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Conserved domains on  [gi|402794658|ref|NP_001258049|]
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pro-neuregulin-1, membrane-bound isoform isoform 3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Neuregulin super family cl20026
Neuregulin intracellular region;
323-479 1.59e-77

Neuregulin intracellular region;


The actual alignment was detected with superfamily member pfam02158:

Pssm-ID: 426627  Cd Length: 360  Bit Score: 247.44  E-value: 1.59e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402794658  323 TKKQRQKLHDRLRQSLRSERSNLvNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTT 402
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402794658  403 VTQTPSH---SWSNGHTESIISESNSVIMMSSVENSRHSSPAG-GPRGRLHGLGGPRD-NSFLRHARETPDSYRDSPHSE 477
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDpNSYLRQYRDSPDSLRDSPHSE 158


                  ..
gi 402794658  478 RH 479
Cdd:pfam02158 159 RY 160
PHA02887 super family cl31518
EGF-like protein; Provisional
 237-279 1.63e-03

EGF-like protein; Provisional


The actual alignment was detected with superfamily member PHA02887:

Pssm-ID: 165214  Cd Length: 126  Bit Score: 38.75  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 402794658 237 KCAEKEKTFCVNGgECFTVKDLSnpsRYLCKCQPGFTGARCTE 279
Cdd:PHA02887  85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
323-479 1.59e-77

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 247.44  E-value: 1.59e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402794658  323 TKKQRQKLHDRLRQSLRSERSNLvNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTT 402
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402794658  403 VTQTPSH---SWSNGHTESIISESNSVIMMSSVENSRHSSPAG-GPRGRLHGLGGPRD-NSFLRHARETPDSYRDSPHSE 477
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDpNSYLRQYRDSPDSLRDSPHSE 158


                  ..
gi 402794658  478 RH 479
Cdd:pfam02158 159 RY 160
PHA02887 PHA02887
EGF-like protein; Provisional
 237-279 1.63e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 38.75  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 402794658 237 KCAEKEKTFCVNGgECFTVKDLSnpsRYLCKCQPGFTGARCTE 279
Cdd:PHA02887  85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 246-276 1.89e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 402794658  246 CVNGGECFTVkdlsnPSRYLCKCQPGFTGAR 276
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 246-278 2.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 2.96e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 402794658 246 CVNGGECftvKDLsnPSRYLCKCQPGFTGARCT 278
Cdd:cd00054   11 CQNGGTC---VNT--VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
323-479 1.59e-77

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 247.44  E-value: 1.59e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402794658  323 TKKQRQKLHDRLRQSLRSERSNLvNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTT 402
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402794658  403 VTQTPSH---SWSNGHTESIISESNSVIMMSSVENSRHSSPAG-GPRGRLHGLGGPRD-NSFLRHARETPDSYRDSPHSE 477
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDpNSYLRQYRDSPDSLRDSPHSE 158


                  ..
gi 402794658  478 RH 479
Cdd:pfam02158 159 RY 160
PHA02887 PHA02887
EGF-like protein; Provisional
 237-279 1.63e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 38.75  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 402794658 237 KCAEKEKTFCVNGgECFTVKDLSnpsRYLCKCQPGFTGARCTE 279
Cdd:PHA02887  85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 246-276 1.89e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 402794658  246 CVNGGECFTVkdlsnPSRYLCKCQPGFTGAR 276
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 246-278 2.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 2.96e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 402794658 246 CVNGGECftvKDLsnPSRYLCKCQPGFTGARCT 278
Cdd:cd00054   11 CQNGGTC---VNT--VGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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