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Conserved domains on  [gi|426214088|ref|NP_001258766|]
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reticulocalbin-2 isoform b precursor [Homo sapiens]

Protein Classification

CREC-EF hand family protein; EF-hand domain-containing protein( domain architecture ID 11610930)

CREC (Cab45/reticulocalbin/ERC45/calumenin)-EF hand family protein; the family consists of a group of six EF-hand, low-affinity Ca2+-binding proteins, including reticulocalbin (RCN-1), ER Ca2+-binding protein of 55, reticulocalbin-3 (RCN-3), cab45 Ca2+-binding protein, and calumenin (also known as crocalbin or CBP-50)| EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh_CREC_RCN2 cd16224
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed ...
 29-314 2.52e-165

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


:

Pssm-ID: 320022 [Multi-domain]  Cd Length: 268  Bit Score: 461.13  E-value: 2.52e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  29 HYPLGERRSDYDREALLGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVE 108
Cdd:cd16224    1 HYPNGEHNAEYDKEAFLGGEEDADEFAKLSPEEQQKRLKSIIKKIDTDSDGFLTEEELSSWIQQSFRHYALEDAKQQFPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 109 YDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKefaickkqsfcfwllrfnLHLKDKKRFEKANQDSGPGLS 188
Cdd:cd16224   81 YDKDGDGAVTWDEYNMQMYDRVIDYDEDTVLDDEEEESFRQ------------------LHLKDKKRFDKANTDGGPGLN 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 189 LEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQ 268
Cdd:cd16224  143 LTEFIAFEHPEEVDYMTEFVIQEALEEHDKDGDGFISLEEFLGDYRKDPTANEDPEWIIVEKDRFVNDYDKDNDGKLDPQ 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 426214088 269 ELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16224  223 ELLPWVVPNNYGIAQEEALHLIDEMDLNGDGRLSEEEILENQDLFL 268
 
Name Accession Description Interval E-value
EFh_CREC_RCN2 cd16224
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed ...
 29-314 2.52e-165

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320022 [Multi-domain]  Cd Length: 268  Bit Score: 461.13  E-value: 2.52e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  29 HYPLGERRSDYDREALLGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVE 108
Cdd:cd16224    1 HYPNGEHNAEYDKEAFLGGEEDADEFAKLSPEEQQKRLKSIIKKIDTDSDGFLTEEELSSWIQQSFRHYALEDAKQQFPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 109 YDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKefaickkqsfcfwllrfnLHLKDKKRFEKANQDSGPGLS 188
Cdd:cd16224   81 YDKDGDGAVTWDEYNMQMYDRVIDYDEDTVLDDEEEESFRQ------------------LHLKDKKRFDKANTDGGPGLN 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 189 LEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQ 268
Cdd:cd16224  143 LTEFIAFEHPEEVDYMTEFVIQEALEEHDKDGDGFISLEEFLGDYRKDPTANEDPEWIIVEKDRFVNDYDKDNDGKLDPQ 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 426214088 269 ELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16224  223 ELLPWVVPNNYGIAQEEALHLIDEMDLNGDGRLSEEEILENQDLFL 268
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
171-308 1.32e-10

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 58.65  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 171 KDKKRFEKANQDSGPGLSLEEFIAfehpeevdyMTEFVIQEALEEHDKNGDGFVSLEEFLGDYrwdptANEDPEWILVEK 250
Cdd:COG5126    6 KLDRRFDLLDADGDGVLERDDFEA---------LFRRLWATLFSEADTDGDGRISREEFVAGM-----ESLFEATVEPFA 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 426214088 251 DRFVNDYDKDNDGRLDPQELLPWVvpNNQGIAQEEALHLIDEMDLNGDKKLSEEEILE 308
Cdd:COG5126   72 RAAFDLLDTDGDGKISADEFRRLL--TALGVSEEEADELFARLDTDGDGKISFEEFVA 127
EF-hand_7 pfam13499
EF-hand domain pair;
257-308 2.44e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.77  E-value: 2.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 426214088  257 YDKDNDGRLDPQELLPWVVPNNQG--IAQEEALHLIDEMDLNGDKKLSEEEILE 308
Cdd:pfam13499  11 LDSDGDGYLDVEELKKLLRKLEEGepLSDEEVEELFKEFDLDKDGRISFEEFLE 64
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
61-121 1.88e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 39.28  E-value: 1.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 426214088  61 EQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWDE 121
Cdd:NF041410  24 RSQQFQKQLFAKLDSDGDGSVSQDELSSALSSKSDDGSLIDLSELFSDLDSDGDGSLSSDE 84
PTZ00183 PTZ00183
centrin; Provisional
 217-313 8.76e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 36.59  E-value: 8.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 217 DKNGDGFVSLEEFLgDYRWDPTANEDPEwilVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLN 296
Cdd:PTZ00183  63 DKDGSGKIDFEEFL-DIMTKKLGERDPR---EEILKAFRLFDDDKTGKISLKNLKRVAKELGETITDEELQEMIDEADRN 138

                         90       100
                 ....*....|....*....|
gi 426214088 297 GDKKLSEEE---ILENPDLF 313
Cdd:PTZ00183 139 GDGEISEEEfyrIMKKTNLF 158
 
Name Accession Description Interval E-value
EFh_CREC_RCN2 cd16224
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed ...
 29-314 2.52e-165

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320022 [Multi-domain]  Cd Length: 268  Bit Score: 461.13  E-value: 2.52e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  29 HYPLGERRSDYDREALLGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVE 108
Cdd:cd16224    1 HYPNGEHNAEYDKEAFLGGEEDADEFAKLSPEEQQKRLKSIIKKIDTDSDGFLTEEELSSWIQQSFRHYALEDAKQQFPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 109 YDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKefaickkqsfcfwllrfnLHLKDKKRFEKANQDSGPGLS 188
Cdd:cd16224   81 YDKDGDGAVTWDEYNMQMYDRVIDYDEDTVLDDEEEESFRQ------------------LHLKDKKRFDKANTDGGPGLN 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 189 LEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQ 268
Cdd:cd16224  143 LTEFIAFEHPEEVDYMTEFVIQEALEEHDKDGDGFISLEEFLGDYRKDPTANEDPEWIIVEKDRFVNDYDKDNDGKLDPQ 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 426214088 269 ELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16224  223 ELLPWVVPNNYGIAQEEALHLIDEMDLNGDGRLSEEEILENQDLFL 268
EFh_CREC cd15899
EF-hand, calcium binding motif, found in CREC-EF hand family; The CREC (Cab45/reticulocalbin ...
 29-314 2.96e-121

EF-hand, calcium binding motif, found in CREC-EF hand family; The CREC (Cab45/reticulocalbin/ERC45/calumenin)-EF hand family contains a group of six EF-hand, low-affinity Ca2+-binding proteins, including reticulocalbin (RCN-1), ER Ca2+-binding protein of 55 kDa (ERC-55, also known as TCBP-49 or E6BP), reticulocalbin-3 (RCN-3), Ca2+-binding protein of 45 kDa (Cab45 and its splice variant Cab45b), and calumenin ( also known as crocalbin or CBP-50). The proteins are not only localized in various parts of the secretory pathway, but also found in the cytosolic compartment and at the cell surface. They interact with different ligands or proteins and have been implicated in the secretory process, chaperone activity, signal transduction as well as in a large variety of disease processes.


Pssm-ID: 320021 [Multi-domain]  Cd Length: 267  Bit Score: 349.43  E-value: 2.96e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  29 HYPLGERRSDYDREALLGVqEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVE 108
Cdd:cd15899    1 HEMDGHLNSDYDHEAFLGK-EEAEEFDQLTPEESKRRLGVIVSKMDVDKDGFISAKELHSWILESFKRHAMEESKEQFRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 109 YDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKefaickkqsfcfwllrfnLHLKDKKRFEKANQDSGPGLS 188
Cdd:cd15899   80 VDPDEDGHVSWDEYKNDTYGSVGDDEENVADNIKEDEEYKK------------------LLLKDKKRFEAADQDGDLILT 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 189 LEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQ 268
Cdd:cd15899  142 LEEFLAFLHPEESPYMLDFVIKETLEDLDKNGDGFISLEEFISDPYSADENEEEPEWVKVEKERFVELRDKDKDGKLDGE 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 426214088 269 ELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd15899  222 ELLSWVDPSNQEIALEEAKHLIAESDENKDGKLSPEEILDNHELFV 267
EFh_CREC_Calumenin_like cd16226
EF-hand, calcium binding motif, found in calumenin, reticulocalbin-1 (RCN-1), reticulocalbin-3 ...
 29-313 2.59e-74

EF-hand, calcium binding motif, found in calumenin, reticulocalbin-1 (RCN-1), reticulocalbin-3 (RCN-3), and similar proteins; The family corresponds to a group of six EF-hand Ca2+-binding proteins, including calumenin (also known as crocalbin or CBP-50), reticulocalbin-1 (RCN-1), reticulocalbin-3 (RCN-3), and similar proteins. Calumenin is an endo/sarcoplasmic reticulum (ER/SR) resident low-affinity Ca2+-binding protein that contains six EF-hand domains and a C-terminal SR retention signal His-Asp-Glu-Phe (HDEF) tetrapeptide. It functions as a novel regulator of SERCA2, and its expressional changes are tightly coupled with Ca2+-cycling of cardiomyocytes. It is also broadly involved in haemostasis and in the pathophysiology of thrombosis. Moreover, the extracellular calumenin acts as a suppressor of cell migration and tumor metastasis. RCN-1 is an endoplasmic reticulum resident Ca2+-binding protein with a carboxyl-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide signal. It acts as a potential negative regulator of B-RAF activation and can negatively modulate cardiomyocyte hypertrophy by inhibition of the mitogen-activated protein kinase signalling cascade. It also plays a key role in the development of doxorubicin-associated resistance. RCN-3 is a putative six EF-hand Ca2+-binding protein that contains five RXXR (X is any amino acid) motifs and a C-terminal ER retrieval signal HDEL tetrapeptide. The RXXR motif represents the target sequence of subtilisin-like proprotein convertases (SPCs). RCN-3 is specifically bound to the paired basic amino-acid-cleaving enzyme-4 (PACE4) precursor protein and plays an important role in the biosynthesis of PACE4.


Pssm-ID: 320024 [Multi-domain]  Cd Length: 264  Bit Score: 229.78  E-value: 2.59e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  29 HYPLGERRSDYDREALLGvQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVE 108
Cdd:cd16226    1 HDDDGEHNPEYDHEAFLG-KEEAKEFDQLTPEESKERLGIIVDKIDKNGDGFVTEEELKDWIKYVQKKYIREDVDRQWKE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 109 YDKNSDDTVTWDEYNIQMYDrvidFDENTALDDAEEESFRKEFAickkqsfcfwllrfnlhlKDKKRFEKANQDSGPGLS 188
Cdd:cd16226   80 YDPNKDGKLSWEEYKKATYG----FLDDEEEDDDLHESYKKMIR------------------RDERRWKAADQDGDGKLT 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 189 LEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQ 268
Cdd:cd16226  138 KEEFTAFLHPEEFPHMRDIVVQETLEDIDKNKDGFISLEEYIGDMYRDDDEEEDPDWVKSEREQFKEFRDKNKDGKMDRE 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 426214088 269 ELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLF 313
Cdd:cd16226  218 EVKDWILPEDYDHAEAEAKHLIYEADDDKDGKLTKEEILDKYDLF 262
EFh_CREC_RCN2_like cd16227
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2) mainly from protostomes; This ...
 29-314 5.80e-66

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2) mainly from protostomes; This family corresponds to a group of uncharacterized RCN2-like proteins, which are mainly found in protostomes. Although their biological function remains unclear, they show high sequence similarity with RCN2 (also known as E6BP or TCBP-49), which is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. Members in this family contain six copies of the EF-hand Ca2+-binding motif, but may lack a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320025 [Multi-domain]  Cd Length: 263  Bit Score: 208.71  E-value: 5.80e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  29 HYPLGERRSDYDREALLGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVE 108
Cdd:cd16227    1 HAKDGEHNPEFDHEAVLGSRKEAEEFDELPPEEAKRRLAVLAKKMDLNDDGFIDRKELKAWILRSFKMLDEEEANERFEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 109 YDKNSDDTVTWDEYNIQMYDrvIDFDENTALDDAEEESFRKEFAickkqsfcfwllrfnlhlKDKKRFEKANQDSGPGLS 188
Cdd:cd16227   81 ADEDGDGKVTWEEYLADSFG--YDDEDNEEMIKDSTEDDLKLLE------------------DDKEMFEAADLNKDGKLD 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 189 LEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYrwdpTANEDPEWILVEKDRFVNDYDKDNDGRLDPQ 268
Cdd:cd16227  141 KTEFSAFQHPEEYPHMHPVLIEQTLRDKDKDNDGFISFQEFLGDR----AGHEDKEWLLVEKDRFDEDYDKDGDGKLDGE 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 426214088 269 ELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16227  217 EILSWLVPDNEEIAEEEVDHLFASADDDHDDRLSFDEILDHHEIFV 262
EFh_CREC_Calumenin cd16228
EF-hand, calcium binding motif, found in calumenin; Calumenin, also termed crocalbin, or IEF ...
 38-314 3.80e-54

EF-hand, calcium binding motif, found in calumenin; Calumenin, also termed crocalbin, or IEF SSP 9302, is an endo/sarcoplasmic reticulum (ER/SR) resident low-affinity Ca2+-binding protein that contains six EF-hand domains and a C-terminal SR retention signal His-Asp-Glu-Phe (HDEF) tetrapeptide. It is highly expressed in various brain regions. Thus it plays an important role in migration and differentiation of neurons, and/or in Ca2+ signaling between glial cells and neurons. Calumenin is involved in Ca2+ homeostasis through interacting with ryanodine receptor RyR2 and SERCA2. It acts as a novel regulator of SERCA2, and its expressional changes are tightly coupled with Ca2+-cycling of cardiomyocytes. Calumenin also forms a Ca2+-dependent complex with thrombospondin-1, which is broadly involved in haemostasis and thrombosis. Moreover, calumenin is a molecular chaperone that endogenously regulates the vitamin K-dependent gamma-carboxylation of several proteins, including blood coagulation factors (such as FII, FVII, FIX, FX, and proteins C, S and Z), cell survival factors (Gas6) and bone metabolism proteins (such as matrix Gla protein or MGP, osteocalcin and periostin), through targeting the gamma-glutamyl carboxylase. It also functions as a charged F508del-cystic fibrosis transmembrane regulator (CFTR) folding modulator, as well as a G551D-CFTR associated protein. Furthermore, the extracellular calumenin acts as a suppressor of cell migration and tumor metastasis. It binds to and stabilizes fibulin-1, and further inactivates extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling.


Pssm-ID: 320026 [Multi-domain]  Cd Length: 263  Bit Score: 178.21  E-value: 3.80e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  38 DYDREALLGvQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTV 117
Cdd:cd16228   10 DYDHDAFLG-AEEAKTFDQLTPEESKERLGKIVGKIDEDKDGFVTEDELKAWIKFAQKRWIYEDVERQWKGHDLNEDGLV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 118 TWDEYNIQMYDRVIDfdentalDDAEEESFRKEfaickkqsfcfwllrfNLHLKDKKRFEKANQDSGPGLSLEEFIAFEH 197
Cdd:cd16228   89 SWEEYKNATYGYILD-------DPDPDDGFNYK----------------QMMVRDERRFKMADKDGDLRATKEEFTAFLH 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 198 PEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGD-YRWDPTANEdPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVP 276
Cdd:cd16228  146 PEEYDYMKDIVVLETMEDIDKNGDGFIDLEEYIGDmYSQDGDADE-PEWVKTEREQFTEFRDKNKDGKMDKEETKDWILP 224

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 426214088 277 NNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16228  225 SDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFV 262
EFh_CREC_RCN3 cd16230
EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3); RCN-3, also termed EF-hand ...
 39-314 8.65e-52

EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3); RCN-3, also termed EF-hand calcium-binding protein RLP49, is a putative six EF-hand Ca2+-binding protein that contains five RXXR (X is any amino acid) motifs and a C-terminal ER retrieval signal His-Asp-Glu-Leu (HDEL) tetrapeptide. The RXXR motif represents the target sequence of subtilisin-like proprotein convertases (SPCs). RCN-3 is specifically bound to the paired basic amino-acid-cleaving enzyme-4 (PACE4) precursor protein and plays an important role in the biosynthesis of PACE4.


Pssm-ID: 320028 [Multi-domain]  Cd Length: 268  Bit Score: 172.47  E-value: 8.65e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  39 YDREALLGvQEDVDEYVKLGHEEQQKRLQAIIKKIDL--DSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDT 116
Cdd:cd16230   11 YDHEAFLG-REVAKEFDQLSPEESQARLGRIVDRMDRagDGDGWVSLAELRAWIAHTQQRHIRDSVSAAWQTYDTDRDGR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 117 VTWDEYNIQMYDRVIDFDENTALDDAEeeSFRKEFAickkqsfcfwllrfnlhlKDKKRFEKANQDSGPGLSLEEFIAFE 196
Cdd:cd16230   90 VGWEELRNATYGHYEPGEEFHDVEDAE--TYKKMLA------------------RDERRFRVADQDGDSMATREELTAFL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 197 HPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVP 276
Cdd:cd16230  150 HPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSGEPGEEEPAWVQTERQQFRQFRDLNKDGRLDGSEVGHWVLP 229

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 426214088 277 NNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16230  230 PSQDQPLVEANHLLHESDTDKDGRLSKAEILGNWNMFV 267
EFh_CREC_RCN1 cd16229
EF-hand, calcium binding motif, found in reticulocalbin-1 (RCN-1); RCN-1 is an endoplasmic ...
 39-314 2.09e-50

EF-hand, calcium binding motif, found in reticulocalbin-1 (RCN-1); RCN-1 is an endoplasmic reticulum resident low-affinity Ca2+-binding protein with six EF-hand motifs and a carboxyl-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide signal. It is expressed at the cell surface. RCN-1 acts as a potential negative regulator of B-RAF activation and can negatively modulate cardiomyocyte hypertrophy by inhibition of the mitogen-activated protein kinase signaling cascade. It also plays a key role in the development of doxorubicin-associated resistance.


Pssm-ID: 320027 [Multi-domain]  Cd Length: 267  Bit Score: 168.52  E-value: 2.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  39 YDREALLGvQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVT 118
Cdd:cd16229   11 YDHEAFLG-KEEAKTFDQLTPEESKERLGKIVDRIDDDKDGFVTTEELKAWIKRVQKRYIYENVAKVWKDYDLNKDNKIS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 119 WDEYNIQMYDRVIDfDENTALDDAEEESFRKEFAickkqsfcfwllrfnlhlKDKKRFEKANQDSGPGLSLEEFIAFEHP 198
Cdd:cd16229   90 WEEYKQATYGYYLG-NPEEFQDATDQFSFKKMLP------------------RDERRFKAADLDGDLAATREEFTAFLHP 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 199 EEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNN 278
Cdd:cd16229  151 EEFEHMKDIVVLETLEDIDKNGDGFVDEDEYIADMFSHEEGGPEPDWVKTEREQFSDFRDLNKDGKMDKEEIRHWILPQD 230

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 426214088 279 QGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16229  231 YDHAQAEARHLVYESDKDKDQKLTKEEILDNWNMFV 266
EFh_CREC_cab45 cd16225
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also ...
 33-314 7.17e-36

EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.


Pssm-ID: 320023 [Multi-domain]  Cd Length: 278  Bit Score: 130.88  E-value: 7.17e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  33 GERRSDYDREALLGvqEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFK-HY--AMQEAKQQFVEY 109
Cdd:cd16225    5 GHLNKEFHKEVFLG--NEKEEFEEDSEPKKRKKLKEIFKKVDVNTDGFLSAEELEDWIMEKTQeHFqeAVEENEQIFKAV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 110 DKNSDDTVTWDEYNIQM-----YDRV-----IDFDENTALDDAEEESFrkefaickkqsfcfwllrfnlhLKDKKRFEKA 179
Cdd:cd16225   83 DTDKDGNVSWEEYRVHFllskgYSEEeaeekIKNNEELKLDEDDKEVL----------------------DRYKDRWSQA 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 180 NQDSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFL-GDYRWDP--TANEDPEWILVEKDRFVND 256
Cdd:cd16225  141 DEPEDGLLDVEEFLSFRHPEHSRGMLKNMVKEILHDLDQDGDEKLTLDEFVsLPPGTVEeqQAEDDDEWKKERKKEFEEV 220

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 426214088 257 YDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFL 314
Cdd:cd16225  221 IDLNHDGKVTKEELEEYMDPRNERHALNEAKQLIAVADENKDGKLSLEEILKNSDLFT 278
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
171-308 1.32e-10

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 58.65  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 171 KDKKRFEKANQDSGPGLSLEEFIAfehpeevdyMTEFVIQEALEEHDKNGDGFVSLEEFLGDYrwdptANEDPEWILVEK 250
Cdd:COG5126    6 KLDRRFDLLDADGDGVLERDDFEA---------LFRRLWATLFSEADTDGDGRISREEFVAGM-----ESLFEATVEPFA 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 426214088 251 DRFVNDYDKDNDGRLDPQELLPWVvpNNQGIAQEEALHLIDEMDLNGDKKLSEEEILE 308
Cdd:COG5126   72 RAAFDLLDTDGDGKISADEFRRLL--TALGVSEEEADELFARLDTDGDGKISFEEFVA 127
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
173-274 8.85e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 47.48  E-value: 8.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 173 KKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEFViQEALEEHDKNGDGFVSLEEFLgdyrwdpTANEDPEWILVEKDR 252
Cdd:COG5126   36 ATLFSEADTDGDGRISREEFVAGMESLFEATVEPFA-RAAFDLLDTDGDGKISADEFR-------RLLTALGVSEEEADE 107

                         90       100
                 ....*....|....*....|..
gi 426214088 253 FVNDYDKDNDGRLDPQELLPWV 274
Cdd:COG5126  108 LFARLDTDGDGKISFEEFVAAV 129
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
60-230 9.45e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 44.78  E-value: 9.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  60 EEQQKRLQAIIKKIDLDSDGFLTESELSSwiqmsfkhYAMQEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTAl 139
Cdd:COG5126    1 DLQRRKLDRRFDLLDADGDGVLERDDFEA--------LFRRLWATLFSEADTDGDGRISREEFVAGMESLFEATVEPFA- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 140 ddaeeesfrkefaickkqsfcfwllrfnlhlkdKKRFEKANQDSGPGLSLEEFIAFEHPEEVdymTEFVIQEALEEHDKN 219
Cdd:COG5126   72 ---------------------------------RAAFDLLDTDGDGKISADEFRRLLTALGV---SEEEADELFARLDTD 115

                        170
                 ....*....|.
gi 426214088 220 GDGFVSLEEFL 230
Cdd:COG5126  116 GDGKISFEEFV 126
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 65-121 2.64e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 41.38  E-value: 2.64e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 426214088  65 RLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWDE 121
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEE 57
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 209-274 3.28e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 40.99  E-value: 3.28e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 426214088 209 IQEALEEHDKNGDGFVSLEEF---LGDYRWDPTaneDPEWilvekDRFVNDYDKDNDGRLDPQELLPWV 274
Cdd:cd00051    2 LREAFRLFDKDGDGTISADELkaaLKSLGEGLS---EEEI-----DEMIREVDKDGDGKIDFEEFLELM 62
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 255-308 5.42e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 40.61  E-value: 5.42e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 426214088 255 NDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILE 308
Cdd:cd00051    7 RLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLE 60
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
36-121 8.78e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 41.70  E-value: 8.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088  36 RSDYDREALLGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMsfKHYAMQEAKQQFVEYDKNSDD 115
Cdd:COG5126   41 EADTDGDGRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTA--LGVSEEEADELFARLDTDGDG 118


                 ....*.
gi 426214088 116 TVTWDE 121
Cdd:COG5126  119 KISFEE 124
EF-hand_7 pfam13499
EF-hand domain pair;
257-308 2.44e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 38.77  E-value: 2.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 426214088  257 YDKDNDGRLDPQELLPWVVPNNQG--IAQEEALHLIDEMDLNGDKKLSEEEILE 308
Cdd:pfam13499  11 LDSDGDGYLDVEELKKLLRKLEEGepLSDEEVEELFKEFDLDKDGRISFEEFLE 64
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
61-121 1.88e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 39.28  E-value: 1.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 426214088  61 EQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWDE 121
Cdd:NF041410  24 RSQQFQKQLFAKLDSDGDGSVSQDELSSALSSKSDDGSLIDLSELFSDLDSDGDGSLSSDE 84
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 187-230 2.80e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.60  E-value: 2.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 426214088 187 LSLEEFIAFeHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFL 230
Cdd:cd00051   17 ISADELKAA-LKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFL 59
EF-hand_7 pfam13499
EF-hand domain pair;
64-127 5.92e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 34.92  E-value: 5.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 426214088   64 KRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAM--QEAKQQFVEYDKNSDDTVTWDEYNIQMY 127
Cdd:pfam13499   2 EKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLsdEEVEELFKEFDLDKDGRISFEEFLELYS 67
EF-hand_7 pfam13499
EF-hand domain pair;
206-271 6.93e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 34.54  E-value: 6.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 426214088  206 EFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEwilVEKDRFVNDYDKDNDGRLDPQELL 271
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSD---EEVEELFKEFDLDKDGRISFEEFL 63
PTZ00183 PTZ00183
centrin; Provisional
 217-313 8.76e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 36.59  E-value: 8.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 426214088 217 DKNGDGFVSLEEFLgDYRWDPTANEDPEwilVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLN 296
Cdd:PTZ00183  63 DKDGSGKIDFEEFL-DIMTKKLGERDPR---EEILKAFRLFDDDKTGKISLKNLKRVAKELGETITDEELQEMIDEADRN 138

                         90       100
                 ....*....|....*....|
gi 426214088 297 GDKKLSEEE---ILENPDLF 313
Cdd:PTZ00183 139 GDGEISEEEfyrIMKKTNLF 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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