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Conserved domains on  [gi|320545715|ref|NP_001189074|]
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galactokinase, isoform D [Drosophila melanogaster]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 32-485 2.41e-120

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 361.72  E-value: 2.41e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  32 GRVQQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPSDSQLQLRNLEEaKFTG--YD 109
Cdd:PLN02521  30 LRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVND-KYTTctFP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 110 A------DLKTLRielpksggpaWYNYFLCGIKGIQESLGSQWK----PIGMRIAVDGNVPLAAGLSSSSAMVSSAVLAT 179
Cdd:PLN02521 109 AdpdqevDLANHK----------WGNYFICGYKGVFEFLKSKGVdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAI 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 180 AHVQGKKLDRRELASISAMCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLPAGKCFVVANSLAQKNKA-- 257
Cdd:PLN02521 179 MAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLPAGGTFVIANSLAESNKAvt 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 258 ASSDYNERVVECRLATRWLAKRKGLINWEDIVRF---IDLEEAC-----QMDNETFEKLIKDNLTKSNYTRADICKELGv 329
Cdd:PLN02521 258 AATNYNNRVVECRLAAIVLAVKLGMSAEEAISKVktlSDVEGLCvsfagSHGSSDPAVAVKELLHEGPYTAEEIEEILG- 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 330 teQELETKFLSANT-----RHMEQFKLRQRALHVIQESGRVAKFRKICEELAGGANKegAKQLGELMRQSHESLRELYEC 404
Cdd:PLN02521 337 --ESLTSIFKNSPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVSSSLSEEEK--LKKLGDLMNESHYSCSVLYEC 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 405 SHPDVERLIAISNQQN-VSARVTGAGWGGCIVAMCDSiEAADEYIKVLKRDYYAQLPTHllERHQPNNFSEVVFATLPGN 483
Cdd:PLN02521 413 SCPELEELVKVCRDNGaLGARLTGAGWGGCAVALVKE-AIVPQFILALKEKFYKSRIEK--GVIKEEDLGLYVFASKPSS 489


                 ..
gi 320545715 484 GA 485
Cdd:PLN02521 490 GA 491
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 32-485 2.41e-120

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 361.72  E-value: 2.41e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  32 GRVQQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPSDSQLQLRNLEEaKFTG--YD 109
Cdd:PLN02521  30 LRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVND-KYTTctFP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 110 A------DLKTLRielpksggpaWYNYFLCGIKGIQESLGSQWK----PIGMRIAVDGNVPLAAGLSSSSAMVSSAVLAT 179
Cdd:PLN02521 109 AdpdqevDLANHK----------WGNYFICGYKGVFEFLKSKGVdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAI 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 180 AHVQGKKLDRRELASISAMCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLPAGKCFVVANSLAQKNKA-- 257
Cdd:PLN02521 179 MAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLPAGGTFVIANSLAESNKAvt 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 258 ASSDYNERVVECRLATRWLAKRKGLINWEDIVRF---IDLEEAC-----QMDNETFEKLIKDNLTKSNYTRADICKELGv 329
Cdd:PLN02521 258 AATNYNNRVVECRLAAIVLAVKLGMSAEEAISKVktlSDVEGLCvsfagSHGSSDPAVAVKELLHEGPYTAEEIEEILG- 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 330 teQELETKFLSANT-----RHMEQFKLRQRALHVIQESGRVAKFRKICEELAGGANKegAKQLGELMRQSHESLRELYEC 404
Cdd:PLN02521 337 --ESLTSIFKNSPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVSSSLSEEEK--LKKLGDLMNESHYSCSVLYEC 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 405 SHPDVERLIAISNQQN-VSARVTGAGWGGCIVAMCDSiEAADEYIKVLKRDYYAQLPTHllERHQPNNFSEVVFATLPGN 483
Cdd:PLN02521 413 SCPELEELVKVCRDNGaLGARLTGAGWGGCAVALVKE-AIVPQFILALKEKFYKSRIEK--GVIKEEDLGLYVFASKPSS 489


                 ..
gi 320545715 484 GA 485
Cdd:PLN02521 490 GA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
33-458 6.09e-69

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 225.04  E-value: 6.09e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  33 RVQQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPsDSQLQLRNL---EEAKFtgyD 109
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRD-DRKVRVYSAdfdEEVEF---D 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 110 ADlktlriELPKSGGPAWYNYflcgIKGIQESLGSQWKPI-GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLD 188
Cdd:COG0153   77 LD------DLEPGEEDGWANY----VRGVAWALQERGYKLgGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 189 RRELASISAMCE-QYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLP-AGKCFVVANSLAqKNKAASSDYNERV 266
Cdd:COG0153  147 PVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRS-LEYEYVPLPlEGYALVIVDTNV-KHSLADSEYNERR 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 267 VECrlatrwlakrkglinwEDIVRFIDLEEACQMDNETFEKLikdnltksnytRADICKELgvteqeletkflsantrhm 346
Cdd:COG0153  225 AEC----------------EAAAAILGVKSLRDVTLEDLEAA-----------RARLGDEV------------------- 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 347 eqfkLRQRALHVIQESGRVAKFrkiCEELAGGankeGAKQLGELMRQSHESLRELYECSHPDVERLIAISNQQN--VSAR 424
Cdd:COG0153  259 ----LRRRARHVVTENQRVLEA---VEALRAG----DLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAgvLGAR 327

                        410       420       430
                 ....*....|....*....|....*....|....
gi 320545715 425 VTGAGWGGCIVAMCDSiEAADEYIKVLKRDYYAQ 458
Cdd:COG0153  328 MTGGGFGGCTIALVPK-DAVDEFIEAVAEAYAEK 360
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 35-456 1.89e-61

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 205.83  E-value: 1.89e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715   35 QQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKnpsdsqlqlRNLEEAKFTGYDADLKT 114
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAV---------RDDKNVRIYLANADNKF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  115 ----LRIELPKSGGPAWYNYFLCGIKGIQESLGSqwKPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLDRR 190
Cdd:TIGR00131  73 aersLDLPLDGSEVSDWANYFKGVLHVAQERFNS--FPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  191 ELA-SISAMCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLP-AGKCFVVANSLAQKNKAASSdYNERVVE 268
Cdd:TIGR00131 151 QILlRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR-SLKATPFKFPqLGIAFVIANTNVKRTLAPSN-YNTRRQE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  269 CRLATRWLAKRK----GLINWEDIVRFIdlEEACQMDNETFEklikdnltksnytradickelgvteqeletkflsantr 344
Cdd:TIGR00131 229 CTTAANFLAATDkgalRDFMNEYFARYI--ARLTKMLPLVEE-------------------------------------- 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  345 hmeqfklrqRALHVIQESGRVAKFRKICEElaggankEGAKQLGELMRQSHESLRELYECSHPDVERLIAISNQQNVS-- 422
Cdd:TIGR00131 269 ---------RAKHVVSENLRVLKAVKAMKD-------NDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSgg 332

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 320545715  423 ARVTGAGWGGCIVAMC--DSIEA-----ADEYIKV--LKRDYY 456
Cdd:TIGR00131 333 SRMTGAGFGGCTVHLVpnENVDKvrqavADKYPKKtgLELTFY 375
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 39-88 1.89e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 1.89e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545715   39 AFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAK 88
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 32-485 2.41e-120

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 361.72  E-value: 2.41e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  32 GRVQQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPSDSQLQLRNLEEaKFTG--YD 109
Cdd:PLN02521  30 LRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVND-KYTTctFP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 110 A------DLKTLRielpksggpaWYNYFLCGIKGIQESLGSQWK----PIGMRIAVDGNVPLAAGLSSSSAMVSSAVLAT 179
Cdd:PLN02521 109 AdpdqevDLANHK----------WGNYFICGYKGVFEFLKSKGVdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAI 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 180 AHVQGKKLDRRELASISAMCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLPAGKCFVVANSLAQKNKA-- 257
Cdd:PLN02521 179 MAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLPAGGTFVIANSLAESNKAvt 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 258 ASSDYNERVVECRLATRWLAKRKGLINWEDIVRF---IDLEEAC-----QMDNETFEKLIKDNLTKSNYTRADICKELGv 329
Cdd:PLN02521 258 AATNYNNRVVECRLAAIVLAVKLGMSAEEAISKVktlSDVEGLCvsfagSHGSSDPAVAVKELLHEGPYTAEEIEEILG- 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 330 teQELETKFLSANT-----RHMEQFKLRQRALHVIQESGRVAKFRKICEELAGGANKegAKQLGELMRQSHESLRELYEC 404
Cdd:PLN02521 337 --ESLTSIFKNSPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVSSSLSEEEK--LKKLGDLMNESHYSCSVLYEC 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 405 SHPDVERLIAISNQQN-VSARVTGAGWGGCIVAMCDSiEAADEYIKVLKRDYYAQLPTHllERHQPNNFSEVVFATLPGN 483
Cdd:PLN02521 413 SCPELEELVKVCRDNGaLGARLTGAGWGGCAVALVKE-AIVPQFILALKEKFYKSRIEK--GVIKEEDLGLYVFASKPSS 489


                 ..
gi 320545715 484 GA 485
Cdd:PLN02521 490 GA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
33-458 6.09e-69

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 225.04  E-value: 6.09e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  33 RVQQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPsDSQLQLRNL---EEAKFtgyD 109
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRD-DRKVRVYSAdfdEEVEF---D 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 110 ADlktlriELPKSGGPAWYNYflcgIKGIQESLGSQWKPI-GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLD 188
Cdd:COG0153   77 LD------DLEPGEEDGWANY----VRGVAWALQERGYKLgGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 189 RRELASISAMCE-QYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLP-AGKCFVVANSLAqKNKAASSDYNERV 266
Cdd:COG0153  147 PVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRS-LEYEYVPLPlEGYALVIVDTNV-KHSLADSEYNERR 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 267 VECrlatrwlakrkglinwEDIVRFIDLEEACQMDNETFEKLikdnltksnytRADICKELgvteqeletkflsantrhm 346
Cdd:COG0153  225 AEC----------------EAAAAILGVKSLRDVTLEDLEAA-----------RARLGDEV------------------- 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 347 eqfkLRQRALHVIQESGRVAKFrkiCEELAGGankeGAKQLGELMRQSHESLRELYECSHPDVERLIAISNQQN--VSAR 424
Cdd:COG0153  259 ----LRRRARHVVTENQRVLEA---VEALRAG----DLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAgvLGAR 327

                        410       420       430
                 ....*....|....*....|....*....|....
gi 320545715 425 VTGAGWGGCIVAMCDSiEAADEYIKVLKRDYYAQ 458
Cdd:COG0153  328 MTGGGFGGCTIALVPK-DAVDEFIEAVAEAYAEK 360
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 35-456 1.89e-61

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 205.83  E-value: 1.89e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715   35 QQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKnpsdsqlqlRNLEEAKFTGYDADLKT 114
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAV---------RDDKNVRIYLANADNKF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  115 ----LRIELPKSGGPAWYNYFLCGIKGIQESLGSqwKPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLDRR 190
Cdd:TIGR00131  73 aersLDLPLDGSEVSDWANYFKGVLHVAQERFNS--FPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  191 ELA-SISAMCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLP-AGKCFVVANSLAQKNKAASSdYNERVVE 268
Cdd:TIGR00131 151 QILlRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR-SLKATPFKFPqLGIAFVIANTNVKRTLAPSN-YNTRRQE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  269 CRLATRWLAKRK----GLINWEDIVRFIdlEEACQMDNETFEklikdnltksnytradickelgvteqeletkflsantr 344
Cdd:TIGR00131 229 CTTAANFLAATDkgalRDFMNEYFARYI--ARLTKMLPLVEE-------------------------------------- 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  345 hmeqfklrqRALHVIQESGRVAKFRKICEElaggankEGAKQLGELMRQSHESLRELYECSHPDVERLIAISNQQNVS-- 422
Cdd:TIGR00131 269 ---------RAKHVVSENLRVLKAVKAMKD-------NDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSgg 332

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 320545715  423 ARVTGAGWGGCIVAMC--DSIEA-----ADEYIKV--LKRDYY 456
Cdd:TIGR00131 333 SRMTGAGFGGCTVHLVpnENVDKvrqavADKYPKKtgLELTFY 375
PRK03817 PRK03817
galactokinase; Provisional
 53-460 4.56e-39

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 145.14  E-value: 4.56e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  53 VRVPGRVNIIGEHVDYC-GYsVLPMAVSQSIFLAVAKNpSDSQLQLRNLEEAKFTGYDadlktlriELPKSGgpAWYNYf 131
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKS-EKFIFYSENFNEEKTFELD--------KLEKLN--SWADY- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 132 lcgIKGIQESLGSQ-WKPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLDRRELASISAMCE-QYIGTHSGG 209
Cdd:PRK03817  70 ---IKGVIWVLEKRgYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAEnEFVGVPCGI 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 210 MDQAIAYLGRVGCAHHIEFHpKLKGTPVTLPAGKCFVVANSlAQKNKAASSDYNERVVECRLATRWLAKRkglinwediv 289
Cdd:PRK03817 147 MDQFAVAFGKKDHAIFLDTM-TLEYEYVPFPEDYEILVFDT-GVKRELASSEYNERRQECEEALKILGKK---------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 290 rfidleeacqmdneTFeklikdnltksnytradicKElgVTEQELEtkflsantrHMEQFkLRQRALHVIQESGRVAKFR 369
Cdd:PRK03817 215 --------------SS-------------------KE--VTEEDLS---------KLPPL-LRKRAGYVLRENERVLKVR 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 370 KiceelaggANKEGAKQ-LGELMRQSHESLRELYECSHPD----VERLIaisNQQNVSARVTGAGWGGCIVAMCDSiEAA 444
Cdd:PRK03817 250 D--------ALKEGDIEtLGELLTESHWDLADNYEVSCEEldffVEFAL---ELGAYGARLTGAGFGGSAIALVDK-GKF 317

                        410
                 ....*....|....*.
gi 320545715 445 DEYIKVLKRDYYAQLP 460
Cdd:PRK03817 318 ESIGEELLEEYKKRFG 333
PRK05322 PRK05322
galactokinase; Provisional
 35-455 4.48e-36

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 137.68  E-value: 4.48e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  35 QQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNpSDSQLQLR--NLEEAKFTgyDADL 112
Cdd:PRK05322   4 EELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKR-DDKKVRLYsaNFEDLGII--EFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 113 KTLRIElpKSGGpaWYNYFlcgiKGIQESLGSQWKPI--GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLDRR 190
Cdd:PRK05322  81 DDLSFD--KEDD--WANYP----KGVLKFLQEAGYKIdhGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 191 ELASISAMCE-QYIGTHSGGMDQ-AIAyLGRVGCA-----HHIEFhpklKGTPVTLpAGKCFVVANSlaqkNKA---ASS 260
Cdd:PRK05322 153 ELVKLGQKTEnEFIGVNSGIMDQfAIG-MGKKDHAilldcNTLEY----EYVPLDL-GDYVIVIMNT----NKRrelADS 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 261 DYNERVVECRLATRWLAKRkglinwedivrfIDLEEACQMDNETFEK---LIKDNltksnytradickelgvteqeletk 337
Cdd:PRK05322 223 KYNERRAECEKALEELQKK------------LDIKSLGELTEEEFDEysyLIKDE------------------------- 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 338 flsantrhmeqfKLRQRALHVIQESGRVAKFRKiceelaggANKEGA-KQLGELMRQSHESLRELYECSHPDVERLIAIS 416
Cdd:PRK05322 266 ------------TLLKRARHAVTENQRTLKAVK--------ALKAGDlEKFGRLMNASHVSLRDDYEVTGLELDTLVEAA 325

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 320545715 417 NQQN--VSARVTGAGWGGCIVAMCDSiEAADEYIKVLKRDY 455
Cdd:PRK05322 326 WKQEgvLGARMTGAGFGGCAIAIVKK-DKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 35-458 7.84e-34

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 131.20  E-value: 7.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  35 QQLTAFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNpSDSQLQLrnleeakftgYDADLKT 114
Cdd:PRK05101   5 QKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKR-DDRIVRV----------IAADYDN 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 115 LR--------IELPKSggPAWYNYFLCGIKGIQESlGSQWKpiGMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKK 186
Cdd:PRK05101  74 QQdefsldapIVPHPE--QQWANYVRGVVKHLQER-NPDFG--GADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLP 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 187 LDRRELASISAMCE-QYIGTHSGGMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLPAGKCFVVANSlAQKNKAASSDYNER 265
Cdd:PRK05101 149 LSGAEIALNGQEAEnQFVGCNCGIMDQLISALGKKDHALLIDCR-SLETKAVPMPEGVAVVIINS-NVKRGLVDSEYNTR 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 266 VVECRLATRWLAKrKGLinwedivRFIDLEEacqmdnetFEKlIKDNLTKSNYtradickelgvteqeletkflsantrh 345
Cdd:PRK05101 227 RQQCETAARFFGV-KAL-------RDVTLEQ--------FNA-VAAELDPVVA--------------------------- 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 346 meqfklrQRALHVIQESGRVakfrkiceELAGGANKEG-AKQLGELMRQSHESLRELYECSHPDVERLIAISNQ---QNV 421
Cdd:PRK05101 263 -------KRARHVITENART--------LEAASALAAGdLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAvigDQG 327

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 320545715 422 SARVTGAGWGGCIVAMCDSiEAADEYIKVLKRDYYAQ 458
Cdd:PRK05101 328 GVRMTGGGFGGCIVALVPE-ELVEAVRQAVAEQYEAK 363
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 39-88 1.89e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 1.89e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545715   39 AFFKQQFGANPDFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAK 88
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK00555 PRK00555
galactokinase; Provisional
 56-453 2.42e-20

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 92.23  E-value: 2.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  56 PGRVNIIGEHVDY-CGYSvLPMAVSQSiflAVAK-NPSDSQ-LQLRNLEEakftgyDADlktLRIELPKSGG--PAWYNY 130
Cdd:PRK00555   8 PGRINLIGEHTDYnLGFA-LPIALPQR---TVVTfTPEHTDaITASSDRA------DGS---ARIPLDTTPGqvTGWAAY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 131 flcgIKGIQESLGSQWKPI-GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGKKLDRRELASISAMCE-QYIGTHSG 208
Cdd:PRK00555  75 ----AAGVIWALRGAGHPVpGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAEnEYVGAPTG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 209 GMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLPAGKCFVV---ANSLAqKNKAASSDYNERVVECRLATrwlakrkglinw 285
Cdd:PRK00555 151 LLDQLAALFGAPKTALLIDFR-DLTVRPVAFDPDAAGVVlllMDSRA-RHRHAGGEYAARRASCERAA------------ 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 286 edivrfidleeacqmdnetfeklikdnltksnytradicKELGVTE-QELETKFLSANTRHMEQFKLRqRALHVIQESGR 364
Cdd:PRK00555 217 ---------------------------------------ADLGVSSlRAVQDRGLAALGAIADPIDAR-RARHVLTENQR 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 365 VAKFrkiceelAGGANKEGAKQLGELMRQSHESLRELYECSHPDVErLIAISNQQ--NVSARVTGAGWGGCIVAMCdSIE 442
Cdd:PRK00555 257 VLDF-------AAALADSDFTAAGQLLTASHASMRDDFEITTERID-LIADSAVRagALGARMTGGGFGGCVIALV-PAD 327

                        410
                 ....*....|.
gi 320545715 443 AADEYIKVLKR 453
Cdd:PRK00555 328 RAEDVADTVRR 338
PTZ00290 PTZ00290
galactokinase; Provisional
 26-435 9.54e-14

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 73.32  E-value: 9.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  26 PESKVYGRVQQLTAFFKQQFGANPDFIVR------VPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKnpsdsqlqLRN 99
Cdd:PTZ00290   7 SDERLDSTLSTLKPIFLETFKVENDADVEwllftfAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGR--------VKH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 100 LEEAK--FTGYDADlktlRIELPKSGG----PAWYNyFLCGIKGIQesLGSQWKPI------GMRIAVDGNVPLAAGLSS 167
Cdd:PTZ00290  79 FCDHKlrFATETDE----HFVLDHLGGakhnKAWTT-FVRGAATLR--LNRLGVAIdapslqGVCMVVHGTLPMGAGMSA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 168 SSA-----MVSSAVLATAHVQGKKL---------------DRRELASISAMCE-QYIGTHSGGMDQAIAYLGRVG----- 221
Cdd:PTZ00290 152 SASfgvalLNAINTVVTRRYKGCPTspgrrysilppmskeELIELAKQARRIEtEFCGVNVGIMDQFISAFAEEDkfmfl 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 222 -CAH-HIEFHPKlkgTPVtLPAGKCFVVANSLAQKN--KAASSDYNErvvecrlatrwlakrkglinwediVRfIDLEEA 297
Cdd:PTZ00290 232 dCKSlTFESHDM---TPL-LGDGACFLLIDSMIKHDllGGTAGMYNT------------------------VR-SDQEGA 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 298 CqmdnetfEKLIKDNLTKSNYTRADIC---KELGVTEQELetKFLSANTRHME--QFklrQRALHVIQESGRVAKFRKIC 372
Cdd:PTZ00290 283 Q-------KKIGKHRYRGKPFTFSDLVrnpKKYTFDGDVV--AFMESCKPLMTpgEF---ERGTYNIMEQIRTLEFIKLN 350

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320545715 373 EELAGGANKEGAKQLGELMRQSHESLRELYECSHPDVERLI-AISNQQNVS-ARVTGAGWGGCIV 435
Cdd:PTZ00290 351 DPELPLSREERFRKAGEILNAGHQGMRDLMKITTPELDFIHeLINEEKGVAgGRMMGGGFGGCII 415
PLN02865 PLN02865
galactokinase
 53-487 1.72e-13

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 72.14  E-value: 1.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  53 VRV---PGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPsDSQLQLRNleeAKFTG---YDADLKTLRIELPKSGGPA 126
Cdd:PLN02865  30 VRVvvsPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSG-DPEVLLRS---AQFEGevrFRVDEIQHPIANVSSDSKE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 127 ---WYNY---------------------FLCGIKGIQES-LGSQwkpigmriavdgnvpLAAGLSSSSAMVSSAVLATAH 181
Cdd:PLN02865 106 esnWGDYargavyalqsrghalsqgitgYISGSEGLDSSgLSSS---------------AAVGVAYLLALENANNLTVSP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 182 VQGKKLDRRelasisaMCEQYIGTHSGGMDQAIAYLGRVGCAHHI---EFHPKLKGTPVTLPAG-KCF--VVANSLAQKN 255
Cdd:PLN02865 171 EDNIELDRL-------IENEYLGLRNGILDQSAILLSRYGCLTFMdckTLDHKLVSLQFQQPGGeKPFkiLLAFSGLRHA 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 256 KAASSDYNERVVECRLATRWLAKRKGLINWEDIVRFIDLEEacqmdnetfeklikdnltksnYTRadickelgvteqele 335
Cdd:PLN02865 244 LTNKPGYNLRVSECQEAARFLLEASGNDELEPLLCNVEPEV---------------------YEA--------------- 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 336 tkflsanTRHMEQFKLRQRALHVIQESGRVAKFRkicEELAGGANKEgakqLGELMRQSHESLRELYECSHPDVERL--I 413
Cdd:PLN02865 288 -------HKCKLEAVLARRAEHYFSENMRVIKGV---EAWASGNLEE----FGKLISASGLSSIENYECGCEPLIQLyeI 353

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320545715 414 AISNQQNVSARVTGAGWGGCIVAMCDSiEAADEYIKVLKRDYyaqlpthllERHQPNNFSEV-----VFATLPGNGAEL 487
Cdd:PLN02865 354 LLKAPGVYGARFSGAGFRGCCVAFVDA-EMAEEAASFVRDEY---------EKAQPELASNIngdkpVLICEAGDCARV 422
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 55-438 7.75e-12

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 65.63  E-value: 7.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  55 VPGRVNIIGEH-VDYcGYSVLPMAVSQSIFLAVAKNPsDSQLQLrnleEAKFTGYDADLKTLRielpksggPAWYNYFLC 133
Cdd:COG1577    1 APGKLILFGEHaVVY-GQPAIAVAVDRRATVTVEPSD-DDKLRI----ESPDLGGTLDLDPLA--------DAALRYIKA 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 134 GIKGIQESLGSQWKPIgmRIAVDGNVPLAAGL-----------SsssamvssavlATAHVQGKKLDRRELASISAMCEQY 202
Cdd:COG1577   67 AIEAALEYLGLPLKGF--DIEIDSEIPRKRGLgssaavavaviR-----------ALAAFYGVELSKEELFKLALEAEKI 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 203 IGTHSGGMDQAIAYLGrvGCahhIEFHPKLKGTPVTLPAGKCFVVANSlaqKNKAASSDYNERVvecrlatrwlakrkgl 282
Cdd:COG1577  134 VHGNPSGLDTAASTYG--GP---IYYQRGDRAEPLELPKNLPLVVGDT---GVPASTKELVAKV---------------- 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 283 inwedivrfidleeacqmdnetfekliKDNLTKSNYTRADICKELGVTEQELETKFLSANtrhmeqfklrqralhviqes 362
Cdd:COG1577  190 ---------------------------RKLKERNPELYEAFLEEIGDLVEEAIEALEEGD-------------------- 222

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320545715 363 grvakfrkiceelaggankegAKQLGELMRQSHESLRELYeCSHPDVERLIAISNQQNV-SARVTGAGWGGCIVAMC 438
Cdd:COG1577  223 ---------------------LEALGELMNENHGLLRALG-VSTPELDRLVEAARKAGAlGAKLTGAGGGGCVIALA 277
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 375-457 7.83e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 55.55  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  375 LAGGANKEGAKQLGELMRQSHESLREL--YECSHPDVERLIAISNQQNVSARVTGAGWGGCIVAMCDSIEAADEYIKVLK 452
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLEPLlvVGILPPELDELLEALLELGLGAKLSGSGGGPTVFALFKDEDDAEEVARALR 80


                  ....*
gi 320545715  453 RDYYA 457
Cdd:pfam08544  81 EAGKK 85
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 344-436 1.30e-07

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 53.06  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715  344 RHMEQFKLRQRALHVIQESGR-------VAKFRKICEELA----------GGANKEG--------AKQLGELMRQSHESL 398
Cdd:TIGR00549 155 EGEFTKLISLDGYFVIADTGVsgstkeaVARVRQLLERFPelidsimdaiGELTLEAkaalqdgdVESLGELMNINQGLL 234

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 320545715  399 RELyECSHPDVERLIAISNQQNV-SARVTGAGWGGCIVA 436
Cdd:TIGR00549 235 KAL-GVSHPKLDQLVEIARKAGAlGAKLTGAGGGGCMIA 272
PRK03926 PRK03926
mevalonate kinase; Provisional
 336-440 3.07e-03

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 39.65  E-value: 3.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545715 336 TKFLSANTRhmeqfKLRQRALHVIQ---ESgrVAKFRKICEELAggaNKEGAKQLGELMRQSHESLRELyECSHPDVERL 412
Cdd:PRK03926 172 TKELVANVR-----KLKEEYPELIEpilSS--IGKISEKGEELI---LSGDYVSLGELMNINQGLLDAL-GVSTKELSEL 240

                         90       100
                 ....*....|....*....|....*....
gi 320545715 413 IAISNQQN-VSARVTGAGWGGCIVAMCDS 440
Cdd:PRK03926 241 IYAARTAGaLGAKITGAGGGGCMVALAAP 269
TRAPP pfam04051
Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or ...
 117-143 5.12e-03

Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits. This family contains many TRAPP family proteins. The Bet3 subunit is one of the better characterized TRAPP proteins and has a dimeric structure with hydrophobic channels. The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues. Bet3 is proposed to localize TRAPP to the Golgi.


Pssm-ID: 461147  Cd Length: 148  Bit Score: 37.46  E-value: 5.12e-03
                          10        20
                  ....*....|....*....|....*...
gi 320545715  117 IELPKSGGPAWYNYFLCG-IKGIQESLG 143
Cdd:pfam04051  97 VELPKDGSQLNYLAFLCGiIRGALEMLG 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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