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Conserved domains on  [gi|665394832|ref|NP_001247252|]
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p53, isoform E [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P53 pfam00870
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ...
 32-224 1.94e-68

P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.


:

Pssm-ID: 459972 [Multi-domain]  Cd Length: 191  Bit Score: 212.15  E-value: 1.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832   32 LENHNIGGYCFSMVLDEPP---KSLWMYSIPLNKLYIRMNKAFNVDVQFKSKMPiQPLNLRVFLCFSN--DVSAPVVRCQ 106
Cdd:pfam00870   1 SEEDYPGSLNFNVLLDESKeakKSSWTYSPKLNKLFVKMNKSCPFNFKTDPPPP-PGLYIRAMLVYSKseHANDPVERCP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832  107 NHLSVEPLtaNNAKMRESLLRSENPNSVYCGNAQGkgiSERFSVVVPLNMSRSVTRSgltrQTLAFKFVCQNSC---IGR 183
Cdd:pfam00870  80 NHRAKDDG--NNDPIREHVIRCENPDAEYVGTDEG---DERLSVVVPLEHPQAGSES----VTLLLKFMCKSSCpggINR 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 665394832  184 KETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDERQL 224
Cdd:pfam00870 151 RPTALVFTLEDPDGQVLGRQSISVKVCSCPKRDRRKEEKAL 191
P53_C pfam11619
Transcription factor P53 - C terminal domain; This family of proteins is the C terminal domain ...
 268-334 5.68e-38

Transcription factor P53 - C terminal domain; This family of proteins is the C terminal domain of the transcription factor P53. While the rest of the protein is quite conserved between the different transcription factors such as p53 and p73, the C terminal domain is highly divergent. The DM-p53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix.


:

Pssm-ID: 314489  Cd Length: 67  Bit Score: 129.60  E-value: 5.68e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394832  268 AEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRHANKLLSLKKRAYELP 334
Cdd:pfam11619   1 ADWDVSRTDDGDYRLVITCPNKEWLLQSIEGMIKEAAVAVLRNPNKDKLRQHANSLLNLKKRAYELP 67
 
Name Accession Description Interval E-value
P53 pfam00870
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ...
 32-224 1.94e-68

P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.


Pssm-ID: 459972 [Multi-domain]  Cd Length: 191  Bit Score: 212.15  E-value: 1.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832   32 LENHNIGGYCFSMVLDEPP---KSLWMYSIPLNKLYIRMNKAFNVDVQFKSKMPiQPLNLRVFLCFSN--DVSAPVVRCQ 106
Cdd:pfam00870   1 SEEDYPGSLNFNVLLDESKeakKSSWTYSPKLNKLFVKMNKSCPFNFKTDPPPP-PGLYIRAMLVYSKseHANDPVERCP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832  107 NHLSVEPLtaNNAKMRESLLRSENPNSVYCGNAQGkgiSERFSVVVPLNMSRSVTRSgltrQTLAFKFVCQNSC---IGR 183
Cdd:pfam00870  80 NHRAKDDG--NNDPIREHVIRCENPDAEYVGTDEG---DERLSVVVPLEHPQAGSES----VTLLLKFMCKSSCpggINR 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 665394832  184 KETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDERQL 224
Cdd:pfam00870 151 RPTALVFTLEDPDGQVLGRQSISVKVCSCPKRDRRKEEKAL 191
P53 cd08367
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 42-222 4.41e-57

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


Pssm-ID: 176262  Cd Length: 179  Bit Score: 182.85  E-value: 4.41e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832  42 FSMVLDEPP---KSLWMYSIPLNKLYIRMNKafNVDVQFKSKM-PIQPLNLRVFLCFSN--DVSAPVVRCQNHLSVEplT 115
Cdd:cd08367    1 FEVTLDESGvakSSTWTYSPKLNKLFVKMAK--TCPIQFKVNPsPPPGLYVRAMLVYKDpeHVKEPVERCPNHRQGD--D 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832 116 ANNAKmRESLLRSENPNSVYCGNAQgkgiSERFSVVVPLNMsrsvTRSGLTRQTLAFKFVCQNSC---IGRKETSLVFCL 192
Cdd:cd08367   77 GHTAP-NSHVIRCENPQAEYVGDAF----TGRLSVVVPLEP----PQVGSEYVTVLLQFMCQNSCpggINRRPIQLVFTL 147

                        170       180       190
                 ....*....|....*....|....*....|
gi 665394832 193 EKACGDIVGQHVIHVKICTCPKRDRIQDER 222
Cdd:cd08367  148 EDENGNVLGRRVIEVRVCACPGRDRKNEEK 177
P53_C pfam11619
Transcription factor P53 - C terminal domain; This family of proteins is the C terminal domain ...
 268-334 5.68e-38

Transcription factor P53 - C terminal domain; This family of proteins is the C terminal domain of the transcription factor P53. While the rest of the protein is quite conserved between the different transcription factors such as p53 and p73, the C terminal domain is highly divergent. The DM-p53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix.


Pssm-ID: 314489  Cd Length: 67  Bit Score: 129.60  E-value: 5.68e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394832  268 AEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRHANKLLSLKKRAYELP 334
Cdd:pfam11619   1 ADWDVSRTDDGDYRLVITCPNKEWLLQSIEGMIKEAAVAVLRNPNKDKLRQHANSLLNLKKRAYELP 67
 
Name Accession Description Interval E-value
P53 pfam00870
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ...
 32-224 1.94e-68

P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.


Pssm-ID: 459972 [Multi-domain]  Cd Length: 191  Bit Score: 212.15  E-value: 1.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832   32 LENHNIGGYCFSMVLDEPP---KSLWMYSIPLNKLYIRMNKAFNVDVQFKSKMPiQPLNLRVFLCFSN--DVSAPVVRCQ 106
Cdd:pfam00870   1 SEEDYPGSLNFNVLLDESKeakKSSWTYSPKLNKLFVKMNKSCPFNFKTDPPPP-PGLYIRAMLVYSKseHANDPVERCP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832  107 NHLSVEPLtaNNAKMRESLLRSENPNSVYCGNAQGkgiSERFSVVVPLNMSRSVTRSgltrQTLAFKFVCQNSC---IGR 183
Cdd:pfam00870  80 NHRAKDDG--NNDPIREHVIRCENPDAEYVGTDEG---DERLSVVVPLEHPQAGSES----VTLLLKFMCKSSCpggINR 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 665394832  184 KETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDERQL 224
Cdd:pfam00870 151 RPTALVFTLEDPDGQVLGRQSISVKVCSCPKRDRRKEEKAL 191
P53 cd08367
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 42-222 4.41e-57

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


Pssm-ID: 176262  Cd Length: 179  Bit Score: 182.85  E-value: 4.41e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832  42 FSMVLDEPP---KSLWMYSIPLNKLYIRMNKafNVDVQFKSKM-PIQPLNLRVFLCFSN--DVSAPVVRCQNHLSVEplT 115
Cdd:cd08367    1 FEVTLDESGvakSSTWTYSPKLNKLFVKMAK--TCPIQFKVNPsPPPGLYVRAMLVYKDpeHVKEPVERCPNHRQGD--D 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394832 116 ANNAKmRESLLRSENPNSVYCGNAQgkgiSERFSVVVPLNMsrsvTRSGLTRQTLAFKFVCQNSC---IGRKETSLVFCL 192
Cdd:cd08367   77 GHTAP-NSHVIRCENPQAEYVGDAF----TGRLSVVVPLEP----PQVGSEYVTVLLQFMCQNSCpggINRRPIQLVFTL 147

                        170       180       190
                 ....*....|....*....|....*....|
gi 665394832 193 EKACGDIVGQHVIHVKICTCPKRDRIQDER 222
Cdd:cd08367  148 EDENGNVLGRRVIEVRVCACPGRDRKNEEK 177
P53_C pfam11619
Transcription factor P53 - C terminal domain; This family of proteins is the C terminal domain ...
 268-334 5.68e-38

Transcription factor P53 - C terminal domain; This family of proteins is the C terminal domain of the transcription factor P53. While the rest of the protein is quite conserved between the different transcription factors such as p53 and p73, the C terminal domain is highly divergent. The DM-p53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix.


Pssm-ID: 314489  Cd Length: 67  Bit Score: 129.60  E-value: 5.68e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394832  268 AEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRHANKLLSLKKRAYELP 334
Cdd:pfam11619   1 ADWDVSRTDDGDYRLVITCPNKEWLLQSIEGMIKEAAVAVLRNPNKDKLRQHANSLLNLKKRAYELP 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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