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Conserved domains on  [gi|334182590|ref|NP_001184999|]
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protein-protein interaction regulator family protein [Arabidopsis thaliana]

Protein Classification

pinin family protein( domain architecture ID 11152381)

pinin family protein similar to Schizosaccharomyces pombe pinin homolog 1, a transcriptional activator that may participate in the regulation of mRNA splicing

Gene Ontology:  GO:0005681|GO:0045292
PubMed:  9332356

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 157-293 1.28e-21

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


:

Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 90.04  E-value: 1.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182590  157 PKLVNRNRRMLGNLLGTLEKFRKEDKQRSgtDAYARRTAALQRAEEKAREESERL---RLQERENLTEKRRRdltLRARV 233
Cdd:pfam04696   1 EEEKKRNRRLFGGLLGTLQKFKKEESKQK--EKEERRAEIEKRLEEKAKQEKEELeerKREEREELFEERRA---EQIEL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182590  234 AAKAEQKKLELLFLQWSEHQKKLSNFIRlltamTKAEPRIYYAPVKPLEEDTSEVEQQKE 293
Cdd:pfam04696  76 RALEEKLELKELMETWHENLKALANFLK-----TKTEPPIYYLPWKLTEKTEELLEEQIE 130
 
Name Accession Description Interval E-value
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 157-293 1.28e-21

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 90.04  E-value: 1.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182590  157 PKLVNRNRRMLGNLLGTLEKFRKEDKQRSgtDAYARRTAALQRAEEKAREESERL---RLQERENLTEKRRRdltLRARV 233
Cdd:pfam04696   1 EEEKKRNRRLFGGLLGTLQKFKKEESKQK--EKEERRAEIEKRLEEKAKQEKEELeerKREEREELFEERRA---EQIEL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182590  234 AAKAEQKKLELLFLQWSEHQKKLSNFIRlltamTKAEPRIYYAPVKPLEEDTSEVEQQKE 293
Cdd:pfam04696  76 RALEEKLELKELMETWHENLKALANFLK-----TKTEPPIYYLPWKLTEKTEELLEEQIE 130
 
Name Accession Description Interval E-value
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 157-293 1.28e-21

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 90.04  E-value: 1.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182590  157 PKLVNRNRRMLGNLLGTLEKFRKEDKQRSgtDAYARRTAALQRAEEKAREESERL---RLQERENLTEKRRRdltLRARV 233
Cdd:pfam04696   1 EEEKKRNRRLFGGLLGTLQKFKKEESKQK--EKEERRAEIEKRLEEKAKQEKEELeerKREEREELFEERRA---EQIEL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182590  234 AAKAEQKKLELLFLQWSEHQKKLSNFIRlltamTKAEPRIYYAPVKPLEEDTSEVEQQKE 293
Cdd:pfam04696  76 RALEEKLELKELMETWHENLKALANFLK-----TKTEPPIYYLPWKLTEKTEELLEEQIE 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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