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Conserved domains on  [gi|1694849141|ref|NP_001180810|]
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putative uncharacterized protein C6orf52 homolog [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Trnau1ap pfam17654
Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of ...
 15-147 7.69e-39

Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) pfam00076 and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.


:

Pssm-ID: 465438  Cd Length: 101  Bit Score: 127.07  E-value: 7.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694849141  15 QNNYYCYwqslpsaiRVKQEFQPNQGYlYGNW-YARQHSSYLLSGYSYGCavdgngrdcfsahktpehtagilvMPKETT 93
Cdd:pfam17654   1 SGQYQQY--------QYQQYYQQYQNY-YSQWgYDQYNGYYSYSYPQYGY------------------------TPAPTT 47

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1694849141  94 PLAENQDEDPLEDPHLHLNIEESNQEFMVKSEELYDSLMNCHWQPLDTVHSEIP 147
Cdd:pfam17654  48 QEAEQQDEDPLEDPNLELDVEELNKEFMERSEELYDALMNCHWQPLDSVTSEIP 101
 
Name Accession Description Interval E-value
Trnau1ap pfam17654
Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of ...
 15-147 7.69e-39

Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) pfam00076 and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.


Pssm-ID: 465438  Cd Length: 101  Bit Score: 127.07  E-value: 7.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694849141  15 QNNYYCYwqslpsaiRVKQEFQPNQGYlYGNW-YARQHSSYLLSGYSYGCavdgngrdcfsahktpehtagilvMPKETT 93
Cdd:pfam17654   1 SGQYQQY--------QYQQYYQQYQNY-YSQWgYDQYNGYYSYSYPQYGY------------------------TPAPTT 47

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1694849141  94 PLAENQDEDPLEDPHLHLNIEESNQEFMVKSEELYDSLMNCHWQPLDTVHSEIP 147
Cdd:pfam17654  48 QEAEQQDEDPLEDPNLELDVEELNKEFMERSEELYDALMNCHWQPLDSVTSEIP 101
 
Name Accession Description Interval E-value
Trnau1ap pfam17654
Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of ...
 15-147 7.69e-39

Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) pfam00076 and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.


Pssm-ID: 465438  Cd Length: 101  Bit Score: 127.07  E-value: 7.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694849141  15 QNNYYCYwqslpsaiRVKQEFQPNQGYlYGNW-YARQHSSYLLSGYSYGCavdgngrdcfsahktpehtagilvMPKETT 93
Cdd:pfam17654   1 SGQYQQY--------QYQQYYQQYQNY-YSQWgYDQYNGYYSYSYPQYGY------------------------TPAPTT 47

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1694849141  94 PLAENQDEDPLEDPHLHLNIEESNQEFMVKSEELYDSLMNCHWQPLDTVHSEIP 147
Cdd:pfam17654  48 QEAEQQDEDPLEDPNLELDVEELNKEFMERSEELYDALMNCHWQPLDSVTSEIP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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