NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442622647|ref|NP_001260757|]
View 

late bloomer, isoform B [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 11992915)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 109-169 8.60e-18

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


:

Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 74.85  E-value: 8.60e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442622647 109 WQANNMDSLQQKHECCGQSSAQDYIHLSLLIPPSCY-ADLQQTPDHLYLDGCIEKVQSFYES 169
Cdd:cd03127   27 DFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCkGTDGNCGLNLYTEGCLEKLVDFLRS 88
Tetraspanin pfam00335
Tetraspanin family;
47-196 1.52e-08

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 52.32  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647   47 IACSLILVFALLGIFAAIRESVVLTATSAVFLLILAILQIVSTCLFLH---------------EFDVKSGRDMVEVAWQA 111
Cdd:pfam00335  50 VLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVyrdklsgllsnwlkkSLEDGYRDWLDLYSCLN 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647  112 NNMDSLQQKHECCGqssaqdyihlsllippscyadlqqtpdhlyldGCIEKVQSFYESDKLRFIIVSWVLVAFELICFAL 191
Cdd:pfam00335 130 SALDSLQSEFGCCG--------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIIL 177


                  ....*
gi 442622647  192 AVFLA 196
Cdd:pfam00335 178 ACCLC 182
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 109-169 8.60e-18

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 74.85  E-value: 8.60e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442622647 109 WQANNMDSLQQKHECCGQSSAQDYIHLSLLIPPSCY-ADLQQTPDHLYLDGCIEKVQSFYES 169
Cdd:cd03127   27 DFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCkGTDGNCGLNLYTEGCLEKLVDFLRS 88
Tetraspanin pfam00335
Tetraspanin family;
47-196 1.52e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 52.32  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647   47 IACSLILVFALLGIFAAIRESVVLTATSAVFLLILAILQIVSTCLFLH---------------EFDVKSGRDMVEVAWQA 111
Cdd:pfam00335  50 VLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVyrdklsgllsnwlkkSLEDGYRDWLDLYSCLN 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647  112 NNMDSLQQKHECCGqssaqdyihlsllippscyadlqqtpdhlyldGCIEKVQSFYESDKLRFIIVSWVLVAFELICFAL 191
Cdd:pfam00335 130 SALDSLQSEFGCCG--------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIIL 177


                  ....*
gi 442622647  192 AVFLA 196
Cdd:pfam00335 178 ACCLC 182
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 109-169 8.60e-18

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 74.85  E-value: 8.60e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442622647 109 WQANNMDSLQQKHECCGQSSAQDYIHLSLLIPPSCY-ADLQQTPDHLYLDGCIEKVQSFYES 169
Cdd:cd03127   27 DFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCkGTDGNCGLNLYTEGCLEKLVDFLRS 88
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 95-167 6.60e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 54.70  E-value: 6.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647  95 EFDVKSGRDMVEVAWqannmDSLQQKHECCGQSSAQDYIHLSL-------LIPPSCY------------ADLQQTPD--- 152
Cdd:cd03160   22 NYGGNPENKTAEEAW-----DYVQFQLQCCGWTGPQDWTDNSLiknssepLYPCSCCnssatadsprpsKGFCEAPAsld 96

                         90
                 ....*....|....*.
gi 442622647 153 -HLYLDGCIEKVQSFY 167
Cdd:cd03160   97 wPVYQEGCMEKLQSWL 112
Tetraspanin pfam00335
Tetraspanin family;
47-196 1.52e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 52.32  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647   47 IACSLILVFALLGIFAAIRESVVLTATSAVFLLILAILQIVSTCLFLH---------------EFDVKSGRDMVEVAWQA 111
Cdd:pfam00335  50 VLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVyrdklsgllsnwlkkSLEDGYRDWLDLYSCLN 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647  112 NNMDSLQQKHECCGqssaqdyihlsllippscyadlqqtpdhlyldGCIEKVQSFYESDKLRFIIVSWVLVAFELICFAL 191
Cdd:pfam00335 130 SALDSLQSEFGCCG--------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIIL 177


                  ....*
gi 442622647  192 AVFLA 196
Cdd:pfam00335 178 ACCLC 182
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 99-166 1.63e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 42.35  E-value: 1.63e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442622647  99 KSGRDMVEVAWqannmDSLQQKHECCGQSSAQDY--IHLSLLIPPSCYADLQQ-----TPDHLYLDGCIEKVQSF 166
Cdd:cd03165   24 TRNNRGLTNAW-----DITQTEFRCCGVTNYTDWyeVLGENRVPDSCCQEDSQdcgrnPTELWWKTGCYEKVQQW 93
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 100-166 5.88e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 35.40  E-value: 5.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647 100 SGRDMVEVAWqannmDSLQQKHECCGQSSAQDYIHlSLLIPPSCyADLQQTPD--------------------HLYLDGC 159
Cdd:cd03155   26 SGEEALTLTV-----DELQQEFKCCGSNNYTDWQD-SEWINSNE-ANGRLVPDsccktvvdrcgclrdhpsniYKVEGGC 98


                 ....*..
gi 442622647 160 IEKVQSF 166
Cdd:cd03155   99 IPKLEDF 105
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 95-166 8.81e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 34.37  E-value: 8.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622647  95 EFDvKSGRDMVEvAWQANN-----MDSLQQKHECCGQSSAQDYIHLSLL----IPPSCYADLQQ------TPDHLYLDGC 159
Cdd:cd03166   10 EFN-DSFNQMIS-NYNKTNdfrkiLDRMQKDLKCCGANNYTDWENIPSLdtdsVPDSCCINVTKgcginfDEKVIHLEGC 87


                 ....*..
gi 442622647 160 IEKVQSF 166
Cdd:cd03166   88 VTKIEGW 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH