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Conserved domains on  [gi|614458207|ref|NP_001278438|]
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pre-B-cell leukemia transcription factor 1 isoform d [Mus musculus]

Protein Classification

PBC and homeodomain domain-containing protein( domain architecture ID 11145417)

PBC and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 42-232 3.68e-110

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


:

Pssm-ID: 461052  Cd Length: 181  Bit Score: 318.17  E-value: 3.68e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458207   42 DIGDILQQIMTITDQSLDEA--QARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAG 119
Cdd:pfam03792   1 DISDLLQQIMKITDMSLDEAavNKLKHALNCHPMYPALFSVLCEIKEKTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458207  120 PEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIER 199
Cdd:pfam03792  81 PEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEFRPITPKEIER 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 614458207  200 MVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 232
Cdd:pfam03792 149 MVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 252-282 2.12e-10

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 55.21  E-value: 2.12e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 614458207  252 FYSHLSNPYPSEEAKEELAKKCGITVSQVDT 282
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISN 31
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 42-232 3.68e-110

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 318.17  E-value: 3.68e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458207   42 DIGDILQQIMTITDQSLDEA--QARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAG 119
Cdd:pfam03792   1 DISDLLQQIMKITDMSLDEAavNKLKHALNCHPMYPALFSVLCEIKEKTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458207  120 PEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIER 199
Cdd:pfam03792  81 PEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEFRPITPKEIER 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 614458207  200 MVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 232
Cdd:pfam03792 149 MVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 252-282 2.12e-10

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 55.21  E-value: 2.12e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 614458207  252 FYSHLSNPYPSEEAKEELAKKCGITVSQVDT 282
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISN 31
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 234-280 5.73e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 54.56  E-value: 5.73e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 614458207 234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQV 280
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQV 44
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 234-280 2.26e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 52.64  E-value: 2.26e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 614458207   234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQV 280
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQV 45
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
 42-232 3.68e-110

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 318.17  E-value: 3.68e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458207   42 DIGDILQQIMTITDQSLDEA--QARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAG 119
Cdd:pfam03792   1 DISDLLQQIMKITDMSLDEAavNKLKHALNCHPMYPALFSVLCEIKEKTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458207  120 PEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIER 199
Cdd:pfam03792  81 PEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEFRPITPKEIER 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 614458207  200 MVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 232
Cdd:pfam03792 149 MVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 252-282 2.12e-10

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 55.21  E-value: 2.12e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 614458207  252 FYSHLSNPYPSEEAKEELAKKCGITVSQVDT 282
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISN 31
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 234-280 5.73e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 54.56  E-value: 5.73e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 614458207 234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQV 280
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQV 44
Homeodomain pfam00046
Homeodomain;
234-280 1.57e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 53.27  E-value: 1.57e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 614458207  234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQV 280
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQV 44
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 234-280 2.26e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 52.64  E-value: 2.26e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 614458207   234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQV 280
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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