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Conserved domains on  [gi|392921500|ref|NP_001256508|]
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FERM domain-containing protein 8 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
B41 super family cl33382
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 13-112 1.40e-09

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


The actual alignment was detected with superfamily member smart00295:

Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 56.53  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921500    13 ENTIRVAAFLFCLQFGNFDETRHDVAfIRNHIDEILPERTCDSivattifgkaiNKKTVQEERLLSEWKNIskIGDKSKK 92
Cdd:smart00295 116 EEALLLAALALQAEFGDYDEELHDLR-GELSLKRFLPKQLLDS-----------RKLKEWRERIVELHKEL--IGLSPEE 181

                           90       100
                   ....*....|....*....|
gi 392921500    93 EHDLLMELTQNSSCYGAAWF 112
Cdd:smart00295 182 AKLKYLELARKLPTYGVELF 201
 
Name Accession Description Interval E-value
B41 smart00295
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 13-112 1.40e-09

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 56.53  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921500    13 ENTIRVAAFLFCLQFGNFDETRHDVAfIRNHIDEILPERTCDSivattifgkaiNKKTVQEERLLSEWKNIskIGDKSKK 92
Cdd:smart00295 116 EEALLLAALALQAEFGDYDEELHDLR-GELSLKRFLPKQLLDS-----------RKLKEWRERIVELHKEL--IGLSPEE 181

                           90       100
                   ....*....|....*....|
gi 392921500    93 EHDLLMELTQNSSCYGAAWF 112
Cdd:smart00295 182 AKLKYLELARKLPTYGVELF 201
 
Name Accession Description Interval E-value
B41 smart00295
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 13-112 1.40e-09

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 56.53  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921500    13 ENTIRVAAFLFCLQFGNFDETRHDVAfIRNHIDEILPERTCDSivattifgkaiNKKTVQEERLLSEWKNIskIGDKSKK 92
Cdd:smart00295 116 EEALLLAALALQAEFGDYDEELHDLR-GELSLKRFLPKQLLDS-----------RKLKEWRERIVELHKEL--IGLSPEE 181

                           90       100
                   ....*....|....*....|
gi 392921500    93 EHDLLMELTQNSSCYGAAWF 112
Cdd:smart00295 182 AKLKYLELARKLPTYGVELF 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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