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Conserved domains on  [gi|392900632|ref|NP_001255517|]
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Pyruvate kinase [Caenorhabditis elegans]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-460 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 679.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmKEVQLENGKSVRVSTDPSMEf 80
Cdd:cd00288   23 LIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG-KDISLKAGDKFLVTTDPAAK- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDL 159
Cdd:cd00288  101 KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 160 LFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:cd00288  181 RFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLA 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:cd00288  261 QKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKAL 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 320 FHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGI 399
Cdd:cd00288  341 SHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGV 420

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900632 400 FPVYYPKGRIDeWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVA 460
Cdd:cd00288  421 YPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-460 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 679.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmKEVQLENGKSVRVSTDPSMEf 80
Cdd:cd00288   23 LIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG-KDISLKAGDKFLVTTDPAAK- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDL 159
Cdd:cd00288  101 KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 160 LFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:cd00288  181 RFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLA 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:cd00288  261 QKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKAL 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 320 FHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGI 399
Cdd:cd00288  341 SHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGV 420

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900632 400 FPVYYPKGRIDeWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVA 460
Cdd:cd00288  421 YPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 1-457 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 615.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632    1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnmKEVQLENGKSVRVSTDPSMEf 80
Cdd:TIGR01064  22 LLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKG--GEVKLKKGDKVIITTDDIKG- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:TIGR01064  99 EGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  161 FGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:TIGR01064 179 FGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIA 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:TIGR01064 259 QKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAEKAL 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  320 FHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGI 399
Cdd:TIGR01064 339 AYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGV 418

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 392900632  400 FPVYypkgrIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITG-WKQGAGFTNTMRI 457
Cdd:TIGR01064 419 FPFL-----VDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-459 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 604.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmkEVQLENGKSVRVSTDpsmEF 80
Cdd:COG0469   24 LIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG--PVELKKGDTFTLTTD---DV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:COG0469   99 EGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 161 FGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQ 240
Cdd:COG0469  179 FALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQ 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 241 KMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFF 320
Cdd:COG0469  259 KRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLD 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 321 HMKHFEEliLHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIF 400
Cdd:COG0469  339 YRRILDR--LRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVY 416

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 401 PVYYPKgridewDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIVV 459
Cdd:COG0469  417 PVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTLKVHR 470
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-443 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 517.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnmKEVQLENGKSVRVSTDPSMEf 80
Cdd:PRK05826  25 LIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE--GKITLKTGDKFTLDTDQKEE- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 aATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:PRK05826 102 -GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 161 FGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:PRK05826 181 FAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:PRK05826 261 QKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEF 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 320 FHMKHFEELILHTKKptgMTHTTAIAAV-SATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRG 398
Cdd:PRK05826 341 SINLSKHRLDRQFDR---IDEAIAMSAMyAANHLKGVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRG 417

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 392900632 399 IFPVYYPK-GRIDEWDVDVEervqygvNLGKTRGFIHLGDpLIVIT 443
Cdd:PRK05826 418 VYPVLFDSaADTDDAAEEAL-------RLLLEKGLVESGD-LVVVT 455
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-325 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 516.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632    1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEF 80
Cdd:pfam00224  23 LIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGKKDIELKAGDEMIVSTDAKYKG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESC-EETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDL 159
Cdd:pfam00224 103 ACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  160 LFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:pfam00224 183 RFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIPAEEVFLA 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:pfam00224 263 QKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKAL 342


                  ....*.
gi 392900632  320 FHMKHF 325
Cdd:pfam00224 343 PHRNLF 348
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-460 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 679.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmKEVQLENGKSVRVSTDPSMEf 80
Cdd:cd00288   23 LIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG-KDISLKAGDKFLVTTDPAAK- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDL 159
Cdd:cd00288  101 KGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 160 LFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:cd00288  181 RFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLA 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:cd00288  261 QKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKAL 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 320 FHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGI 399
Cdd:cd00288  341 SHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGV 420

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900632 400 FPVYYPKGRIDeWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVA 460
Cdd:cd00288  421 YPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 1-457 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 615.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632    1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnmKEVQLENGKSVRVSTDPSMEf 80
Cdd:TIGR01064  22 LLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKG--GEVKLKKGDKVIITTDDIKG- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:TIGR01064  99 EGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  161 FGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:TIGR01064 179 FGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIA 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:TIGR01064 259 QKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAEKAL 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  320 FHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGI 399
Cdd:TIGR01064 339 AYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGV 418

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 392900632  400 FPVYypkgrIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITG-WKQGAGFTNTMRI 457
Cdd:TIGR01064 419 FPFL-----VDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-459 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 604.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmkEVQLENGKSVRVSTDpsmEF 80
Cdd:COG0469   24 LIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG--PVELKKGDTFTLTTD---DV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:COG0469   99 EGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 161 FGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQ 240
Cdd:COG0469  179 FALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQ 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 241 KMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFF 320
Cdd:COG0469  259 KRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLD 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 321 HMKHFEEliLHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIF 400
Cdd:COG0469  339 YRRILDR--LRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVY 416

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 401 PVYYPKgridewDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIVV 459
Cdd:COG0469  417 PVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTLKVHR 470
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-443 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 517.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnmKEVQLENGKSVRVSTDPSMEf 80
Cdd:PRK05826  25 LIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE--GKITLKTGDKFTLDTDQKEE- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 aATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:PRK05826 102 -GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 161 FGVEQGVDIIFASFIRNADGIHKIRQVLGEKG-KHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:PRK05826 181 FAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:PRK05826 261 QKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEF 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 320 FHMKHFEELILHTKKptgMTHTTAIAAV-SATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRG 398
Cdd:PRK05826 341 SINLSKHRLDRQFDR---IDEAIAMSAMyAANHLKGVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRG 417

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 392900632 399 IFPVYYPK-GRIDEWDVDVEervqygvNLGKTRGFIHLGDpLIVIT 443
Cdd:PRK05826 418 VYPVLFDSaADTDDAAEEAL-------RLLLEKGLVESGD-LVVVT 455
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-325 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 516.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632    1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEF 80
Cdd:pfam00224  23 LIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGKKDIELKAGDEMIVSTDAKYKG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESC-EETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDL 159
Cdd:pfam00224 103 ACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  160 LFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:pfam00224 183 RFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIPAEEVFLA 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAF 319
Cdd:pfam00224 263 QKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKAL 342


                  ....*.
gi 392900632  320 FHMKHF 325
Cdd:pfam00224 343 PHRNLF 348
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 6-461 4.19e-180

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 511.52  E-value: 4.19e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   6 MNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmkEVQLENGKSVRVSTDPSMEFAATSS 85
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGG--EAVMERGATCYVTTDPAFADKGTKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  86 HIYADYRNLPKVVQPGSRIYIDDGLISLIVESCE-ETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVE 164
Cdd:PTZ00300  79 KFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEdEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 165 QGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLI 244
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 245 AKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKH 324
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVF 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 325 FEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYY 404
Cdd:PTZ00300 319 FNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392900632 405 PKGRIDEwDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVAT 461
Cdd:PTZ00300 399 DAERLGH-DEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PLN02461 PLN02461
Probable pyruvate kinase
 1-440 1.33e-171

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 491.80  E-value: 1.33e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmKEVQLENGKSVRVSTDPSMEf 80
Cdd:PLN02461  42 LLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDG-KPVQLKQGQEITITTDYSIK- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 aATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETA--VICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIED 158
Cdd:PLN02461 120 -GDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAgtVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKED 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 159 LL-FGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVF 237
Cdd:PLN02461 199 ILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIF 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 238 LAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAES 317
Cdd:PLN02461 279 LAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEA 358

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 318 AFFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITV-------------S 384
Cdd:PLN02461 359 SLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPAVPILSVvvpeittdsfdwsC 438

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 392900632 385 RDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERVQYGVNLGKTRGFIHLGDPLI 440
Cdd:PLN02461 439 SDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVV 494
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-461 2.26e-163

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 473.64  E-value: 2.26e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmkEVQLENGKSVRVSTDpsmEF 80
Cdd:PRK06354  29 LIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG--PIELKTGDEFILTSR---EV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETA--VICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIED 158
Cdd:PRK06354 104 LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDRED 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 159 LLFGVEQGVDIIFASFIRNADGIHKIRQVLGEK-GKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVF 237
Cdd:PRK06354 184 LIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDNIDAILELCDGLMVARGDLGVEIPAEEVP 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 238 LAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAES 317
Cdd:PRK06354 264 LLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEK 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 318 AFFHMKhfeelILHTKKPTGMTHTTAI-AAVSAT-ITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHL 395
Cdd:PRK06354 344 DLPYRD-----ILSKRPEFTTTITNAIsQAVSHIaLQLDAAAIVTLTKSGATARNVSKYRPKTPILAVTPNESVARRLQL 418

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392900632 396 HRGIFPVYYPKgridewDVDVEERVQYGVNLGKTRGFIHLGDpLIVIT-GWKQG-AGFTNTMRIVVAT 461
Cdd:PRK06354 419 VWGVTPLLVLD------APSTDETFDAAINVAQESGLLKQGD-LVVITaGTLVGeSGSTDLMKVHVVG 479
PRK09206 PRK09206
pyruvate kinase PykF;
1-459 3.03e-158

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 456.44  E-value: 3.03e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNmKEVQLENGKSVRVSTDPSmeF 80
Cdd:PRK09206  23 LLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG-NDVSLKAGQTFTFTTDKS--V 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:PRK09206 100 VGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLI 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 161 FGVEQGVDIIFASFIRNADGIHKIRQVLGE-KGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:PRK09206 180 FGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFA 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAf 319
Cdd:PRK09206 260 QKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRV- 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 320 fhMKHFEELILHTKKptgMTHTTAIA--AVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHR 397
Cdd:PRK09206 339 --MNSRLESNNDNRK---LRITEAVCrgAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILALTTNEKTARQLVLSK 413

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392900632 398 GIFPVYypkgrIDEWDvDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVV 459
Cdd:PRK09206 414 GVVPQL-----VKEIA-STDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTASVHV 469
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 1-458 3.74e-158

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 457.69  E-value: 3.74e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFP-VAIALDTKGPEIRTGMFANNmKEVQLENGKSVRVSTDPSME 79
Cdd:PTZ00066  59 LIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNAnLGILLDTKGPEIRTGFLKNH-KPITLKEGQTLKITTDYTFL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  80 faATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDL 159
Cdd:PTZ00066 138 --GDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDI 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 160 L-FGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFL 238
Cdd:PTZ00066 216 LnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 239 AQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESA 318
Cdd:PTZ00066 296 AQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETC 375

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 319 FFHMKHFEELILHTKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRG 398
Cdd:PTZ00066 376 IDYRVLYHAIHLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARG 455

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900632 399 IFPVYYPKgrIDEWDVDVEErvqyGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIV 458
Cdd:PTZ00066 456 VTTYVVNS--FQGTDVVIRN----AIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVV 510
PRK06247 PRK06247
pyruvate kinase; Provisional
 5-457 2.02e-138

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 405.85  E-value: 2.02e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   5 GMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANnmKEVQLENGKSVRVSTDpsmEFAATS 84
Cdd:PRK06247  30 GADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFAD--GKVQLANGQTFRLDVD---DAPGDH 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  85 SHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFGVE 164
Cdd:PRK06247 105 DRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGTVLSVSALTEKDRADLEFALE 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 165 QGVDIIFASFIRNADGIHKIRQVLGEKgkhIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKMLI 244
Cdd:PRK06247 185 LGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRII 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 245 AKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAffhmKH 324
Cdd:PRK06247 262 RAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEAVRTMARIIRQVERD----PT 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 325 FEELILHTKKPTGMTHTTAIAAVSATI--TCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPV 402
Cdd:PRK06247 338 YPPLIHAQRPQPEATKRDAISYAARDIaeRLDLAALVAYTSSGDTALRAARERPPLPILALTPNPETARRLALTWGVHCV 417

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 392900632 403 YYPKGRidewdvDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRI 457
Cdd:PRK06247 418 VVDDAR------DTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPGSTNMLRI 467
PLN02765 PLN02765
pyruvate kinase
 1-458 1.31e-106

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 326.24  E-value: 1.31e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTgmfaNNMKE--VQLENGKSVRVSTDPSM 78
Cdd:PLN02765  49 CLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQV----INKTEkpISLKAGNTVTLTPDQSK 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  79 EfaATSSHIYADYRNLPKVVQPGSRIYIDDGLIS--------LIVESCEETAVICTIENGGAL-GTRKGVNLPGTIVDLP 149
Cdd:PLN02765 125 E--ASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCTVKNSATLaGSLFTLHVSQVRIDLP 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 150 AVTSKDIEDL-LFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKH-IYIIAKIESEDGVTNCDEIIEASDGVMVARGDL 227
Cdd:PLN02765 203 TLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSqTQIFAKIENVEGLTHFDEILQEADGIILSRGNL 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 228 GIEIPAEKVFLAQKMLIAKCNLAGKPVIcATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAI 307
Cdd:PLN02765 283 GIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETIST 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 308 MHNICKEAESAFFHMKHFEELILHTKKPtgMTHTTAIA--AVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITV-- 383
Cdd:PLN02765 362 VGRICAEAEKVFNQDLYFKKTVKYVGEP--MSHLESIAssAVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVvi 439

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 384 -----------SRDERISRQLHLHRGIFPVYYPKGRIDEWDVDVEERV-QYGVNLGKTRGFIHLGDPLIVItgwkQGAGF 451
Cdd:PLN02765 440 prlktnqlkwsFTGAFQARQCLIVRGLFPMLADPRHSAESTSATNESVlKVALDHGKAAGVIKSHDRVVVC----QKVGD 515


                 ....*..
gi 392900632 452 TNTMRIV 458
Cdd:PLN02765 516 SSVVKII 522
PLN02623 PLN02623
pyruvate kinase
 4-447 1.34e-104

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 323.03  E-value: 1.34e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   4 TGMNIARLNFSHGTHEAHAATIKTIRE-AAENAPFPVAIALDTKGPEIRTGMFAnnmKEVQLENGKSVRVSTDPSMEFAA 82
Cdd:PLN02623 134 AGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSGDLP---QPIMLEEGQEFTFTIKRGVSTED 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  83 TSSHIYADYRNlpkVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLLFG 162
Cdd:PLN02623 211 CVSVNYDDFVN---DVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFG 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 163 VEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLAQKM 242
Cdd:PLN02623 288 VENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEE 367

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 243 LIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFfhm 322
Cdd:PLN02623 368 IIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATL--- 444

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 323 khFEELILHTKKPTGMTHTTAIAAVSATITCRAV--AIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIF 400
Cdd:PLN02623 445 --PEGTTPPNLGQAFKNHMSEMFAFHATMMANTLgtSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVC 522

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 392900632 401 PVYYpkgridEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQ 447
Cdd:PLN02623 523 PIYM------QFSDDAEETFARALSLLLNKGMVKEGEEVALVQSGRQ 563
PRK06739 PRK06739
pyruvate kinase; Validated
 1-329 1.61e-88

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 274.13  E-value: 1.61e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   1 MINTGMNIARLNFSHGTHEAHAATIKTIREAAENapfpVAIALDTKGPEIRTGMFANnmKEVQLENGKSVRVSTDPsmeF 80
Cdd:PRK06739  22 LINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----IKILGDVQGPKIRLGEIKG--EQITLQAGDSFILHTQP---V 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AATSSHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLPAVTSKDIEDLL 160
Cdd:PRK06739  93 TGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLPAITEKDKKDIQ 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 161 FGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHI-YIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEIPAEKVFLA 239
Cdd:PRK06739 173 FLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGIMIARGDLGVELPYQFIPLL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 240 QKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAES-- 317
Cdd:PRK06739 253 QKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTLRLVSEFAEHvk 332

                        330
                 ....*....|....
gi 392900632 318 --AFFHMKHFEELI 329
Cdd:PRK06739 333 kdGPFVMKDVLELL 346
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 5-443 1.80e-82

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 263.14  E-value: 1.80e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   5 GMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFaNNMKEVQLENGK----SVRVSTDPSMEF 80
Cdd:PLN02762  50 GMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDL-GGASSAKAEDGEewtfTVRKFDGSRPEF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  81 AatsshIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNL--PGTIVD-----LPAVTS 153
Cdd:PLN02762 129 T-----IQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANLTFwrDGSLVRernamLPTISS 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 154 KDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEK--GKHIYIIAKIESEDGVTNCDEIIEASDGVMVARGDLGIEI 231
Cdd:PLN02762 204 KDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARsrDSDIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQI 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 232 PAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNI 311
Cdd:PLN02762 284 PLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSV 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 312 CKEAESAFFHMKHFEELILH---TKKPTGMTHTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDER 388
Cdd:PLN02762 364 SLRMELWSREEKRHEALELPqlsSSLSDRISEEICNSAAKMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTS 443

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 392900632 389 ISRQLHLHRGIFPVyypkgRIDEWDvDVEERVQYGVNLGKTRGFIHLGDPLIVIT 443
Cdd:PLN02762 444 VRRRLNLQWGLIPF-----RLDFSD-DMESNLNKTFSLLKARGMIKSGDLVIAVS 492
PRK08187 PRK08187
pyruvate kinase; Validated
 5-311 3.62e-53

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 185.60  E-value: 3.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632   5 GMNIARLNFSHGTHEAHAATIKTIREAAENAPFPVAIALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSME----- 79
Cdd:PRK08187 159 GMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGPLGKTRLYTGDRLALVAQGPPRridee 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  80 -FAATSSH--IYADyrnlpkvVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTR----KGVNLPGTIVDLPAVT 152
Cdd:PRK08187 239 hFQVTCTLpeILAR-------LAVGARVWIDDGKLGARVERVGPGGALLEVTHARPKGLKlkpeKGLNFPDTALDLPALT 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 153 SKDIEDLLFGVEQGvDIIFASFIRNADGIHKIRQVLGEKG----KHIYIIAKIESEDGVTNCDEIIEASDG-----VMVA 223
Cdd:PRK08187 312 EKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRpddwRKLGLVLKIETPRAVANLPELIVQAAGrqpfgVMIA 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 224 RGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAvlDGVDCVMLSgetaKGDYPVE 303
Cdd:PRK08187 391 RGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--ARAECVMLN----KGPYLVE 464


                 ....*...
gi 392900632 304 ALAIMHNI 311
Cdd:PRK08187 465 AVTFLDDL 472
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
246-460 7.10e-44

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 156.60  E-value: 7.10e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 246 KCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHmkhf 325
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEY---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 326 EELILHTKKPTGMTHTTAIAAVSATITCR--AVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVY 403
Cdd:COG3848   77 REQRVPRAKESSTTITDAISHAVATTAADlgAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLL 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 392900632 404 YPKGRidewdvDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIVVA 460
Cdd:COG3848  157 VEESA------STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGvSGTTNLLKVHVV 208
PRK14725 PRK14725
pyruvate kinase; Provisional
 94-317 2.41e-41

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 155.49  E-value: 2.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  94 LPKV---VQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTR----KGVNLPGTIVDLPAVTSKDIEDLLFGVEQG 166
Cdd:PRK14725 366 LPEAfraARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKHA 445

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 167 vDIIFASFIRNADGIHKIRQVLGE-KGKHIYIIAKIESEDGVTNCDEII-EA----SDGVMVARGDLGIEIPAEKVFLAQ 240
Cdd:PRK14725 446 -DIVALSFVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRILlEAmrhpRFGVMIARGDLAVEVGFERLAEVQ 524

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392900632 241 KMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVANAVLdgVDCVMLSgetaKGDYPVEALAIMHNI-CKEAES 317
Cdd:PRK14725 525 EEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDIlRRMEEH 596
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 340-458 1.27e-34

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 125.29  E-value: 1.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  340 HTTAIAAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKgridewDVDVEER 419
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 392900632  420 VQYGVNLGKTRGFIHLGDPLIVITGWKQG-AGFTNTMRIV 458
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
HpcH_HpaI pfam03328
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ...
 144-251 8.94e-04

HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.


Pssm-ID: 427247 [Multi-domain]  Cd Length: 221  Bit Score: 40.80  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632  144 TIVDLPAVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVL-------GEKGKHIYIIAKIESEDGVTNCDEIIeA 216
Cdd:pfam03328  62 VVVRVNSLDSPFGKQDLAVLDLGAQVVLVPKVETAEDARAAVSAIryppkgiRRANGNTCLLAQIESALGVLNADEIA-A 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 392900632  217 SDGVM-VARG------DLGIEIPAE--KVFLAQKMLIAKCNLAG 251
Cdd:pfam03328 141 VEGVDgIFLGaedlsaDLGTLRSPGgpEVLYARERIVTAARAAG 184
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
157-255 1.51e-03

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 40.52  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900632 157 EDLLFGVEQGVDIIFASFIRNADGIHKIRQVL---GEKGKHIYIIAKIESEDGVTNCDEIIEASDGVMVAR-------GD 226
Cdd:COG2301   79 DDLAALVGAGLDGIVLPKVESAEDVRALAALLtelEAEGGSIPLMALIETARGLLNAAEIAAASPRVEALVfgaedlaAD 158

                         90       100       110
                 ....*....|....*....|....*....|..
gi 392900632 227 LGIEIPAEKVFLA---QKMLIAkCNLAGKPVI 255
Cdd:COG2301  159 LGARRTRDGDELLyarSRIVLA-ARAAGLAAI 189
HpcH COG3836
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];
194-254 8.57e-03

2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];


Pssm-ID: 443047 [Multi-domain]  Cd Length: 237  Bit Score: 37.78  E-value: 8.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900632 194 HIYIIAKIESEDGVTNCDEIieAS----DGVMVARGDLGI------EIPAEKVFLAQKMLIAKCNLAGKPV 254
Cdd:COG3836  141 ETLVIVQIETAEAVENLDEI--AAvpgvDGVFIGPADLSAslghpgQPDHPEVQAAIERVIAAARAAGKPA 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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