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Conserved domains on  [gi|428982004|ref|NP_001258777|]
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zinc finger protein 700 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 428982004   26 PVAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-636 2.20e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 2.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 224 TYKCKFCGKAFHSFSLYLIHERTHTGEKPYEC--KQCGKSFTYSATLQIHERTHTGEKPYECSKCDKAFHSSSSYHRHER 301
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 302 SHMGE-KPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQY-GEGLSYLISFQTHIRMNSgerpykcKICGKGFYSAKS 379
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 380 FQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYEC--KQCGKAFRSASQLRVHGGTHTgeKPYECKECGKA 457
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 458 FRSTSHLRVHGRTHTGE-------KPYECKECGKAFRYVKHLQIHERTEKHIRMPSgeRPYKC--SICEKGFYSAKSFQT 528
Cdd:COG5048  264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESL--KPFSCpySLCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 529 HEKTHTGEKPYEC--NQCGKAFR-----CCNSLRYHERTHTGEKPYEC--KQCGKAFRSASHLRMHERTHTGEKPYECK- 598
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 428982004 599 -QCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSAS 636
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 677-728 4.80e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 428982004 677 KPYeCKHCGNGFTSAKILQIHARthigEKHYECKECGKAFNYFSSLHIHART 728
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
637-660 5.74e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|....
gi 428982004  637 NLQMHERTHTGEKPYECKECEKAF 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 428982004   26 PVAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
27-69 1.14e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 1.14e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 428982004    27 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIGKK 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-66 4.37e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.28  E-value: 4.37e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 428982004  27 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSI 66
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-636 2.20e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 2.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 224 TYKCKFCGKAFHSFSLYLIHERTHTGEKPYEC--KQCGKSFTYSATLQIHERTHTGEKPYECSKCDKAFHSSSSYHRHER 301
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 302 SHMGE-KPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQY-GEGLSYLISFQTHIRMNSgerpykcKICGKGFYSAKS 379
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 380 FQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYEC--KQCGKAFRSASQLRVHGGTHTgeKPYECKECGKA 457
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 458 FRSTSHLRVHGRTHTGE-------KPYECKECGKAFRYVKHLQIHERTEKHIRMPSgeRPYKC--SICEKGFYSAKSFQT 528
Cdd:COG5048  264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESL--KPFSCpySLCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 529 HEKTHTGEKPYEC--NQCGKAFR-----CCNSLRYHERTHTGEKPYEC--KQCGKAFRSASHLRMHERTHTGEKPYECK- 598
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 428982004 599 -QCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSAS 636
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 428982004  581 HLRMHERTHTGEKPYECKQCGKAFSC 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 677-728 4.80e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 428982004 677 KPYeCKHCGNGFTSAKILQIHARthigEKHYECKECGKAFNYFSSLHIHART 728
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
637-660 5.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|....
gi 428982004  637 NLQMHERTHTGEKPYECKECEKAF 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 428982004   26 PVAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
27-69 1.14e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 1.14e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 428982004    27 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIGKK 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-66 4.37e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.28  E-value: 4.37e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 428982004  27 VAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSI 66
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-636 2.20e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 2.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 224 TYKCKFCGKAFHSFSLYLIHERTHTGEKPYEC--KQCGKSFTYSATLQIHERTHTGEKPYECSKCDKAFHSSSSYHRHER 301
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 302 SHMGE-KPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQY-GEGLSYLISFQTHIRMNSgerpykcKICGKGFYSAKS 379
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 380 FQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYEC--KQCGKAFRSASQLRVHGGTHTgeKPYECKECGKA 457
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 458 FRSTSHLRVHGRTHTGE-------KPYECKECGKAFRYVKHLQIHERTEKHIRMPSgeRPYKC--SICEKGFYSAKSFQT 528
Cdd:COG5048  264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESL--KPFSCpySLCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 529 HEKTHTGEKPYEC--NQCGKAFR-----CCNSLRYHERTHTGEKPYEC--KQCGKAFRSASHLRMHERTHTGEKPYECK- 598
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 428982004 599 -QCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSAS 636
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-685 2.16e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 279 KPYECSKCDKAFHSSSSYHRHERSHMGEKPYQCKECGKAFAYT--SSLRRHERTHSGKKPYECKQyGEGLSYLISFQTHI 356
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSK-SLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 357 RMNSGERPYKCKICGKGFYSAKSFQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYECKQCGKAFRSASQL 436
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 437 RVhggTHTGEKPYECKECGKAFRSTSHLRVHGRTHTgEKPYECKECGKAFRYVKHLQIHERTEKHIRMPSGERPYKCSIC 516
Cdd:COG5048  191 NV---STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 517 EKGFYSAKSFQTHEKTHTG-EKPYECNQCGKAFRCCNSLRYHERT--HTGE--KPYEC--KQCGKAFRSASHLRMHERTH 589
Cdd:COG5048  267 TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 590 TGEKPYECK--QCGKAFSCASNLRKHGRTH-----TGEKPYEC--KQCGKAFRSASNLQMHERTHTGEKPYECK--ECEK 658
Cdd:COG5048  347 TSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                        410       420
                 ....*....|....*....|....*..
gi 428982004 659 AFCKFSSFQIHERKHRGEKPYECKHCG 685
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
141-580 1.69e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 141 NSSFNMSIRGDTGHKAYEYQeygPKPYKCqqPKNKKAFRYRPSIRTQERDHTGEKPYACKV--CGKTFIFHSSIRRHMVM 218
Cdd:COG5048   11 SNNSVLSSTPKSTLKSLSNA---PRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 219 HSGDG-TYKCKFCGKAFHSFSLYLIHERTHTGEKPYECKQCGKSFTYSATLQIHERTHTGEKPYECSKC--DKAFHSSSS 295
Cdd:COG5048   86 HHNNPsDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNTPQSN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 296 YHRHERSHMgekpyqcKECGKAFAYTSSLRRHERTHSGKKPYECKQYGEGLSYLISFQTHIRMNSGErPYKCKICGKGF- 374
Cdd:COG5048  166 SLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSp 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 375 ------YSAKSFQTHEKTHTGEKRYKCKQcGKAFNLSSSFRYHERIHTG-EKPYECKQCGKAFRSASQLRVH--GGTHTG 445
Cdd:COG5048  238 ksllsqSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSG 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 446 E--KPYECKE--CGKAFRSTSHLRVHGRTHTGEKPYECKECGkafRYVKHLQI-----HERTEKHIRmPSGERPYKC--S 514
Cdd:COG5048  317 EslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLN---SSSKFSPLlnnepPQSLQQYKD-LKNDKKSETlsN 392

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 428982004 515 ICEKGFYSAKSFQTHEKTHTGEKPYECN--QCGKAFRCCNSLRYHERTHTGEKPYECKQCGKAFRSAS 580
Cdd:COG5048  393 SCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
447-745 5.06e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 5.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 447 KPYECKECGKAFRSTSHLRVHGRTHTGEKPYECKECGKAFRYV----------KHLQIHERTEKHIRMPSGERPYKCSIC 516
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsrhlrTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 517 EKGFYSAKSFQTHEKTHTGEKPY------------------ECNQCGKAFRCCNSLR-------------------YHER 559
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDpqlpdllsisnlrnnplpGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 560 THTGEKPYECKQCG--------------------------------------------------------------KAFR 577
Cdd:COG5048  192 VSTSIPSSSENSPLsssysipssssdqnlensssslplttnsqlspksllsqspsslsssdssssasesprsslptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 578 SASHLRMHERTHTG-EKPYECKQCGKAFSCASNLRKHGRT--HTGE--KPYEC--KQCGKAFRSASNLQMHERTHTGEKP 650
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 651 YECK--ECEKAF------CKFSSFQIHERKHRGEKPYECKHCGNG-FTSAKILQIHARTHIGEKHYECK--ECGKAFNYF 719
Cdd:COG5048  352 AKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRnFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420
                 ....*....|....*....|....*.
gi 428982004 720 SSLHIHARTHMGEKPYECKDCGKAFS 745
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-412 8.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 8.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 232 KAFHSFSLYLIHERTHTG-EKPYECKQCGKSFTYSATLQIHERT--HTGE--KPYEC--SKCDKAFHSSSSYHRHERSHM 304
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 305 GEKPYQCKEC-------GKAFAYTSSLRRHERTHSGKKPYEC----KQYGEGLSYLISFQTHIRMNSGERPYKCKICGKG 373
Cdd:COG5048  348 SISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKS 427

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 428982004 374 FYSAKSFQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHE 412
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 499-562 1.10e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 499 EKHIRMPS------GERPYKCSI--CEKGFYSAKSFQTH-------EKTH------------TGEKPYECNQCGKAFRCC 551
Cdd:COG5189  332 ERNIDTPSrmlkvkDGKPYKCPVegCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNL 411

                         90
                 ....*....|.
gi 428982004 552 NSLRYHeRTHT 562
Cdd:COG5189  412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 428982004  581 HLRMHERTHTGEKPYECKQCGKAFSC 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 677-728 4.80e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 4.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 428982004 677 KPYeCKHCGNGFTSAKILQIHARthigEKHYECKECGKAFNYFSSLHIHART 728
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-578 5.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 428982004  553 SLRYHERTHTGEKPYECKQCGKAFRS 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
637-660 5.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|....
gi 428982004  637 NLQMHERTHTGEKPYECKECEKAF 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 249-332 1.89e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428982004 249 GEKPYECK--QCGKSFTYSATLQIHeRTHtgekpyecSKCDKAFHSSSSYHRHERSHMGEKPYQCKECGKAFAYTSSLRR 326
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 428982004 327 HeRTHS 332
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 2.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 428982004  407 SFRYHERIHTGEKPYECKQCGKAFRS 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-320 2.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.50e-03
                          10        20
                  ....*....|....*....|...
gi 428982004  298 RHERSHMGEKPYQCKECGKAFAY 320
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
609-634 2.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 428982004  609 NLRKHGRTHTGEKPYECKQCGKAFRS 634
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-264 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|..
gi 428982004  243 HERTHTGEKPYECKQCGKSFTY 264
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-550 4.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 428982004  525 SFQTHEKTHTGEKPYECNQCGKAFRC 550
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-290 4.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.34e-03
                          10        20
                  ....*....|....*....|...
gi 428982004  268 LQIHERTHTGEKPYECSKCDKAF 290
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-488 5.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 428982004  463 HLRVHGRTHTGEKPYECKECGKAFRY 488
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-403 9.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.16e-03
                          10        20
                  ....*....|....*....|....*
gi 428982004  379 SFQTHEKTHTGEKRYKCKQCGKAFN 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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