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Conserved domains on  [gi|334183160|ref|NP_001185173|]
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uncharacterized protein AT1G48560 [Arabidopsis thaliana]

Protein Classification

PWWP domain-containing protein( domain architecture ID 10142404)

PWWP domain-containing protein similar to Arabidopsis thaliana PWWP domain-containing proteins that mediate H3K27 trimethylation on FLC and regulate flowering time

Gene Ontology:  GO:0003677|GO:0000166|GO:0005515
PubMed:  28510146|10802047|25277115

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PWWP cd05162
PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ...
 5-77 9.92e-07

PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids and is composed of a five-stranded antiparallel beta-barrel followed by a helical region. It is found in numerous proteins that are involved in cell division, growth, and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. PWWP domains specifically recognize DNA and histone methylated lysines at the level of the nucleosome. Based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors.


:

Pssm-ID: 438958 [Multi-domain]  Cd Length: 86  Bit Score: 47.11  E-value: 9.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183160   5 GELVWVSVSfSNTWIPGRIIDPSESL----------GVLVSFFGLMDPRYVP----KPFLRSFDRDFKTLISDSRWIRRF 70
Cdd:cd05162    1 GDLVWAKLK-GYPWWPARVVDPEELPeevgkkkkkgGVLVQFFGDNDYAWVKskniKPFEEGFKKEFKKKKKKSKKFKKA 79


                 ....*..
gi 334183160  71 VNRALRA 77
Cdd:cd05162   80 VEEAEEA 86
 
Name Accession Description Interval E-value
PWWP cd05162
PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ...
 5-77 9.92e-07

PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids and is composed of a five-stranded antiparallel beta-barrel followed by a helical region. It is found in numerous proteins that are involved in cell division, growth, and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. PWWP domains specifically recognize DNA and histone methylated lysines at the level of the nucleosome. Based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors.


Pssm-ID: 438958 [Multi-domain]  Cd Length: 86  Bit Score: 47.11  E-value: 9.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183160   5 GELVWVSVSfSNTWIPGRIIDPSESL----------GVLVSFFGLMDPRYVP----KPFLRSFDRDFKTLISDSRWIRRF 70
Cdd:cd05162    1 GDLVWAKLK-GYPWWPARVVDPEELPeevgkkkkkgGVLVQFFGDNDYAWVKskniKPFEEGFKKEFKKKKKKSKKFKKA 79


                 ....*..
gi 334183160  71 VNRALRA 77
Cdd:cd05162   80 VEEAEEA 86
 
Name Accession Description Interval E-value
PWWP cd05162
PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ...
 5-77 9.92e-07

PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids and is composed of a five-stranded antiparallel beta-barrel followed by a helical region. It is found in numerous proteins that are involved in cell division, growth, and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. PWWP domains specifically recognize DNA and histone methylated lysines at the level of the nucleosome. Based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors.


Pssm-ID: 438958 [Multi-domain]  Cd Length: 86  Bit Score: 47.11  E-value: 9.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183160   5 GELVWVSVSfSNTWIPGRIIDPSESL----------GVLVSFFGLMDPRYVP----KPFLRSFDRDFKTLISDSRWIRRF 70
Cdd:cd05162    1 GDLVWAKLK-GYPWWPARVVDPEELPeevgkkkkkgGVLVQFFGDNDYAWVKskniKPFEEGFKKEFKKKKKKSKKFKKA 79


                 ....*..
gi 334183160  71 VNRALRA 77
Cdd:cd05162   80 VEEAEEA 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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