NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|334187123|ref|NP_001190900|]
View 

Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
149-416 3.59e-54

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 3.59e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAW--NNH 226
Cdd:COG2319  141 DGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFspDGK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 227 ILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSA 306
Cdd:COG2319  218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 307 VKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVD-TGSQVCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKM 385
Cdd:COG2319  291 VNSVAFSP-DGKLLAS--GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELL 365

                        250       260       270
                 ....*....|....*....|....*....|.
gi 334187123 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
149-416 3.59e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 3.59e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAW--NNH 226
Cdd:COG2319  141 DGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFspDGK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 227 ILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSA 306
Cdd:COG2319  218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 307 VKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVD-TGSQVCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKM 385
Cdd:COG2319  291 VNSVAFSP-DGKLLAS--GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELL 365

                        250       260       270
                 ....*....|....*....|....*....|.
gi 334187123 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-416 2.10e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 148.64  E-value: 2.10e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKGgHQSRVGSLAW--NNH 226
Cdd:cd00200   30 DGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVAFspDGR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 227 ILTTGGMDGLIINNDVRIRSPIVeTYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDrsvASSNSTtqwLHRLEEHTSA 306
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD---LRTGKC---VATLTGHTGE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 307 VKALAWCPFQANLLAtggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNeRELLSShGFTQNQLTLWKYPSMVKM 385
Cdd:cd00200  180 VNSVAFSPDGEKLLS---SSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLAS-GSEDGTIRVWDLRTGECV 254

                        250       260       270
                 ....*....|....*....|....*....|.
gi 334187123 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 237-416 4.71e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 4.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 237 IINNDVRIRSPIVETyrGHTQEVCGLKW-SGSGQQLASGGNDNVVHIWDrsVASSNSTTQwlhrLEEHTSAVKALAWCPF 315
Cdd:PLN00181 515 IIKDGRDIHYPVVEL--ASRSKLSGICWnSYIKSQVASSNFEGVVQVWD--VARSQLVTE----MKEHEKRVWSIDYSSA 586

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 316 QANLLATGGGGGdrTIKFWNTHTGACLNSVDTGSQVCSLLW-SKNERELL---SSHGFTQNQLTLWKYPsmvkMAELTGH 391
Cdd:PLN00181 587 DPTLLASGSDDG--SVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAfgsADHKVYYYDLRNPKLP----LCTMIGH 660

                        170       180
                 ....*....|....*....|....*
gi 334187123 392 TSRVLYMaQSPDGCTVASAAGDETL 416
Cdd:PLN00181 661 SKTVSYV-RFVDSSTLVSSSTDNTL 684
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 4.76e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 4.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 334187123   249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 1.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 334187123  249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
149-416 3.59e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 3.59e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAW--NNH 226
Cdd:COG2319  141 DGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFspDGK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 227 ILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSA 306
Cdd:COG2319  218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLRTLTGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 307 VKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVD-TGSQVCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKM 385
Cdd:COG2319  291 VNSVAFSP-DGKLLAS--GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELL 365

                        250       260       270
                 ....*....|....*....|....*....|.
gi 334187123 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
143-416 6.98e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.03  E-value: 6.98e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 143 VLAIALDHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLA 222
Cdd:COG2319   93 LASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-GHSGAVTSVA 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 223 W--NNHILTTGGMDGLiinndVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQW 296
Cdd:COG2319  170 FspDGKLLASGSDDGT-----VRLWDLatgkLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL------ATGKL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 297 LHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNERELLSshGFTQNQLT 375
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSP-DGRLLAS--GSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVR 313

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 334187123 376 LWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:COG2319  314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-416 2.10e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 148.64  E-value: 2.10e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 149 DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKGgHQSRVGSLAW--NNH 226
Cdd:cd00200   30 DGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG-HTSYVSSVAFspDGR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 227 ILTTGGMDGLIINNDVRIRSPIVeTYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDrsvASSNSTtqwLHRLEEHTSA 306
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD---LRTGKC---VATLTGHTGE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 307 VKALAWCPFQANLLAtggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNeRELLSShGFTQNQLTLWKYPSMVKM 385
Cdd:cd00200  180 VNSVAFSPDGEKLLS---SSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLAS-GSEDGTIRVWDLRTGECV 254

                        250       260       270
                 ....*....|....*....|....*....|.
gi 334187123 386 AELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
135-416 4.02e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.14  E-value: 4.02e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 135 LLDWGSANVLAIALDHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGH 214
Cdd:COG2319   43 AASPDGARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GH 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 215 QSRVGSLAW--NNHILTTGGMDGliinnDVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRsva 288
Cdd:COG2319  120 TGAVRSVAFspDGKTLASGSADG-----TVRLWDLatgkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 289 ssnSTTQWLHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLNSVDT-GSQVCSLLWSKNERELLSSH 367
Cdd:COG2319  192 ---ATGKLLRTLTGHTGAVRSVAFSP-DGKLLAS--GSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGS 265

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 334187123 368 GftQNQLTLWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:COG2319  266 A--DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312
WD40 COG2319
WD40 repeat [General function prediction only];
142-338 5.79e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 5.79e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 142 NVLAIA-LDHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLkGGHQSRVGS 220
Cdd:COG2319  217 KLLASGsADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-TGHSGGVNS 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 221 LAW--NNHILTTGGMDGliinnDVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRSvassnsTT 294
Cdd:COG2319  294 VAFspDGKLLASGSDDG-----TVRLWDLatgkLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA------TG 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 334187123 295 QWLHRLEEHTSAVKALAWCPfQANLLATGGGggDRTIKFWNTHT 338
Cdd:COG2319  363 ELLRTLTGHTGAVTSVAFSP-DGRTLASGSA--DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
133-286 1.88e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 1.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 133 LNLLDWGSANVLAIAL------------DHTVYLWDASTGStsELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWD 200
Cdd:COG2319  239 LRTLTGHSGSVRSVAFspdgrllasgsaDGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 201 SASNRQLRTLKGgHQSRVGSLAW--NNHILTTGGMDGLiinndVRIRSP----IVETYRGHTQEVCGLKWSGSGQQLASG 274
Cdd:COG2319  317 LATGKLLRTLTG-HTGAVRSVAFspDGKTLASGSDDGT-----VRLWDLatgeLLRTLTGHTGAVTSVAFSPDGRTLASG 390

                        170
                 ....*....|..
gi 334187123 275 GNDNVVHIWDRS 286
Cdd:COG2319  391 SADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-284 2.22e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.03  E-value: 2.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 143 VLAIALDHTVYLWDASTGSTSElvTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKGgHQSRVGSLA 222
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HENGVNSVA 226

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334187123 223 W--NNHILTTGGMDGLIINNDVRIRSPiVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:cd00200  227 FspDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
181-416 7.09e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 7.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 181 APDGRHVAVGLNNSEVQLWDSASNRQLRTLKGGHQSRVGSLAWNNHILTTGGMDGLIINNDVRIRSPIVETYRGHTQEVC 260
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 261 GLKWSGSGQQLASGGNDNVVHIWDRsvassnSTTQWLHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWNTHTGA 340
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDL------ATGLLLRTLTGHTGAVRSVAFSP-DGKTLAS--GSADGTVRLWDLATGK 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334187123 341 CLNSVDTGSQ-VCSLLWSKNERELLSshGFTQNQLTLWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:COG2319  154 LLRTLTGHSGaVTSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 297-416 4.69e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 4.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 297 LHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWNTHTGACLnSVDTG--SQVCSLLWSKNERELLSSHGFtqNQL 374
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP-DGKLLAT--GSGDGTIKVWDLETGELL-RTLKGhtGPVRDVAASADGTYLASGSSD--KTI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 334187123 375 TLWKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETL 416
Cdd:cd00200   76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 237-416 4.71e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 4.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 237 IINNDVRIRSPIVETyrGHTQEVCGLKW-SGSGQQLASGGNDNVVHIWDrsVASSNSTTQwlhrLEEHTSAVKALAWCPF 315
Cdd:PLN00181 515 IIKDGRDIHYPVVEL--ASRSKLSGICWnSYIKSQVASSNFEGVVQVWD--VARSQLVTE----MKEHEKRVWSIDYSSA 586

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 316 QANLLATGGGGGdrTIKFWNTHTGACLNSVDTGSQVCSLLW-SKNERELL---SSHGFTQNQLTLWKYPsmvkMAELTGH 391
Cdd:PLN00181 587 DPTLLASGSDDG--SVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAfgsADHKVYYYDLRNPKLP----LCTMIGH 660

                        170       180
                 ....*....|....*....|....*
gi 334187123 392 TSRVLYMaQSPDGCTVASAAGDETL 416
Cdd:PLN00181 661 SKTVSYV-RFVDSSTLVSSSTDNTL 684
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 4.76e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 4.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 334187123   249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 1.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 334187123  249 VETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 133-367 5.80e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 5.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 133 LNLLDWGS---ANVLAIALDHTVYLWDASTgstSELVT-IDEEKGPVTSINWAP-DGRHVAVGLNNSEVQLWDSASNRQL 207
Cdd:PLN00181 535 LSGICWNSyikSQVASSNFEGVVQVWDVAR---SQLVTeMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSI 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 208 RTLKGghQSRVGSLAW---NNHILTTGGMDGLIINNDVRIRSPIVETYRGHTQEVCGLKWSGSgQQLASGGNDNVVHIWD 284
Cdd:PLN00181 612 GTIKT--KANICCVQFpseSGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWD 688

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 285 RSVASSNSTTQWLHRLEEHTSaVKALAWCPFQANLLATGGGGGD------------RTIKFWNTHTGACLnSVDTGSQ-V 351
Cdd:PLN00181 689 LSMSISGINETPLHSFMGHTN-VKNFVGLSVSDGYIATGSETNEvfvyhkafpmpvLSYKFKTIDPVSGL-EVDDASQfI 766

                        250
                 ....*....|....*.
gi 334187123 352 CSLLWSKNERELLSSH 367
Cdd:PLN00181 767 SSVCWRGQSSTLVAAN 782
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 297-335 1.38e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.38e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 334187123   297 LHRLEEHTSAVKALAWCPfQANLLATggGGGDRTIKFWN 335
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSP-DGKYLAS--GSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 169-224 3.64e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 3.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 334187123  169 DEEKGPVTSINWAPDGRHVAVGLNNSEVQLWDSASNRQLRTLKgGHQSRVGSLAWN 224
Cdd:pfam12894  35 DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFS-AGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 213-354 1.31e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187123 213 GHQSRVGSLAWN---NHILTTGGMDGLIINNDVRiRSPIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWD-RS-- 286
Cdd:PTZ00421 123 GHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVE-RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDpRDgt 201

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334187123 287 -VASSNSttqwlhrleeHTSAVKALA-WCPfQANLLATGG--GGGDRTIKFWNTHTGACLNSVDTGSQVCSL 354
Cdd:PTZ00421 202 iVSSVEA----------HASAKSQRClWAK-RKDLIITLGcsKSQQRQIMLWDTRKMASPYSTVDLDQSSAL 262
WD40 pfam00400
WD domain, G-beta repeat;
297-335 2.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 334187123  297 LHRLEEHTSAVKALAWCPFQaNLLATggGGGDRTIKFWN 335
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDG-KLLAS--GSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 296-359 2.59e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334187123  296 WLHRL----------EEHTSAVKALAWCPfQANLLATGGGGGdrTIKFWNTHTGACLNSVDTGS-QVCSLLWSKN 359
Cdd:pfam12894  20 LLHRLnwqrvwtlspDKEDLEVTSLAWRP-DGKLLAVGYSDG--TVRLLDAENGKIVHHFSAGSdLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 161-200 6.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 334187123   161 STSELVTIDEEKGPVTSINWAPDGRHVAVGLNNSEVQLWD 200
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH