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Conserved domains on  [gi|526118165|ref|NP_001267720|]
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surfeit locus protein 4 isoform 4 [Homo sapiens]

Protein Classification

DoxX family protein( domain architecture ID 229470)

DoxX family protein similar to Saccharomyces cerevisiae ER-derived vesicles protein ERV29, a constituent of COPII-coated endoplasmic reticulum-derived transport vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DoxX super family cl21527
DoxX; These proteins appear to have some sequence similarity with pfam04173 but their function ...
 1-226 2.37e-114

DoxX; These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.


The actual alignment was detected with superfamily member pfam02077:

Pssm-ID: 451291  Cd Length: 267  Bit Score: 327.43  E-value: 2.37e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118165    1 MWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLAL 80
Cdd:pfam02077  41 MLFQWSDQVNYMDYSWGCGYFFATVFVIVNLVGQLIGSLLVMLRKKVTYACGVLFFIVILQTIAYGLLTDLKFLLRNISV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118165   81 GGGLLLLLAESRSEGKSMFAGVPTMRES-SPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTK 159
Cdd:pfam02077 121 IGGLLLLLAESRIEKKSLFAGLPTMGEEnKPKSYMLLAGRVLLVLMFISLLHFEMSWTRILLCIIGTALMILVAIGFKTK 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 526118165  160 LAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW 226
Cdd:pfam02077 201 LAAIMLVLWLFAYNIYLNAFWTIPSDKPLRDFLKYDFFQTLSVIGGLLLVVNTGPGGVSVDEKKKIW 267
 
Name Accession Description Interval E-value
SURF4 pfam02077
SURF4 family;
1-226 2.37e-114

SURF4 family;


Pssm-ID: 111019  Cd Length: 267  Bit Score: 327.43  E-value: 2.37e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118165    1 MWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLAL 80
Cdd:pfam02077  41 MLFQWSDQVNYMDYSWGCGYFFATVFVIVNLVGQLIGSLLVMLRKKVTYACGVLFFIVILQTIAYGLLTDLKFLLRNISV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118165   81 GGGLLLLLAESRSEGKSMFAGVPTMRES-SPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTK 159
Cdd:pfam02077 121 IGGLLLLLAESRIEKKSLFAGLPTMGEEnKPKSYMLLAGRVLLVLMFISLLHFEMSWTRILLCIIGTALMILVAIGFKTK 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 526118165  160 LAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW 226
Cdd:pfam02077 201 LAAIMLVLWLFAYNIYLNAFWTIPSDKPLRDFLKYDFFQTLSVIGGLLLVVNTGPGGVSVDEKKKIW 267
 
Name Accession Description Interval E-value
SURF4 pfam02077
SURF4 family;
1-226 2.37e-114

SURF4 family;


Pssm-ID: 111019  Cd Length: 267  Bit Score: 327.43  E-value: 2.37e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118165    1 MWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLAL 80
Cdd:pfam02077  41 MLFQWSDQVNYMDYSWGCGYFFATVFVIVNLVGQLIGSLLVMLRKKVTYACGVLFFIVILQTIAYGLLTDLKFLLRNISV 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118165   81 GGGLLLLLAESRSEGKSMFAGVPTMRES-SPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTK 159
Cdd:pfam02077 121 IGGLLLLLAESRIEKKSLFAGLPTMGEEnKPKSYMLLAGRVLLVLMFISLLHFEMSWTRILLCIIGTALMILVAIGFKTK 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 526118165  160 LAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW 226
Cdd:pfam02077 201 LAAIMLVLWLFAYNIYLNAFWTIPSDKPLRDFLKYDFFQTLSVIGGLLLVVNTGPGGVSVDEKKKIW 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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