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Conserved domains on  [gi|334183596|ref|NP_001185297|]
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Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein [Arabidopsis thaliana]

Protein Classification

SPX domain-containing membrane protein( domain architecture ID 12997668)

SPX domain-containing membrane protein with a major facilitator superfamily (MFS) transporter domain may function in phosphate homeostasis and in the transport across cytoplasmic or internal membranes various substrates including sugar phosphates

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  22403821|26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPX-MFS_plant cd14479
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ...
 2-150 1.30e-81

SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.


:

Pssm-ID: 269900 [Multi-domain]  Cd Length: 140  Bit Score: 255.29  E-value: 1.30e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   2 VAFGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQGGSQHPRHVLKDFSRMLDTQIlkvnhclqiETTVLFMLEQQGL 81
Cdd:cd14479    1 VNFGKKLKEDQIPEWEGYYINYKLLKKKVKQYVQQTQDGGQDRRDVLKDFSKLLDDQI---------EKIVLFLLEQQGL 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183596  82 LSGRLAKLRESHDAILEQPDISRIFELREAYRDVGRDLLQLLKFVELNAIGLRKILKKFDKRFGYRFAD 150
Cdd:cd14479   72 LASRLEKLGEQREALQEQPDLSQISELREAYRAVGLDLLKLLKFVELNATGLRKILKKFDKRFGYRFTD 140
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 258-666 5.36e-23

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17326:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 374  Bit Score: 101.52  E-value: 5.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 258 SLLLNLGNTFLYMvntyIIVPTADDYSmsLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFKPLVFSSIALFIGN 335
Cdd:cd17326    8 MFLSSLQFSIVLT----SIWPYLQKID--PTATASFFGWVVAAYSLGQLVFSPVFGYWSNKtsSVKEPLIVSILIAIVGN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 336 LMYALAYDA--NSIALLLLGRVCCGLG-SARAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL-----QIK 407
Cdd:cd17326   82 ILYALAEYFpsNRKYVMLVARFLIGVGaGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFtpigyPGY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 408 FKFYKFTFNQSTLPGWVMAVAWLFYLVWLCISFREplrdtedgeknnrnettsatdrvessrveeglrlpllitsgikpe 487
Cdd:cd17326  162 VIGIKLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------------------------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 488 deeecdeseespedshkpansfieayrlltpsvkVQLLIYFMLKYSMEILL-SESSVITSYYFSWT----TSSVAIFLAC 562
Cdd:cd17326  197 ----------------------------------VVCIFLFFVVLFIFANLeTIGTPLTMDMYGWTreeaVLYNGIILAV 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 563 LGLTVLPINILVGSYISNMFEDRQILLTSEIIVFLGILFsfnlfvpyTVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSS 642
Cdd:cd17326  243 SGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVV--------TLPWGITGVILFGLGYPIGNVMLYTLYSKILGP 314

                        410       420
                 ....*....|....*....|....
gi 334183596 643 RlSKGTYNGGLlsTEAGTLARVVA 666
Cdd:cd17326  315 K-PQGTMQGVL--TASGSLARTLG 335
 
Name Accession Description Interval E-value
SPX-MFS_plant cd14479
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ...
 2-150 1.30e-81

SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.


Pssm-ID: 269900 [Multi-domain]  Cd Length: 140  Bit Score: 255.29  E-value: 1.30e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   2 VAFGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQGGSQHPRHVLKDFSRMLDTQIlkvnhclqiETTVLFMLEQQGL 81
Cdd:cd14479    1 VNFGKKLKEDQIPEWEGYYINYKLLKKKVKQYVQQTQDGGQDRRDVLKDFSKLLDDQI---------EKIVLFLLEQQGL 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183596  82 LSGRLAKLRESHDAILEQPDISRIFELREAYRDVGRDLLQLLKFVELNAIGLRKILKKFDKRFGYRFAD 150
Cdd:cd14479   72 LASRLEKLGEQREALQEQPDLSQISELREAYRAVGLDLLKLLKFVELNATGLRKILKKFDKRFGYRFTD 140
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 258-666 5.36e-23

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 101.52  E-value: 5.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 258 SLLLNLGNTFLYMvntyIIVPTADDYSmsLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFKPLVFSSIALFIGN 335
Cdd:cd17326    8 MFLSSLQFSIVLT----SIWPYLQKID--PTATASFFGWVVAAYSLGQLVFSPVFGYWSNKtsSVKEPLIVSILIAIVGN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 336 LMYALAYDA--NSIALLLLGRVCCGLG-SARAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL-----QIK 407
Cdd:cd17326   82 ILYALAEYFpsNRKYVMLVARFLIGVGaGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFtpigyPGY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 408 FKFYKFTFNQSTLPGWVMAVAWLFYLVWLCISFREplrdtedgeknnrnettsatdrvessrveeglrlpllitsgikpe 487
Cdd:cd17326  162 VIGIKLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------------------------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 488 deeecdeseespedshkpansfieayrlltpsvkVQLLIYFMLKYSMEILL-SESSVITSYYFSWT----TSSVAIFLAC 562
Cdd:cd17326  197 ----------------------------------VVCIFLFFVVLFIFANLeTIGTPLTMDMYGWTreeaVLYNGIILAV 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 563 LGLTVLPINILVGSYISNMFEDRQILLTSEIIVFLGILFsfnlfvpyTVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSS 642
Cdd:cd17326  243 SGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVV--------TLPWGITGVILFGLGYPIGNVMLYTLYSKILGP 314

                        410       420
                 ....*....|....*....|....
gi 334183596 643 RlSKGTYNGGLlsTEAGTLARVVA 666
Cdd:cd17326  315 K-PQGTMQGVL--TASGSLARTLG 335
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
258-655 7.93e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.47  E-value: 7.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 258 SLLLNLGNTFLYMVNTYIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALF-IGNL 336
Cdd:COG2814   11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFaLGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 337 MYALaydANSIALLLLGRVCCGLGSA--RAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLqikfkfykft 414
Cdd:COG2814   91 LCAL---APSLWLLLAARFLQGLGAGalFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL---------- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 415 fNQSTLPGWVMAVAWLFYLV-WLCISFREPlrdtedgeknnrnETTSATDRVESSRVEEGLRLPLLITSgikpedeeecd 493
Cdd:COG2814  158 -ADLFGWRWVFLVNAVLALLaLLLLLRLLP-------------ESRPAARARLRGSLRELLRRPRLLLL----------- 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 494 eseespedshkpansfieayrlltpsvkvqLLIYFMLKYSMEILLSESSVITSYYFSWTTSSVAIFLACLGLTVLPINIL 573
Cdd:COG2814  213 ------------------------------LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALL 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 574 VGsYISNMFEDRQILLTSEIIVFLGILFsfnLFVPYTVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSSRLsKGTYNGGL 653
Cdd:COG2814  263 AG-RLADRFGRRRLLLIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA-RGRASGLY 337


                 ..
gi 334183596 654 LS 655
Cdd:COG2814  338 NS 339
MFS_1 pfam07690
Major Facilitator Superfamily;
266-651 4.58e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 4.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  266 TFLYMVNTYIIVPTADDYSM-SLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFIgnLMYALAYDA 344
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFA--LGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  345 NSIALLLLGRVCCGLGSA--RAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLqIKFKFYKFTFnqstlpg 422
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGalFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWRAAF------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  423 WVMAVAWLFYLVWLCISFREPLRDTEDGEKnnrnettsatdrvessrveeglrlpllitsgikpedeeecdeseespeds 502
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAE-------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  503 hKPANSFIEAYRLLTPSVKVQLLIYFMLKYSMEILLSESSVITSYYFSWTTSSVAIFLACLGLTVLPINILVGsYISNMF 582
Cdd:pfam07690 185 -EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG-RLSDRL 262

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183596  583 EDRQILLTSEIIVFLGILFSFNLFVPYTVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSSRLSkGTYNG 651
Cdd:pfam07690 263 GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER-GTASG 330
SPX pfam03105
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ...
 117-156 1.73e-08

SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.


Pssm-ID: 460807 [Multi-domain]  Cd Length: 339  Bit Score: 56.80  E-value: 1.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 334183596  117 RDLLQLLKFVELNAIGLRKILKKFDKRFGYRFADYYVKTR 156
Cdd:pfam03105 300 RGLELLKSYSELNRTAFRKILKKFDKVTSLNASKDYMKEV 339
COG5408 COG5408
SPX domain-containing protein [Signal transduction mechanisms];
118-161 1.15e-03

SPX domain-containing protein [Signal transduction mechanisms];


Pssm-ID: 227695 [Multi-domain]  Cd Length: 296  Bit Score: 41.74  E-value: 1.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 334183596 118 DLLQLLKFVELNAIGLRKILKKFDKRFGYRFADYYVKtRANHPY 161
Cdd:COG5408  253 QLHQLKSFIELNYTGFSKITKKYDKTLHQNLRHEYMS-RSVNEY 295
 
Name Accession Description Interval E-value
SPX-MFS_plant cd14479
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ...
 2-150 1.30e-81

SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.


Pssm-ID: 269900 [Multi-domain]  Cd Length: 140  Bit Score: 255.29  E-value: 1.30e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   2 VAFGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQGGSQHPRHVLKDFSRMLDTQIlkvnhclqiETTVLFMLEQQGL 81
Cdd:cd14479    1 VNFGKKLKEDQIPEWEGYYINYKLLKKKVKQYVQQTQDGGQDRRDVLKDFSKLLDDQI---------EKIVLFLLEQQGL 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183596  82 LSGRLAKLRESHDAILEQPDISRIFELREAYRDVGRDLLQLLKFVELNAIGLRKILKKFDKRFGYRFAD 150
Cdd:cd14479   72 LASRLEKLGEQREALQEQPDLSQISELREAYRAVGLDLLKLLKFVELNATGLRKILKKFDKRFGYRFTD 140
SPX cd14447
Domain found in Syg1, Pho81, XPR1, and related proteins; This region has been named the SPX ...
 4-142 5.43e-27

Domain found in Syg1, Pho81, XPR1, and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). This domain is found at the amino terminus of a variety of proteins. In the yeast protein Syg1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2. NUC-2 contains several ankyrin repeats. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with xenotropic and polytropic murine leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signaling and result in cell toxicity and death. The similarity between Syg1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, S. cerevisiae, and many other diverse organisms.


Pssm-ID: 269894 [Multi-domain]  Cd Length: 143  Bit Score: 106.88  E-value: 5.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQGGSQHP----------RHVLKDFSRMLDTQILKVNhclqieTTVL 73
Cdd:cd14447    2 FGKRLREEAVPEWRDKYVDYKALKKLIKNLVASADEASNSSealelsesggEEFESEFFEALDAELEKVN------EFYQ 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183596  74 FMLEQQGLLSGRLAKLRESHDAiLEQPDISRIFELREAYRDVGRDLLQLLKFVELNAIGLRKILKKFDK 142
Cdd:cd14447   76 ELLEELQELLKRLEALEPDLPA-LRGSLKEELEDLRKELVESYSELEELERFVELNYTAFRKILKKYDK 143
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 258-666 5.36e-23

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 101.52  E-value: 5.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 258 SLLLNLGNTFLYMvntyIIVPTADDYSmsLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFKPLVFSSIALFIGN 335
Cdd:cd17326    8 MFLSSLQFSIVLT----SIWPYLQKID--PTATASFFGWVVAAYSLGQLVFSPVFGYWSNKtsSVKEPLIVSILIAIVGN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 336 LMYALAYDA--NSIALLLLGRVCCGLG-SARAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL-----QIK 407
Cdd:cd17326   82 ILYALAEYFpsNRKYVMLVARFLIGVGaGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFtpigyPGY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 408 FKFYKFTFNQSTLPGWVMAVAWLFYLVWLCISFREplrdtedgeknnrnettsatdrvessrveeglrlpllitsgikpe 487
Cdd:cd17326  162 VIGIKLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------------------------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 488 deeecdeseespedshkpansfieayrlltpsvkVQLLIYFMLKYSMEILL-SESSVITSYYFSWT----TSSVAIFLAC 562
Cdd:cd17326  197 ----------------------------------VVCIFLFFVVLFIFANLeTIGTPLTMDMYGWTreeaVLYNGIILAV 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 563 LGLTVLPINILVGSYISNMFEDRQILLTSEIIVFLGILFsfnlfvpyTVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSS 642
Cdd:cd17326  243 SGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVV--------TLPWGITGVILFGLGYPIGNVMLYTLYSKILGP 314

                        410       420
                 ....*....|....*....|....
gi 334183596 643 RlSKGTYNGGLlsTEAGTLARVVA 666
Cdd:cd17326  315 K-PQGTMQGVL--TASGSLARTLG 335
SPX_PHO81_NUC-2_like cd14483
SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain ...
 4-143 2.69e-21

SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. NUC-2 plays an important role in the phosphate-regulated signal transduction pathway in N. crassa. It shows high similarity to a cyclin-dependent kinase inhibitory protein Pho81, which is part of the phosphate regulatory cascade in S. cerevisiae. Both, NUC-2 and Pho81, have multi-domain architecture, including the SPX N-terminal domain following by several ankyrin repeats and a putative C-terminal glycerophosphodiester phosphodiesterase domain (GDPD) with unknown function.


Pssm-ID: 269904 [Multi-domain]  Cd Length: 162  Bit Score: 91.16  E-value: 2.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIE--EWSGYYINYKLMKKKVKQYA-------------------EQIQGGSQHPRhvLKD----FSRMLDTQ 58
Cdd:cd14483    2 FGKYIQARQLElpEYSAYFLDYKALKKLIKSLAaprvaaaaallaggrplspDGTDESDAQTS--LQAnkaaFFFKLERE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  59 ILKVNhclqiettvLFMLEQQGLLSGRLAKLRESHDAILEQ--PDISRIFE---LREAYRDVGRDLLQLLKFVELNAIGL 133
Cdd:cd14483   80 LEKVN---------AFYLQKEAELKLRLDTLLDKKRVLQSRgkLASKKSASfvtLEEGFRQFERDLNKLQQFVELNATGF 150

                        170
                 ....*....|
gi 334183596 134 RKILKKFDKR 143
Cdd:cd14483  151 SKILKKWDKR 160
SPX_GDE1_like cd14484
SPX domain of Gde1 and similar proteins; This region has been named the SPX domain after (Syg1, ...
 4-145 5.66e-20

SPX domain of Gde1 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The yeast protein Gde1/Ypl110c is similar to both, NUC-2 and Pho81, in sharing their multi-domain architecture, which includes the SPX N-terminal domain followed by several ankyrin repeats and a C-terminal glycerophosphodiester phosphodiesterase domain (GDPD). Gde1 hydrolyzes intracellular glycerophosphocholine into glycerolphosphate and choline, and plays a role in the utilization of glycerophosphocholine as a source for phosphate.


Pssm-ID: 269905 [Multi-domain]  Cd Length: 134  Bit Score: 86.43  E-value: 5.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQGGSQhprHVLKDFSRMLDTQILKVNHclqiettvlFMLEQQGLLS 83
Cdd:cd14484    2 FGKNLPRNQVPEWSSSYINYKGLKKLIKAIAEQQKEGVK---VDLAEFFFALDRNLEDVDT---------FYNKKFAEYS 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183596  84 GRLAKLRESH------DAILEQPDISRI----FELREAYRDvgrdllqLLKFVELNAIGLRKILKKFDKRFG 145
Cdd:cd14484   70 RRLKLLLDRYgfspdlVQNLDSDELEELmgalLELRSQLRN-------LQWFGELNRRGFVKILKKLDKKVP 134
SPX_SYG1_like cd14475
SPX domain of the yeast plasma protein Syg1 and related proteins; This region has been named ...
 4-142 3.34e-15

SPX domain of the yeast plasma protein Syg1 and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. In the yeast protein Syg1, the N-terminus binds directly to the G-protein beta subunit and inhibits transduction of the mating pheromone signal, and it co-occurs with a C-terminal domain from the EXS family.


Pssm-ID: 269896 [Multi-domain]  Cd Length: 139  Bit Score: 72.98  E-value: 3.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIEEWSGYYINYKLMKKKVKQyaeqiqggsqhprhvlKDFSRMLDTQILKVN---HCLQIETTVLFMLEQQG 80
Cdd:cd14475    2 FAKYLEENLVPEWRKKYLDYKGGKKKIKA----------------REFFEFLDSELDKVEsfyKEKEDEARERLDLLRDQ 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334183596  81 LLSGRLAKLRESHDailEQPDISR----IFELREAYRDVGRDL----------LQLLK-FVELNAIGLRKILKKFDK 142
Cdd:cd14475   66 LHELRDHRIQEADD---GRRDYSRrpeqNAHDPVSYRSARRKLkkalqeyyrgLELLKsYRLLNRTAFRKINKKFDK 139
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
258-655 7.93e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.47  E-value: 7.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 258 SLLLNLGNTFLYMVNTYIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALF-IGNL 336
Cdd:COG2814   11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFaLGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 337 MYALaydANSIALLLLGRVCCGLGSA--RAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLqikfkfykft 414
Cdd:COG2814   91 LCAL---APSLWLLLAARFLQGLGAGalFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL---------- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 415 fNQSTLPGWVMAVAWLFYLV-WLCISFREPlrdtedgeknnrnETTSATDRVESSRVEEGLRLPLLITSgikpedeeecd 493
Cdd:COG2814  158 -ADLFGWRWVFLVNAVLALLaLLLLLRLLP-------------ESRPAARARLRGSLRELLRRPRLLLL----------- 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 494 eseespedshkpansfieayrlltpsvkvqLLIYFMLKYSMEILLSESSVITSYYFSWTTSSVAIFLACLGLTVLPINIL 573
Cdd:COG2814  213 ------------------------------LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALL 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 574 VGsYISNMFEDRQILLTSEIIVFLGILFsfnLFVPYTVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSSRLsKGTYNGGL 653
Cdd:COG2814  263 AG-RLADRFGRRRLLLIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA-RGRASGLY 337


                 ..
gi 334183596 654 LS 655
Cdd:COG2814  338 NS 339
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 266-470 2.87e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.84  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 266 TFLYMVNTYIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK-SYFKPLVFSSIALFIGNLMYALaydA 344
Cdd:cd17325    5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRfGRKRLLLLGLLLLAVSTLLFAF---A 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 345 NSIALLLLGRVCCGLGSARA--VNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLqIKFKFYKFTFnqstlpg 422
Cdd:cd17325   82 TSYWQLLLARFLQGLASAAVwpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL-ADALGYRAPF------- 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 334183596 423 WVMAVAWLFYLVWLCISFREPLRDTEDGEKNNRNETTSATDRVESSRV 470
Cdd:cd17325  154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL 201
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 267-672 3.54e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 68.37  E-value: 3.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 267 FLYMVNTYIIVPTADDYSMS---LGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKP-LVFSSIALFIGNLMYALAy 342
Cdd:cd17330    6 FLDALGFGIVFPVLPFYVREfnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPvLLLSLAGSAVSYVLLGLS- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 343 daNSIALLLLGRVCCGLGSAR-AVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLQikfkfykfTFNQSTLP 421
Cdd:cd17330   85 --RNLWLLFLARFLDGLTGGNvSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS--------TPYGYALP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 422 GWVMAVAWLFylvwlcisfreplrdtedgeknnrnettsatdrvessrveeglrlpllitsgikpedeeecdeseesped 501
Cdd:cd17330  155 FLVAAALALL---------------------------------------------------------------------- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 502 shkpanSFIEAYRLLtPSVKVQLLIYFMLKYSMEILLSESSVITSYYFSWTTSSVAIFLACLGLTVLPINILVGSYISNM 581
Cdd:cd17330  165 ------NLVLVLFFL-PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKR 237

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 582 FEDRQILLTSEIIVFLGilfsfNLFVPY--TVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSSRlSKGTYNGGLLSteAG 659
Cdd:cd17330  238 LGERKLLRLGLLLAIIG-----LLLLPFasSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSK-EQGKAQGIIQS--LQ 309

                        410
                 ....*....|...
gi 334183596 660 TLARVVADATITL 672
Cdd:cd17330  310 SLARIIGPLLAGP 322
SPX_AtSPX1_like cd14481
SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX ...
 4-143 1.87e-11

SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. This family of plant proteins contains a single SPX domain. Arabidopsis thaliana SPX1 and SPX3 have been reported to play roles in the adaptation to low-phosphate conditions, SPX3 may be involved in the regulation of SPX1 activity. Oryza sativa SPX1 suppresses the regulation of expression of OsPT2, a low-affinity phosphate transporter, by the MYB-like OsPHR2.


Pssm-ID: 269902 [Multi-domain]  Cd Length: 149  Bit Score: 62.67  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRkQIE----EWSGYYINYKLMKKKVKQYAE---------QIQGGSQHPRHVLK---DFSRMLDTQILKVNHclq 67
Cdd:cd14481    2 FGKSLKR-QIEetlpEWRDKFLSYKELKKLLKLISPgnadkpnskRDRRGGGAARAMTKeeaDFVRLLNAELDKFNA--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  68 iettvlFMLEQQGLLSGRLAKLRESHDAILEQPDISRifelrEAYRDVGRDLLQ-------LLKFVELNAIGLRKILKKF 140
Cdd:cd14481   78 ------FFVEKEEEYVIRLKELQDRVAEAKETPRDSN-----EELMRIRREIVDfhgemvlLENYSSLNYTGLVKILKKY 146


                 ...
gi 334183596 141 DKR 143
Cdd:cd14481  147 DKR 149
SPX_VTC2_like cd14480
SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been ...
 4-142 1.65e-10

SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. Vtc2 is part of the Saccharomyces cerevisiae membrane-integral VTC complex, together with Vtc1, Vtc3, and Vtc4. It contains an N-terminal SPX domain next to a central polyphosphate polymerase domain and a C-terminal domain of unknown function.


Pssm-ID: 269901 [Multi-domain]  Cd Length: 135  Bit Score: 59.48  E-value: 1.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQGGSQhprhvlKD---FSRMLDTQILKVNhclqiettvLFMLEQQG 80
Cdd:cd14480    2 FGKTLKSSIYPPWKDYYIDYDKLKKLLKERETDRGWWTE------DDerfFVELLEVELEKVY---------TFQKEKYS 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183596  81 LLSGRLAKLRESHDAILEQPDISRIFELREAYRDVGRDLLQLL-------KFVELNAIGLRKILKKFDK 142
Cdd:cd14480   67 ELRRRIDACEKKVKELVSNLDSSEDDPSEEDFKELEEELDDILadvhdlaKFTRLNYTGFLKIVKKHDK 135
MFS_1 pfam07690
Major Facilitator Superfamily;
266-651 4.58e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 4.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  266 TFLYMVNTYIIVPTADDYSM-SLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFIgnLMYALAYDA 344
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFA--LGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  345 NSIALLLLGRVCCGLGSA--RAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLqIKFKFYKFTFnqstlpg 422
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGalFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWRAAF------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  423 WVMAVAWLFYLVWLCISFREPLRDTEDGEKnnrnettsatdrvessrveeglrlpllitsgikpedeeecdeseespeds 502
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAE-------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  503 hKPANSFIEAYRLLTPSVKVQLLIYFMLKYSMEILLSESSVITSYYFSWTTSSVAIFLACLGLTVLPINILVGsYISNMF 582
Cdd:pfam07690 185 -EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG-RLSDRL 262

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183596  583 EDRQILLTSEIIVFLGILFSFNLFVPYTVPQYVISGLIMFVAAEVLEGVNLSLLSRVMSSRLSkGTYNG 651
Cdd:pfam07690 263 GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER-GTASG 330
SPX_PHO87_PHO90_like cd14478
SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This ...
 15-142 8.95e-09

SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The SPX domain of the Saccharomyces cerevisiae membrane-localized low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2. Pho91 is involved in the export of inorganic phosphate from the vacuole to the cytosol. While both, Pho87 and Pho90, transport phosphate into the cell, only Pho87 appears to also function as a sensor for high extracellular phosphate concentrations.


Pssm-ID: 269899 [Multi-domain]  Cd Length: 148  Bit Score: 54.85  E-value: 8.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  15 EWSGYYINYKLMKKKV----KQYAEQIQGGSQHPRHVL------------KDFSRMLDTQILKVnhclqiettVLFMLEQ 78
Cdd:cd14478   13 EWSDHYIAYSNLKKLIyqleKDQLQLQNGGDDEEEEESsllllstdedpdDVFVRALDKELEKI---------DSFYKEK 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183596  79 QGLLSGRLAKLREshdaileqpDISRiFELREAYRDVGRDL--------LQL--LK-FVELNAIGLRKILKKFDK 142
Cdd:cd14478   84 EAELYAEVDELLK---------DVEE-FEEENYLYDSRISLkkriinlyVSLseLKsYIELNRTGFSKILKKYDK 148
SPX_YDR089W cd14474
SPX domain of the yeast protein YDR089W and related proteins; This region has been named the ...
 4-142 1.45e-08

SPX domain of the yeast protein YDR089W and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The uncharacterized yeast protein YDR089W has not been shown to be involved in phosphate homeostasis, in contrast to most of the other SPX-domain containing proteins.


Pssm-ID: 269895 [Multi-domain]  Cd Length: 144  Bit Score: 54.16  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQGGS----QHPRHVLKDFSRMLDTQILKVNhclqiettvLFMLEQQ 79
Cdd:cd14474    2 FGEQLLQRSVPEWKLYNIDYNELKHLIKEHTTRDQGTAiaipSALEKFEDSLYNEFCEQFDRVN---------LFVSSKA 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183596  80 GLLSGRLAKLRESHDAILEQ------PDISRIFELREAYRDV---GRDLLQLLKFVELNAIGLRKILKKFDK 142
Cdd:cd14474   73 DEISRRLEHLESSILRLLERsasnsgSRRRQKRRLAKIEQELlrcGEELQKLSRFIIAQKIAFRKILKKYKK 144
SPX pfam03105
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ...
 117-156 1.73e-08

SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.


Pssm-ID: 460807 [Multi-domain]  Cd Length: 339  Bit Score: 56.80  E-value: 1.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 334183596  117 RDLLQLLKFVELNAIGLRKILKKFDKRFGYRFADYYVKTR 156
Cdd:pfam03105 300 RGLELLKSYSELNRTAFRKILKKFDKVTSLNASKDYMKEV 339
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 261-405 1.75e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 57.22  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 261 LNLGNTFLYMVNtYIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALF-IGNLMYA 339
Cdd:cd17489    1 ILLANFFFFLSF-YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFaLATLLYL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334183596 340 LaydANSIALLLLGRVCCGLG--SARAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLQ 405
Cdd:cd17489   80 L---ATSVALLLVLRLIHGIGwgAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY 144
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 258-404 4.20e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 4.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 258 SLLLNLGNTFLYMVNTYIIVPTADDYSMSLGAA-ATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFssIALFIGNL 336
Cdd:cd17325  200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLsPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL--IGLLLSAV 277

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 337 MYALAYDANSIALLLLGRVCCGLGSA--RAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL 404
Cdd:cd17325  278 ALLLLPLATSFWLLLLLLALLGLGLGlvFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 255-442 1.07e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 54.54  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 255 HFNSLLLNLGntfLYMVNTYIIVPTADDYSMSLGAAatvcGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFssIALFIG 334
Cdd:cd17329    5 LIGSFLNRLG---FFMVWPFMAIYLHQQLGLSASIV----GLVLALSAVAGIVASLIGGRLADRFGRKPVML--AGLLLR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 335 NLMYALAYDANSIALLLLGRVCCGLGSA--RAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLqikfkfYK 412
Cdd:cd17329   76 ALGFALLGFAHSPWLFAIALVLTGFGGGlfEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL------LL 149

                        170       180       190
                 ....*....|....*....|....*....|
gi 334183596 413 FTFNqstLPGWVMAVAWLFYLVWLCISFRE 442
Cdd:cd17329  150 YSFR---LLFLAAAVLFLLAALVLLFLLPE 176
SPX_PHO1_like cd14476
SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain ...
 4-142 1.57e-07

SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The PHO1 gene family conserved in plants is involved in a variety of processes, most notably the transport of inorganic phosphate from the root to the shoot of the plant and mediating the response to low levels of inorganic phosphate. More recently it has become evident that PHO1 gene families have diverged in various plants and may play roles in stress response as well as the stomatal response to abscisic acid.


Pssm-ID: 269897 [Multi-domain]  Cd Length: 139  Bit Score: 51.11  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQIQG--------GSQHPRHVLKDFSRmLDTQILKVNHCL-QIETTVL- 73
Cdd:cd14476    2 FGKEFESQMVPEWQEAYVDYKQLKKDLKRIQKFRDEyettfleaAEEGGEYELVFFRR-LDDELNKVNKFYrSKVEEVLk 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183596  74 --FMLEQQGLLsgrLAKLREshdaILEQPDIsrifelreaYRDvgrdlLQLLK-FVELNAIGLRKILKKFDK 142
Cdd:cd14476   81 eaAALNKQMDA---LIAFRV----KVENPQF---------YRK-----LRLLKsYSFLNMLAFSKILKKYDK 131
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 275-440 3.26e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 53.00  E-value: 3.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 275 IIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIAL-FIGnlmYALAYDANSIALLLLG 353
Cdd:cd17390   14 MILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLtALG---YVLLGFSTSLALLFLS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 354 RVCCGL-GSARAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL-QIKFKFYKFTFnqstlpgwvmAVAWLF 431
Cdd:cd17390   91 RIPLGIfKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLaETDGGFYYVAL----------LCSAIF 160

                        170
                 ....*....|...
gi 334183596 432 Y----LVWLCISF 440
Cdd:cd17390  161 IlnagLVWFLLSK 173
SPX_XPR1_like cd14477
SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins; ...
 4-142 1.08e-06

SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-terminus of the human XPR1 protein (xenotropic and polytropic retrovirus receptor 1) binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all members of this family are involved in G-protein associated signal transduction. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with xenotropic and polytropic murine leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signaling and result in cell toxicity and death. Similarity between Syg1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organisms.


Pssm-ID: 269898 [Multi-domain]  Cd Length: 161  Bit Score: 49.21  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596   4 FGKYLQRKQIEEWSGYYINYKLMKKKVKQYAEQ---IQGGSQHP--RHVLK---DFSRMLDTQILKVNH----------- 64
Cdd:cd14477    2 FGEHLSAHITPEWRKQYINYEELKAMLYAAVEQapsPEVTDEDVvkRYFAKfeeEFFQECDKELAKVNTffseklaeaqr 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  65 ---CLQIEttVLFMLEQQGLLSGRLAKLREShDAILEQPDISR--IFELREAYRDVGRDLLQLLKFVELNAIGLRKILKK 139
Cdd:cd14477   82 kfaTLKNE--LLSSLEAQGESGAASSLIRRV-FALLRKERVKPrkLRDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKK 158


                 ...
gi 334183596 140 FDK 142
Cdd:cd14477  159 HDK 161
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 266-404 1.41e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 50.58  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 266 TFLYMVNTYIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFIgnLMYALAYDAN 345
Cdd:COG0477   23 TFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG--LASLLCGLAP 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334183596 346 SIALLLLGRVCCGLGSA--RAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL 404
Cdd:COG0477  101 SPELLIAARALQGIGAGglMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 266-404 1.75e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 50.63  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 266 TFLYMVNTYIIVP----TADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKsyfKPLVFSSIALFIGNLMYALA 341
Cdd:cd17324    8 AFAIGTTEYVIQGllpdIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERR---RLLLVLLLLFILGNLLAALA 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183596 342 ydaNSIALLLLGRVCCGLGSAR--AVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL 404
Cdd:cd17324   85 ---PSFALLLLARALAGLAHGGfwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL 146
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 267-411 2.63e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 50.29  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 267 FLYMVNTYIIVPTADDYSMSL-GAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFI-GNLmyaLAYDA 344
Cdd:cd17472    6 SLRMLGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIaGSL---LAAYA 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183596 345 NSIALLLLGRVCCGLGSARAVNRRYISDCVPLRIRMQASAgFVSAS-----ALGMACGPALAGLLQIKFKFY 411
Cdd:cd17472   83 TSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMA-LIGASigiafAISMVLGPLLAAHLGVSGLFL 153
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 276-603 2.97e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 49.94  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 276 IVPT-ADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFigNLMYALAYDANSIALLLLGR 354
Cdd:cd17388   21 VLPTlLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGA--ALDYLLMAFAPTLWWLYLGR 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 355 VCCGL-GSARAVNRRYISDCVPLRIRMQAsAGFVSAS-ALGMACGPALAGLL-QIkfkfykftfnQSTLPGWVMAVAWLF 431
Cdd:cd17388   99 IIAGItGATGAVAAAYIADVTPPEQRARN-FGLLGAAfGLGFIAGPALGGLLgEI----------SPRAPFLVAAGLNGL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 432 YLVWLCISFREPLRdtedGEKNNRNETTSAtdrvessrveeglrlpllitsgikpedeeecdeseespedshKPANSFie 511
Cdd:cd17388  168 NFLLGLFVLPESLP----PERRRAFRWRRA------------------------------------------NPFGSL-- 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 512 AYRLLTPSVKVQLLIYFMLKYSMEILLSESSVITSYYFSWTTSSVAIFLACLGLTVLPINILVGSYISNMFEDRQILLTS 591
Cdd:cd17388  200 RWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLG 279

                        330
                 ....*....|...
gi 334183596 592 EIIVFLG-ILFSF 603
Cdd:cd17388  280 LAADALGfLLLAF 292
SPX pfam03105
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ...
 4-46 9.18e-06

SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.


Pssm-ID: 460807 [Multi-domain]  Cd Length: 339  Bit Score: 48.33  E-value: 9.18e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 334183596    4 FGKYLQRKQIEEWSGYYINYKLMKKKVK--QYAEQIQGGSQHPRH 46
Cdd:pfam03105   3 FGKELEENLVPEWRDAYLDYKQLKKLIKkiQRELESTPPSSSPSS 47
Sugar_tr pfam00083
Sugar (and other) transporter;
269-360 6.86e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.11  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596  269 YMVNTYIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK-SYFKPLVFSSIALFIGNLMYALAYDANSI 347
Cdd:pfam00083  23 LTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRfGRKKSLLIANVLFVIGAVLQGAAKGKWSV 102

                          90
                  ....*....|...
gi 334183596  348 ALLLLGRVCCGLG 360
Cdd:pfam00083 103 YQLIVGRVLVGIG 115
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
259-440 7.32e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 7.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 259 LLLNLGNTFLYMVNT---YIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKsyfKPLVFSSIALFIGN 335
Cdd:COG2271   13 ALLFLAYFLNYLDRSnlsVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRR---RVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 336 LMYALAydaNSIALLLLGRVCCGLGSARA--VNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLQIKFKfYKF 413
Cdd:COG2271   90 LLFGFA---TSFWQLLLLRFLLGLGEAGFfpAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRA 165

                        170       180
                 ....*....|....*....|....*....
gi 334183596 414 TFNQSTLPGWVMAVA--WLFYLVWLCISF 440
Cdd:COG2271  166 AFLILGLPGLLLALLrfWLLALAYFLVYF 194
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 267-451 7.47e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.50  E-value: 7.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 267 FLYMVNTYIIVPTADDYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFIgnLMYALAYDANS 346
Cdd:cd06174    6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFA--LGALLFAFAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 347 IALLLLGRVCCGLGSA---RAVNrRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLqikfkFYKFTFNQSTLPGW 423
Cdd:cd06174   84 FWLLLLGRFLLGLGSGlidPAVL-ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL-----ASSLGFGWRAVFLI 157

                        170       180
                 ....*....|....*....|....*...
gi 334183596 424 VMAVAWLFYLVWLCISFREPLRDTEDGE 451
Cdd:cd06174  158 AAALALLAAILLLLVVPDPPESARAKNE 185
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 288-404 1.68e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.46  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 288 GAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFIgnLMYALAYDANSIALLLLGRVCCGLG--SARAV 365
Cdd:cd17324  230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAA--ALLLLTLLGPSPLLLLVGLVLWGLGffAAHSA 307

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 334183596 366 NRRYISDCVPlRIRMQASAGFVSASALGMACGPALAGLL 404
Cdd:cd17324  308 LQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLV 345
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 263-434 2.58e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.95  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 263 LGNTFLYMVNTYIIVPTADDYSMSLGAAatvcGVVIGSMAVAQVFSSVYFSAWSNKSYF-KPLVFSSIALFIGNLMYALA 341
Cdd:cd06174  214 LVNLAYYSFSTLLPLFLLDLGGLSVAVA----GLLLSLFGLAGALGSLLLGLLSDRLIGrKPLLLIGLLLMALGLALLLL 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 342 YDANSIALLLLGRVCCGLGSARAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLLQIKFKFYKFTFnqstlp 421
Cdd:cd06174  290 APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF------ 363

                        170
                 ....*....|...
gi 334183596 422 gWVMAVAWLFYLV 434
Cdd:cd06174  364 -LVLAVLLLLAAI 375
SPX_BAH1-like cd14482
SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has ...
 88-142 1.01e-03

SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. BAH1 (benzoic acid hypersensitive 1) appears to function as an E3 ubiquitin ligase; the protein contains an SPX and a RING finger domain. It has been suggested that BAH1/NLA is involved in the regulation of plant immune responses, probably via a pathway of salicylic acid biosynthesis that includes benzoic acid as an intermediate.


Pssm-ID: 269903  Cd Length: 156  Bit Score: 40.41  E-value: 1.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334183596  88 KLRESHDAILEQpdisrifelreayrdvGRDLLQllkFVELNAIGLRKILKKFDK 142
Cdd:cd14482  113 CFKDDHQALIQE----------------GRDLVN---YATMNAIAIRKILKKYDK 148
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
263-395 1.04e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.88  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 263 LGNTFLYMVNTYIIVPTADDYSMSLGAAatvcGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFIgnLMYALAY 342
Cdd:COG2814  218 LLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA--LGLLLLA 291

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334183596 343 DANSIALLLLGRVCCGLG--SARAVNRRYISDCVPLRIRMQASAGFVSASALGMA 395
Cdd:COG2814  292 LAGSLWLLLLALFLLGFGfgLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
COG5408 COG5408
SPX domain-containing protein [Signal transduction mechanisms];
118-161 1.15e-03

SPX domain-containing protein [Signal transduction mechanisms];


Pssm-ID: 227695 [Multi-domain]  Cd Length: 296  Bit Score: 41.74  E-value: 1.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 334183596 118 DLLQLLKFVELNAIGLRKILKKFDKRFGYRFADYYVKtRANHPY 161
Cdd:COG5408  253 QLHQLKSFIELNYTGFSKITKKYDKTLHQNLRHEYMS-RSVNEY 295
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 258-436 1.22e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 258 SLLLNLGNTFLYMVNTYIIVPTADDYSMSLG-AAATVCGVVIGSMAVAQVFSSVYFSawsnksYFKPLVFSSIALFIGNL 336
Cdd:cd17473  198 RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFG------RLKRRLGKRRLLAIGFA 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 337 MYALAY----DANSIALLLLGRVCCGLGSA---RAVNRRyISDCVPLRIRMQASAGFVSASALGMACGPALAGLLQIKFK 409
Cdd:cd17473  272 LMALGFlllaLASGLWVVLLGAILAGLGFGlllPTLNSW-AMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350

                        170       180
                 ....*....|....*....|....*..
gi 334183596 410 FYKFTFnqsTLPGWVMAVAWLFYLVWL 436
Cdd:cd17473  351 GLSGAF---LILGVLALVLAIVLLLLR 374
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 263-431 2.03e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 41.02  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 263 LGNtFLYMVNTYIIVPTADDYSMSLGAA--ATVCGVVIGSMAVAQVFSSVyFSAWSNKSY--FKPLVFSSIALFIGNLMY 338
Cdd:cd17315    4 LGG-LLFGYDLGVINGALLYIAKDLGFGlsTSLQGLVVSSLLLGAAIGSL-FGGPLADRFgrRKSLLIAAVLYVIGALLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 339 ALAydaNSIALLLLGRVCCGL--GSARAVNRRYISDCVPLRIR--------MQASAGFVSASALGMACGPALAGLLQIKF 408
Cdd:cd17315   82 ALA---PNVWVLIVGRFLLGLgvGLASVLVPLYISEIAPAKIRgalgtlnqLMITFGILLAYLLGLALSLSPPGWWRLMF 158

                        170       180
                 ....*....|....*....|...
gi 334183596 409 KFykftfnqSTLPGWVMAVAWLF 431
Cdd:cd17315  159 AL-------AAVPALLQLLLMFF 174
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 287-441 4.43e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.84  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 287 LGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFKPLVFSSIALFIGNLMYALAydANSIALLLLGRVCCGLGSAR- 363
Cdd:cd17471   27 LGASPLQIGIFMTLSALSGIVVSQWLGRLSDRggDRKPLILLALLAGALGYLLFAFL--RNYWVLLLVGVVLLSLGAAAf 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 364 ----AVNRRYISDCVPLRIRMqASAGFVSASALGMACGPALAGLLQIKFKFYkftfnqstlpgWVMAVAWLFYLVWLCIS 439
Cdd:cd17471  105 pqlfALAREYADRSSGRDATL-FNSVLRAAFSLAWVIGPPLAFLLLDVLGFT-----------GLFLLAALLYLVVALLV 172


                 ..
gi 334183596 440 FR 441
Cdd:cd17471  173 LF 174
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 283-404 4.49e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 283 YSMSLGAAATvcGVVIGSMAVAQVFSSVYFSAWSNKsyFKPLVFSSIALFIGNLMYALAYDANSIALLLLGRVCCGLGSA 362
Cdd:cd17489  220 YAAERGISNA--GLFFTVYAIALLLSRPFSGKLSDR--KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFG 295

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 334183596 363 RAVN--RRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL 404
Cdd:cd17489  296 LLFPalQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
256-404 6.17e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.47  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 256 FNSLLLNLGNTFLYMVNTYIIV--PT--ADDYSMSLGAAATVCGVVIGSMAVAQVFSSvYFSAWSNKSYFKPLVFSSIAL 331
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTwlPTylVEVRGLSLAQAGLLLSLPFLAGIVGSLLGG-WLSDRLGRRRKLVLAIGLLLA 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334183596 332 FIGnLMYALAYDANSIALLLLGRVCCGLGSARAVNRRYISDCVPLRIRMQASAGFVSASALGMACGPALAGLL 404
Cdd:COG2271  259 ALA-LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
259-434 6.67e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 259 LLLNLGNTFLYMVNTYIIVptaddYSMSLGAAATvcGVVIGSMAVAQVFSSVYFSAWSNKSYFKPLVFSSIALFIGNLMY 338
Cdd:COG2211  238 LLFFLALALVAALLLYYFK-----YVLGLSAALV--GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 339 ALAYDANSIALLLLGRVCCGLGSA--RAVNRRYISDCVPL-------RIRMQASAGFVSASALGMACGPALAGLLqikFK 409
Cdd:COG2211  311 LFFLGPGNLWLLLVLAALAGIGLGaiLVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGLL---LA 387

                        170       180
                 ....*....|....*....|....*
gi 334183596 410 FYKFTFNQSTLPGWVMAVAWLFYLV 434
Cdd:COG2211  388 LFGYVAGAAQSPSALTGIRLLFFLL 412
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
263-436 8.25e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.09  E-value: 8.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 263 LGNTFLYMVNTYIivPTaddYSMSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFKPLVFSSIALFIGNLMYAL 340
Cdd:COG2807  226 LQSLLYYAVVAWL--PP---ILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRlgDRRPLLLLLGLLGLAGLLGLLL 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183596 341 AYDANS-IALLLLGrvcCGLGSARAVNRRYISDCVP-LRIRMQASAGFVSASALGMACGPALAGLLqikfkfykFTFNQS 418
Cdd:COG2807  301 APGSLPwLWAVLLG---LGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGAL--------HDATGS 369

                        170
                 ....*....|....*...
gi 334183596 419 TLPGWVMAVAWLFYLVWL 436
Cdd:COG2807  370 WTAALLLLAALAVLMLVA 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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