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Conserved domains on  [gi|1890342769|ref|NP_001275707|]
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transcription factor E4F1 isoform 3 [Homo sapiens]

Protein Classification

zf-C2H2 and zf-H2C2_2 domain-containing protein( domain architecture ID 11779662)

protein containing domains SFP1, zf-C2H2, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-408 5.64e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 5.64e-06
                          10        20
                  ....*....|....*....|....*
gi 1890342769 384 SLVRHVRHHTGEKPFKCYKCGRGFA 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-257 2.20e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.20e-05
                          10        20
                  ....*....|....*....|....
gi 1890342769 234 SLIRHHRRHTDERPYKCSKCGKSF 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 1.77e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.77e-04
                          10        20
                  ....*....|....*....|...
gi 1890342769 220 HECKLCGASFRTKGSLIRHHRRH 242
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 114-268 3.33e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890342769 114 PITVAHIVVEAASLAADISHASDLVGGGHIKEVIVaaeaelgDGEMA--EAPGSPRQQGLGLAGEGEQAQV----KLLVN 187
Cdd:COG5189   272 PSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGIS-------TGEMIdvRKLPCTNSSSNGKLAHGGERNIdtpsRMLKV 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890342769 188 KDGR-YVCAL--CHKTFKTGSILKAHMVT-HSSRKDHEcklcgasfrtKGSLIRHHRRHTDERPYKCSKCGKSFRESGAL 263
Cdd:COG5189   345 KDGKpYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*
gi 1890342769 264 TRHLK 268
Cdd:COG5189   415 KYHRK 419
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-408 5.64e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 5.64e-06
                          10        20
                  ....*....|....*....|....*
gi 1890342769 384 SLVRHVRHHTGEKPFKCYKCGRGFA 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-257 2.20e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.20e-05
                          10        20
                  ....*....|....*....|....
gi 1890342769 234 SLIRHHRRHTDERPYKCSKCGKSF 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 1.77e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.77e-04
                          10        20
                  ....*....|....*....|...
gi 1890342769 220 HECKLCGASFRTKGSLIRHHRRH 242
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 114-268 3.33e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890342769 114 PITVAHIVVEAASLAADISHASDLVGGGHIKEVIVaaeaelgDGEMA--EAPGSPRQQGLGLAGEGEQAQV----KLLVN 187
Cdd:COG5189   272 PSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGIS-------TGEMIdvRKLPCTNSSSNGKLAHGGERNIdtpsRMLKV 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890342769 188 KDGR-YVCAL--CHKTFKTGSILKAHMVT-HSSRKDHEcklcgasfrtKGSLIRHHRRHTDERPYKCSKCGKSFRESGAL 263
Cdd:COG5189   345 KDGKpYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*
gi 1890342769 264 TRHLK 268
Cdd:COG5189   415 KYHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 248-269 1.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|..
gi 1890342769 248 YKCSKCGKSFRESGALTRHLKS 269
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRT 22
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-408 5.64e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 5.64e-06
                          10        20
                  ....*....|....*....|....*
gi 1890342769 384 SLVRHVRHHTGEKPFKCYKCGRGFA 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-257 2.20e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.20e-05
                          10        20
                  ....*....|....*....|....
gi 1890342769 234 SLIRHHRRHTDERPYKCSKCGKSF 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 1.77e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.77e-04
                          10        20
                  ....*....|....*....|...
gi 1890342769 220 HECKLCGASFRTKGSLIRHHRRH 242
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 114-268 3.33e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890342769 114 PITVAHIVVEAASLAADISHASDLVGGGHIKEVIVaaeaelgDGEMA--EAPGSPRQQGLGLAGEGEQAQV----KLLVN 187
Cdd:COG5189   272 PSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGIS-------TGEMIdvRKLPCTNSSSNGKLAHGGERNIdtpsRMLKV 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890342769 188 KDGR-YVCAL--CHKTFKTGSILKAHMVT-HSSRKDHEcklcgasfrtKGSLIRHHRRHTDERPYKCSKCGKSFRESGAL 263
Cdd:COG5189   345 KDGKpYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*
gi 1890342769 264 TRHLK 268
Cdd:COG5189   415 KYHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 248-269 1.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|..
gi 1890342769 248 YKCSKCGKSFRESGALTRHLKS 269
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRT 22
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 220-242 7.44e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.16  E-value: 7.44e-03
                          10        20
                  ....*....|....*....|...
gi 1890342769 220 HECKLCGASFRTKGSLIRHHRRH 242
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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