NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|333944020|ref|NP_001207419|]
View 

cadherin-13 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 234-327 3.38e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 3.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020 234 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 312
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944020 313 GTGTLLITLEDVNDN 327
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-105 5.10e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 5.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020   1 MEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYELIIEAQ 80
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 333944020  81 DMAGLdvGLTGTATATIMIDDKNDH 105
Cdd:cd11304   76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
114-215 2.16e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  114 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 191
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944020  192 NEDPlvpdvsYGPSSTATVHITVL 215
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 335-426 1.79e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  335 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 410
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944020  411 GKPPMTNITDLRVQVC 426
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 234-327 3.38e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 3.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020 234 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 312
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944020 313 GTGTLLITLEDVNDN 327
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-105 5.10e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 5.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020   1 MEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYELIIEAQ 80
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 333944020  81 DMAGLdvGLTGTATATIMIDDKNDH 105
Cdd:cd11304   76 DGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 246-329 9.30e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 9.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020   246 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 324
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 333944020   325 NDNAP 329
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
114-215 2.16e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  114 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 191
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944020  192 NEDPlvpdvsYGPSSTATVHITVL 215
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
234-322 2.46e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  234 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 312
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 333944020  313 GTGTLLITLE 322
Cdd:pfam00028  83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1-97 3.02e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 3.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020    1 MEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYELIIEAQ 80
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYELTVEAT 74

                          90
                  ....*....|....*..
gi 333944020   81 DMAGldVGLTGTATATI 97
Cdd:pfam00028  75 DSGG--PPLSSTATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-219 1.03e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020 113 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 190
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 333944020 191 enEDPLVPdvsyGPSSTATVHITVLDVNE 219
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 14-107 1.09e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020    14 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 93
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 333944020    94 TATIMIDDKNDHSP 107
Cdd:smart00112  68 TVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 130-221 4.81e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 4.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020   130 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 209
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 333944020   210 VHITVLDVNEGP 221
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
335-426 1.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  335 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 410
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944020  411 GKPPMTNITDLRVQVC 426
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 335-426 2.59e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020 335 VAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 410
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 333944020 411 GKPPMTNITDLRVQVC 426
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 352-426 1.29e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.71  E-value: 1.29e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333944020   352 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 426
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 234-327 3.38e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 3.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020 234 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 312
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944020 313 GTGTLLITLEDVNDN 327
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-105 5.10e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 5.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020   1 MEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYELIIEAQ 80
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 333944020  81 DMAGLdvGLTGTATATIMIDDKNDH 105
Cdd:cd11304   76 DGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 246-329 9.30e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 9.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020   246 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 324
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 333944020   325 NDNAP 329
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
114-215 2.16e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  114 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 191
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944020  192 NEDPlvpdvsYGPSSTATVHITVL 215
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
234-322 2.46e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  234 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 312
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 333944020  313 GTGTLLITLE 322
Cdd:pfam00028  83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1-97 3.02e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 3.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020    1 MEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYELIIEAQ 80
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYELTVEAT 74

                          90
                  ....*....|....*..
gi 333944020   81 DMAGldVGLTGTATATI 97
Cdd:pfam00028  75 DSGG--PPLSSTATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-219 1.03e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020 113 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 190
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 333944020 191 enEDPLVPdvsyGPSSTATVHITVLDVNE 219
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 14-107 1.09e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020    14 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 93
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 333944020    94 TATIMIDDKNDHSP 107
Cdd:smart00112  68 TVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 130-221 4.81e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 4.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020   130 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 209
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 333944020   210 VHITVLDVNEGP 221
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
335-426 1.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020  335 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 410
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944020  411 GKPPMTNITDLRVQVC 426
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 335-426 2.59e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944020 335 VAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 410
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 333944020 411 GKPPMTNITDLRVQVC 426
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 352-426 1.29e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.71  E-value: 1.29e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333944020   352 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 426
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH