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Conserved domains on  [gi|386763439|ref|NP_001245420|]
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host cell factor, isoform E [Drosophila melanogaster]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 13286889)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02193 super family cl31837
nitrile-specifier protein
 59-363 1.10e-21

nitrile-specifier protein


The actual alignment was detected with superfamily member PLN02193:

Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 100.42  E-value: 1.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   59 RWKRV-LNPTGPQPRPRHGHRAINIKelMVVFGGG---NEGIVDELHVYNTVTNQWYVPVLKGDVPN-GCAAYGFVVEGT 133
Cdd:PLN02193  152 KWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  134 RMFVFGGMIEYGKYsNELYELQATKWEWRKMYPESPdsglSPCPRLGHSFTMVGEKIFLFGGLANESDdpknnipkylnd 213
Cdd:PLN02193  230 TLYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEE----GPTPRSFHSMAADEENVYVFGGVSATAR------------ 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  214 LYILDTRGVHSHngKWIVPKTYGDSpppreshtgisFATKSNGNLNLL-----IYGGMSGCRLGDLWLLETDSMTWSKPK 288
Cdd:PLN02193  293 LKTLDSYNIVDK--KWFHCSTPGDS-----------FSIRGGAGLEVVqgkvwVVYGFNGCEVDDVHYYDPVQDKWTQVE 359

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386763439  289 TSGEAPLPRSLHSSTMIGNKMYVFGGWVPLvinDSKSTTEREWKCTNTLAvLDLETMTWENVTLDTVEENVPRAR 363
Cdd:PLN02193  360 TFGVRPSERSVFASAAVGKHIVIFGGEIAM---DPLAHVGPGQLTDGTFA-LDTETLQWERLDKFGEEEETPSSR 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1291-1322 4.44e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 4.44e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 386763439 1291 TNLEPGTAYRFRLSAINSCGRGEWGEISSFKT 1322
Cdd:cd00063    62 TGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1291-1365 3.72e-03

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 3.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386763439 1291 TNLEPGTAYRFRLSAINSCG-RGEWGEISSFKTCLPGfPGAPSAIKISKDVKEGAHLTWEPPPaqkTKEIIEYSVY 1365
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTP-PAAPSGLTATAVGSSSITLSWTASS---DADVTGYNVY 361
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1328-1432 4.20e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439 1328 PGAPSAIKISKDVKEGAHLTWEPPPAqKTKEIIEYSVYLavkptakdKALSTPQLAFVRVYVGAANQCTVPNASLSNAHV 1407
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPED-DGGPITGYVVEY--------REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71

                          90       100
                  ....*....|....*....|....*
gi 386763439 1408 dcsnkpaiiFRIAARNQKGYGPATQ 1432
Cdd:cd00063    72 ---------FRVRAVNGGGESPPSE 87
 
Name Accession Description Interval E-value
PLN02193 PLN02193
nitrile-specifier protein
 59-363 1.10e-21

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 100.42  E-value: 1.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   59 RWKRV-LNPTGPQPRPRHGHRAINIKelMVVFGGG---NEGIVDELHVYNTVTNQWYVPVLKGDVPN-GCAAYGFVVEGT 133
Cdd:PLN02193  152 KWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  134 RMFVFGGMIEYGKYsNELYELQATKWEWRKMYPESPdsglSPCPRLGHSFTMVGEKIFLFGGLANESDdpknnipkylnd 213
Cdd:PLN02193  230 TLYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEE----GPTPRSFHSMAADEENVYVFGGVSATAR------------ 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  214 LYILDTRGVHSHngKWIVPKTYGDSpppreshtgisFATKSNGNLNLL-----IYGGMSGCRLGDLWLLETDSMTWSKPK 288
Cdd:PLN02193  293 LKTLDSYNIVDK--KWFHCSTPGDS-----------FSIRGGAGLEVVqgkvwVVYGFNGCEVDDVHYYDPVQDKWTQVE 359

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386763439  289 TSGEAPLPRSLHSSTMIGNKMYVFGGWVPLvinDSKSTTEREWKCTNTLAvLDLETMTWENVTLDTVEENVPRAR 363
Cdd:PLN02193  360 TFGVRPSERSVFASAAVGKHIVIFGGEIAM---DPLAHVGPGQLTDGTFA-LDTETLQWERLDKFGEEEETPSSR 430
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-385 1.00e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.99  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   66 PTGPQPRPRHGHRAINIKELMVVFGGGNEG-IVDELHVYNTVTNQWYVpvlKGDVPnGCAAYGF--VVEGTRMFVFGGMI 142
Cdd:COG3055     5 SLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTWSE---LAPLP-GPPRHHAaaVAQDGKLYVFGGFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  143 EY---GKYSNELYELQATKWEWRKMYPespdsglSPCPRLGHSFTMVGEKIFLFGGlanesddpkNNIPKYLNDLYILDT 219
Cdd:COG3055    81 GAnpsSTPLNDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYDP 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  220 RgvhshNGKWivpKTYGDSPPPRESHTGisfATKSNGNLnlLIYGGMSGcrlgdlwllETDSMTWSKPKTsgeAPLPRSL 299
Cdd:COG3055   145 A-----TGTW---TQLAPLPTPRDHLAA---AVLPDGKI--LVIGGRNG---------SGFSNTWTTLAP---LPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  300 HSSTMIGNKMYVFGGwvplvindskstterEWKCTNTLAVLDLETMTWENVTldtveeNVPRARAGHCAVGIQSRLYVWS 379
Cdd:COG3055   200 HAAAVLGGKILVFGG---------------ESGFSDEVEAYDPATNTWTALG------ELPTPRHGHAAVLTDGKVYVIG 258


                  ....*...
gi 386763439  380 G--RDGYR 385
Cdd:COG3055   259 GetKPGVR 266
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1291-1322 4.44e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 4.44e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 386763439 1291 TNLEPGTAYRFRLSAINSCGRGEWGEISSFKT 1322
Cdd:cd00063    62 TGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
Kelch_3 pfam13415
Galactose oxidase, central domain;
306-371 4.78e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 4.78e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386763439   306 GNKMYVFGGWvplvindsksTTEREwKCTNTLAVLDLETMTWENVTldtveeNVPRARAGHCAVGI 371
Cdd:pfam13415    1 GDKLYIFGGL----------GFDGQ-TRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1291-1365 3.72e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 3.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386763439 1291 TNLEPGTAYRFRLSAINSCG-RGEWGEISSFKTCLPGfPGAPSAIKISKDVKEGAHLTWEPPPaqkTKEIIEYSVY 1365
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTP-PAAPSGLTATAVGSSSITLSWTASS---DADVTGYNVY 361
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1328-1432 4.20e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439 1328 PGAPSAIKISKDVKEGAHLTWEPPPAqKTKEIIEYSVYLavkptakdKALSTPQLAFVRVYVGAANQCTVPNASLSNAHV 1407
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPED-DGGPITGYVVEY--------REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71

                          90       100
                  ....*....|....*....|....*
gi 386763439 1408 dcsnkpaiiFRIAARNQKGYGPATQ 1432
Cdd:cd00063    72 ---------FRVRAVNGGGESPPSE 87
 
Name Accession Description Interval E-value
PLN02193 PLN02193
nitrile-specifier protein
 59-363 1.10e-21

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 100.42  E-value: 1.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   59 RWKRV-LNPTGPQPRPRHGHRAINIKelMVVFGGG---NEGIVDELHVYNTVTNQWYVPVLKGDVPN-GCAAYGFVVEGT 133
Cdd:PLN02193  152 KWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  134 RMFVFGGMIEYGKYsNELYELQATKWEWRKMYPESPdsglSPCPRLGHSFTMVGEKIFLFGGLANESDdpknnipkylnd 213
Cdd:PLN02193  230 TLYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEE----GPTPRSFHSMAADEENVYVFGGVSATAR------------ 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  214 LYILDTRGVHSHngKWIVPKTYGDSpppreshtgisFATKSNGNLNLL-----IYGGMSGCRLGDLWLLETDSMTWSKPK 288
Cdd:PLN02193  293 LKTLDSYNIVDK--KWFHCSTPGDS-----------FSIRGGAGLEVVqgkvwVVYGFNGCEVDDVHYYDPVQDKWTQVE 359

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386763439  289 TSGEAPLPRSLHSSTMIGNKMYVFGGWVPLvinDSKSTTEREWKCTNTLAvLDLETMTWENVTLDTVEENVPRAR 363
Cdd:PLN02193  360 TFGVRPSERSVFASAAVGKHIVIFGGEIAM---DPLAHVGPGQLTDGTFA-LDTETLQWERLDKFGEEEETPSSR 430
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-385 1.00e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.99  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   66 PTGPQPRPRHGHRAINIKELMVVFGGGNEG-IVDELHVYNTVTNQWYVpvlKGDVPnGCAAYGF--VVEGTRMFVFGGMI 142
Cdd:COG3055     5 SLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTWSE---LAPLP-GPPRHHAaaVAQDGKLYVFGGFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  143 EY---GKYSNELYELQATKWEWRKMYPespdsglSPCPRLGHSFTMVGEKIFLFGGlanesddpkNNIPKYLNDLYILDT 219
Cdd:COG3055    81 GAnpsSTPLNDVYVYDPATNTWTKLAP-------MPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEVYDP 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  220 RgvhshNGKWivpKTYGDSPPPRESHTGisfATKSNGNLnlLIYGGMSGcrlgdlwllETDSMTWSKPKTsgeAPLPRSL 299
Cdd:COG3055   145 A-----TGTW---TQLAPLPTPRDHLAA---AVLPDGKI--LVIGGRNG---------SGFSNTWTTLAP---LPTARAG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  300 HSSTMIGNKMYVFGGwvplvindskstterEWKCTNTLAVLDLETMTWENVTldtveeNVPRARAGHCAVGIQSRLYVWS 379
Cdd:COG3055   200 HAAAVLGGKILVFGG---------------ESGFSDEVEAYDPATNTWTALG------ELPTPRHGHAAVLTDGKVYVIG 258


                  ....*...
gi 386763439  380 G--RDGYR 385
Cdd:COG3055   259 GetKPGVR 266
PLN02153 PLN02153
epithiospecifier protein
 67-348 1.16e-17

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 86.19  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   67 TGPQPRPRHGHRAINIKelMVVFGGG---NEGIVDELHVYNTVTNQWYVPVLKGDVPN-GCAAYGFVVEGTRMFVFGGMI 142
Cdd:PLN02153   18 KGPGPRCSHGIAVVGDK--LYSFGGElkpNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  143 EYGKYSNeLYELQATKWEWRKMYPESPDSGlsPCPRLGHSFTMVGEKIFLFGGLaneSDDPKNNIPKYLndlyildtRGV 222
Cdd:PLN02153   96 EKREFSD-FYSYDTVKNEWTFLTKLDEEGG--PEARTFHSMASDENHVYVFGGV---SKGGLMKTPERF--------RTI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  223 HSHN---GKWIVPKTYGDSpppRESHTGISFATKSN------GNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEA 293
Cdd:PLN02153  162 EAYNiadGKWVQLPDPGEN---FEKRGGAGFAVVQGkiwvvyGFATSILPGGKSDYESNAVQFFDPASGKWTEVETTGAK 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 386763439  294 PLPRSLHSSTMIGNKMYVFGG--WVPLVINDSKSTTerewkcTNTLAVLDLETMTWE 348
Cdd:PLN02153  239 PSARSVFAHAVVGKYIIIFGGevWPDLKGHLGPGTL------SNEGYALDTETLVWE 289
PLN02153 PLN02153
epithiospecifier protein
 160-314 1.11e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 58.84  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  160 EWRKMypeSPDSGLSPCPRLGHSFTMVGEKIFLFGGLANesddPKNNIPKylnDLYILDtrgVHSHNgkWIVPKTYGDsp 239
Cdd:PLN02153    8 GWIKV---EQKGGKGPGPRCSHGIAVVGDKLYSFGGELK----PNEHIDK---DLYVFD---FNTHT--WSIAPANGD-- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386763439  240 PPRESHTGISFATKSNgnlNLLIYGGMSGCR-LGDLWLLETDSMTW---SKPKTSGeAPLPRSLHSSTMIGNKMYVFGG 314
Cdd:PLN02153   71 VPRISCLGVRMVAVGT---KLYIFGGRDEKReFSDFYSYDTVKNEWtflTKLDEEG-GPEARTFHSMASDENHVYVFGG 145
PLN02193 PLN02193
nitrile-specifier protein
 233-386 3.19e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 58.04  E-value: 3.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  233 KTY-GDSPPPRESHTGISFATKSNgnlNLLIYGGMSGCRLGDLWLLETDSMT------WSKPKTSGEAPLPRSLHSSTMI 305
Cdd:PLN02193   98 KTYkGKTSHPIEKRPGVKFVLQGG---KIVGFHGRSTDVLHSLGAYISLPSTpkllgkWIKVEQKGEGPGLRCSHGIAQV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  306 GNKMYVFGG-WVPLVINDSKstterewkctntLAVLDLETMTWenvTLDTVEENVPRARA-GHCAVGIQSRLYVWSGRDG 383
Cdd:PLN02193  175 GNKIYSFGGeFTPNQPIDKH------------LYVFDLETRTW---SISPATGDVPHLSClGVRMVSIGSTLYVFGGRDA 239


                  ...
gi 386763439  384 YRK 386
Cdd:PLN02193  240 SRQ 242
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-155 1.27e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 48.61  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   66 PTGPQPRPRHGHRAINIKELMVVFGGGNeGIVDELHVYNTVTNQWYVpvlKGDVPNGCAAYGFVVEGTRMFVFGGMIEYG 145
Cdd:COG3055   189 TLAPLPTARAGHAAAVLGGKILVFGGES-GFSDEVEAYDPATNTWTA---LGELPTPRHGHAAVLTDGKVYVIGGETKPG 264

                          90
                  ....*....|
gi 386763439  146 KYSNELYELQ 155
Cdd:COG3055   265 VRTPLVTSAE 274
PRK14131 PRK14131
N-acetylneuraminate epimerase;
51-314 1.29e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 49.24  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439   51 LDSNLTGFRWKRVLNPTGPqprPRHGHRAINIKELMVVFGG----GNEG---IVDELHVYNTVTNQWYvpVLKGDVPNGC 123
Cdd:PRK14131   55 LDLNAPSKGWTKIAAFPGG---PREQAVAAFIDGKLYVFGGigktNSEGspqVFDDVYKYDPKTNSWQ--KLDTRSPVGL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  124 A-AYGFVVEGTRMFVFGGMIE---------------------------YGK------YSNELYELQATKWEWRkmypesp 169
Cdd:PRK14131  130 AgHVAVSLHNGKAYITGGVNKnifdgyfedlaaagkdktpkdkindayFDKkpedyfFNKEVLSYDPSTNQWK------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  170 DSGLSP-CPRLGHSFTMVGEKIFLFGGLANESddpknnipkylndlyiLDTRGVH----SHNG-KWivpKTYGDSPPPR- 242
Cdd:PRK14131  203 NAGESPfLGTAGSAVVIKGNKLWLINGEIKPG----------------LRTDAVKqgkfTGNNlKW---QKLPDLPPAPg 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  243 -ESHTGIS--FATKSNGnlNLLIYGGMS--GCRL----GDLWLLETDSMTWSKP---------KTSGEAPLPRSLHSSTM 304
Cdd:PRK14131  264 gSSQEGVAgaFAGYSNG--VLLVAGGANfpGAREnyqnGKLYAHEGLKKSWSDEiyalvngkwQKVGELPQGLAYGVSVS 341

                         330
                  ....*....|
gi 386763439  305 IGNKMYVFGG 314
Cdd:PRK14131  342 WNNGVLLIGG 351
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
283-389 1.79e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 48.23  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  283 TWSkpkTSGEAPLPRSLHSSTMIGNKMYVFGGWvplvindskstteREWKCTNTLAVLDLETMTWENVTldtveeNVPRA 362
Cdd:COG3055     2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGL-------------SGGSASNSFEVYDPATNTWSELA------PLPGP 59

                          90       100
                  ....*....|....*....|....*...
gi 386763439  363 RAGH-CAVGIQSRLYVWSGRDGYRKAWN 389
Cdd:COG3055    60 PRHHaAAVAQDGKLYVFGGFTGANPSST 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1291-1322 4.44e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 4.44e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 386763439 1291 TNLEPGTAYRFRLSAINSCGRGEWGEISSFKT 1322
Cdd:cd00063    62 TGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
Kelch_3 pfam13415
Galactose oxidase, central domain;
306-371 4.78e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 4.78e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386763439   306 GNKMYVFGGWvplvindsksTTEREwKCTNTLAVLDLETMTWENVTldtveeNVPRARAGHCAVGI 371
Cdd:pfam13415    1 GDKLYIFGGL----------GFDGQ-TRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 284-385 1.62e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 45.75  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  284 WSK-PKTSGEAPLPRSLHSSTMIGNKMYVFGGwvPLVINDSkstterewkCTNTLAVLDLETMTWenvTLDTVEENVPRA 362
Cdd:PLN02153    9 WIKvEQKGGKGPGPRCSHGIAVVGDKLYSFGG--ELKPNEH---------IDKDLYVFDFNTHTW---SIAPANGDVPRI 74

                          90       100
                  ....*....|....*....|....
gi 386763439  363 RA-GHCAVGIQSRLYVWSGRDGYR 385
Cdd:PLN02153   75 SClGVRMVAVGTKLYIFGGRDEKR 98
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 175-221 1.86e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 40.24  E-value: 1.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 386763439   175 PCPRLGHSFTMVGEKIFLFGGLANESDdpknnipKYLNDLYILDTRG 221
Cdd:pfam13854    1 PVPRYGHCAVTVGDYIYLYGGYTGGEG-------QPSDDVYVLSLPT 40
PLN02193 PLN02193
nitrile-specifier protein
 178-380 8.58e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.79  E-value: 8.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  178 RLGHSFTMVGEKIFLFGGlanESDDPKNNIPKYLNdlyILDTRGVHshnGKWIVPKTYGDSPPPRESHtGISfatkSNGN 257
Cdd:PLN02193  111 RPGVKFVLQGGKIVGFHG---RSTDVLHSLGAYIS---LPSTPKLL---GKWIKVEQKGEGPGLRCSH-GIA----QVGN 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  258 lNLLIYGG-MSGCRLGD--LWLLETDSMTWSKPKTSGEAPLPRSLHSSTM-IGNKMYVFGGwvplvindskSTTEREWkc 333
Cdd:PLN02193  177 -KIYSFGGeFTPNQPIDkhLYVFDLETRTWSISPATGDVPHLSCLGVRMVsIGSTLYVFGG----------RDASRQY-- 243

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 386763439  334 tNTLAVLDLETMTWENVTldTVEENvPRARAGHCAVGIQSRLYVWSG 380
Cdd:PLN02193  244 -NGFYSFDTTTNEWKLLT--PVEEG-PTPRSFHSMAADEENVYVFGG 286
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 296-351 1.04e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 1.04e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 386763439   296 PRSLHSSTMIGNKMYVFGGWvplvindskstteREWKCTNTLAVLDLETMTWENVT 351
Cdd:pfam01344    1 RRSGAGVVVVGGKIYVIGGF-------------DGNQSLNSVEVYDPETNTWSKLP 43
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 120-159 1.23e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.93  E-value: 1.23e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386763439   120 PNGCAAYGFVVEGTRMFVFGGMI-EYGKYSNELYELQATKW 159
Cdd:pfam13854    1 PVPRYGHCAVTVGDYIYLYGGYTgGEGQPSDDVYVLSLPTF 41
Kelch_3 pfam13415
Galactose oxidase, central domain;
260-303 1.30e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.04  E-value: 1.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 386763439   260 LLIYGG---MSGCRLGDLWLLETDSMTWskpKTSGEAPLPRSLHSST 303
Cdd:pfam13415    4 LYIFGGlgfDGQTRLNDLYVYDLDTNTW---TQIGDLPPPRSGHSAT 47
PLN02772 PLN02772
guanylate kinase
 172-281 2.19e-03

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 42.13  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439  172 GLSPCPRLGHSFTMVGEKIFLFGGlaneSDDPKNnipkYLNDLYILDTRgvhshNGKWIVPKTYGDSPPPRESHTGISFa 251
Cdd:PLN02772   19 GFGVKPKNRETSVTIGDKTYVIGG----NHEGNT----LSIGVQILDKI-----TNNWVSPIVLGTGPKPCKGYSAVVL- 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 386763439  252 tksnGNLNLLIYGGMSGcRLGDLWLLETDS 281
Cdd:PLN02772   85 ----NKDRILVIKKGSA-PDDSIWFLEVDT 109
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 73-110 2.75e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 2.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 386763439    73 PRHGHRAINIKELMVVFGGGNEG-IVDELHVYNTVTNQW 110
Cdd:pfam01344    1 RRSGAGVVVVGGKIYVIGGFDGNqSLNSVEVYDPETNTW 39
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1291-1365 3.72e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 3.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386763439 1291 TNLEPGTAYRFRLSAINSCG-RGEWGEISSFKTCLPGfPGAPSAIKISKDVKEGAHLTWEPPPaqkTKEIIEYSVY 1365
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTP-PAAPSGLTATAVGSSSITLSWTASS---DADVTGYNVY 361
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1328-1432 4.20e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763439 1328 PGAPSAIKISKDVKEGAHLTWEPPPAqKTKEIIEYSVYLavkptakdKALSTPQLAFVRVYVGAANQCTVPNASLSNAHV 1407
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPED-DGGPITGYVVEY--------REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71

                          90       100
                  ....*....|....*....|....*
gi 386763439 1408 dcsnkpaiiFRIAARNQKGYGPATQ 1432
Cdd:cd00063    72 ---------FRVRAVNGGGESPPSE 87
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 296-351 8.28e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.77  E-value: 8.28e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 386763439   296 PRSLHSSTMIGNKMYVFGGwvplvINDSKSTTerewkcTNTLAVLDLETMTWENVT 351
Cdd:pfam07646    1 PRYPHASSVPGGKLYVVGG-----SDGLGDLS------SSDVLVYDPETNVWTEVP 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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