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Conserved domains on  [gi|320545160|ref|NP_001188828|]
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beaten path IIIa, isoform D [Drosophila melanogaster]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 87-183 1.46e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.52  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545160   87 KSATLGCRYALD-GESLYSVKWYK------DGHEIYRYVPRDKPPGQSfplPGVNI-DLRNSSDTQILLRRVTLQSSGLY 158
Cdd:pfam07686  12 GSVTLPCTYSSSmSEASTSVYWYRqppgkgPTFLIAYYSNGSEEGVKK---GRFSGrGDPSNGDGSLTIQNLTLSDSGTY 88

                          90       100
                  ....*....|....*....|....*
gi 320545160  159 RCEVSGeapaFNTVSESETMTVVVT 183
Cdd:pfam07686  89 TCAVIP----SGEGVFGKGTRLTVL 109
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 188-227 5.35e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam08205:

Pssm-ID: 472250  Cd Length: 89  Bit Score: 35.86  E-value: 5.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 320545160  188 PKITGGQPRYQIGDIVRV-NCTSSPSKPVCHLSWLINGEPV 227
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVaTCSSAGGKPAPRITWYLDGKPL 41
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 87-183 1.46e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.52  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545160   87 KSATLGCRYALD-GESLYSVKWYK------DGHEIYRYVPRDKPPGQSfplPGVNI-DLRNSSDTQILLRRVTLQSSGLY 158
Cdd:pfam07686  12 GSVTLPCTYSSSmSEASTSVYWYRqppgkgPTFLIAYYSNGSEEGVKK---GRFSGrGDPSNGDGSLTIQNLTLSDSGTY 88

                          90       100
                  ....*....|....*....|....*
gi 320545160  159 RCEVSGeapaFNTVSESETMTVVVT 183
Cdd:pfam07686  89 TCAVIP----SGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 88-182 4.33e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545160    88 SATLGCRYAldGESLYSVKWYKDGHEIYRYVPRdkppgqsfplpgvnIDLRNSSDTQIL-LRRVTLQSSGLYRCEVSGEA 166
Cdd:smart00410  11 SVTLSCEAS--GSPPPEVTWYKQGGKLLAESGR--------------FSVSRSGSTSTLtISNVTPEDSGTYTCAATNSS 74

                           90
                   ....*....|....*.
gi 320545160   167 pafntVSESETMTVVV 182
Cdd:smart00410  75 -----GSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 89-163 1.48e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 1.48e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320545160  89 ATLGCRYalDGESLYSVKWYKDGHEIyryvprdkppgqsfPLPGVNIDLRNSSDTQILLRRVTLQSSGLYRCEVS 163
Cdd:cd00096    1 VTLTCSA--SGNPPPTITWYKNGKPL--------------PPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVAS 59
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 188-227 5.35e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 35.86  E-value: 5.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 320545160  188 PKITGGQPRYQIGDIVRV-NCTSSPSKPVCHLSWLINGEPV 227
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVaTCSSAGGKPAPRITWYLDGKPL 41
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 87-183 1.46e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.52  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545160   87 KSATLGCRYALD-GESLYSVKWYK------DGHEIYRYVPRDKPPGQSfplPGVNI-DLRNSSDTQILLRRVTLQSSGLY 158
Cdd:pfam07686  12 GSVTLPCTYSSSmSEASTSVYWYRqppgkgPTFLIAYYSNGSEEGVKK---GRFSGrGDPSNGDGSLTIQNLTLSDSGTY 88

                          90       100
                  ....*....|....*....|....*
gi 320545160  159 RCEVSGeapaFNTVSESETMTVVVT 183
Cdd:pfam07686  89 TCAVIP----SGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 88-182 4.33e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545160    88 SATLGCRYAldGESLYSVKWYKDGHEIYRYVPRdkppgqsfplpgvnIDLRNSSDTQIL-LRRVTLQSSGLYRCEVSGEA 166
Cdd:smart00410  11 SVTLSCEAS--GSPPPEVTWYKQGGKLLAESGR--------------FSVSRSGSTSTLtISNVTPEDSGTYTCAATNSS 74

                           90
                   ....*....|....*.
gi 320545160   167 pafntVSESETMTVVV 182
Cdd:smart00410  75 -----GSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 89-163 1.48e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.92  E-value: 1.48e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320545160  89 ATLGCRYalDGESLYSVKWYKDGHEIyryvprdkppgqsfPLPGVNIDLRNSSDTQILLRRVTLQSSGLYRCEVS 163
Cdd:cd00096    1 VTLTCSA--SGNPPPTITWYKNGKPL--------------PPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVAS 59
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 88-180 2.24e-03

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 37.13  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545160  88 SATLGCRYAlDGESLYSVKWYKDGHEIYRYVprdkppgqsFPLPGVNIDLRNSS---DTQILLRRVTLQSSGLYRCEVSG 164
Cdd:cd20946   16 EVILSCKTP-KKTSSPRVEWKKLQRDVTFVV---------FQNNKIQGDYKGRAeilGTNITIKNVTRSDSGKYRCEVSA 85

                         90
                 ....*....|....*.
gi 320545160 165 EAPAFNTVSESETMTV 180
Cdd:cd20946   86 RSDGQNLGEVTVTLEV 101
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 87-163 2.86e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.40  E-value: 2.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320545160   87 KSATLGCRYAlDGESLYSVKWYKDGheiyryvprdkppgQSFPLP-GVNIDLRNSSDTQILLRRVTLQSSGLYRCEVS 163
Cdd:pfam00047  12 DSATLTCSAS-TGSPGPDVTWSKEG--------------GTLIESlKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVN 74
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 188-227 5.35e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 35.86  E-value: 5.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 320545160  188 PKITGGQPRYQIGDIVRV-NCTSSPSKPVCHLSWLINGEPV 227
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVaTCSSAGGKPAPRITWYLDGKPL 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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