NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1371977145|ref|NP_001235331|]
View 

cyclin box fold protein binding domain-containing protein [Glycine max]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycU-like cd20604
cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs ...
 41-166 4.74e-79

cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs interact with cyclin-dependent kinase A-1 (CDKA-1) to trigger its kinase activity. CycUs contain one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410307  Cd Length: 126  Bit Score: 232.28  E-value: 4.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  41 KISVFHGLTRPNISIQCYLERIFKYANCSPSCFVVAYVYLDRFTQRQPSLPINSFNVHRLLITSVMVAAKFMDDMFYNNA 120
Cdd:cd20604     1 KVTVFHGVRAPSISIASYLERIFKYTNCSPSCFVVAYVYIDRFIHKQPGLPISSLNVHRLLITSVMVAAKFLDDLYYNNA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1371977145 121 HYAKVGGITKVEMNFLELDFLFGLGFHLNVTPGTFQAYCVHLQREM 166
Cdd:cd20604    81 YYAKVGGVSTEELNRLELEFLFLLDFKLNVTVSVFESYCCHLEREM 126
 
Name Accession Description Interval E-value
CYCLIN_AtCycU-like cd20604
cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs ...
 41-166 4.74e-79

cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs interact with cyclin-dependent kinase A-1 (CDKA-1) to trigger its kinase activity. CycUs contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410307  Cd Length: 126  Bit Score: 232.28  E-value: 4.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  41 KISVFHGLTRPNISIQCYLERIFKYANCSPSCFVVAYVYLDRFTQRQPSLPINSFNVHRLLITSVMVAAKFMDDMFYNNA 120
Cdd:cd20604     1 KVTVFHGVRAPSISIASYLERIFKYTNCSPSCFVVAYVYIDRFIHKQPGLPISSLNVHRLLITSVMVAAKFLDDLYYNNA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1371977145 121 HYAKVGGITKVEMNFLELDFLFGLGFHLNVTPGTFQAYCVHLQREM 166
Cdd:cd20604    81 YYAKVGGVSTEELNRLELEFLFLLDFKLNVTVSVFESYCCHLEREM 126
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 14-148 1.36e-42

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 140.28  E-value: 1.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  14 KVITFLCSLLERVAESNDHNQHLQQHQKI-----------SVFHGLTRPNISIQCYLERIFKYANCSPSCFVVAYVYLDR 82
Cdd:pfam08613   2 KLIQMISGELDRLIANNDGTATASSDAQSplepsqlqspeLSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLSALIYLDR 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1371977145  83 FTQR--QPSLPINSFNVHRLLITSVMVAAKFMDDMFYNNAHYAKVGGITKVEMNFLELDFLFGLGFHL 148
Cdd:pfam08613  82 LVKRcdSEAFVVTSANAHRLLITAVTVATKFLSDGFYSNSRFAKVGGISLHELNHLEIDFLFLVDFDL 149
 
Name Accession Description Interval E-value
CYCLIN_AtCycU-like cd20604
cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs ...
 41-166 4.74e-79

cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs interact with cyclin-dependent kinase A-1 (CDKA-1) to trigger its kinase activity. CycUs contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410307  Cd Length: 126  Bit Score: 232.28  E-value: 4.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  41 KISVFHGLTRPNISIQCYLERIFKYANCSPSCFVVAYVYLDRFTQRQPSLPINSFNVHRLLITSVMVAAKFMDDMFYNNA 120
Cdd:cd20604     1 KVTVFHGVRAPSISIASYLERIFKYTNCSPSCFVVAYVYIDRFIHKQPGLPISSLNVHRLLITSVMVAAKFLDDLYYNNA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1371977145 121 HYAKVGGITKVEMNFLELDFLFGLGFHLNVTPGTFQAYCVHLQREM 166
Cdd:cd20604    81 YYAKVGGVSTEELNRLELEFLFLLDFKLNVTVSVFESYCCHLEREM 126
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 51-151 4.24e-48

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 152.71  E-value: 4.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  51 PNISIQCYLERIFKYANCSPSCFVVAYVYLDRFTQRQPSLPINSFNVHRLLITSVMVAAKFMDDMFYNNAHYAKVGGITK 130
Cdd:cd20558     1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATINGFVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYAKVGGVSV 80

                          90       100
                  ....*....|....*....|.
gi 1371977145 131 VEMNFLELDFLFGLGFHLNVT 151
Cdd:cd20558    81 SELNKLELEFLFLLDFDLHVS 101
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 14-148 1.36e-42

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 140.28  E-value: 1.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  14 KVITFLCSLLERVAESNDHNQHLQQHQKI-----------SVFHGLTRPNISIQCYLERIFKYANCSPSCFVVAYVYLDR 82
Cdd:pfam08613   2 KLIQMISGELDRLIANNDGTATASSDAQSplepsqlqspeLSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLSALIYLDR 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1371977145  83 FTQR--QPSLPINSFNVHRLLITSVMVAAKFMDDMFYNNAHYAKVGGITKVEMNFLELDFLFGLGFHL 148
Cdd:pfam08613  82 LVKRcdSEAFVVTSANAHRLLITAVTVATKFLSDGFYSNSRFAKVGGISLHELNHLEIDFLFLVDFDL 149
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 54-146 5.57e-18

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 75.39  E-value: 5.57e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  54 SIQCYLERIFKYANCSPSCFVVAYVYLDRFTQRQPSLPINS-FNVHRLLITSVMVAAKFMDDMFYNNAHYAKVGGITKVE 132
Cdd:cd20557     1 SLRSFIARLLRRTRLSPSVVLLALVYLERLRRRLPEALLGQeGSPYRLFLVALMLASKYLDDESYSNKSWAEISGLPVRE 80

                          90
                  ....*....|....
gi 1371977145 133 MNFLELDFLFGLGF 146
Cdd:cd20557    81 LNAMEREFLEALDW 94
CYCLIN_CCNY_like cd20540
cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and ...
 54-146 2.58e-12

cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and CCNY-like protein 1 (CCNYL1). They can enhance Wnt/beta-catenin signaling in mitosis. CCNY, also called Cyc-Y, cyclin box protein 1 (CBCP1), cyclin fold protein 1 (CFP1), or cyclin-X (CCNX), is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. It is a positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. It acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410243  Cd Length: 97  Bit Score: 60.70  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  54 SIQCYLERIFKYANCSPSCFVVAYVYLDRFTQRQPsLPINSFNVHRLLITSVMVAAKFMDDMFYNNAHYAKVGGITKVE- 132
Cdd:cd20540     5 DIYRFVLTLFSAAQLTAECAIVTLIYIERLIEYAE-IDLHPSNWRRIVLGALLLASKVWDDQAVWNVDFAKILPILTVEd 83

                          90
                  ....*....|....
gi 1371977145 133 MNFLELDFLFGLGF 146
Cdd:cd20540    84 LNRLERSFLELLQF 97
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 58-149 2.65e-10

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 55.99  E-value: 2.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  58 YLERIFKYANCSPSCFVVAYVYLDRFTQRQpslPINSFNVHRLLITSVMVAAKF--MDDMFYNNAHYAKVGGITKVEMNF 135
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKK---SVPKNKLQLVGVTCLFIAAKYeeIYPPTVEDLVYITDNAYTREEILR 113

                          90
                  ....*....|....
gi 1371977145 136 LELDFLFGLGFHLN 149
Cdd:pfam00134 114 MERLILETLNFDLS 127
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 58-139 8.52e-04

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 37.00  E-value: 8.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371977145  58 YLERIFKYANCSPSCFVVAYVYLDRFTQRQpslPINSFNVHRLLITSVMVAAKFMDDMFyNNAHYAKVGGITKVEMNFLE 137
Cdd:cd00043     5 FIRRLCSKLGLPEEVLELAIELLDRFLSKG---LLLGRSPELIAAACLYLACKLEELPR-TLKEIAKVSGVSEKELRKAE 80


                  ..
gi 1371977145 138 LD 139
Cdd:cd00043    81 KE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH