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Conserved domains on  [gi|394025686|ref|NP_001257362|]
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cyclin-dependent kinase 2-associated protein 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDK2AP super family cl10779
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 16-86 1.89e-20

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


The actual alignment was detected with superfamily member pfam09806:

Pssm-ID: 430840  Cd Length: 211  Bit Score: 80.71  E-value: 1.89e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394025686   16 PPSLGYTQGTGNSQvpqSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNAR 86
Cdd:pfam09806 144 DNNSGGSNSTANIV---DKYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHARVLVRECLLLLERDQR 211
 
Name Accession Description Interval E-value
CDK2AP pfam09806
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 16-86 1.89e-20

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


Pssm-ID: 430840  Cd Length: 211  Bit Score: 80.71  E-value: 1.89e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394025686   16 PPSLGYTQGTGNSQvpqSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNAR 86
Cdd:pfam09806 144 DNNSGGSNSTANIV---DKYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHARVLVRECLLLLERDQR 211
 
Name Accession Description Interval E-value
CDK2AP pfam09806
Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are ...
 16-86 1.89e-20

Cyclin-dependent kinase 2-associated protein; Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.


Pssm-ID: 430840  Cd Length: 211  Bit Score: 80.71  E-value: 1.89e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394025686   16 PPSLGYTQGTGNSQvpqSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNAR 86
Cdd:pfam09806 144 DNNSGGSNSTANIV---DKYSNLLAVIAEMQRNLGPTAMGLRAPKERLLRDIAHARVLVRECLLLLERDQR 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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