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Conserved domains on  [gi|573459770|ref|NP_001275979|]
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solute carrier family 22 member 17 isoform c [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 88-258 9.53e-96

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17445:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 346  Bit Score: 286.29  E-value: 9.53e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  88 KNLLILGFTNFIAHAIRHCYQPVGGG--GSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLL 165
Cdd:cd17445  174 KNLLILGFTTFIAHAISHCYQSFSDDvrGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILL 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 166 GLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAA 245
Cdd:cd17445  254 GLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLAS 333

                        170
                 ....*....|...
gi 573459770 246 CALLCILSIMLLP 258
Cdd:cd17445  334 LALLAILSIMLLP 346
 
Name Accession Description Interval E-value
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 88-258 9.53e-96

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 286.29  E-value: 9.53e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  88 KNLLILGFTNFIAHAIRHCYQPVGGG--GSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLL 165
Cdd:cd17445  174 KNLLILGFTTFIAHAISHCYQSFSDDvrGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILL 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 166 GLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAA 245
Cdd:cd17445  254 GLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLAS 333

                        170
                 ....*....|...
gi 573459770 246 CALLCILSIMLLP 258
Cdd:cd17445  334 LALLAILSIMLLP 346
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-267 4.17e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 95.85  E-value: 4.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770    2 ITAPCILFLFYGWpgLFLESARWLIVKRQIEEAQSVLRILAERNRPHgQMLGEEAQEALQDLENTCPLPatssfSFASLL 81
Cdd:TIGR00898 249 VSLPTFLFFLLSW--FVPESPRWLISQGRIEEALKILQRIAKINGKK-LPAEVLSLSLEKDLSSSKKQY-----SFLDLF 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   82 NYRNIWKNLLILgftNFIAHAIRHCYQ--PVGGGGSPSDFYLcSLLASGTAALACVFLG-VTVDRFGRRGILLLSMTLTG 158
Cdd:TIGR00898 321 RTPNLRKTTLCL---MMLWFTTAFSYYglVLDLGNLGGNIYL-DLFISGLVELPAKLITlLLIDRLGRRYTMAASLLLAG 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  159 IASLVLLGLWDYLnEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFL 238
Cdd:TIGR00898 397 VALLLLLFVPVDL-YFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFL 475

                         250       260
                  ....*....|....*....|....*....
gi 573459770  239 QHVVLAACALLCILSIMLLPETKRKLLPE 267
Cdd:TIGR00898 476 PLVLFGGLALLAGILTLFLPETKGVPLPE 504
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-282 2.70e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.29  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  84 RNIWKNLLILGFTNFIAHAIRHCYQPVGG------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLT 157
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPliaadlGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 158 GIASLVLLGLWDYlneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP------AQRLH 231
Cdd:COG2814   86 ALGSLLCALAPSL---WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPllggllADLFG 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 573459770 232 MgHGAFLqhVVLAACALLCILSIMLLPETKRKLLPEVLRD-GELCRRPSLLR 282
Cdd:COG2814  163 W-RWVFL--VNAVLALLALLLLLRLLPESRPAARARLRGSlRELLRRPRLLL 211
xylE PRK10077
D-xylose transporter XylE; Provisional
 5-216 1.73e-07

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 52.00  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   5 PCILFLFYgwpgLFL--ESARWLIVKRQIEEAQSVLRILaernrphgqMLGEEAQEALQDLENTCPLPATSS---FSFAS 79
Cdd:PRK10077 203 PALLFLML----LYFvpETPRYLMSRGKQEQAEGILRKI---------MGNTLATQALQEIKHSLDHGRKTGgklLMFGV 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  80 LLnyrnIWKNLLILGFTNFIAHAIRHCYQP--VGGGGSPSDFYLCSLLASGTAALACVFLGV-TVDRFGRRGiLLLSMTL 156
Cdd:PRK10077 270 GV----IVIGVMLSVFQQFVGINVVLYYAPeiFKTLGASTDIALLQTIIVGVINLTFTVLAImTVDKFGRKP-LQIIGAL 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 573459770 157 TGIASLVLLGLWDYLNeaAITTFSVLGLFSSQAAAILS-----TLLAAEVIPTTVRGRGLGLIMA 216
Cdd:PRK10077 345 GMAIGMFSLGTAFYTQ--APGIVALLSMLFYVAAFAMSwgpvcWVLLSEIFPNAIRGKALAIAVA 407
MFS_1 pfam07690
Major Facilitator Superfamily;
113-226 6.58e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.03  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAI 192
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                          90       100       110
                  ....*....|....*....|....*....|....
gi 573459770  193 LSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP 226
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 88-258 9.53e-96

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 286.29  E-value: 9.53e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  88 KNLLILGFTNFIAHAIRHCYQPVGGG--GSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLL 165
Cdd:cd17445  174 KNLLILGFTTFIAHAISHCYQSFSDDvrGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILL 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 166 GLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAA 245
Cdd:cd17445  254 GLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLAS 333

                        170
                 ....*....|...
gi 573459770 246 CALLCILSIMLLP 258
Cdd:cd17445  334 LALLAILSIMLLP 346
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 88-258 3.41e-81

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 249.36  E-value: 3.41e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  88 KNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 167
Cdd:cd17373  163 KNILILGFNSLTGYGIRHCFARSMMGHEPENFYLDYYLTAGIAAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGL 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 168 WDY---------------LNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHM 232
Cdd:cd17373  243 LNLigkysqhpdsgmsdsVKDKFSIAFSVLGLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHN 322

                        170       180
                 ....*....|....*....|....*.
gi 573459770 233 GHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17373  323 QKGYFLQHVVFACCALLCILCILLLP 348
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 88-258 5.83e-46

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 158.40  E-value: 5.83e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  88 KNLLILGFTNFIAHAIRHCYQPVGGGGSPSdFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 167
Cdd:cd17443  174 RNGLILGFTAFIGGGIRYCFARNLAPFVPT-FYLPYFLQAGLEALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLAL 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 168 WDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACA 247
Cdd:cd17443  253 TQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFASFA 332

                        170
                 ....*....|.
gi 573459770 248 LLCILSIMLLP 258
Cdd:cd17443  333 VLSVLCILLLP 343
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 71-258 7.15e-33

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 123.46  E-value: 7.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  71 ATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPsDFYLCSLLASGTAALACVFLGVTVDRFGRRGIL 150
Cdd:cd17317  146 AISLPGLLFLLLLWWLPRRTIIVGLIWFVTSLVYYGLSLNSSNLGG-NLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTL 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 151 LLSMTLTGIASLVLLGLWDYLNeAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRL 230
Cdd:cd17317  225 SGSLLLAGLACLVTALLPDDEN-TLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVL 303

                        170       180
                 ....*....|....*....|....*...
gi 573459770 231 HMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17317  304 LGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 88-258 2.87e-29

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 114.56  E-value: 2.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  88 KNLLILGFTNFIAHAIRHCY-----QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASL 162
Cdd:cd17444  174 KNIVVLCVNSLTGYGIHHCFaksmmDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASL 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 163 VLLGLWDYL---------------NEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPA 227
Cdd:cd17444  254 LQLGLLNLIgkysqhpdsgmsdevKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLGLVLASAGFGMLTAPI 333

                        170       180       190
                 ....*....|....*....|....*....|.
gi 573459770 228 QRLHMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17444  334 MELHNQKGYFLHHIIFACCTLICIICILLLP 364
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-267 4.17e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 95.85  E-value: 4.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770    2 ITAPCILFLFYGWpgLFLESARWLIVKRQIEEAQSVLRILAERNRPHgQMLGEEAQEALQDLENTCPLPatssfSFASLL 81
Cdd:TIGR00898 249 VSLPTFLFFLLSW--FVPESPRWLISQGRIEEALKILQRIAKINGKK-LPAEVLSLSLEKDLSSSKKQY-----SFLDLF 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   82 NYRNIWKNLLILgftNFIAHAIRHCYQ--PVGGGGSPSDFYLcSLLASGTAALACVFLG-VTVDRFGRRGILLLSMTLTG 158
Cdd:TIGR00898 321 RTPNLRKTTLCL---MMLWFTTAFSYYglVLDLGNLGGNIYL-DLFISGLVELPAKLITlLLIDRLGRRYTMAASLLLAG 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  159 IASLVLLGLWDYLnEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFL 238
Cdd:TIGR00898 397 VALLLLLFVPVDL-YFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFL 475

                         250       260
                  ....*....|....*....|....*....
gi 573459770  239 QHVVLAACALLCILSIMLLPETKRKLLPE 267
Cdd:TIGR00898 476 PLVLFGGLALLAGILTLFLPETKGVPLPE 504
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 86-256 1.88e-11

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 63.77  E-value: 1.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  86 IWKNLLILGFTNFIAHAIRHCYQ-------PVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTG 158
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTtflptylQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 159 IaSLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP--AQRLHMGHGA 236
Cdd:cd17316  255 I-LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPplIALLLASTGG 333

                        170       180
                 ....*....|....*....|
gi 573459770 237 FLQHVVLAACALLCILSIML 256
Cdd:cd17316  334 TGVPALILALLAIVALIVAL 353
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 117-258 1.85e-10

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 60.77  E-value: 1.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 117 SDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLnEAAITTFSVLGLFSSQAAAILSTL 196
Cdd:cd17374  201 LNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEM-QTLRTVLAVLGKGSSAAAFTISYV 279

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 573459770 197 LAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17374  280 YTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-282 2.70e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.29  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  84 RNIWKNLLILGFTNFIAHAIRHCYQPVGG------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLT 157
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPliaadlGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 158 GIASLVLLGLWDYlneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP------AQRLH 231
Cdd:COG2814   86 ALGSLLCALAPSL---WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPllggllADLFG 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 573459770 232 MgHGAFLqhVVLAACALLCILSIMLLPETKRKLLPEVLRD-GELCRRPSLLR 282
Cdd:COG2814  163 W-RWVFL--VNAVLALLALLLLLRLLPESRPAARARLRGSlRELLRRPRLLL 211
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
123-263 4.63e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 4.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 123 SLLASGTAALACVFLGVTVDRFGRRGILLLsMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVI 202
Cdd:COG2271  222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 573459770 203 PTTVRGRGLGLIMALGALGGLSGP------AQRLHMgHGAFLqhvVLAACALLCILSIMLLPETKRK 263
Cdd:COG2271  301 PKKARGTASGLVNTFGFLGGALGPllvgylLDATGY-QAAFL---LLAALALLAALLALLLLRETRK 363
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 115-256 9.02e-09

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 56.00  E-value: 9.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 115 SPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAA--AI 192
Cdd:cd17369  262 DRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMmyGP 341

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 573459770 193 LSTLLaAEVIPTTVRGRGLGLIMALGA-LGGLSGP---AQRLHMGHGAFLQHVVLAACALLCILSIML 256
Cdd:cd17369  342 QAAFL-AELFPTRVRYTGASLGYQLGAiLGGGFAPliaTALVAATGSWWPVALYLAALAVISLVAALF 408
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 140-271 9.38e-09

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 55.89  E-value: 9.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  140 TVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAA-ITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALG 218
Cdd:TIGR00887 358 LVDIIGRKPIQLMGFFILTVLFFVLGFAYNHLSTHGfLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASG 437

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 573459770  219 ALGGLSG----------PAQRLHMGHGAFLQHV--VLAACALLCILSIMLLPETKRKLLPEVLRD 271
Cdd:TIGR00887 438 KAGAIIGqfgflylaqhGDPTKGYPTGIWMGHVleIFALFMFLGILFTLLIPETKGKSLEELSGE 502
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 107-261 3.41e-08

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 54.21  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 107 YQPVGGGGSPSDFYLCSLLASGTAALACV-------FLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTF 179
Cdd:cd17364  223 ISAIGFSKTMNAYQELFNIAVGQLIIALAgtvpgywFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTIGFF 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 180 SVLGL--FSSQAAAILST-LLAAEVIPTTVRGRGLGLIMALGALGGLSG----PAQRLHMGHGAFLqhVVLAACALLCIL 252
Cdd:cd17364  303 VLYGLtfFFSNFGPNTTTfIVPAEVFPARVRSTCHGISAASGKIGAIVGsflfLSLTQNIGVRNVL--IILAGVALLGII 380


                 ....*....
gi 573459770 253 SIMLLPETK 261
Cdd:cd17364  381 LTLLFPEEK 389
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 4-267 7.54e-08

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 53.35  E-value: 7.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   4 APCILFLfygwPGLFL--ESARWLIVKRQIEEAQSVLRILaeRNRPHGqmLGEEAQEALQDLENTCPLPATSSFSfasLL 81
Cdd:cd17358  164 IPPVVFL----ILLFFipESPRWLAKKGREEEAEKSLQFL--RGKDAD--ISKEAAEIQEELAELEKEAKESSFS---DL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  82 NYRNIWKNLLI-------------LGFTNFIAHAIRHcyqpvGGGGSPSDfyLCSLLASGTAALACVFLGVTVDRFGRRG 148
Cdd:cd17358  233 FQRKYLKPLVIglglmlfqqlsgiNAVIFYASSIFDE-----AGSGLDPN--TATIIIGVVQVVGTLVATLLVDRLGRRP 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 149 ILLLSMTLTGIASLvLLGLWDYLNE--AAITTFSVLGLFSSQAAAILST--------LLAAEVIPTTVRGRGLGLIMALG 218
Cdd:cd17358  306 LLLVSAIGMGIGLL-ALGLYFYLQEhgALLSSVSWLPLVGLVIYIISFSiglgplpwVIMSEIFPAKIKGLAGSLVTLVN 384

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 573459770 219 ALGG----LSGPAQRLHMG-HGAFLqhvVLAACALLCIL-SIMLLPETKRKLLPE 267
Cdd:cd17358  385 WLFAfivtKTFPFLTLAWGaSGTFW---IFAGICGLALVfVLLFVPETKGKSLEE 436
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
113-263 8.94e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.96  E-value: 8.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNeAAITTFSVLGLFSSQAAAI 192
Cdd:COG2223  237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLW-LFLVLFLLLGLALGGGNGA 315

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 573459770 193 LSTLLaAEVIPTTVRGRGLGLIMALGALGGLSGPaqrlhMGHGAFLQH--------VVLAACALLCILSIMLLPETKRK 263
Cdd:COG2223  316 VFALV-PDIFPTKNAGAVYGLVGAAGGLGGFLGP-----LLFGALLDAtgsytaafLVFAVLALVALVLTLLLYRRPRR 388
xylE PRK10077
D-xylose transporter XylE; Provisional
 5-216 1.73e-07

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 52.00  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   5 PCILFLFYgwpgLFL--ESARWLIVKRQIEEAQSVLRILaernrphgqMLGEEAQEALQDLENTCPLPATSS---FSFAS 79
Cdd:PRK10077 203 PALLFLML----LYFvpETPRYLMSRGKQEQAEGILRKI---------MGNTLATQALQEIKHSLDHGRKTGgklLMFGV 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  80 LLnyrnIWKNLLILGFTNFIAHAIRHCYQP--VGGGGSPSDFYLCSLLASGTAALACVFLGV-TVDRFGRRGiLLLSMTL 156
Cdd:PRK10077 270 GV----IVIGVMLSVFQQFVGINVVLYYAPeiFKTLGASTDIALLQTIIVGVINLTFTVLAImTVDKFGRKP-LQIIGAL 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 573459770 157 TGIASLVLLGLWDYLNeaAITTFSVLGLFSSQAAAILS-----TLLAAEVIPTTVRGRGLGLIMA 216
Cdd:PRK10077 345 GMAIGMFSLGTAFYTQ--APGIVALLSMLFYVAAFAMSwgpvcWVLLSEIFPNAIRGKALAIAVA 407
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 109-258 4.21e-07

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 50.82  E-value: 4.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 109 PVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQ 188
Cdd:cd17378  193 PLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAA 272

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 189 AAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17378  273 GAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLGLFALGLP 342
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 90-258 9.77e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 49.73  E-value: 9.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  90 LLILGFTNFIAHAIRHCYQPV---GGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLG 166
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPAllqSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 167 LWDYLneAAITTFSVLGLFSSQAAAILSTLLaAEVIPTTVRGRGLGLIMALGALGGLSGP-AQRLHMGHGAFLQHVVLAA 245
Cdd:cd06174   81 APSFW--LLLLGRFLLGLGSGLIDPAVLALI-ADLFPERERGRALGLLQAFGSVGGILGPlLGGILASSLGFGWRAVFLI 157

                        170
                 ....*....|...
gi 573459770 246 CALLCILSIMLLP 258
Cdd:cd06174  158 AAALALLAAILLL 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 64-257 1.35e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 49.35  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  64 ENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIrHCYQPV----GGGGSPSDFYLCSLLASGTAALACVFLGV 139
Cdd:cd06174  183 KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF-STLLPLflldLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 140 TVDR-FGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFssqAAAILSTLLAAEVIPTTVRGRGLGLIMALG 218
Cdd:cd06174  262 LSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG---GLLPLSFALIAELFPPEIRGTAFGLLNTFG 338

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 573459770 219 ALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLL 257
Cdd:cd06174  339 FLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 139-258 5.59e-06

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 47.03  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 139 VTVDRFGRR----GILLLSMTLTGIASLVLLGLWdylneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLI 214
Cdd:cd17447  223 LLLDRIGRRltqaGSLILTGLSIGINILIPSEFT-----VVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYT 297

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 573459770 215 MALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17447  298 SFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
87-227 5.71e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 5.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  87 WKNLLILGFTNFIAHAIRHCYQPVGG------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIA 160
Cdd:COG2271    9 WRILALLFLAYFLNYLDRSNLSVAAPplqadlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 573459770 161 SLVLLGLWDYLneAAITTFSVLGLFSSqAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPA 227
Cdd:COG2271   89 TLLFGFATSFW--QLLLLRFLLGLGEA-GFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
76-222 5.99e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 5.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  76 SFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGG---GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLL 152
Cdd:COG2814  199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQevlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI 278

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 153 SMTLTGIAsLVLLGLWDYLneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGG 222
Cdd:COG2814  279 GLLLLALG-LLLLALAGSL--WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 110-258 6.27e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 47.19  E-value: 6.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 110 VGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGiASLVLLGLWDYLNEAAITTFSVLGLFSSqA 189
Cdd:cd17365  199 VEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGA-VSLALLGVSPASLVLLYVLVFLAGACVN-G 276

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 573459770 190 AAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP---AQRLHMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17365  277 AQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPllgGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
MFS_1 pfam07690
Major Facilitator Superfamily;
113-226 6.58e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.03  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAI 192
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                          90       100       110
                  ....*....|....*....|....*....|....
gi 573459770  193 LSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP 226
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 7-227 6.72e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.97  E-value: 6.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770    7 ILFLFYGWPGLFL---------ESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEAlQDLENTCPLPATSSFSF 77
Cdd:TIGR00895 172 SLFYVGGIAPLLLllllmrflpESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQ-GTKRSVFKALFQGKTAR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   78 ASLLnyrnIWknlLILGFTNFIAHAIRHC--YQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMT 155
Cdd:TIGR00895 251 ITVL----LW---LLYFMLLVGVYFLTNWlpKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLL 323

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 573459770  156 LTGIASLVLLGLWDYLNeaAITTFSVLGLFSSQAAAILSTLlAAEVIPTTVRGRGLGLIMALGALGGLSGPA 227
Cdd:TIGR00895 324 GAVFAVLVGSTLFSPTL--LLLLGAIAGFFVNGGQSGLYAL-MALFYPTAIRATGVGWAIGIGRLGAIIGPI 392
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
84-260 7.28e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.80  E-value: 7.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  84 RNIWKNLLILGFTNFIAHAIRHCYQPVGG------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLT 157
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPplaeefGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 158 GIASLVL---LGLWDYLNEAAITTFSVLGLFSSqaaailSTLLAAEVIPTTVRGRGLGLIMALGALGGLSG--PAQRLHM 232
Cdd:COG2223   81 GIGLLLLalaVSYWLLLLLGLLLGIGGGGSFAV------GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAafLAPLLIA 154

                        170       180       190
                 ....*....|....*....|....*....|.
gi 573459770 233 GHG---AFLqhVVLAACALLCILSIMLLPET 260
Cdd:COG2223  155 AFGwrnAFL--ILGILLLVVAVLAWLFLRDP 183
MFS_1 pfam07690
Major Facilitator Superfamily;
113-285 7.40e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 46.64  E-value: 7.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLlgLWDYLNEAAITTFSVLGLFSSqAAAI 192
Cdd:pfam07690  28 GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL--LFASSLWLLLVLRVLQGLGAG-ALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  193 LSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP------AQRLHMgHGAFLQHVVLAACALLCILSIMLLPETKRKLLP 266
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPllggllASLFGW-RAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183

                         170
                  ....*....|....*....
gi 573459770  267 EVLRDGELCRRPSLLRQPP 285
Cdd:pfam07690 184 EEARLSLIVAWKALLRDPV 202
Sugar_tr pfam00083
Sugar (and other) transporter;
8-268 1.21e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.50  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770    8 LFLFYGWpgLFL-ESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGE-EAQEALQDLENTcplpatssfSFASLLNYRN 85
Cdd:pfam00083 182 LLLIIGL--LFLpESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIkDSLEAGQEAEKA---------SWKELFSTKT 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   86 IWKNLLI----LGFTNFIAHAIRHCYQPV--GGGGSPSDFYLcSLLASGTAALACVFLGVTVDRFGRRGILLLS------ 153
Cdd:pfam00083 251 RRQRLLIgvmlQIFQQLTGINAIFYYSTTifENLGLSDSFLV-TIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGaagmai 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  154 -MTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALG----ALGGLSGPAQ 228
Cdd:pfam00083 330 cFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANwlanFLIGFLFPII 409

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 573459770  229 RLHMGHGAFlqHVVLAACALLCILSIML-LPETKRKLLPEV 268
Cdd:pfam00083 410 TDAIGLGYT--FFIFAGLLVLFIIFVFFfVPETKGRTLEEI 448
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 130-259 1.35e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.20  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  130 AALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAIlstLLAAEVIPTTVRGR 209
Cdd:TIGR00895  65 MAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLN---ALVSEYAPKRFRGT 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 573459770  210 GLGLIM---ALGALGG--LSGPAQRLHMGHGAFLqhVVLAACALLCILSIMLLPE 259
Cdd:TIGR00895 142 AVGLMFcgyPIGAAVGgfLAGWLIPVFGWRSLFY--VGGIAPLLLLLLLMRFLPE 194
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 129-286 1.42e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.03  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 129 TAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLlglwdylneAAITTFSVL-------GLFSSQAAAIlSTLLAAEV 201
Cdd:cd17325   43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF---------AFATSYWQLllarflqGLASAAVWPA-AMALIADI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 202 IPTTVRGRGLGLIMALGALGGLSGP------AQRLHMgHGAFLqhvVLAACALLC-ILSIMLLPETKRKLLPEVLRDGEL 274
Cdd:cd17325  113 APPEERGRAMGIFSSAIGLGFLIGPllggllADALGY-RAPFL---VCAALALLAlVLALLLLPEPRPPPNKRAVSAARL 188

                        170
                 ....*....|..
gi 573459770 275 CRRPSLLRQPPP 286
Cdd:cd17325  189 RSGLRLLLRDRR 200
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 130-257 1.54e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.02  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 130 AALACVFLGVTVDRF--GRRGILLLSMTLTGIASLVLLGLWDylNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVR 207
Cdd:cd17319  228 GAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTT--SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAA 305

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 573459770 208 GRGLGLIMALGALGGLSGPA------QRLHMGHGAFLqhvVLAACALLCILSIMLL 257
Cdd:cd17319  306 ATAGGLINSGGNLGGFVAPLligylvDATGSYTAAFL---FLAAVALLAALLVLLL 358
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 123-282 2.71e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.23  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 123 SLLASGTA---ALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYlnEAAITTFSVLGLFSSQAAAILSTlLAA 199
Cdd:cd17324   37 GLLVSAYAlgyALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--ALLLLARALAGLAHGGFWAIAAA-YAA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 200 EVIPTTVRGRGLGLIMALGALGGLSG-PAQRLhMG-----HGAFLqhvVLAACALLCILSIMLL----PETKRKLLPEVL 269
Cdd:cd17324  114 DLVPPEKRGRAIGLVFSGLTLGLVLGrPLGGL-LGqllgwRAAFL---AIAVLALLAALLLWRLlpslPPKKPGSLGLLS 189

                        170
                 ....*....|...
gi 573459770 270 RDGELCRRPSLLR 282
Cdd:cd17324  190 SLLLLLRNPRLRL 202
Sugar_tr pfam00083
Sugar (and other) transporter;
91-265 3.17e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 44.96  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770   91 LILGFTNFIAhAIRHCYQPVGGGGSPSDFYLCSLLASGT---AALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGL 167
Cdd:pfam00083  18 VIGAFLTLID-FFKNFGLSKSVSSLAALSVLSGLIVSIFsvgCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  168 WDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGR---GLGLIMALGALGGlSGPAQRLHMGHGAFLQHVVLA 244
Cdd:pfam00083  97 KGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGAlgsLYQLAITFGILLA-YIFGLGLNKTSNSDGWRIPLG 175

                         170       180
                  ....*....|....*....|....
gi 573459770  245 AC---ALLCILSIMLLPETKRKLL 265
Cdd:pfam00083 176 LQlvpALLLIIGLLFLPESPRWLV 199
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 125-267 4.22e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 4.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 125 LASGTAALACVFLGVTVDRFGRRGILLLSMTLT--GIASLVLL-GLWDYLNEAAITTFSvLGLFSSQAAAILstllaAEV 201
Cdd:cd17329   43 LSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRalGFALLGFAhSPWLFAIALVLTGFG-GGLFEPASEAMI-----ADV 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 573459770 202 IPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIML--LPETKRKLLPE 267
Cdd:cd17329  117 TTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLflLPETRPKRRAA 184
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 124-252 4.48e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 124 LLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIAsLVLLGLWDYLnEAAITTFSVLGLFSSQAAAILSTLLaAEVIP 203
Cdd:cd17325  242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA-LLLLPLATSF-WLLLLLLALLGLGLGLVFPATLALL-ADIVP 318

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 573459770 204 TTVRGRGLGLIMALGALGGLSGP------AQRLHMGHGAFLQHVVLAACALLCIL 252
Cdd:cd17325  319 PEGRGTAMGLFNTAFSLGMVLGPllggflYDAFGFATPFLAAAALLLLAAVLFLL 373
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 130-253 5.05e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 130 AALACVFLGVTVDRFGRRGILLLsMTLTGIASLVLLGLWDYLNEAAITTFsVLGLFSSQAAAILSTLlAAEVIPTTVRGR 209
Cdd:PRK11551 268 GALGSLLIGALMDRLRPRRVVLL-IYAGILASLAALAAAPSFAGMLLAGF-AAGLFVVGGQSVLYAL-APLFYPTQVRGT 344

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 573459770 210 GLGLIMALGALGGLSGP---AQRLHMGH------GAFLQHVVLAACALLCILS 253
Cdd:PRK11551 345 GVGAAVAVGRLGSMAGPllaGQLLALGRstvgviGASIPVILVAALAALLLVS 397
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
68-263 6.05e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  68 PLPATSSFSFASLLnyRNIWKN-----LLILGFTNFIAHAIRHCYQPVGG----GGSPSDFYLCSLLASGTAALACVFLG 138
Cdd:COG2211  208 PVPEEEKVSLKESL--KALLKNrpfllLLLAYLLFFLALALVAALLLYYFkyvlGLSAALVGLLLALYFLAALLGAPLWP 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 139 VTVDRFGRRGILLLSMTLTGIAsLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIP-----TTVRGRG--- 210
Cdd:COG2211  286 RLAKRFGKKKAFIIGLLLAALG-LLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewkTGRRREGlyf 364

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 573459770 211 --------LGLIMA-------LGALGGLSGPAQRLHMGHGAFLQHVVL-AACALLCILSIMLLPETKRK 263
Cdd:COG2211  365 giftfaikLGQALAgalagllLALFGYVAGAAQSPSALTGIRLLFFLLpAVLLLLAALLLLFYPLTRER 433
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 123-249 8.91e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 43.78  E-value: 8.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 123 SLLASGTAALACV-FLGVTV--DRFGRRGILLLSMTLTGIASLVLLGLWDyLNEAAITTFSVLGLFSSQAAAILSTLLAA 199
Cdd:cd17327  271 NLLSVPIGALGAVsLLIAALlsDRFKKRGLFAIFACVLALVGSIILLAAP-NPPGAYFAAYILGGGSYAGFPILLSWISS 349

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 573459770 200 EVIPTTVRGRGLGLIMALGALGGLSGP-------AQRLHMGHGAFLQHVVLAACALL 249
Cdd:cd17327  350 NCAGYTKRATVLAIMLIFYNVGNIVAPqifragdAPRYIPGNIALLVCACVSIVLSV 406
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 63-257 1.38e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.95  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  63 LENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIA--HAIRHCYQPVGG-------GGSPSDFYLCSLLASGTAALA 133
Cdd:cd17320  174 LPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGlsFAGLFAYLAAAPfiyieqlGLSPAQFGLLFALNAIALILG 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 134 CVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIP-TTVRGRGLG 212
Cdd:cd17320  254 SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPfPHVAGTASA 333

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 573459770 213 LIMALG-ALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLL 257
Cdd:cd17320  334 LLGFLQfLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 123-259 1.45e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 43.03  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 123 SLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTgIASLVLLGLWdylneAAITTFSVLGLFSSQAAAILSTLLAAEVI 202
Cdd:cd17360  229 SLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGV-IVALVVLAVW-----LALVGLILYLAFFAPGMGPVPWTVNSEIY 302

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 573459770 203 PTTVRGRGLGLIMALGALGGLSGPAQRLHMGH-----GAFLQHVVLAACALLCILsiMLLPE 259
Cdd:cd17360  303 PLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQaigpyGTFLLFAGLAVLGLIFIY--FCVPE 362
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 113-249 1.98e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLneAAITTFSVLGLFSSQAAAI 192
Cdd:cd17370  230 GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLW--LLLLGFILWGLYMGAQESI 307

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 573459770 193 LSTlLAAEVIPTTVRGRGLGLIMALGALGGLSGPA------QRLHMGhGAFLQHVVLAACALL 249
Cdd:cd17370  308 ERA-AVADLVPAELRGTAYGLFNTVVGIGWLLASLiagylwDLISPS-AAFLFSAVLALIALL 368
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 135-225 2.20e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.20  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 135 VFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLneaAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLI 214
Cdd:cd17316   54 LLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPI---LLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLL 130

                         90
                 ....*....|.
gi 573459770 215 MALGALGGLSG 225
Cdd:cd17316  131 QSGWALGALLA 141
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 132-261 3.23e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.90  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 132 LACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFsVLGLFSSQAAAILSTLLAaEVIPTTVRGRGL 211
Cdd:cd17371  260 LGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGF-PLGFFASGPFSGMGAYLT-ELFPTAVRATAQ 337

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 573459770 212 GLIMALGALGGLSGPaqrlhMGHGAFLQH-------VVLAACALLCILSIMLLPETK 261
Cdd:cd17371  338 GFCYNVGRIIGALFP-----FLVGFLATSgslgtaiAVFAAVYYIAGLVLALLLPET 389
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 111-263 4.68e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 4.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 111 GGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVllglwdYLNEAAITTFSVLGLFSSQAA 190
Cdd:cd17489   25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL------YLLATSVALLLVLRLIHGIGW 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 573459770 191 AILST---LLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGH--GAFLQHVVLAACALLCILSIMLLPETKRK 263
Cdd:cd17489   99 GAFTTaaaTLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhlGFAVLFIVAAVLALLALLLVFLVKDPPPV 176
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 129-281 5.76e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.95  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 129 TAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYlneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRG 208
Cdd:COG0477   61 GRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP---ELLIAARALQGIGAGGLMPGALALIAELFPARERG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 209 RGLGLIMALGALGGLSGPaqrlhMGHGAFLQHV-------VLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLL 281
Cdd:COG0477  138 RALGLWGAAIGLGLALGP-----LLGGLLVAALgwrwiflINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALA 212
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 130-270 5.83e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 41.22  E-value: 5.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 130 AALACVFLGVTVDRFGRRG----------ILLLSMTLTGIASLVLLGLWDYLNEaaittfsvlgLFSSQAAAILSTLLAA 199
Cdd:PRK03893 324 AAVGCCVGGFLGDWLGTRKayvcsllisqLLIIPVFAIGGANVWVLGLLLFFQQ----------MLGQGISGLLPKLIGG 393

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 573459770 200 eVIPTTVRGRGLGLIMALGALGGLSGP------AQRLHMGHGAFLQHVVLaacALLCILSIML-LPETKRKLL-PEVLR 270
Cdd:PRK03893 394 -YFDTEQRAAGLGFTYNVGALGGALAPilgaliAQRLDLGTALASLSFSL---TFVVILLIGLdMPSRVQRWLrPEALR 468
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 141-257 6.26e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 40.98  E-value: 6.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 141 VDRFGRRgillLSMTLT-GIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGA 219
Cdd:cd17372  253 IDRLGRK----ASMASMlFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGR 328

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 573459770 220 LGGLSGPAQRLHMGHGAFLQHVVL-AACALLCILSIMLL 257
Cdd:cd17372  329 IGAILCPFIAQVLVHGSQTIALLLfSVVCLVSAICVCLL 367
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 113-288 7.51e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.68  E-value: 7.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAI 192
Cdd:cd06173   30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 193 LSTLLAA--EVIPTTVRGRGLGLIMALGALGGLSGPA-----QRLHMGHGAFLQHVVLAACALLCILSImLLPETKRKLL 265
Cdd:cd06173  110 GPARQALlpELVPKEQLVRANALNSLATQLARIIGPAlggllVALLGPGGAFAINALSFLLSALLLLFI-RRPPPAAPGE 188

                        170       180
                 ....*....|....*....|...
gi 573459770 266 PEVLRDGELCRRPSLLRQPPPTR 288
Cdd:cd06173  189 SSSLLLRDLREGLRYLRRSPLLR 211
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 113-258 1.32e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.95  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSmTLTGIASLVLLGLWdylNEAA--ITTFSVLGLFSSQAA 190
Cdd:cd17355   34 GWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLG-LLLLAAGLVLLALA---TSLWqlYLLWGLLGGGGAGTL 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 191 AILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP--AQRLHMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd17355  110 AAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLplGAALIEAFGWRTALLVLALLALLVLVPVLLLL 179
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 121-223 1.33e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 39.98  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 121 LCSLLASGTAALAcVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAilsTLLAAE 200
Cdd:cd17371   39 LGTVTLAGGAIGG-ILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAG---AALMAE 114

                         90       100
                 ....*....|....*....|...
gi 573459770 201 VIPTTVRGRGLGLIMALGALGGL 223
Cdd:cd17371  115 YVPARHRGKALGYVQSGWAVGWL 137
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 76-258 1.77e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 39.64  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770  76 SFASLLNYRNIWKNLLILGFTNFIAHAIrhcYQP------VGGGGSPSDFYLCSLLASGTAALACVflgvTVDRFGRRGI 149
Cdd:cd17379  159 NFLFLLYYWFIPKHTFILMYAWFTSAVV---YQGlimrlgITGGNLYLDFFISALVELPAAFIILL----TIDRIGRRLP 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 150 LLLSMTLTGIASLVLLGLWDYLNeAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP--A 227
Cdd:cd17379  232 FAASNIVAGAACLITAFIPPDLH-WLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPflL 310

                        170       180       190
                 ....*....|....*....|....*....|....
gi 573459770 228 QRLhmghGAFLQH---VVLAACALLCILSIMLLP 258
Cdd:cd17379  311 YRL----AEIWLElplIVFGVLALVAGGLVLLLP 340
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 120-212 2.57e-03

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 38.96  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 120 YLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTfSVLGLFSSQAAAILSTLLAA 199
Cdd:cd17375  204 YLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVL-SMTGKFAIAIAFGLIYLYTA 282

                         90
                 ....*....|...
gi 573459770 200 EVIPTTVRGRGLG 212
Cdd:cd17375  283 ELYPTIVRSLAVG 295
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 132-265 4.28e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.33  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 132 LACVFLGVTVDRFGRRGILLLSMTLTgIASLVLLGLWDYLNEAAITTFsVLGLFSSQAAAILSTllAAEVIPTTVRGRGL 211
Cdd:cd17330   49 LASPLWGRLSDRYGRKPVLLLSLAGS-AVSYVLLGLSRNLWLLFLARF-LDGLTGGNVSVAQAY--IADITDEEERAKAF 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 573459770 212 GLIMALGALGGLSGPA--QRLHMGHGAFLQHVVLAACALLC-ILSIMLLPETKRKLL 265
Cdd:cd17330  125 GIISAAFGLGFILGPAlgGFLSTPYGYALPFLVAAALALLNlVLVLFFLPPLRRLLL 181
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 107-259 4.47e-03

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 38.39  E-value: 4.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 107 YQPVGGGGSPSdfyLCSLLASGTAALACVFLGV-TVDRFGRRGILL---LSMTLTGIASLVLLGLWDYLNE--------A 174
Cdd:cd17361  227 FQTLGFGSDAS---LISAVITGAVNVVSTLVSIyLVDRFGRRFLLLeggVQMLASQVAIGILLAVKFGDGGelpkayaiA 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 175 AITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLI----MALGALGGLSGPAQRLHMGHGAFLqhvVLAACALLC 250
Cdd:cd17361  304 VVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTvavnFLFTFVIAQAFLSMLCAMKFGIFL---FFAGWVVVM 380

                        170
                 ....*....|
gi 573459770 251 IL-SIMLLPE 259
Cdd:cd17361  381 SLfVYFLLPE 390
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 112-217 4.85e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 38.32  E-value: 4.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 112 GGGSPSDfyLCSLLASGTAALACVFLGVTVDRFGRRgILLLSMTLTGIASLVLLGLWDYLN--EAAITTFSVLGLFSSQA 189
Cdd:cd17315  211 GGGTASI--LASIIVGVVNLLATLVAIRLVDKVGRR-PLLLIGFAGMAASLLLLAIAFLLPalAKAAGWLALLGILLYIA 287

                         90       100       110
                 ....*....|....*....|....*....|...
gi 573459770 190 AAILS-----TLLAAEVIPTTVRGRGLGLIMAL 217
Cdd:cd17315  288 AFAMGagpvpWLLLSEIFPLRIRGKGMAIATLV 320
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 135-226 6.33e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 37.92  E-value: 6.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 135 VFLGVTVDRFGRRGILLLSMTLTGIASLvLLGLWDylNEAAITTFSVLGLFSsqAAAILSTLLA--AEVIPTTVRGRGLG 212
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASL-LCALAP--SLAFLIAARALQGIG--AAAIMPASLAliAATFPGERRGRALG 123

                         90
                 ....*....|....
gi 573459770 213 LIMALGALGGLSGP 226
Cdd:cd17321  124 LWGAVVGIGAALGP 137
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 113-258 7.52e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.59  E-value: 7.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 113 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLneAAITTFSVLGLFSSQAAAI 192
Cdd:cd06173  240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLW--LLLAALFLLGLAGGLFNVP 317

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 573459770 193 LSTLLaAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 258
Cdd:cd06173  318 LNTLL-QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 130-265 9.05e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 37.24  E-value: 9.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459770 130 AALACVFLGVTVDRFGRRGILLLSMTLTGIASLV-LLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLaAEVIPTTVRG 208
Cdd:cd17357   62 GAIGSFISAFLANRFGRKNGLLISNALLVVSSLLmFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYL-QEISPSELRG 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 573459770 209 R-------GLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLaacALLCILSIMLLPETKRKLL 265
Cdd:cd17357  141 AlgsltqiGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIP---ALLQLAALPFFPESPKFLL 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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