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Conserved domains on  [gi|1212982788|ref|NP_001181465|]
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zinc finger protein 668 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-414 1.30e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788  80 KPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRCAH-CPKAYGALSKLK 156
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 157 IHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK----------------------DLRNH 214
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 215 ERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA---------------------AQKPYRCPACGKG 260
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdssssASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 261 FTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYHC--EKCGKDFRQPADLAMHRRVHTGD 333
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 334 RPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRVHSGERP--FHCNACGKSFV 402
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                         410
                  ....*....|..
gi 1212982788 403 VSSSLRKHERTH 414
Cdd:COG5048   430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-595 9.96e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 9.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAM 325
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 326 HRRVHTGdrPFKCLQCDKtfvaswdlkrHALVHSGQRPFRCEEcgrafaerasltkHSRVHSGERPFH-CNacGKSFVVS 404
Cdd:COG5048   110 LSSSSSN--SNDNNLLSS----------HSLPPSSRDPQLPDL-------------LSISNLRNNPLPgNN--SSSVNTP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 405 SSLRKHERTHRSSEAAGAPPAQELVVGLALPVG-----VAGEGSATPAAGAGLGDP----PAGLLGLPPESGGV--MATQ 473
Cdd:COG5048   163 QSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSipsssENSPLSSSYSIPSSSSDQnlenSSSSLPLTTNSQLSpkSLLS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 474 WQVVG--MTVEHVECQDagVREAPGPLEGAGEVGGEEADEKPPQ-----FVCRECKETFSTVTLLRRHERSH----PELR 542
Cdd:COG5048   243 QSPSSlsSSDSSSSASE--SPRSSLPTASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLRSVnhsgESLK 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1212982788 543 PFPCT--QCGKSFSDRAGLRKHSRTHSSVRPYTCP--HCPKAFLSASDLRKHERTHP 595
Cdd:COG5048   321 PFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-414 1.30e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788  80 KPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRCAH-CPKAYGALSKLK 156
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 157 IHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK----------------------DLRNH 214
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 215 ERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA---------------------AQKPYRCPACGKG 260
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdssssASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 261 FTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYHC--EKCGKDFRQPADLAMHRRVHTGD 333
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 334 RPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRVHSGERP--FHCNACGKSFV 402
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                         410
                  ....*....|..
gi 1212982788 403 VSSSLRKHERTH 414
Cdd:COG5048   430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-595 9.96e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 9.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAM 325
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 326 HRRVHTGdrPFKCLQCDKtfvaswdlkrHALVHSGQRPFRCEEcgrafaerasltkHSRVHSGERPFH-CNacGKSFVVS 404
Cdd:COG5048   110 LSSSSSN--SNDNNLLSS----------HSLPPSSRDPQLPDL-------------LSISNLRNNPLPgNN--SSSVNTP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 405 SSLRKHERTHRSSEAAGAPPAQELVVGLALPVG-----VAGEGSATPAAGAGLGDP----PAGLLGLPPESGGV--MATQ 473
Cdd:COG5048   163 QSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSipsssENSPLSSSYSIPSSSSDQnlenSSSSLPLTTNSQLSpkSLLS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 474 WQVVG--MTVEHVECQDagVREAPGPLEGAGEVGGEEADEKPPQ-----FVCRECKETFSTVTLLRRHERSH----PELR 542
Cdd:COG5048   243 QSPSSlsSSDSSSSASE--SPRSSLPTASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLRSVnhsgESLK 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1212982788 543 PFPCT--QCGKSFSDRAGLRKHSRTHSSVRPYTCP--HCPKAFLSASDLRKHERTHP 595
Cdd:COG5048   321 PFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1212982788 210 DLRNHERSHTGERPFLCSECGKSFSR 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 2.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1212982788 559 LRKHSRTHSSVRPYTCPHCPKAFLS 583
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
80-414 1.30e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788  80 KPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGR--RFMQPVCLRVHLASHAGELPFRCAH-CPKAYGALSKLK 156
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 157 IHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELK----------------------DLRNH 214
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 215 ERSHTGERPFLCSECGKSFSR-------------SSSLTCHQRIHA---------------------AQKPYRCPACGKG 260
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLspksllsqspsslsssdssssASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 261 FTQLSSYQSHERTHSG-EKPFLCPRCGRMFSDPSSFRRHQRAH----EGVKPYHC--EKCGKDFRQPADLAMHRRVHTGD 333
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 334 RPFKC--LQCDKTFVASWDLKRHALVH-----SGQRPFRCE--ECGRAFAERASLTKHSRVHSGERP--FHCNACGKSFV 402
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                         410
                  ....*....|..
gi 1212982788 403 VSSSLRKHERTH 414
Cdd:COG5048   430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-385 6.22e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 6.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 223 PFLCSECGKSFSRSSSLTCHQR--IH--AAQKPYRCPA--CGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSF- 295
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 296 -RRHQRAH-----EGVKPYHCE--KCGKDFRQPADLAMHRRVHTGDRP--FKCLQCDKTFVASWDLKRHALVHSGQRPFR 365
Cdd:COG5048   369 nEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170       180
                  ....*....|....*....|
gi 1212982788 366 CEECGRaFAERASLTKHSRV 385
Cdd:COG5048   449 CSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-595 9.96e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 9.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 248 AQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGR--MFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAM 325
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 326 HRRVHTGdrPFKCLQCDKtfvaswdlkrHALVHSGQRPFRCEEcgrafaerasltkHSRVHSGERPFH-CNacGKSFVVS 404
Cdd:COG5048   110 LSSSSSN--SNDNNLLSS----------HSLPPSSRDPQLPDL-------------LSISNLRNNPLPgNN--SSSVNTP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 405 SSLRKHERTHRSSEAAGAPPAQELVVGLALPVG-----VAGEGSATPAAGAGLGDP----PAGLLGLPPESGGV--MATQ 473
Cdd:COG5048   163 QSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSipsssENSPLSSSYSIPSSSSDQnlenSSSSLPLTTNSQLSpkSLLS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 474 WQVVG--MTVEHVECQDagVREAPGPLEGAGEVGGEEADEKPPQ-----FVCRECKETFSTVTLLRRHERSH----PELR 542
Cdd:COG5048   243 QSPSSlsSSDSSSSASE--SPRSSLPTASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLRSVnhsgESLK 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1212982788 543 PFPCT--QCGKSFSDRAGLRKHSRTHSSVRPYTCP--HCPKAFLSASDLRKHERTHP 595
Cdd:COG5048   321 PFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-299 2.66e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 138 LPFRCAHCPKAYGALSKLKIHQRG--HTGE--RPYAC--ADCGKSFADPSVFRKHRRTHAGLRPYSC--ERCGKAYAELK 209
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 210 DLRNHERSH-----TGERPFLC--SECGKSFSRSSSLTCHQRIHAAQKP--YRCPACGKGFTQLSSYQSHERTHSGEKPF 280
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1212982788 281 LCPRCGRMFSDPSSFRRHQ 299
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 192-275 4.67e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 192 GLRPYSCE--RCGKAYAELKDLRNHErshtgerpfLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQS 269
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1212982788 270 HeRTHS 275
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1212982788 210 DLRNHERSHTGERPFLCSECGKSFSR 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
98-121 8.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.97e-04
                          10        20
                  ....*....|....*....|....
gi 1212982788  98 ELRSHGRSHTGEKPFPCPECGRRF 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 2.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1212982788 559 LRKHSRTHSSVRPYTCPHCPKAFLS 583
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-414 2.43e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212982788 321 ADLAMHRRVHTGDRPFKC--LQCDKTFVASWDLKRHALvHSGQRPfrceecgrAFAERASLTKHSRVHSGERPFHCNACG 398
Cdd:COG5189   335 IDTPSRMLKVKDGKPYKCpvEGCNKKYKNQNGLKYHML-HGHQNQ--------KLHENPSPEKMNIFSAKDKPYRCEVCD 405

                          90
                  ....*....|....*.
gi 1212982788 399 KSFVVSSSLRKHeRTH 414
Cdd:COG5189   406 KRYKNLNGLKYH-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-346 2.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.54e-03
                          10        20
                  ....*....|....*....|....*
gi 1212982788 322 DLAMHRRVHTGDRPFKCLQCDKTFV 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
155-178 2.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.67e-03
                          10        20
                  ....*....|....*....|....
gi 1212982788 155 LKIHQRGHTGERPYACADCGKSFA 178
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-554 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....
gi 1212982788 531 LRRHERSHPELRPFPCTQCGKSFS 554
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 2.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|....*
gi 1212982788 378 SLTKHSRVHSGERPFHCNACGKSFV 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 5.18e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.18e-03
                          10        20
                  ....*....|....*....|...
gi 1212982788 544 FPCTQCGKSFSDRAGLRKHSRTH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-374 5.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.31e-03
                          10        20
                  ....*....|....*....|....*
gi 1212982788 350 DLKRHALVHSGQRPFRCEECGRAFA 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 572-594 8.54e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.54e-03
                          10        20
                  ....*....|....*....|...
gi 1212982788 572 YTCPHCPKAFLSASDLRKHERTH 594
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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