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Conserved domains on  [gi|590122050|ref|NP_001277214|]
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DNA excision repair protein ERCC-8 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-208 1.59e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050   4 KYITIGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDVRRASgCLITLdqhngkks 81
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDLATGK-LLRTL-------- 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  82 qavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS 161
Cdd:COG2319  243 -------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNS-----VAFSPDGK 301

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 590122050 162 TIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:COG2319  302 LLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-208 1.59e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050   4 KYITIGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDVRRASgCLITLdqhngkks 81
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDLATGK-LLRTL-------- 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  82 qavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS 161
Cdd:COG2319  243 -------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNS-----VAFSPDGK 301

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 590122050 162 TIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:COG2319  302 LLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-208 3.51e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 3.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  15 VQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLITLDQHNG----------KKSQAV 84
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTDwvnsvafspdGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  85 ESAN-----------------TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKvcNNSKKGLKFTVS 147
Cdd:cd00200  153 SSQDgtiklwdlrtgkcvatlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAFSPD 230

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 590122050 148 ----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:cd00200  231 gyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 22-62 1.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 1.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 590122050    22 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 62
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
23-62 3.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 3.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 590122050   23 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 62
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 19-129 6.49e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 6.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  19 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 74
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 590122050  75 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 129
Cdd:PTZ00420 191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-208 1.59e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050   4 KYITIGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDVRRASgCLITLdqhngkks 81
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDLATGK-LLRTL-------- 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  82 qavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS 161
Cdd:COG2319  243 -------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNS-----VAFSPDGK 301

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 590122050 162 TIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:COG2319  302 LLAsgsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
4-208 1.72e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.72e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050   4 KYITIGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPryD-YILATASADSRVKLWDVRRASgCLITLdqhngkksq 82
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--DgRLLASGSADGTVRLWDLATGE-LLRTL--------- 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  83 avesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYG 160
Cdd:COG2319  285 ------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDG 342

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 590122050 161 STIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:COG2319  343 KTLAsgsddgtvrLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
4-208 1.33e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050   4 KYITIGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPryD-YILATASADSRVKLWDVrrASG-CLITLdqhngkks 81
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--DgKTLASGSADGTVRLWDL--ATGkLLRTL-------- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  82 qavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPY 159
Cdd:COG2319  159 -------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPD 215

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 590122050 160 GSTIA---------VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:COG2319  216 GKLLAsgsadgtvrLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-208 3.51e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 3.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  15 VQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLITLDQHNG----------KKSQAV 84
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTDwvnsvafspdGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  85 ESAN-----------------TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKvcNNSKKGLKFTVS 147
Cdd:cd00200  153 SSQDgtiklwdlrtgkcvatlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAFSPD 230

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 590122050 148 ----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:cd00200  231 gyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
4-120 2.09e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050   4 KYITIGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRrASGCLITLdqhngkksqa 83
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLA-TGELLRTL---------- 368

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 590122050  84 vesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 120
Cdd:COG2319  369 -----TGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-208 3.07e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 3.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  25 CSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVrrasgclitldqhngkKSQAVESANTAHNGKVNGLCFTSDG 104
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL----------------ETGELLRTLKGHTGPVRDVAASADG 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050 105 LHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS---------TIAVYTVYSGEQIT 175
Cdd:cd00200   64 TYLASGSSDKTIRLWDLETGE---------CVRTLTGHTSYVSS-----VAFSPDGRilssssrdkTIKVWDVETGKCLT 129

                        170       180       190
                 ....*....|....*....|....*....|...
gi 590122050 176 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-208 3.10e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 3.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  14 KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVrRASGCLITLdqhngkksqavesanTAHNG 93
Cdd:cd00200   32 TIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL-ETGECVRTL---------------TGHTS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  94 KVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCGCSSEF-VFVPYGS---TIAVYTVY 169
Cdd:cd00200   95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGK---------CLTTLRGHTDWVNSVAFSPDgTFVASSSqdgTIKLWDLR 165

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 590122050 170 SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-120 7.05e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 7.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  19 DLKSGSCSHILQGHRQEILAVSWSPRyDYILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGL 98
Cdd:cd00200  205 DLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGE-CVQTL---------------SGHTNSVTSL 267

                         90       100
                 ....*....|....*....|..
gi 590122050  99 CFTSDGLHLLTVGTDNRMRLWN 120
Cdd:cd00200  268 AWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-64 6.16e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 6.16e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 590122050   4 KYITIGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVR 64
Cdd:COG2319  343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 22-62 1.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 1.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 590122050    22 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 62
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
19-208 1.45e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  19 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAsgCLITLdqhngkksqavesanTAHNGKVNGL 98
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA--LLATL---------------LGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  99 CFTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCGCSSE----FVFVPYGSTIAVYTVYSGEQI 174
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGL---------LLRTLTGHTGAVRSVAFSPdgktLASGSADGTVRLWDLATGKLL 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 590122050 175 TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 pfam00400
WD domain, G-beta repeat;
23-62 3.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 3.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 590122050   23 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 62
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 19-129 6.49e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 6.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  19 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 74
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 590122050  75 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 129
Cdd:PTZ00420 191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
PTZ00421 PTZ00421
coronin; Provisional
 20-124 4.94e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 4.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050  20 LKSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRasgclitldqhnGKKSQAVESantaHNGKVNG 97
Cdd:PTZ00421 110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER------------GKAVEVIKC----HSDQITS 173

                         90       100
                 ....*....|....*....|....*..
gi 590122050  98 LCFTSDGLHLLTVGTDNRMRLWNSSNG 124
Cdd:PTZ00421 174 LEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 89-120 2.79e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.79e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 590122050    89 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 120
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 39-125 1.28e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 590122050   39 VSWSPRYDyILATASADSRVklwDVRRASGclitldqhngkksQAVESANT-AHNGKVNGLCFTSDGlHLLTVGT-DNRM 116
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGEL---LLHRLNW-------------QRVWTLSPdKEDLEVTSLAWRPDG-KLLAVGYsDGTV 62


                  ....*....
gi 590122050  117 RLWNSSNGE 125
Cdd:pfam12894  63 RLLDAENGK 71
WD40 pfam00400
WD domain, G-beta repeat;
89-120 2.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 590122050   89 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 120
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 170-208 3.53e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 3.53e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 590122050   170 SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
171-208 3.81e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 3.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 590122050  171 GEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 208
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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