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Conserved domains on  [gi|442630599|ref|NP_001261481|]
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dikar, isoform G [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 750-849 1.89e-46

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 162.72  E-value: 1.89e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  750 LQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNN 829
Cdd:cd05509     2 LYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDT 81

                          90       100
                  ....*....|....*....|
gi 442630599  830 EYTEMVNNLQDAFEKATKKY 849
Cdd:cd05509    82 EYYKCANKLEKFFWKKLKEL 101
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1799-2115 4.36e-07

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 55.85  E-value: 4.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1799 EEASPKNSSPPTTPNTEAPKPfealhelskrgksSEPSKSEASQKEKpnlsawlkafgGPkvSKKSEDEEKQQTPVQDLQ 1878
Cdd:PTZ00449  501 EEDSDKHDEPPEGPEASGLPP-------------KAPGDKEGEEGEH-----------ED--SKESDEPKEGGKPGETKE 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1879 GDSKVAPpahSPAgdnfslptvmRQRKPSTGSTNSERSSFSQDPDSPRIAIDERYGS--YAAGSYTSPIGASPIGASPIM 1956
Cdd:PTZ00449  555 GEVGKKP---GPA----------KEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKrpRSAQRPTRPKSPKLPELLDIP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1957 VSPKPNDDMGKPASPYPLNGAIKVGFYQDTTTKSSPDKSCSPRemnSPY-PQYSQHIYSSASSPNVSTPDmSGTSPYGGG 2035
Cdd:PTZ00449  622 KSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPK---PPFdPKFKEKFYDDYLDAAAKSKE-TKTTVVLDE 697

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2036 NSYNPSGSEASKTPAYSSTSPLPIydQYKQPRSQESDYNSSMSPSTPnphspyqQPQSSPYTTPQQSQST--HPSPYHNQ 2113
Cdd:PTZ00449  698 SFESILKETLPETPGTPFTTPRPL--PPKLPRDEEFPFEPIGDPDAE-------QPDDIEFFTPPEEERTffHETPADTP 768


                  ..
gi 442630599 2114 SP 2115
Cdd:PTZ00449  769 LP 770
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 2082-2190 2.32e-04

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2082 PNPHSPYQQPQSSPYTTPQQSQSTHPSPYHN---QSPYHQQQHSPYHPPAAQQQQQSSQPSHSPAAHQQALSPmhSVESP 2158
Cdd:PRK10263  364 PGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNeplQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAP--APEQP 441

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442630599 2159 ASSAATQPP---TPLAQSPAEQQHSPYQQPVLSPY 2190
Cdd:PRK10263  442 VAGNAWQAEeqqSTFAPQSTYQTEQTYQQPAAQEP 476
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 750-849 1.89e-46

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 162.72  E-value: 1.89e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  750 LQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNN 829
Cdd:cd05509     2 LYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDT 81

                          90       100
                  ....*....|....*....|
gi 442630599  830 EYTEMVNNLQDAFEKATKKY 849
Cdd:cd05509    82 EYYKCANKLEKFFWKKLKEL 101
BROMO smart00297
bromo domain;
747-849 1.09e-26

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 106.59  E-value: 1.09e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599    747 EEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNG 826
Cdd:smart00297    5 QKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNG 84

                            90       100
                    ....*....|....*....|...
gi 442630599    827 HNNEYTEMVNNLQDAFEKATKKY 849
Cdd:smart00297   85 PDSEVYKDAKKLEKFFEKKLREL 107
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 756-835 1.90e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 87.75  E-value: 1.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599   756 KVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMV 835
Cdd:pfam00439    3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 738-844 5.25e-18

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 88.71  E-value: 5.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  738 KSGDDFTETEEVLQIG-MHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRL 816
Cdd:COG5076   136 PKIEDELLYADNKAIAkFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNL 215

                          90       100
                  ....*....|....*....|....*...
gi 442630599  817 IVNNCRLYNGHNNEYTEMVNNLQDAFEK 844
Cdd:COG5076   216 MFDNCKLYNGPDSSVYVDAKELEKYFLK 243
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1799-2115 4.36e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 55.85  E-value: 4.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1799 EEASPKNSSPPTTPNTEAPKPfealhelskrgksSEPSKSEASQKEKpnlsawlkafgGPkvSKKSEDEEKQQTPVQDLQ 1878
Cdd:PTZ00449  501 EEDSDKHDEPPEGPEASGLPP-------------KAPGDKEGEEGEH-----------ED--SKESDEPKEGGKPGETKE 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1879 GDSKVAPpahSPAgdnfslptvmRQRKPSTGSTNSERSSFSQDPDSPRIAIDERYGS--YAAGSYTSPIGASPIGASPIM 1956
Cdd:PTZ00449  555 GEVGKKP---GPA----------KEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKrpRSAQRPTRPKSPKLPELLDIP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1957 VSPKPNDDMGKPASPYPLNGAIKVGFYQDTTTKSSPDKSCSPRemnSPY-PQYSQHIYSSASSPNVSTPDmSGTSPYGGG 2035
Cdd:PTZ00449  622 KSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPK---PPFdPKFKEKFYDDYLDAAAKSKE-TKTTVVLDE 697

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2036 NSYNPSGSEASKTPAYSSTSPLPIydQYKQPRSQESDYNSSMSPSTPnphspyqQPQSSPYTTPQQSQST--HPSPYHNQ 2113
Cdd:PTZ00449  698 SFESILKETLPETPGTPFTTPRPL--PPKLPRDEEFPFEPIGDPDAE-------QPDDIEFFTPPEEERTffHETPADTP 768


                  ..
gi 442630599 2114 SP 2115
Cdd:PTZ00449  769 LP 770
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1949-2167 1.39e-05

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 51.05  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1949 PIGASPIMVSPKPNDDMGKPASPYPLNGAIKvGFYQDTTTKSSPDksCSPREMNSPYPQYSQHIYSSASSPNVSTPDMsg 2028
Cdd:COG5422    38 QRKLNPISIRNGADNDIINSESKESFGKYAL-GHQIFSSFSSSPK--LFQRRNSAGPITHSPSATSSTSSLNSNDGDQ-- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2029 TSPYGGGNSYNPSGSEASKTPAYSSTSP--------LPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQS------- 2093
Cdd:COG5422   113 FSPASDSLSFNPSSTQSRKDSGPGDGSPvqkrknplLPSSSTHGTHPPIVFTDNNGSHAGAPNARSRKEIPSLgsqsmql 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2094 -SPYTTPQQSQSTHPSPYHNQSPYHQQQHSPYHPPAAQQQQQSSQPSHSPAAHQQALS-----PMHsVESPASSAATQPP 2167
Cdd:COG5422   193 pSPHFRQKFSSSDTSNGFSYPSIRKNSRHSSNSMPSFPHSSTAVLLKRHSGSSGASLIssnitPSS-SNSEAMSTSSKRP 271
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1942-2188 1.51e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 1.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  1942 TSPIGA-SPIGASPIMVSPKPNDDMGKPASPyplngaikvgfyqDTTTKSSPDKSCSPrEMNSPYPQYsqhiysSASSPN 2020
Cdd:pfam05109  474 TSPTPAgTTSGASPVTPSPSPRDNGTESKAP-------------DMTSPTSAVTTPTP-NATSPTPAV------TTPTPN 533

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2021 VSTPDMSGTSPYGGGNSYNPSGSeaSKTPAYSSTSPlpiydQYKQPRSQESDYNSSMSPSTPNPHSPyqqpqSSPYTTPQ 2100
Cdd:pfam05109  534 ATSPTLGKTSPTSAVTTPTPNAT--SPTPAVTTPTP-----NATIPTLGKTSPTSAVTTPTPNATSP-----TVGETSPQ 601

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2101 QSQSTHPSPYHNQSPYhqqqhspyhppaaqqqqqssQPSHSPAAHQQALSPMHSVESPASSAATQPPTPLAQ--SPAEQQ 2178
Cdd:pfam05109  602 ANTTNHTLGGTSSTPV--------------------VTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISEtlSPSTSD 661

                          250
                   ....*....|
gi 442630599  2179 HSPYQQPVLS 2188
Cdd:pfam05109  662 NSTSHMPLLT 671
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2082-2190 2.32e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2082 PNPHSPYQQPQSSPYTTPQQSQSTHPSPYHN---QSPYHQQQHSPYHPPAAQQQQQSSQPSHSPAAHQQALSPmhSVESP 2158
Cdd:PRK10263  364 PGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNeplQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAP--APEQP 441

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442630599 2159 ASSAATQPP---TPLAQSPAEQQHSPYQQPVLSPY 2190
Cdd:PRK10263  442 VAGNAWQAEeqqSTFAPQSTYQTEQTYQQPAAQEP 476
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 2011-2226 7.21e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.41  E-value: 7.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2011 HIYSSASSPNVSTPDMSGTSPYGGGNSYNPSGSEASKTPAYSSTSplpiYDQYKQPrsqesDY------NSS---MSPST 2081
Cdd:pfam09770   99 QVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTG----YEKYKEP-----EPipdlqvDASlwgVAPKK 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2082 PNPHSPYQQPQSSPYTTPQQS---------------QSTHPSP-----------YHNQSPYHQQQHSPYHPPAAQQQQQS 2135
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSrkmmsleeveaamraQAKKPAQqpapapaqppaAPPAQQAQQQQQFPPQIQQQQQPQQQ 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2136 SQPSHSPAAHQQALSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQQP--------VLSPYQQPQQQVQPPVVPPVQP 2207
Cdd:pfam09770  250 PQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPtqilqnpnRLSAARVGYPQNPQPGVQPAPA 329

                          250
                   ....*....|....*....
gi 442630599  2208 SAGAQASTALGNNGYAPTH 2226
Cdd:pfam09770  330 HQAHRQQGSFGRQAPIITH 348
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 750-849 1.89e-46

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 162.72  E-value: 1.89e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  750 LQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNN 829
Cdd:cd05509     2 LYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDT 81

                          90       100
                  ....*....|....*....|
gi 442630599  830 EYTEMVNNLQDAFEKATKKY 849
Cdd:cd05509    82 EYYKCANKLEKFFWKKLKEL 101
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 764-844 1.01e-27

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 109.38  E-value: 1.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  764 HRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFE 843
Cdd:cd04369    17 RDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLEKLFE 96


                  .
gi 442630599  844 K 844
Cdd:cd04369    97 K 97
BROMO smart00297
bromo domain;
747-849 1.09e-26

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 106.59  E-value: 1.09e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599    747 EEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNG 826
Cdd:smart00297    5 QKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNG 84

                            90       100
                    ....*....|....*....|...
gi 442630599    827 HNNEYTEMVNNLQDAFEKATKKY 849
Cdd:smart00297   85 PDSEVYKDAKKLEKFFEKKLREL 107
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 754-844 2.19e-24

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 99.70  E-value: 2.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  754 MHKVLVYVKNHRDAWPF---VDPVEEDIaPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNE 830
Cdd:cd05500     9 LLSSIRSLKRLKDARPFlvpVDPVKLNI-PHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHP 87

                          90
                  ....*....|....
gi 442630599  831 YTEMVNNLQDAFEK 844
Cdd:cd05500    88 VSQMGKRLQAAFEK 101
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 747-844 8.78e-22

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 92.35  E-value: 8.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  747 EEVLqigmhKVLVYVKNHRDAWPFVDPVEEDI--APRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLY 824
Cdd:cd05499     6 EEVL-----KELMKPKHSAYNWPFLDPVDPVAlnIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTF 80

                          90       100
                  ....*....|....*....|
gi 442630599  825 NGHNNEYTEMVNNLQDAFEK 844
Cdd:cd05499    81 NPEGTDVYMMGHQLEEVFND 100
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 761-834 1.22e-21

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 92.33  E-value: 1.22e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442630599  761 VKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEM 834
Cdd:cd05511    12 LKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKK 85
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 754-848 1.20e-20

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 89.76  E-value: 1.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  754 MHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTE 833
Cdd:cd05504    17 LEQLLVEIVKHKDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVYK 96

                          90
                  ....*....|....*
gi 442630599  834 MVNNLQDAFEKATKK 848
Cdd:cd05504    97 AGTRLQRFFIKRCRK 111
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 756-835 1.90e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 87.75  E-value: 1.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599   756 KVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMV 835
Cdd:pfam00439    3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 762-844 5.00e-18

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 81.56  E-value: 5.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  762 KNHRDAWPFVDPV--EEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQ 839
Cdd:cd05498    16 KHKAYAWPFYKPVdpEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQ 95


                  ....*
gi 442630599  840 DAFEK 844
Cdd:cd05498    96 DVFED 100
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 738-844 5.25e-18

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 88.71  E-value: 5.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  738 KSGDDFTETEEVLQIG-MHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRL 816
Cdd:COG5076   136 PKIEDELLYADNKAIAkFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNL 215

                          90       100
                  ....*....|....*....|....*...
gi 442630599  817 IVNNCRLYNGHNNEYTEMVNNLQDAFEK 844
Cdd:COG5076   216 MFDNCKLYNGPDSSVYVDAKELEKYFLK 243
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 764-844 1.95e-17

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 79.73  E-value: 1.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  764 HRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFE 843
Cdd:cd05503    15 HEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGHNMRKFFE 94


                  .
gi 442630599  844 K 844
Cdd:cd05503    95 K 95
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 742-842 1.92e-15

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 74.11  E-value: 1.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  742 DFTETEEVLqigmHKVLVYvknhRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNC 821
Cdd:cd05505     1 ELQKCEEIL----SKILKY----RFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNA 72

                          90       100
                  ....*....|....*....|.
gi 442630599  822 RLYNGHNNEYTEMVNNLQDAF 842
Cdd:cd05505    73 EKYYENGSYVLSCMRKTEQCC 93
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 756-844 5.12e-15

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 73.63  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  756 KVLVYVKNH-RDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGH-NNEYTE 833
Cdd:cd05510    14 KVLNELKTYtEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSDpSHPLRR 93

                          90
                  ....*....|.
gi 442630599  834 MVNNLQDAFEK 844
Cdd:cd05510    94 HANFMKKKAEH 104
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 764-844 1.41e-14

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 71.59  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  764 HRDAWPF---VDPVEEDIaPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQD 840
Cdd:cd05506    15 HKWGWVFnapVDVVALGL-PDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHTMAKELLK 93


                  ....
gi 442630599  841 AFEK 844
Cdd:cd05506    94 IFET 97
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 756-840 1.68e-14

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 71.63  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  756 KVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMV 835
Cdd:cd05507    10 LVYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMA 89


                  ....*
gi 442630599  836 NNLQD 840
Cdd:cd05507    90 VEMQR 94
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 747-843 4.57e-14

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 70.55  E-value: 4.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  747 EEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDI--APRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLY 824
Cdd:cd05495     2 EELRQALMPTLEKLYKQDPESLPFRQPVDPKLlgIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLY 81

                          90
                  ....*....|....*....
gi 442630599  825 NGHNNEYTEMVNNLQDAFE 843
Cdd:cd05495    82 NRKTSRVYKYCTKLAEVFE 100
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 770-825 8.31e-14

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 69.36  E-value: 8.31e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442630599  770 FVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYN 825
Cdd:cd05513    22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYN 77
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 756-850 1.52e-13

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 69.24  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  756 KVLVYVKNHRDAWPFVDPVEEDIaPRYYSIIRRPMDLLKMEDKLDSGEYHKFS---EFRNDFRLIVNNCRLYNGHNNEYT 832
Cdd:cd05502    11 RLLLELYCHELSLPFHEPVSPSV-PNYYKIIKTPMDLSLIRKKLQPKSPQHYSspeEFVADVRLMFKNCYKFNEEDSEVA 89

                          90
                  ....*....|....*...
gi 442630599  833 EMVNNLQDAFEKATKKYF 850
Cdd:cd05502    90 QAGKELELFFEEQLKEIL 107
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 764-842 2.00e-13

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 68.60  E-value: 2.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  764 HRDAWPF---VDPVEEDIaPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQD 840
Cdd:cd05497    20 HKFAWPFqqpVDAVKLNL-PDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLEK 98


                  ..
gi 442630599  841 AF 842
Cdd:cd05497    99 LF 100
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 750-826 6.79e-13

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 67.04  E-value: 6.79e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442630599  750 LQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNG 826
Cdd:cd05512     2 LEVLLRKTLDQLQEKDTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNA 78
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 769-841 7.06e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 67.38  E-value: 7.06e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442630599  769 PFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNN----LQDA 841
Cdd:cd05528    23 AFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRDPADKLIRSraceLRDE 99
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 754-848 1.98e-11

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 63.22  E-value: 1.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  754 MHKVLVYVKNHRD------AWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGH 827
Cdd:cd05516     6 MNKIVDVVIKYKDsdgrqlAEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLE 85

                          90       100
                  ....*....|....*....|.
gi 442630599  828 NNEYTEMVNNLQDAFEKATKK 848
Cdd:cd05516    86 GSLIYEDSIVLQSVFKSARQK 106
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 782-850 1.53e-09

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 57.44  E-value: 1.53e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442630599  782 YYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNgHNNEYTEMVNNLQDAFEKATKKYF 850
Cdd:cd05501    33 YCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFY-KDDDFGQVGITLEKKFEKNFKEVF 100
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 750-825 1.90e-09

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 57.31  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  750 LQIGMHKVLVYVKNHRD------AWPFVD-PVEEDIaPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCR 822
Cdd:cd05515     1 MQQKLWELYNAVKNYTDgrgrrlSLIFMRlPSKSEY-PDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNAC 79


                  ...
gi 442630599  823 LYN 825
Cdd:cd05515    80 KYN 82
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 766-825 3.04e-09

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 57.08  E-value: 3.04e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  766 DAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYN 825
Cdd:cd05496    22 DSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 780-848 4.79e-08

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 53.22  E-value: 4.79e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442630599  780 PRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYnghnNEYTEMVNNLQDAFEKATKK 848
Cdd:cd05518    37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHY----NEEGSQVYEDANILEKVLKE 101
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 780-848 1.12e-07

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 52.72  E-value: 1.12e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  780 PRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCR-LYNGHNNEYTEMVnNLQDAFEKATKK 848
Cdd:cd05524    39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKaYYKPDSPEHKDAC-KLWELFLSARNE 107
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 769-833 2.79e-07

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 50.84  E-value: 2.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442630599  769 PFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTE 833
Cdd:cd05508    22 PFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQ 86
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1799-2115 4.36e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 55.85  E-value: 4.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1799 EEASPKNSSPPTTPNTEAPKPfealhelskrgksSEPSKSEASQKEKpnlsawlkafgGPkvSKKSEDEEKQQTPVQDLQ 1878
Cdd:PTZ00449  501 EEDSDKHDEPPEGPEASGLPP-------------KAPGDKEGEEGEH-----------ED--SKESDEPKEGGKPGETKE 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1879 GDSKVAPpahSPAgdnfslptvmRQRKPSTGSTNSERSSFSQDPDSPRIAIDERYGS--YAAGSYTSPIGASPIGASPIM 1956
Cdd:PTZ00449  555 GEVGKKP---GPA----------KEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKrpRSAQRPTRPKSPKLPELLDIP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1957 VSPKPNDDMGKPASPYPLNGAIKVGFYQDTTTKSSPDKSCSPRemnSPY-PQYSQHIYSSASSPNVSTPDmSGTSPYGGG 2035
Cdd:PTZ00449  622 KSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPK---PPFdPKFKEKFYDDYLDAAAKSKE-TKTTVVLDE 697

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2036 NSYNPSGSEASKTPAYSSTSPLPIydQYKQPRSQESDYNSSMSPSTPnphspyqQPQSSPYTTPQQSQST--HPSPYHNQ 2113
Cdd:PTZ00449  698 SFESILKETLPETPGTPFTTPRPL--PPKLPRDEEFPFEPIGDPDAE-------QPDDIEFFTPPEEERTffHETPADTP 768


                  ..
gi 442630599 2114 SP 2115
Cdd:PTZ00449  769 LP 770
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 780-850 6.17e-07

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 50.03  E-value: 6.17e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442630599  780 PRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYnghnNEYTEMVNNLQDAFEKATKKYF 850
Cdd:cd05519    37 PDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTY----NQEGSIVYEDAVEMEKAFKKKY 103
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 780-854 2.33e-06

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 48.39  E-value: 2.33e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442630599  780 PRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEytemvnNLQDAFEkaTKKYFDNLS 854
Cdd:cd05522    38 PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQ------EYKDAVL--LEKEARLLA 104
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 745-844 8.34e-06

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 47.72  E-value: 8.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  745 ETEEVLQiGMHKVLVYVKNHRDAwPFVDPVEE-DIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRL 823
Cdd:cd05529    25 ERERLIS-GLDKLLLSLQLEIAE-YFEYPVDLrAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAET 102

                          90       100
                  ....*....|....*....|.
gi 442630599  824 YNGHNNEYTEMVNNLQDAFEK 844
Cdd:cd05529   103 FNEPNSEIAKKAKRLSDWLLR 123
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1949-2167 1.39e-05

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 51.05  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1949 PIGASPIMVSPKPNDDMGKPASPYPLNGAIKvGFYQDTTTKSSPDksCSPREMNSPYPQYSQHIYSSASSPNVSTPDMsg 2028
Cdd:COG5422    38 QRKLNPISIRNGADNDIINSESKESFGKYAL-GHQIFSSFSSSPK--LFQRRNSAGPITHSPSATSSTSSLNSNDGDQ-- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2029 TSPYGGGNSYNPSGSEASKTPAYSSTSP--------LPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQS------- 2093
Cdd:COG5422   113 FSPASDSLSFNPSSTQSRKDSGPGDGSPvqkrknplLPSSSTHGTHPPIVFTDNNGSHAGAPNARSRKEIPSLgsqsmql 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2094 -SPYTTPQQSQSTHPSPYHNQSPYHQQQHSPYHPPAAQQQQQSSQPSHSPAAHQQALS-----PMHsVESPASSAATQPP 2167
Cdd:COG5422   193 pSPHFRQKFSSSDTSNGFSYPSIRKNSRHSSNSMPSFPHSSTAVLLKRHSGSSGASLIssnitPSS-SNSEAMSTSSKRP 271
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 761-843 1.89e-05

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 49.80  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  761 VKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGhnnEYTEMVNNLQD 840
Cdd:COG5076   275 SQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNCVMYNG---EVTDYYKNANV 351


                  ...
gi 442630599  841 AFE 843
Cdd:COG5076   352 LED 354
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1794-2186 3.09e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 3.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1794 DDR-PNEEASPKNSSPPTTPNTEAPKPfealhelSKRGKSSEPSKSEASQKEKPNLSAWLKAFGGPKVSKKSEDEEKQQT 1872
Cdd:PHA03247 2603 DDRgDPRGPAPPSPLPPDTHAPDPPPP-------SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ 2675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1873 PVQDLQGDSKVAPPA-----------HSPAGDNFSLPTVMRQRKPSTGSTNSERSSFSQDP-----------------DS 1924
Cdd:PHA03247 2676 ASSPPQRPRRRAARPtvgsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaapappavpagpatpggPA 2755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1925 PRIAIDERYGSYAAGSYTSPIGASPIGASPIMVSPKPNDDMGKPASPYPLNGAIKVgfyqdTTTKSSPDKSCSPREMNSP 2004
Cdd:PHA03247 2756 RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV-----LAPAAALPPAASPAGPLPP 2830

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2005 YPQYSQHIYSSASSPNVSTPDMSGTSPYGGGNSYNPSGSEASKTPAyssTSPLPIYDQYKQPRSQESDYNSSMSPSTPNP 2084
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA---APARPPVRRLARPAVSRSTESFALPPDQPER 2907

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2085 hSPYQQPQSSPYTTPQQSQSTHPSPYHNQSPYHQQQHSPyhppaaqQQQQSSQPSHSPAAHQQALSPMHSVESPASSAAT 2164
Cdd:PHA03247 2908 -PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP-------TTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRV 2979

                         410       420
                  ....*....|....*....|..
gi 442630599 2165 QPPTPLAQSPAEQQHSPYQQPV 2186
Cdd:PHA03247 2980 PQPAPSREAPASSTPPLTGHSL 3001
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 754-841 3.47e-05

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 45.02  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  754 MHKVLVYVKNHRD------AWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGH 827
Cdd:cd05520     5 LWQLYDTIRNARNnqgqllAEPFLKLPSKRKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVP 84

                          90
                  ....*....|....
gi 442630599  828 NNEYTEMVNNLQDA 841
Cdd:cd05520    85 NSRIYKDAEKLQKL 98
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1942-2188 1.51e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 1.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  1942 TSPIGA-SPIGASPIMVSPKPNDDMGKPASPyplngaikvgfyqDTTTKSSPDKSCSPrEMNSPYPQYsqhiysSASSPN 2020
Cdd:pfam05109  474 TSPTPAgTTSGASPVTPSPSPRDNGTESKAP-------------DMTSPTSAVTTPTP-NATSPTPAV------TTPTPN 533

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2021 VSTPDMSGTSPYGGGNSYNPSGSeaSKTPAYSSTSPlpiydQYKQPRSQESDYNSSMSPSTPNPHSPyqqpqSSPYTTPQ 2100
Cdd:pfam05109  534 ATSPTLGKTSPTSAVTTPTPNAT--SPTPAVTTPTP-----NATIPTLGKTSPTSAVTTPTPNATSP-----TVGETSPQ 601

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2101 QSQSTHPSPYHNQSPYhqqqhspyhppaaqqqqqssQPSHSPAAHQQALSPMHSVESPASSAATQPPTPLAQ--SPAEQQ 2178
Cdd:pfam05109  602 ANTTNHTLGGTSSTPV--------------------VTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISEtlSPSTSD 661

                          250
                   ....*....|
gi 442630599  2179 HSPYQQPVLS 2188
Cdd:pfam05109  662 NSTSHMPLLT 671
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2082-2190 2.32e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2082 PNPHSPYQQPQSSPYTTPQQSQSTHPSPYHN---QSPYHQQQHSPYHPPAAQQQQQSSQPSHSPAAHQQALSPmhSVESP 2158
Cdd:PRK10263  364 PGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNeplQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAP--APEQP 441

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442630599 2159 ASSAATQPP---TPLAQSPAEQQHSPYQQPVLSPY 2190
Cdd:PRK10263  442 VAGNAWQAEeqqSTFAPQSTYQTEQTYQQPAAQEP 476
Bromo_ZMYND11 cd05492
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear ...
 775-834 2.90e-04

Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99924  Cd Length: 109  Bit Score: 42.75  E-value: 2.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  775 EEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEM 834
Cdd:cd05492    32 KATKLPKRRRLIHTHLDVADIQEKINSEKYTSLEEFKADALLLLHNTAIFHGADSEQYDA 91
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 2011-2226 7.21e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.41  E-value: 7.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2011 HIYSSASSPNVSTPDMSGTSPYGGGNSYNPSGSEASKTPAYSSTSplpiYDQYKQPrsqesDY------NSS---MSPST 2081
Cdd:pfam09770   99 QVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTG----YEKYKEP-----EPipdlqvDASlwgVAPKK 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2082 PNPHSPYQQPQSSPYTTPQQS---------------QSTHPSP-----------YHNQSPYHQQQHSPYHPPAAQQQQQS 2135
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSrkmmsleeveaamraQAKKPAQqpapapaqppaAPPAQQAQQQQQFPPQIQQQQQPQQQ 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2136 SQPSHSPAAHQQALSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQQP--------VLSPYQQPQQQVQPPVVPPVQP 2207
Cdd:pfam09770  250 PQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPtqilqnpnRLSAARVGYPQNPQPGVQPAPA 329

                          250
                   ....*....|....*....
gi 442630599  2208 SAGAQASTALGNNGYAPTH 2226
Cdd:pfam09770  330 HQAHRQQGSFGRQAPIITH 348
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2078-2190 9.63e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 9.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2078 SPSTPNPHSPYQQP----QSSP-YTTPQQSQSTHPSPYHNQSPYHQ---QQHSPYHPPAAQQQQQSSQPSHSPAAHQQ-A 2148
Cdd:PRK10263  343 TPPVASVDVPPAQPtvawQPVPgPQTGEPVIAPAPEGYPQQSQYAQpavQYNEPLQQPVQPQQPYYAPAAEQPAQQPYyA 422

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442630599 2149 LSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQ-QPVLSPY 2190
Cdd:PRK10263  423 PAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFApQSTYQTE 465
PHA03377 PHA03377
EBNA-3C; Provisional
 1802-2181 9.99e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 45.04  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1802 SPKNSSPPTTPNTEAPKPFEALHELSKRGKSSEPSKSEASQKEKPNLS------------AWLKAFGGPKVSKKSEDEEK 1869
Cdd:PHA03377  519 TTEEEESVTQPAKPHRKVQDGFQRSGRRQKRATPPKVSPSDRGPPKASppvmappstgprVMATPSTGPRDMAPPSTGPR 598

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1870 QQTPVQD---LQGDSKVAPPAHSPagdNFSLPTVMR---QRKPSTGSTNSERSSFSQDPDSPRIAIDERYGSYAAGSYTS 1943
Cdd:PHA03377  599 QQAKCKDgppASGPHEKQPPSSAP---RDMAPSVVRmflRERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQ 675

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1944 PIGASPIGASPIMV-------SPKPNDDMGK----PASPYPLNGAIKVGFYQDTTTKSSPDKSCSPREMNSPYPQYSQHI 2012
Cdd:PHA03377  676 STPPRPSWLPSVFVlpsvdagRAQPSEESHLssmsPTQPISHEEQPRYEDPDDPLDLSLHPDQAPPPSHQAPYSGHEEPQ 755

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2013 YSSASSPNVSTPDmSGTSPYGGGNSYNPSGSEASKTPAYSSTSPL-PIYDQYKQPRSQESDYNSSMSPSTP-NPHSPYQQ 2090
Cdd:PHA03377  756 AQQAPYPGYWEPR-PPQAPYLGYQEPQAQGVQVSSYPGYAGPWGLrAQHPRYRHSWAYWSQYPGHGHPQGPwAPRPPHLP 834

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2091 PQSSPYTTPQQSQSTHPSPYHNQS--PYHQQQHSPyhppaaqqQQQSSQPSHSPAAHQQALSPMHSVESPASSAATQPPT 2168
Cdd:PHA03377  835 PQWDGSAGHGQDQVSQFPHLQSETgpPRLQLSQVP--------QLPYSQTLVSSSAPSWSSPQPRAPIRPIPTRFPPPPM 906

                         410
                  ....*....|...
gi 442630599 2169 PLAQSPAEQQHSP 2181
Cdd:PHA03377  907 PLQDSMAVGCDSS 919
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 777-831 1.01e-03

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 40.89  E-value: 1.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442630599  777 DIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEY 831
Cdd:cd05517    34 VLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQV 88
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1779-2108 1.94e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1779 GKSLEEMSGKKDANEDDRPNEEASPKnsSPPTTPNTEAPKPfealhelskrGKSSEPSKSEASQKeKPNlsawlkafgGP 1858
Cdd:PTZ00449  525 GDKEGEEGEHEDSKESDEPKEGGKPG--ETKEGEVGKKPGP----------AKEHKPSKIPTLSK-KPE---------FP 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1859 KVSKKSEDEEKQQTPVQDLQGDSKVAPPahSPAGDNFS-LPtvmRQRKPSTGSTNSERSSFSQDPDSPRiaiderygsya 1937
Cdd:PTZ00449  583 KDPKHPKDPEEPKKPKRPRSAQRPTRPK--SPKLPELLdIP---KSPKRPESPKSPKRPPPPQRPSSPE----------- 646

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1938 agsytSPIGASPIGASPIMVSPKPnddmgkpaspyPLNGAIKVGFYQDTTTKSSPDKSC-----------SPREMNSPYP 2006
Cdd:PTZ00449  647 -----RPEGPKIIKSPKPPKSPKP-----------PFDPKFKEKFYDDYLDAAAKSKETkttvvldesfeSILKETLPET 710

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2007 QYSQHIYSSASSPNVSTPDMSGTSPYGGGNSYNPSGSEASKTPAYSST--------SPLP--IYDQYKQPrsqesdynsS 2076
Cdd:PTZ00449  711 PGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTffhetpadTPLPdiLAEEFKEE---------D 781

                         330       340       350
                  ....*....|....*....|....*....|..
gi 442630599 2077 MSPSTPNPHSPYQQPQsSPYTTPQQSQSTHPS 2108
Cdd:PTZ00449  782 IHAETGEPDEAMKRPD-SPSEHEDKPPGDHPS 812
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 742-795 2.31e-03

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 40.12  E-value: 2.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442630599  742 DFTETEEVLQigmhkVLVYVKNHRDAWPF---VDPVEEDiAPRYYSIIRRPMDLLKM 795
Cdd:cd05494     1 DYEALERVLR-----ELKRHRRNEDAWPFlepVNPPRRG-APDYRDVIKRPMSFGTK 51
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1981-2181 3.41e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 3.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  1981 GFYQDTTTKSSPDKSCSPREMNSPypqysqhiysSASSPNVSTPDMsgTSPygggnsyNPSGSEASKTPAYSSTSPLPIY 2060
Cdd:pfam05109  438 GFAAPNTTTGLPSSTHVPTNLTAP----------ASTGPTVSTADV--TSP-------TPAGTTSGASPVTPSPSPRDNG 498

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599  2061 DQYKQPrsQESDYNSSMSPSTPNPHSPyqqpqsSPYTTPQQSQSTHPSpyhnqspyhQQQHSPYHPPAAQQQQQSSQPSH 2140
Cdd:pfam05109  499 TESKAP--DMTSPTSAVTTPTPNATSP------TPAVTTPTPNATSPT---------LGKTSPTSAVTTPTPNATSPTPA 561

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 442630599  2141 SPAAHQQALSPMHSVESPASSAATqpPTPLAQSPAEQQHSP 2181
Cdd:pfam05109  562 VTTPTPNATIPTLGKTSPTSAVTT--PTPNATSPTVGETSP 600
dnaA PRK14086
chromosomal replication initiator protein DnaA;
1993-2189 4.13e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.89  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1993 DKSCSPREMNSPYPQysqhiysSASSPNVSTPDMSGTSPYGGgnsynPSGSEASKTPAYSSTSP--LPIYDQYkQPRSQE 2070
Cdd:PRK14086   89 DPSAGEPAPPPPHAR-------RTSEPELPRPGRRPYEGYGG-----PRADDRPPGLPRQDQLPtaRPAYPAY-QQRPEP 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2071 SDYnssmsPSTPNPHSPYQQ----PQSSPYTTPQQ---SQSTHPSPYHNQSPYH----QQQHSP---YHPPAAQQQQQSS 2136
Cdd:PRK14086  156 GAW-----PRAADDYGWQQQrlgfPPRAPYASPASyapEQERDREPYDAGRPEYdqrrRDYDHPrpdWDRPRRDRTDRPE 230

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442630599 2137 QPSHSPAAHQQALSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQQPVLSP 2189
Cdd:PRK14086  231 PPPGAGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLNP 283
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1801-2189 6.78e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 6.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1801 ASPKNSSPPTTPnteAPKPfealhelskrgksSEPS-KSEASQKEKPNLSAWLKAFGGPkvskkSEDEEKQQTPVQDLQG 1879
Cdd:PHA03247 2562 AAPDRSVPPPRP---APRP-------------SEPAvTSRARRPDAPPQSARPRAPVDD-----RGDPRGPAPPSPLPPD 2620

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1880 DSKVAPPAHSPAGDNFSLPTVMRQRKPstgstnsERSSFSQDPDSPRIAIDER--YGSYAAGSYTSPIG----ASPIGAS 1953
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVP-------PPERPRDDPAPGRVSRPRRarRLGRAAQASSPPQRprrrAARPTVG 2693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 1954 PIMVSPKPNDDMGKPAS-PYPLNGAIKVGFYQDTTTKSSPDKSCSPREMNSPYPQYSQHIYSSASSPNVSTPDMSGTSPY 2032
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2033 GggnsynPSGSEASKTPAYSSTSPLPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQSSPYTTPQQSQSTHPSPYHN 2112
Cdd:PHA03247 2774 A------PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630599 2113 QSPYHQQQHSPYHPPAAQQQQQSSQPSHSPAAHqqalSPMHSVESPASSAATQ-----------PPTPLAQSPAEQQHSP 2181
Cdd:PHA03247 2848 PSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPAR----PPVRRLARPAVSRSTEsfalppdqperPPQPQAPPPPQPQPQP 2923


                  ....*...
gi 442630599 2182 YQQPVLSP 2189
Cdd:PHA03247 2924 PPPPQPQP 2931
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 780-845 9.89e-03

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 38.14  E-value: 9.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442630599  780 PRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKA 845
Cdd:cd05525    39 PDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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