665390429  279 LKWSPDNDWLFAATVD---RVFRVwNCHQQWTTErwVCGPGGYVQTACWSPCGRFL 331
Cdd:pfam12894   1 MSWCPTMDLIALATEDgelLLHRL-NWQRVWTLS--PDKEDLEVTSLAWRPDGKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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