|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
37-487 |
1.62e-133 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 392.73 E-value: 1.62e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 37 VRIIYFTMFLMALGFSIILTGIWPYLNKLDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSLFTLA 116
Cdd:cd17326 1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 117 SGIYSSLELRPDNVKYWMLSSRFLIGVSSANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTPLGDQG 196
Cdd:cd17326 81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 197 HVWlWGKMHFNMYTASGWINVLMSIGNFMMFLPGVFEehkiaarevmvmqggtseketwkgikpsylsaWTLIVAFFVLV 276
Cdd:cd17326 161 YVI-GIKLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------------------VVCIFLFFVVL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 277 FNFVLLETLGTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIEPMCKIIAERYVLIWGGFSLMFLGRVLFVPWGp 356
Cdd:cd17326 208 FIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWG- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 357 dppklaqpfnaswnlsesdpiflgcpttqkwcgelpaltltqfIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGW 436
Cdd:cd17326 287 -------------------------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGV 323
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 442630717 437 MTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFWLQCSNRLLI 487
Cdd:cd17326 324 LTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-479 |
4.07e-28 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 115.37 E-value: 4.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 40 IYFTMFLMALGFSIILTGIWPYLNKLDPDAGKEFM-GLIVAANPLGQMIFSPIFGWWGNKLG--KIRLPLLLSLSLFTLA 116
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYvGLLQSSYSLGQFLASPLWGRLSDRYGrkPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 117 SGIYSSLelrpdnvkYWMLSSRFLIGVSSANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTplgdqg 196
Cdd:cd17330 81 LGLSRNL--------WLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS------ 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 197 hvwlwgkmHFNMYTASGWINVLMSIGNFM---MFLPGVFeehkiaarevmvmqggtseketwkgikpsylsaWTLIVAFF 273
Cdd:cd17330 147 --------TPYGYALPFLVAAALALLNLVlvlFFLPPLR---------------------------------RLLLVYFL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 274 VLVFNFVLLETLGTSLtMDMFAWSNDealwYMGIMMTTAAIVSLVTFVLIEPMC-KIIAERYVLIWGGFsLMFLGrVLFV 352
Cdd:cd17330 186 IALAFAGLESVFSLFL-KDRFGFSPS----QIGLLLALVGIAGILAQLLLIPRLaKRLGERKLLRLGLL-LAIIG-LLLL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 353 PWGPDPPklaqpfnaswnlsesdpiflgcpttqkwcgelpaltltQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGV 432
Cdd:cd17330 259 PFASSVP--------------------------------------LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGK 300
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 442630717 433 WMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFWL 479
Cdd:cd17330 301 AQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
40-479 |
3.57e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.39 E-value: 3.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 40 IYFTMFLMALGFSIILTGIWPYLNKLDpdAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKiRLPLLLSLSLFTLASGI 119
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLG--ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGR-KRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 120 YSSLElrpdnvKYWML-SSRFLIGVSSA-NIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTPLGdqGH 197
Cdd:cd17325 78 FAFAT------SYWQLlLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL--GY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 198 VWlwgkmhfnMYTASGwinVLMSIGNFMMFLpgVFEEHKIAAREVMVMQGGTSEKETWKGIKPSYlsaWTLIVAFFVLVF 277
Cdd:cd17325 150 RA--------PFLVCA---ALALLALVLALL--LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL---LALFLAIFVLAF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 278 NFVLLETLGTSLTMDMFAWSndeaLWYMGIMMTTAAIVSLVtfvliepmCKIIAERYVLIWGGFSLMFLGRVLFVpwgpd 357
Cdd:cd17325 214 AFGALEPFLPLYAAELGGLS----PAQIGLLFGAQGLASAL--------SQPPAGKLSDRIGRKPLILIGLLLSA----- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 358 ppklaqpfnaswnlsesdpIFLGCPTTqkwcgelpALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWM 437
Cdd:cd17325 277 -------------------VALLLLPL--------ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 442630717 438 TGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFWL 479
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
31-441 |
1.27e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.40 E-value: 1.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 31 KQRWRSVRIIYFTMFLMALGFSIILTGIWPYLNKLDPDAGkeFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSL 110
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPA--QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 111 SLFTLASGIYSSLELrpdnvkYWMLSSRFLIGVSSA-NIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAV 189
Cdd:COG2814 84 LFALGSLLCALAPSL------WLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 190 TPLGDQGHVWlwgkmhfnmytasgWINVLMSIGNFMMFLPGVFEEHKIAARevmvmQGGTSEKETWKgikpsYLSAWTLI 269
Cdd:COG2814 158 ADLFGWRWVF--------------LVNAVLALLALLLLLRLLPESRPAARA-----RLRGSLRELLR-----RPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 270 VAFFVLVFNFVLLETLGTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIEPMckiiaERYVLIWGGFSLMFLGRV 349
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 350 LFVPWGpdppklaqpfnaswnlsesdpiflgcpttqkwcgelpalTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRP 429
Cdd:COG2814 289 LLALAG---------------------------------------SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
410
....*....|..
gi 442630717 430 QGVWMGWMTGSG 441
Cdd:COG2814 330 RGRASGLYNSAF 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
40-449 |
2.90e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 71.30 E-value: 2.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 40 IYFTMFLMALGFSIILTGIWPYLNKlDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSLFTLASGI 119
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 120 YSSLELrpdnvkYWMLSSRFLIGV-SSANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTPLGDqghv 198
Cdd:pfam07690 80 LFASSL------WLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 199 wlwgkmhfnmYTASGWINVLMSIGNFMMFLpgVFEEHKIAAREVMVMQGGTSEKETWKGIKPSylSAWTLIVAFFVLVFN 278
Cdd:pfam07690 150 ----------WRAAFLILAILSLLAAVLLL--LPRPPPESKRPKPAEEARLSLIVAWKALLRD--PVLWLLLALLLFGFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 279 FVLLETLgTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIEPMCKIIaeRYVLIWGGFSLMFLGRVLFVpwgpdp 358
Cdd:pfam07690 216 FFGLLTY-LPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR--RLLLALLLLILAALGLLLLS------ 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 359 pklaqpfnaswnlsesdpiflgcpttqkwcgelPALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWMT 438
Cdd:pfam07690 287 ---------------------------------LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYN 333
|
410
....*....|.
gi 442630717 439 GSGCLSRVLGP 449
Cdd:pfam07690 334 TAGSLGGALGP 344
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
40-185 |
2.54e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 59.16 E-value: 2.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 40 IYFTMFLMALGFSIILTGIWPYLNKLDpdAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGK--IRLPLLLSLSLFTLAS 117
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRrpVLLICLLLTALGYVLL 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442630717 118 GIYSSLELrpdnvkywMLSSRFLIGVSSANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTL 185
Cdd:cd17390 79 GFSTSLAL--------LFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVV 138
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
40-477 |
1.55e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.58 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 40 IYFTMFLMALGFSIILTGIWPYLnkLDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSLFTLASGI 119
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALL--QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 120 YSSlelrpdNVKYWMLSSRFLIGVSSANIALCR-SYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTPLGDQGHV 198
Cdd:cd06174 79 AFA------PSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 199 WLWgkmhfnmytasgWINVLMSIGNFMMFLPGVFEEHKIAAREVMVMQGGTSEKETWKGIKpsYLSAWTLIVAFFVLVFN 278
Cdd:cd06174 153 AVF------------LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLK--NPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 279 FVLLETLGTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIEpmcKIIAERYVLIWGGFSLMFLGRVLFVpwgpdp 358
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD---RLIGRKPLLLIGLLLMALGLALLLL------ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 359 pklaqpfnaswnlsesdpiflgcpttqkwcgelpALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWMT 438
Cdd:cd06174 290 ----------------------------------APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLN 335
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 442630717 439 GSGCLSRVLGPVFVGSIYTRLGT----FWTFGVTSAMMLVSMF 477
Cdd:cd06174 336 TFGFLGGAIGPLLAGFLLAATFGltgaFLVLAVLLLLAAILLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
31-477 |
2.64e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.48 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 31 KQRWRSVRIIYFTMFLMALGFSIIlTGIWPYLNKlDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGkirlplllsl 110
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNL-SVAAPPLQA-DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG---------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 111 slftlasgiysslelrpdnVKYWMLSSRFLIGVSSANIALCRSYLSAATriserthAVAMVSLAQVLGFIIGPTLQAAVT 190
Cdd:COG2271 74 -------------------RRRVLAIGLLLWGLATLLFGFATSFWQLLL-------LRFLLGLGEAGFFPAALKLIAEWF 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 191 PLGDQGhvwlwgkmhfnmyTASGWINVLMSIGNFMMFLPGVFEEHKIAAREVMVMQGGTseketwkGIKPSYLSAWTLIV 270
Cdd:COG2271 128 PPKERG-------------RALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP-------GLLLALLRFWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 271 AFFVLVFNFVLLETLGTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIEpmcKIIAERYVLIWGGFSLMFLGRVL 350
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD---RLGRRRKLVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 351 FVPWGPdppklaqpfnaswnlsesdpiflgcpttqkwcgelPALTLTQFIIGFAFTSIGYPIGVTLIQTIFskvlGPRPQ 430
Cdd:COG2271 265 LALLPS-----------------------------------PALAIALLFLAGFGLGGAFGLLWALAAELF----PKKAR 305
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 442630717 431 GVWMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMF 477
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAAL 352
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
40-478 |
7.37e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.28 E-value: 7.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 40 IYFTMFLMALGFSIILTGIWPYLNKLDpdAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSLFTLASGI 119
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLG--GSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 120 YSSLELRpdnvkyWMLSSRFLIGVSSANIALCRSYLSA----ATRISErthAVAMVSLAQVLGFIIGPtlqaavtPLGdq 195
Cdd:cd17489 79 LLATSVA------LLLVLRLIHGIGWGAFTTAAATLVAdiipPSRRGE---GIGYYGLATTLAMALGP-------ALG-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 196 ghVWLwgkMHFNMYTASGWINVLMSIGNFMMFLPGVFEEHKIAAREVMVMQGGTSEKEtwKGIKPSYLSawtLIVAFFvl 275
Cdd:cd17489 141 --LFL---YQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVE--KKVLPPALI---LFLASI-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 276 vfnfvlleTLGTSLTMdMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIEPMCKIIAERYVLIwggFSLMFLGRVLFVPWg 355
Cdd:cd17489 209 --------AYGAISTF-LPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVII---PGLLLLALGLLLLS- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 356 pdppklaqpfnaswnlsesdpiflgcpttqkwcgelPALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMG 435
Cdd:cd17489 276 ------------------------------------FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANG 319
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 442630717 436 WMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFW 478
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
37-476 |
1.16e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 37 VRIIYFTMFLMALGFSIILTGIWPYLNKlDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRL--PLLLSLSLFT 114
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQ-QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVmlAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 115 LASGIYSSLelrpdnvkYWMLSSRFLIGVSSA-NIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPtlqAAVTPLG 193
Cdd:cd17329 80 ALLGFAHSP--------WLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGP---LLGGLLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 194 DQGHVWLWgkmhfnmytasgWINVLMSIGnFMMFLPGVFEEHKIAAREvmvmQGGTSEKETWKGIKPSYlSAWTLIVAFF 273
Cdd:cd17329 149 LYSFRLLF------------LAAAVLFLL-AALVLLFLLPETRPKRRA----AEKTEILRGYKIVLRDR-AFLLFLLASF 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 274 VLVFNFVLLETLGTSLTMDMFAWSNdealWYMGIMMTTAAIVSLVTFVLIepmckiiaERYVLIWGGFSLMFLGRVLFVP 353
Cdd:cd17329 211 LISLIYFQLESTLPVYVVEILGLGE----SLLGLLLALNALLIVLLQFPV--------ARLVERFRLRKILMIGILLFAI 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 354 WgpdppklaqpfnaswnlsesdpiFLGCPTtqkwcgelpALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVW 433
Cdd:cd17329 279 G-----------------------FAVLAF---------ANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSY 326
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 442630717 434 MGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSM 476
Cdd:cd17329 327 MGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAA 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-477 |
1.67e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 31 KQRWRSVRIIYFTMFLMALGFSIILTgIWPYLnKLDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSL 110
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGP-LIPAL-KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 111 SLFTLASGIYSSLELrpdnvkYWMLSSRFLIGVSSA--NIAlCRSYLSAAtrisERTHAVAMVSLAQV---LGFIIGPTL 185
Cdd:COG0738 82 LMALGLLLFALAPSY------PLLLLALFLLGLGLGllDVA-ANPYVAAL----GPETAASRLNLLHAffsLGALLGPLL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 186 QAAVTPLGDqGHVWLWgkmhfnMYTASGWINVLMSIGNFMMFLPGVFEEHKIAArevmvmQGGTSEKETWKgikpsYLSA 265
Cdd:COG0738 151 GGLLILLGL-SLSWHL------PYLILAVLLLLLALLFLRSKLPEIEEEEEEAA------GSAASLKSLLK-----NPRL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 266 WTLIVAFFVLVFNFVLLETLGTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLIepmcKIIAERYVLIWGGfSLMF 345
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL----KRFGPVRLLRLSA-LLAA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 346 LGRVLFVPWGPDPpklaqpfnaswnlsesdPIFLGCpttqkwcgelpaltltqFIIGFaFTSIGYPIGVTLIqtifSKVL 425
Cdd:COG0738 288 VGLLLALLAPGPW-----------------LALIGL-----------------ALVGL-GLSLMFPTIFSLA----LDGL 328
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 442630717 426 GPRPQGVwMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMF 477
Cdd:COG0738 329 GKRTAAA-VSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
41-480 |
2.40e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 41 YFTMFLMALGFSIILTGIWPYLNKL---DPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGK----IRlplllslslF 113
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQLgvtSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRkpmlLR---------A 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 114 TLASGIYSSLELRPDNVkYWMLSSRFLIGVSSANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTPLG 193
Cdd:cd17391 73 SLGMAIVIGLMAFVTNV-WQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 194 DqghvwlwgkmhfnmYTASGWINVLMSIGNFMMFLPGVFEEHKIAAREVMVmqggtSEKETWKGIKPSYLsAWTLIVAFF 273
Cdd:cd17391 152 G--------------IRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMV-----STKEVWNSVPNPSL-LISLFVTTF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 274 VLVFNFVLLETLGTSLTMDMFAWSNDEALwYMGIMMTTAAIVSLVTFVLIEPMC-KIIAERYVLIwggfsLMFLGRVLFV 352
Cdd:cd17391 212 IIQLANQSIEPILTLYIRQLMGDASNLAF-ISGLVFSATGVSSLLSAPRLGKLGdRIGHHRILLG-----ALLASALLYI 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 353 PwgpdppklaqpfnaswnlsesdPIFLGCPTtqkwcgELPALtltQFIIGFAFTSIgypigVTLIQTIFSKVLGPRPQGV 432
Cdd:cd17391 286 P----------------------QAFVQTPW------QLGIL---RFLLGLATGGL-----LPAINSLLAKITPKEVAGR 329
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 442630717 433 WMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFWLQ 480
Cdd:cd17391 330 IFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSF 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
395-479 |
3.38e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 395 TLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLV 474
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
|
....*
gi 442630717 475 SMFWL 479
Cdd:pfam07690 164 AAVLL 168
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
393-502 |
3.95e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 3.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 393 ALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMM 472
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
90 100 110
....*....|....*....|....*....|
gi 442630717 473 LVSMFWLqcsnRLLIPPTFEKTTPVELKEL 502
Cdd:COG2814 175 LLALLLL----LRLLPESRPAARARLRGSL 200
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
39-185 |
4.17e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.62 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 39 IIYFTMFLMALGFSIILtgiwPYLNKL------DPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSL 112
Cdd:cd17388 3 FILVTVLLDAMGIGLIM----PVLPTLlrefvgDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGA 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442630717 113 FTLasgiYSSLELRPdnVKYWMLSSRFLIGVSSANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTL 185
Cdd:cd17388 79 ALD----YLLMAFAP--TLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPAL 145
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
31-323 |
8.32e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 8.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 31 KQRWRSVRIIYFTMFLMALGFSIILTGIwPYLNKlDPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSL 110
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVAL-PSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 111 SLFTLASGIYSSLELrpdnvkYWMLSSRFLIGVS-SANIALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAV 189
Cdd:COG0477 88 LFGLASLLCGLAPSP------ELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 190 TPLGdqGHVWLWgkmhfnmytasgWINVLmsIGNFMMFLPGVFEEHKIAAREVMVMQGGTSEKETWKGIKPSYLSAWTLI 269
Cdd:COG0477 162 VAAL--GWRWIF------------LINAP--LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLL 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 442630717 270 VAFFVLVFNFVLLETLGTSLTMDMFAWSNDEALWYMGIMMTTAAIVSLVTFVLI 323
Cdd:COG0477 226 LLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALL 279
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
33-185 |
1.23e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.41 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 33 RWRSVRIIYFTMFLMALGFSIILTGIWPYLNKLDpDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSL 112
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442630717 113 FTLASGIYSSLELrpdnvkYWMLSSRFLIGVSSA--NIALcRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTL 185
Cdd:cd17325 276 AVALLLLPLATSF------WLLLLLLALLGLGLGlvFPAT-LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
393-480 |
1.48e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 41.11 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 393 ALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMM 472
Cdd:cd17389 301 ASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGALLF 380
|
....*...
gi 442630717 473 LVSMFWLQ 480
Cdd:cd17389 381 LLPLLLLA 388
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
44-195 |
2.44e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 44 MFLMALGFSIILTGIWPYLNKLDPDagkeFMGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSLFTLASGIYSSl 123
Cdd:cd17477 7 LLGLGSGLLLPLLSLRLEREGVSTA----LIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT- 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442630717 124 elrpDNVKYWMLSsRFLIGVSSANI-ALCRSYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVTPLGDQ 195
Cdd:cd17477 82 ----DSPWVWFLL-RFVMGIGLAGLfVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL 149
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
74-479 |
3.74e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 74 MGLIVAANPLGQMIFSPIFGWWGNKLGKIRLPLLLSLSLFTLASGIYSSLELRPDNVKYWMLSSrFLIGVSSA-NIALCR 152
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAfFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 153 SYLSAATRISERTHAVAMVSLAQVLGFIIGPTLQAAVtplgdqghvwlwgkMHFNMYTASGWINVLMSI--GNFMMFLPG 230
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--------------VALLGPGGAFAINALSFLlsALLLLFIRR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 231 VFEEHKIAAREVMVMqggtsekETWKGIKpSYLSAWTLIVAFFVLVFNFVLLETLGTSLTMDMFAWSNDEALWYmGIMMT 310
Cdd:cd06173 181 PPPAAPGESSSLLLR-------DLREGLR-YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY-GLLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 311 TAAIVSLVTFVLIEPMCKIIAERYVLIWGGFSLMFLgrVLFVPWGPDppklaqpfnaswnlsesdpiflgcpttqkwcge 390
Cdd:cd06173 252 AFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA--LLVLGLSPS--------------------------------- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 391 LPALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGpRPQGVWMGWMTGSGclsrVLGPVFVGSIYTRLGTFWTFGVTSA 470
Cdd:cd06173 297 LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRG-RVFSVYNALNSGAM----PLGALLAGLLADALGLSAVFLLAGA 371
|
....*....
gi 442630717 471 MMLVSMFWL 479
Cdd:cd06173 372 LLLLAALLL 380
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
387-496 |
7.36e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.71 E-value: 7.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 387 WCGELPALTLTQFIIGFAFTSIGyPIGVTLIqtifSKVLGPRPQGVWMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFG 466
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVW-PAAMALI----ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154
|
90 100 110
....*....|....*....|....*....|
gi 442630717 467 VTSAMMLVSMFWlqcsnRLLIPPTFEKTTP 496
Cdd:cd17325 155 VCAALALLALVL-----ALLLLPEPRPPPN 179
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
264-479 |
9.12e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 9.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 264 SAWTLIVAFFVLVFNFVLLETLGTSLTMDMFawSNDEALWYMGIMMTTAAIVSLVTFVLIEPMCKIIAERYVLIWGGFS- 342
Cdd:COG2814 97 SLWLLLAARFLQGLGAGALFPAALALIADLV--PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLa 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 343 -LMFLGRVLFVPwgPDPPKLAQPFNASWNLSESDPIFLgcpttqkwcgelpALTLTQFIIGFAFTSIgypigVTLIQTIF 421
Cdd:COG2814 175 lLALLLLLRLLP--ESRPAARARLRGSLRELLRRPRLL-------------LLLLLAFLLGFGFFAL-----FTYLPLYL 234
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 442630717 422 SKVLGPRPQGVwmGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFWL 479
Cdd:COG2814 235 QEVLGLSASAA--GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
40-479 |
9.67e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 9.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 40 IYFTMFLMALGFSIILTGIWPYLNKLdPDAGKEFMGLIVAANPLGQMIFSPIFGWWGNKLG-KIRLPLLLSLSLFTLASG 118
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSL-PGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGrKPVILFGLLLFIAGSLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 119 IYSslelrpDNVkYWMLSSRFLIGvSSANIALCRSYLSAATRISERTHAVAMVS----LAQVLGFIIGPTLQAavtplgd 194
Cdd:cd17472 80 AYA------TSI-YGLILGRALQG-SGAISSVVMALLADLTREENRTKAMALIGasigIAFAISMVLGPLLAA------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 195 qghvwlwgkmhfnMYTASG--WINVLMSIGNFMM---FLPGVFEEHKIAAREVMVMQGGTSEKETWKgikpSYLSAWTLi 269
Cdd:cd17472 145 -------------HLGVSGlfLITAILSLVSLLIllfFVPDPPKIVQISEKEKKKLKKLLKNKRLLR----LDFSIFIL- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 270 vaFFVLVFNFVLLETLGTSLTMDmfawSNDEALWYMGIMMttAAIVSLVTFVliepmckIIAERYVLIWGGFSLMFLGrv 349
Cdd:cd17472 207 --HFVLMAFFYILPLLLTQLGGG----KGQLWKVYLPAIL--IGFILMVPFV-------IYAEKKGKMKQVFVSSILL-- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 350 lfvpwgpdppkLAQPFnaswnlsesdpIFLGCPTTQKWcgelpaltltQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRP 429
Cdd:cd17472 270 -----------IAVGF-----------LLLLFAATSLW----------LLIIGLIIFFIGFNLLEALLPSLVSKIAPKEY 317
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 442630717 430 QGVWMGWMTGSGCLSRVLGPVFVGSIYTRLGTFWTFGVTSAMMLVSMFWL 479
Cdd:cd17472 318 RGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVS 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
391-479 |
9.99e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630717 391 LPALTLTQFIIGFAFTSIGYPIGVTLIQTIFSKVLGPRPQGVWMGWMTGSGCLSRVLGPVFVGSIYTRLGT----FWTFG 466
Cdd:COG2223 290 LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSytaaFLVFA 369
|
90
....*....|...
gi 442630717 467 VTSAMMLVSMFWL 479
Cdd:COG2223 370 VLALVALVLTLLL 382
|
|
| |
