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Conserved domains on  [gi|334184369|ref|NP_001189576|]
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Cyclin D2;1 [Arabidopsis thaliana]

Protein Classification

cyclin-D( domain architecture ID 15334368)

cyclin-D such the G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 96-194 1.65e-61

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410246  Cd Length: 99  Bit Score: 192.15  E-value: 1.65e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  96 VRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKDWAAQLLAVSCLSLASKMEETDVPHIVDLQVEDPKFV 175
Cdd:cd20543    1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                         90
                 ....*....|....*....
gi 334184369 176 FEAKTIKRMELLVVTTLNW 194
Cdd:cd20543   81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 200-287 2.43e-15

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410247  Cd Length: 90  Bit Score: 70.80  E-value: 2.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369 200 TPFSFIDYFVDKISGHVSEN-LIYRSSRFILNTTKAIEFLDFRPSEIAAAAAVSVSISGETECIDE-EKALSSLIYVkQQ 277
Cdd:cd20544    2 TPFSFLDYFISKIGLSDSREeLLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDaSSRLSLLLSP-NK 80

                         90
                 ....*....|
gi 334184369 278 ERVKRCLNLM 287
Cdd:cd20544   81 EKVKKCYELM 90
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 96-194 1.65e-61

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 192.15  E-value: 1.65e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  96 VRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKDWAAQLLAVSCLSLASKMEETDVPHIVDLQVEDPKFV 175
Cdd:cd20543    1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                         90
                 ....*....|....*....
gi 334184369 176 FEAKTIKRMELLVVTTLNW 194
Cdd:cd20543   81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 65-196 9.39e-37

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 129.17  E-value: 9.39e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369   65 DRIKEMLVREIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQL 144
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQ--QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK---LQL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 334184369  145 LAVSCLSLASKMEETDVPHIVDLQVEDPKfVFEAKTIKRMELLVVTTLNWRL 196
Cdd:pfam00134  76 VGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDL 126
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 200-287 2.43e-15

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 70.80  E-value: 2.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369 200 TPFSFIDYFVDKISGHVSEN-LIYRSSRFILNTTKAIEFLDFRPSEIAAAAAVSVSISGETECIDE-EKALSSLIYVkQQ 277
Cdd:cd20544    2 TPFSFLDYFISKIGLSDSREeLLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDaSSRLSLLLSP-NK 80

                         90
                 ....*....|
gi 334184369 278 ERVKRCLNLM 287
Cdd:cd20544   81 EKVKKCYELM 90
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 102-189 3.20e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 69.93  E-value: 3.20e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369   102 DWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKdkdWAAQLLAVSCLSLASKMEETDVPHIVDLQVEDpkfVFEAKTI 181
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLK---YSPSLIAAAALYLASKTEETPPWTKELVHYTG---YFTEEEI 74


                   ....*...
gi 334184369   182 KRMELLVV 189
Cdd:smart00385  75 LRMERLLL 82
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
64-208 3.39e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 57.86  E-value: 3.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  64 EDRIKEMLV-REIEFCPGTDYVKRLlsGDLDLSVRNQALDWILKVcaHYHFGHLCICL--SMNYLDRFLTSYELPKDKdw 140
Cdd:COG5024  181 ASDIFEYLLkLELIDLPNPNYLIKQ--SLYEWSMRSILVDWLVEV--HGKFGLLPETLflAINIIDRFLSSRVVSLEK-- 254

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334184369 141 aAQLLAVSCLSLASKMEETDVPHIVDLQVEDPKfVFEAKTIKRMELLVVTTLNWRLQALTPFSFIDYF 208
Cdd:COG5024  255 -YQLVGISALFIASKYEEVNCPSIKDLVYATDG-AFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRI 320
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 96-194 1.65e-61

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 192.15  E-value: 1.65e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  96 VRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKDWAAQLLAVSCLSLASKMEETDVPHIVDLQVEDPKFV 175
Cdd:cd20543    1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                         90
                 ....*....|....*....
gi 334184369 176 FEAKTIKRMELLVVTTLNW 194
Cdd:cd20543   81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 65-196 9.39e-37

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 129.17  E-value: 9.39e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369   65 DRIKEMLVREIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQL 144
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQ--QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK---LQL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 334184369  145 LAVSCLSLASKMEETDVPHIVDLQVEDPKfVFEAKTIKRMELLVVTTLNWRL 196
Cdd:pfam00134  76 VGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDL 126
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 200-287 2.43e-15

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 70.80  E-value: 2.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369 200 TPFSFIDYFVDKISGHVSEN-LIYRSSRFILNTTKAIEFLDFRPSEIAAAAAVSVSISGETECIDE-EKALSSLIYVkQQ 277
Cdd:cd20544    2 TPFSFLDYFISKIGLSDSREeLLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDaSSRLSLLLSP-NK 80

                         90
                 ....*....|
gi 334184369 278 ERVKRCLNLM 287
Cdd:cd20544   81 EKVKKCYELM 90
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 102-189 3.20e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 69.93  E-value: 3.20e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369   102 DWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKdkdWAAQLLAVSCLSLASKMEETDVPHIVDLQVEDpkfVFEAKTI 181
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLK---YSPSLIAAAALYLASKTEETPPWTKELVHYTG---YFTEEEI 74


                   ....*...
gi 334184369   182 KRMELLVV 189
Cdd:smart00385  75 LRMERLLL 82
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 94-194 3.73e-14

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 67.63  E-value: 3.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  94 LSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEETD--VPHIVDLQVED 171
Cdd:cd20528    4 LHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQ---LHLVALTCLLLAAKFEELDdnIPKISDLNRYL 80

                         90       100
                 ....*....|....*....|...
gi 334184369 172 PKFVFEAKTIKRMELLVVTTLNW 194
Cdd:cd20528   81 CNSVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 70-194 2.12e-13

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 66.94  E-value: 2.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  70 MLVREIEFCPGTDYVKRLLSgDLDLSVRNQALDWILKVCAhyhfGHLCIC----LSMNYLDRFLTSYELPKDKdwaAQLL 145
Cdd:cd20515   30 LLSLEERYLPSASYFKCVQT-EIQPFMRKMVTTWMLEVCE----EQNCEEevfpLAVNYLDRFLSLVPIRKSQ---LQLL 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 334184369 146 AVSCLSLASKMEETdVPHIVDLQVEDPKFVFEAKTIKRMELLVVTTLNW 194
Cdd:cd20515  102 GAVCLFLASKLKET-IPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 64-193 2.62e-12

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 63.42  E-value: 2.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  64 EDRIKEMLVREIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQ 143
Cdd:cd20504    4 DDIYEYLRESELKHRPKPDYMRK--QPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSK---LQ 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334184369 144 LLAVSCLSLASKMEETDVPHIVDlqvedpkFVF------EAKTIKRMELLVVTTLN 193
Cdd:cd20504   79 LVGTACMFIAAKYEEIYPPEVEE-------FVYitddtyTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 65-193 6.34e-12

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 62.16  E-value: 6.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  65 DRIKEMLVREIEFCPGTDYvkrlLSGDLDLSVRNQA--LDWILKVcaHYHFG------HLCIclsmNYLDRFLTSYELPK 136
Cdd:cd20507    7 DIYKYLRQLEKKYAIDPDY----LSGQPEITERMRAilVDWLVEV--HLKFKllpetlYLTV----NIIDRYLSKKQVPR 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334184369 137 DKdwaAQLLAVSCLSLASKMEETDVPHIVDlqvedpkFV------FEAKTIKRMELLVVTTLN 193
Cdd:cd20507   77 KK---LQLVGVTALLIASKYEEIYPPEIKD-------FVyitdnaYTREEILQMERDILKTLD 129
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 65-194 6.90e-12

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 62.69  E-value: 6.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  65 DRI-KEMLVREIEFCPGTDYVKrLLSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLtSYElPKDKDWAaQ 143
Cdd:cd20573   23 DRVlQTMLKAEETCLPSVSYFK-CVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFL-SVE-PTKKSRL-Q 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 334184369 144 LLAVSCLSLASKMEETdVPHIVDLQVEDPKFVFEAKTIKRMELLVVTTLNW 194
Cdd:cd20573   99 LLGATCMFLASKMKET-IPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 68-194 9.05e-12

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 61.95  E-value: 9.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  68 KEMLVREIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFL-TSYELPKDKdwaAQLLA 146
Cdd:cd20519   10 DLMLKKEELYKRDRDFLNR--HPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLsTQTNVPKTQ---LQLIG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 334184369 147 VSCLSLASKMEETDVPHIVDLQ-VEDPkfVFEAKTIKRMELLVVTTLNW 194
Cdd:cd20519   85 ITCLFIAAKLEEIYPPKLSEFAyVTDG--ACTEDEILTMELIILKALNW 131
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 73-194 9.43e-12

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 61.93  E-value: 9.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  73 REIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVcaHYHFGHL--CICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCL 150
Cdd:cd20568   19 LELKTLPNPNYMDD--QKELRWKMRGILVDWLVEV--HEKFRLLpeTLFLAVNIIDRFLSKRVVSLNK---LQLVGISAL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 334184369 151 SLASKMEETDVPHIVDLQVEDPKfVFEAKTIKRMELLVVTTLNW 194
Cdd:cd20568   92 FIASKYEEVNSPSIKNFAYMTDG-AYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 97-192 3.35e-11

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 59.26  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  97 RNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEETDVPHIVDLQ-VEDPKFV 175
Cdd:cd20536    2 RAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDC---FQLLGVTSLLIACKQEEIYPPEVKDLLaLCCGAYT 78

                         90
                 ....*....|....*..
gi 334184369 176 FEAktIKRMELLVVTTL 192
Cdd:cd20536   79 REQ--ICNLECIILTKL 93
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 72-194 6.06e-11

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 59.69  E-value: 6.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  72 VREIEF-C-PGTDYVKRllSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSC 149
Cdd:cd20561   12 LREMEVkCkPKVGYMKK--QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGK---LQLVGTAA 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 334184369 150 LSLASKMEETDVPHIVD-LQVEDPKFVfeAKTIKRMELLVVTTLNW 194
Cdd:cd20561   87 MLLASKFEEIYPPEVAEfVYITDDTYT--KKQVLRMEHLVLKVLTF 130
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 70-187 4.39e-10

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 57.03  E-value: 4.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  70 MLVREIEFCPGTDYVKRLLSgDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSC 149
Cdd:cd20562   16 LRVAELKRRPLPDYMEKIQR-DITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQR---LQLLGVSC 91

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 334184369 150 LSLASKMEETDVPhivdlQVEDpkFVF-EAKTIKRMELL 187
Cdd:cd20562   92 MLIASKYEEICAP-----QVEE--FCYiTDNTYTKQEVL 123
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 97-196 9.11e-10

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 55.40  E-value: 9.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  97 RNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYelpKDKDWAAQLLAVSCLSLASKMEETD--VPHIVDLqVEDPKF 174
Cdd:cd20526    2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLASV---KARPKYLRCIAISCLFLAAKTNEEDevIPSTKDL-VRVSKC 77

                         90       100
                 ....*....|....*....|..
gi 334184369 175 VFEAKTIKRMELLVVTTLNWRL 196
Cdd:cd20526   78 GCSVAEVLRMERIILDKLHWDL 99
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
64-208 3.39e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 57.86  E-value: 3.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  64 EDRIKEMLV-REIEFCPGTDYVKRLlsGDLDLSVRNQALDWILKVcaHYHFGHLCICL--SMNYLDRFLTSYELPKDKdw 140
Cdd:COG5024  181 ASDIFEYLLkLELIDLPNPNYLIKQ--SLYEWSMRSILVDWLVEV--HGKFGLLPETLflAINIIDRFLSSRVVSLEK-- 254

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334184369 141 aAQLLAVSCLSLASKMEETDVPHIVDLQVEDPKfVFEAKTIKRMELLVVTTLNWRLQALTPFSFIDYF 208
Cdd:COG5024  255 -YQLVGISALFIASKYEEVNCPSIKDLVYATDG-AFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRI 320
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 64-194 6.30e-09

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 54.23  E-value: 6.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  64 EDRI-KEMLVREIEFCPGTDYVKrLLSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaA 142
Cdd:cd20574   23 DDRVlQNLLTIEERYLPQCSYFK-CVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCH---L 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334184369 143 QLLAVSCLSLASKMEETdVPhivdlQVEDPKFVFEAKTIKRMELL-----VVTTLNW 194
Cdd:cd20574   99 QLLGAVCMFLASKLKET-IP-----LTAEKLCIYTDNSIKPQELLewelvVLGKLKW 149
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 74-194 5.22e-08

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 51.58  E-value: 5.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  74 EIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVcaHYHFGHL--CICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLS 151
Cdd:cd20567   33 EPESCVPPYYMSQ--QPDINEKMRAILIDWLIEV--HLKFELMpeTLYLTVNLIDRFLSVKQVPRKE---LQLVGVTAML 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 334184369 152 LASKMEETDVPhivdlQVEDpkFVF------EAKTIKRMELLVVTTLNW 194
Cdd:cd20567  106 IASKYEEIWAP-----EVND--FVYisdnayTRKQILVMEKTMLNTLEF 147
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 102-196 5.46e-08

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 50.01  E-value: 5.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369 102 DWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEETDVPHIVDL--QVEDpkfVFEAK 179
Cdd:cd20542    6 DWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSL---LQLLGITCLFIACKFEERFPPEVATLcyLTDD---SYSKK 79

                         90
                 ....*....|....*..
gi 334184369 180 TIKRMELLVVTTLNWRL 196
Cdd:cd20542   80 QVLRMERRVLRRLRFDL 96
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 48-194 6.73e-08

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 51.14  E-value: 6.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  48 GNGSIPMMGSSSSSLSEDRIKEMLVR-EIEFCPGTDYVKrLLSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLD 126
Cdd:cd20575    7 GTRRVPRAGPDPRLLGDQRVLQNLLRlEERYVPRVSYFQ-CVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVD 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334184369 127 RFLTSYELPKDKdwaAQLLAVSCLSLASKMEETdVPHIVDLQVEDPKFVFEAKTIKRMELLVVTTLNW 194
Cdd:cd20575   86 RYLSCVPTRKAQ---LQLLGAVCMLLASKLRET-TPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKW 149
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 64-194 2.75e-07

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 49.07  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  64 EDRIKEMLVREIEFCPGTDYVkrLLSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRF-LTSYELPKDKdwaA 142
Cdd:cd20580   12 KDVWLNMLKKESKYVHDKHFL--QLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSM---L 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 334184369 143 QLLAVSCLSLASKMEETDVPHIVDLQ-VEDPKFVFEakTIKRMELLVVTTLNW 194
Cdd:cd20580   87 QLIGITSLFIASKLEEIYPPKLHEFAyVTDGACSED--DILDMELIILKALKW 137
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 101-194 6.66e-07

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 47.94  E-value: 6.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369 101 LDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEETDVPHIVDLqVEDPKFVFEAKT 180
Cdd:cd20566   44 VDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKK---LQLVGVTALLLASKYEEMYSPEIGDF-VYITDNAYTKAQ 119

                         90
                 ....*....|....
gi 334184369 181 IKRMELLVVTTLNW 194
Cdd:cd20566  120 IREMEMLILKELNF 133
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 99-187 7.02e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 46.63  E-value: 7.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  99 QALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEETDVP--HIVDLqvedpkFVF 176
Cdd:cd00043    1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRS---PELIAAACLYLACKLEELPRTlkEIAKV------SGV 71

                         90
                 ....*....|.
gi 334184369 177 EAKTIKRMELL 187
Cdd:cd00043   72 SEKELRKAEKE 82
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 64-194 9.22e-07

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 47.57  E-value: 9.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  64 EDRIKEMLVREIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFL-TSYELPKDKdwaA 142
Cdd:cd20579   12 DEVWKNMLNKDKTYLRDKNFLQK--HPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMaTQENVVKTR---L 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 334184369 143 QLLAVSCLSLASKMEETDVP------HIVDLQ-VEDpkfvfeakTIKRMELLVVTTLNW 194
Cdd:cd20579   87 QLIGISSLFIAAKLEEIYPPklhqfaYVTDGAcTED--------EILSMELIIMKALKW 137
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 74-192 9.14e-06

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 45.22  E-value: 9.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  74 EIEFCPGTDYVKRllSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLA 153
Cdd:cd20560   48 ELKHRPKPGYMRK--QPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGK---LQLVGTAAILLA 122

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 334184369 154 SKMEETDVPHiVDLQVEDPKFVFEAKTIKRMELLVVTTL 192
Cdd:cd20560  123 SKYEEIYPPE-VDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 101-161 1.04e-04

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 40.76  E-value: 1.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334184369 101 LDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEETDV 161
Cdd:cd20521    8 VDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSK---LQLLGIACMVIATRFLGKDI 65
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 85-194 2.67e-04

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 40.63  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  85 KRLLSGDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEETDVPHI 164
Cdd:cd20565   24 KYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKM---LQLVGVTAMFIASKYEEMYPPEI 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 334184369 165 VDLQ-VEDPKFVfeAKTIKRMELLVVTTLNW 194
Cdd:cd20565  101 GDFAfVTDNTYT--KHQIRQMEMKILRALDF 129
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 120-195 2.85e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 36.59  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369 120 LSMNYLDRFLTSYELPKDKdwaAQLLAVSCLSLASKMEET--------DVPHIVDLQVEDPKFVfeaktikRMELLVVTT 191
Cdd:cd20559   22 LSVNLIDRYCSKRIVLKKH---YQLVGCTCLWIASKFWESkarvpllsELSKMCCNSYGEELFI-------QMEMHILNT 91


                 ....
gi 334184369 192 LNWR 195
Cdd:cd20559   92 LNWD 95
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 97-192 5.32e-03

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 35.79  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  97 RNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTsyeLPKDKDWAAQLLAVSCLSLASKM--EETDVPHIVDLqVEDPKF 174
Cdd:cd20523    1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLS---KVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDL-IRISQC 76

                         90
                 ....*....|....*...
gi 334184369 175 VFEAKTIKRMELLVVTTL 192
Cdd:cd20523   77 GCTAADLMRMEGIILEKL 94
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 70-167 7.11e-03

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 36.46  E-value: 7.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184369  70 MLVREIEFcPGTDYVKRLLsgDLDLSVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLTSYELPKDKdwaAQLLAVSC 149
Cdd:cd20508   24 MKEREEKF-VVPDYLEKQT--ELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEK---LQLLGATA 97

                         90
                 ....*....|....*...
gi 334184369 150 LSLASKMEETDVPHIVDL 167
Cdd:cd20508   98 ILIASKFDERCPPCVDDF 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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