F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 334186922  28 PSLPDDLVLVIIARVSILYYPILSLVSKSFRSLLASPELYKVR 70
Cdd:cd22152    3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 334186922  28 PSLPDDLVLVIIARVSILYYPILSLVSKSFRSLLASPELYKVR 70
Cdd:cd22152    3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 334186922   29 SLPDDLVLVIIARVSILYYPILSLVSKSFRSLLASPELYK 68
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42

Kelch domain;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 334186922   156 TSSSVWVLDCRSHTWRQAPSLPVELFRVSVSVLD 189
Cdd:smart00612  13 RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186922 134 RYSLAAVGSNIYNIGVTRYHHLTSSsvwvLDCRS---HTWRQAPSLPVELFRVSVSVLDQKIYVAG---LHQEDGSDSLK 207
Cdd:PHA02713 344 RFSLAVIDDTIYAIGGQNGTNVERT----IECYTmgdDKWKMLPDMPIALSSYGMCVLDQYIYIIGgrtEHIDYTSVHHM 419

                         90
                 ....*....|....*.
gi 334186922 208 NSVTVlDTETQVSDRV 223
Cdd:PHA02713 420 NSIDM-EEDTHSSNKV 434

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 334186922  28 PSLPDDLVLVIIARVSILYYPILSLVSKSFRSLLASPELYKVR 70
Cdd:cd22152    3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 334186922   29 SLPDDLVLVIIARVSILYYPILSLVSKSFRSLLASPELYK 68
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186922 169 TWRQAPSLPVELFRVSVSVLDQKIYVAGlHQEDGSDSlkNSVTVLDTETQV--------SDRVAIPCSVSQGKEIFIsts 240
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAG-GLSGGSAS--NSFEVYDPATNTwselaplpGPPRHHAAAVAQDGKLYV--- 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 334186922 241 VGGKVNLVTGRKVVD----YNPVEGSWEEVGD 268
Cdd:COG3055   76 FGGFTGANPSSTPLNdvyvYDPATNTWTKLAP 107

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 334186922  29 SLPDDLVLVIIARVSILYYPILSLVSKSFRSlLASPELYKVR 70
Cdd:cd22143    4 SLPDEILSIIFSHLPQSDLYNLLFVNKHFYS-LALPELWRSI 44

Kelch domain;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 334186922   156 TSSSVWVLDCRSHTWRQAPSLPVELFRVSVSVLD 189
Cdd:smart00612  13 RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 334186922  180 LFRVSVSVLDQKIYVAGLHQEDGSDSLkNSVTVLDTETQVSDRVAIP 226
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSS-SDVLVYDPETNVWTEVPRL 47

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 334186922  28 PSLPDDLVLVIIARVsilyyPILSL-----VSKSFRSLLASPE 65
Cdd:cd22157    1 SSLPDDLVEEILSRL-----PAKSLlrfrcVCKQWNSLISSPS 38