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Conserved domains on  [gi|501354657|ref|NP_001265143|]
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leucine-rich repeat-containing protein 20 isoform 4 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-88 4.32e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   1 MTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSI 80
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKEL 187


                 ....*...
gi 501354657  81 NLRFNPLN 88
Cdd:COG4886  188 DLSNNQIT 195
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-88 4.32e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   1 MTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSI 80
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKEL 187


                 ....*...
gi 501354657  81 NLRFNPLN 88
Cdd:COG4886  188 DLSNNQIT 195
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-92 8.72e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 8.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   5 SQLRELHLEGNflhRLPSEVS---------ALQH-LKAIDLSRNQFQDfPEQLTALPALETINLEENEIVDVP--VEKLA 72
Cdd:cd21340   90 TNLEELHIENQ---RLPPGEKltfdprslaALSNsLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEelLDLLS 165

                         90       100
                 ....*....|....*....|
gi 501354657  73 AMPALRSINLRFNPLNAEVR 92
Cdd:cd21340  166 SWPSLRELDLTGNPVCKKPK 185
PLN03150 PLN03150
hypothetical protein; Provisional
 20-91 1.64e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.64e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501354657  20 LPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV 91
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
5-63 1.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501354657    5 SQLRELHLEGNFLHRLPSEV-SALQHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEI 63
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-88 4.32e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   1 MTTFSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSI 80
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKEL 187


                 ....*...
gi 501354657  81 NLRFNPLN 88
Cdd:COG4886  188 DLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-87 5.11e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 5.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   4 FSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLR 83
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLS 236


                 ....
gi 501354657  84 FNPL 87
Cdd:COG4886  237 NNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-87 1.43e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   5 SQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPveKLAAMPALRSINLRF 84
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSN 259


                 ...
gi 501354657  85 NPL 87
Cdd:COG4886  260 NQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-88 2.11e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 2.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   4 FSQLRELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLR 83
Cdd:COG4886  135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLS 213


                 ....*
gi 501354657  84 FNPLN 88
Cdd:COG4886  214 GNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-87 3.21e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 3.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   4 FSQLRELHLEGNflhrlpSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPvEKLAAMPALRSINLR 83
Cdd:COG4886   95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLS 167


                 ....
gi 501354657  84 FNPL 87
Cdd:COG4886  168 NNQL 171
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-92 8.72e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 8.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   5 SQLRELHLEGNflhRLPSEVS---------ALQH-LKAIDLSRNQFQDfPEQLTALPALETINLEENEIVDVP--VEKLA 72
Cdd:cd21340   90 TNLEELHIENQ---RLPPGEKltfdprslaALSNsLRVLNISGNNIDS-LEPLAPLRNLEQLDASNNQISDLEelLDLLS 165

                         90       100
                 ....*....|....*....|
gi 501354657  73 AMPALRSINLRFNPLNAEVR 92
Cdd:cd21340  166 SWPSLRELDLTGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-104 4.58e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 4.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   1 MTTFSQLRELHLEGNFLHRLPsEVSALQHLKAIDLSRNQFQDFPEqLTALPALETINLEENEIVDVPVEKLAAMPALRSI 80
Cdd:COG4886  224 LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                         90       100
                 ....*....|....*....|....
gi 501354657  81 NLRFNPLNAEVRVIAPPLIKFDML 104
Cdd:COG4886  302 LLLLLLLNLLELLILLLLLTTLLL 325
PLN03150 PLN03150
hypothetical protein; Provisional
 20-91 1.64e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.64e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 501354657  20 LPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV 91
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
5-63 1.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501354657    5 SQLRELHLEGNFLHRLPSEV-SALQHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEI 63
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
28-87 1.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501354657   28 QHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 87
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 6-91 1.52e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   6 QLRELHLEGN-FLHRLPsEVSALQHLKAIDLSRNQFQD-FPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLR 83
Cdd:PLN00113 453 SLQMLSLARNkFFGGLP-DSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531


                 ....*...
gi 501354657  84 FNPLNAEV 91
Cdd:PLN00113 532 HNQLSGQI 539
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
5-113 5.31e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 5.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   5 SQLRELHLEGNFLHRLPSEVSALQHLKaidLSRNQFQDFPEQLTALPALETINLEENEIVDvpveklAAMPALRSInlrf 84
Cdd:PRK15387 402 SELKELMVSGNRLTSLPMLPSGLLSLS---VYRNQLTRLPESLIHLSSETTVNLEGNPLSE------RTLQALREI---- 468

                         90       100
                 ....*....|....*....|....*....
gi 501354657  85 nplnAEVRVIAPPLIKFDMlmspEGARAP 113
Cdd:PRK15387 469 ----TSAPGYSGPIIRFDM----AGASAP 489
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 7-90 1.20e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   7 LRELHLEGNFLH-----RLPSEVSALQHLKAIDLSRNQF-----QDFPEQLTALPALETINLEENEIVDVPVEKLA-AMP 75
Cdd:cd00116  167 LKELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALAsALL 246

                         90
                 ....*....|....*....
gi 501354657  76 A----LRSINLRFNPLNAE 90
Cdd:cd00116  247 SpnisLLTLSLSCNDITDD 265
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 6-98 2.38e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   6 QLRELHLEGNFLHRLPSE--VSALQHLKAI---DLSRNQFQD-----FPEQLTALPALETINLEENEIVDVPVEKLAAM- 74
Cdd:COG5238  209 TVTTLWLKRNPIGDEGAEilAEALKGNKSLttlDLSNNQIGDegviaLAEALKNNTTVETLYLSGNQIGAEGAIALAKAl 288

                         90       100
                 ....*....|....*....|....*...
gi 501354657  75 ---PALRSINLRFNPLNAE-VRVIAPPL 98
Cdd:COG5238  289 qgnTTLTSLDLSVNRIGDEgAIALAEGL 316
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 7-87 5.12e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   7 LRELHLEGNFLH-----RLPSEVSALQHLKAIDLSRNQFQDF-----PEQLTALPALETINLEENEIVDVPVEKLAA--- 73
Cdd:cd00116  139 LEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDEGASALAEtla 218

                         90
                 ....*....|....*
gi 501354657  74 -MPALRSINLRFNPL 87
Cdd:cd00116  219 sLKSLEVLNLGDNNL 233
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
6-113 1.05e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 36.98  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   6 QLRELHLEGNFLHRLPSEVSALqhLKAIDLSRNQFQDFPEQLTAlpALETINLEENEIVDVPveklAAMPALRS------ 79
Cdd:PRK15370 347 ELQVLDVSKNQITVLPETLPPT--ITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLP----ESLPHFRGegpqpt 418

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 501354657  80 -INLRFNPLNAevRVIAppliKFDMLMSPEGARAP 113
Cdd:PRK15370 419 rIIVEYNPFSE--RTIQ----NMQRLMSSVGYQGP 447
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-91 4.84e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 35.21  E-value: 4.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354657   1 MTTFSQLRELHLEGNFL-HRLPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIV-DVPVEkLAAMPAL 77
Cdd:PLN00113 160 IGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYE-IGGLTSL 238

                         90
                 ....*....|....
gi 501354657  78 RSINLRFNPLNAEV 91
Cdd:PLN00113 239 NHLDLVYNNLTGPI 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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