|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
54-670 |
2.42e-156 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 471.87 E-value: 2.42e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 54 LPvfKYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVD 133
Cdd:COG1643 43 LP--LALLELGWGAGGRI-GMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSA-ATRIEVVTEGILLRELQRD 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 134 PLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLDADKFRDFFNqnetsdPARdtcvILTVEGRTF 212
Cdd:COG1643 119 PELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLDAERFARLLG------DAP----VIESSGRTY 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 213 PVDIFYL--QSPVPDYIKSTVETVVKIHQtEGDGDVLAFLTGQEEvetvvsmlIEQARALARTGMKRHLRVLPMYAGLPS 290
Cdd:COG1643 189 PVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGERE--------IRRTAEALRGRLPPDTEILPLYGRLSA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 291 FEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGK 370
Cdd:COG1643 260 AEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGI 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 371 CYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTePLGM 450
Cdd:COG1643 340 CYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLT-PLGR 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 451 RIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFvvppnqkshairvhRKFAveEGDHLTMLNIYEAFIKHnkd 530
Cdd:COG1643 419 ALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR--------------RGAA--GSDLLARLNLWRRLREQ--- 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 531 skwcQEHFLNYKGLVRAATVREQLKKLLvkfQVPRKSSEGDPDLVLRCIVSGFFAN-AARFHSTGAYRTIRdDHELHIHP 609
Cdd:COG1643 480 ----QREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLLALAYPDRiARRRGEGGRYLLAR-GRGAALFP 551
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 299829255 610 ASVLYAEKpprWVIYNEVIQT---SKyyMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQ 670
Cdd:COG1643 552 GSPLAKKE---WLVAAELVGGaaeAR--IRLAAPIDPEWLEELAAHLIKRYSEPHWDKKRGRVV 610
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
72-652 |
8.77e-137 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 432.66 E-value: 8.77e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 72 VGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERT 151
Cdd:TIGR01967 114 IGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSS-NTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERS 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 152 LYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNEtsdpardtcvILTVEGRTFPVDIFY-----LQSPVP-D 225
Cdd:TIGR01967 193 LNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAP----------IIEVSGRTYPVEVRYrplveEQEDDDlD 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 226 YIKSTVETVVKIHQtEGDGDVLAFLTGQEEVEtvvsmliEQARALARTGMkRHLRVLPMYAGLPSFEQMKVFErvSRSVR 305
Cdd:TIGR01967 263 QLEAILDAVDELFA-EGPGDILIFLPGEREIR-------DAAEILRKRNL-RHTEILPLYARLSNKEQQRVFQ--PHSGR 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 306 KVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQ 385
Cdd:TIGR01967 332 RIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPE 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 386 STVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKD---CRLTePLGMRIAEFPLNPMFA 462
Cdd:TIGR01967 412 FTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDeaePQLT-PIGRQLAQLPVDPRLA 490
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 463 KMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAF------IKHNKDSKWCQE 536
Cdd:TIGR01967 491 RMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIeeqrqaLSANQFRNACRK 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 537 HFLNYKGLVRAATVREQLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRdDHELHIHPASVLyAE 616
Cdd:TIGR01967 571 QYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGAR-GRKFHIFPGSPL-FK 648
|
570 580 590
....*....|....*....|....*....|....*.
gi 299829255 617 KPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPH 652
Cdd:TIGR01967 649 KPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGH 684
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
53-652 |
7.58e-129 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 411.38 E-value: 7.58e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 53 KLPvfKYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFddcTDQLA--TRIKFLTDGMLVREM 130
Cdd:PRK11131 105 QLP--KICLELGRGVKG-LIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRF---NDQVSdnTMVKLMTDGILLAEI 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 131 MVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNEtsdpardtcvILTVEGR 210
Cdd:PRK11131 179 QQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAP----------IIEVSGR 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 211 TFPVDIFYlqSPV--------PDYIKSTVETVVKIhQTEGDGDVLAFLTGQEEVEtvvsmliEQARALARTGMkRHLRVL 282
Cdd:PRK11131 249 TYPVEVRY--RPIveeaddteRDQLQAIFDAVDEL-GREGPGDILIFMSGEREIR-------DTADALNKLNL-RHTEIL 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 283 PMYAGLPSFEQMKVFErvSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGR 362
Cdd:PRK11131 318 PLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGR 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 363 GGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDC 442
Cdd:PRK11131 396 CGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDE 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 443 -----RLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTM 517
Cdd:PRK11131 476 qasayKLT-PLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAF 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 518 LNIYEaFIK-------HNKDSKWCQEHFLNYkglVRaatVRE------QLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFF 584
Cdd:PRK11131 555 VNLWN-YLQeqqkalsSNQFRRLCRTDYLNY---LR---VREwqdiytQLRQVVKELGIPVNSEPAEYREIHTALLTGLL 627
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 299829255 585 A-----NAARFHSTGAyrtiRDDHeLHIHPASVLYaEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPH 652
Cdd:PRK11131 628 ShigmkDAEKQEYTGA----RNAR-FSIFPGSGLF-KKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQH 694
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
58-207 |
1.04e-102 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 310.94 E-value: 1.04e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 58 KYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLT 137
Cdd:cd17980 36 QYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLT 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 138 KYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTV 207
Cdd:cd17980 116 KYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETNDPSKDTATILSV 185
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
60-489 |
4.87e-88 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 292.44 E-value: 4.87e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 60 LAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKY 139
Cdd:TIGR01970 36 LALLDAPGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTVGYRVRGENKVSR-RTRLEVVTEGILTRMIQDDPELDGV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 140 SVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLDADKFRDFFNQnetsdpardtCVILTVEGRTFPVDIFY 218
Cdd:TIGR01970 115 GALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSATLDGERLSSLLPD----------APVVESEGRSFPVEIRY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 219 LQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARAlartgmkrHLRVLPMYAGLPSFEQMKVFE 298
Cdd:TIGR01970 185 LPLRGDQRLEDAVSRAVEHALASETGSILVFLPGQAEIRRVQEQLAERLDS--------DVLICPLYGELSLAAQDRAIK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 299 RVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEE 378
Cdd:TIGR01970 257 PDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEE 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 379 AFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEpLGMRIAEFPLN 458
Cdd:TIGR01970 337 QHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRLTA-HGKAMAALGCH 415
|
410 420 430
....*....|....*....|....*....|.
gi 299829255 459 PMFAKMLLESGNFGCSQEILSIAAMMQIQNI 489
Cdd:TIGR01970 416 PRLAAMLLSAHSTGLAALACDLAALLEERGL 446
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
212-375 |
8.84e-76 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 240.13 E-value: 8.84e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 212 FPVDIFYLQSPV-----------PDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLieqaRALARTGMKRHLR 280
Cdd:cd18791 1 FPVEVYYLEDILellgissekedPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL----REELLSPDLGKLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 281 VLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRA 360
Cdd:cd18791 77 VLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156
|
170
....*....|....*
gi 299829255 361 GRGGRSRSGKCYRLY 375
Cdd:cd18791 157 GRAGRTRPGKCYRLY 171
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
69-483 |
2.69e-73 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 252.54 E-value: 2.69e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 69 GRVVgVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAH 148
Cdd:PRK11664 49 GKII-MLEPRRLAARNVAQRLAEQLGEKPGETVGYRMRAESKVGP-NTRLEVVTEGILTRMIQRDPELSGVGLVILDEFH 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 149 ERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLDADKFRDFFnqnetsdParDTCVILTvEGRTFPVDIFYLQSPVPDYI 227
Cdd:PRK11664 127 ERSLQADLALALLLDVQQGlRDDLKLLIMSATLDNDRLQQLL-------P--DAPVIVS-EGRSFPVERRYQPLPAHQRF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 228 KSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQaralartgMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKV 307
Cdd:PRK11664 197 DEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQLASR--------VASDVLLCPLYGALSLAEQQKAILPAPAGRRKV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 308 IVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQST 387
Cdd:PRK11664 269 VLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQS 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 388 VPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLE 467
Cdd:PRK11664 349 EPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRLT-ARGRKMAALGNDPRLAAMLVA 427
|
410
....*....|....*.
gi 299829255 468 SGNFgcSQEILSIAAM 483
Cdd:PRK11664 428 AKED--DEAALATAAK 441
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
58-191 |
1.85e-65 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 212.70 E-value: 1.85e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 58 KYLAEAGWTAEGRV-VGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLL 136
Cdd:cd17917 20 QFLLEDGLAKGGKGrIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSS-KTRIKFCTDGILLRELLSDPLL 98
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 299829255 137 TKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQ 191
Cdd:cd17917 99 SGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGG 153
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
58-190 |
8.46e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 209.13 E-value: 8.46e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 58 KYLAEAGwTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLT 137
Cdd:cd17978 36 QYLYEAG-FARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGYSVRFDDVTSE-ETRIKYMTDGMLLREAIGDPLLS 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 299829255 138 KYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD-----LRLIVASATLDADKFRDFFN 190
Cdd:cd17978 114 KYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEqklspLKVIIMSATLDADLFSEYFN 171
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
49-189 |
9.62e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 198.48 E-value: 9.62e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 49 QQRQKLPVFK-------------------------------YLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVAEERGAVL 97
Cdd:cd17971 1 EQRESLPIYKlkeqliqavhdnqilvvigetgsgkttqitqYLAEAGYTSRGKI-GCTQPRRVAAMSVAKRVAEEFGCCL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 98 GHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVAS 177
Cdd:cd17971 80 GQEVGYTIRFEDCTSP-ETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTS 158
|
170
....*....|..
gi 299829255 178 ATLDADKFRDFF 189
Cdd:cd17971 159 ATLDAVKFSQYF 170
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
58-191 |
5.27e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 188.10 E-value: 5.27e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 58 KYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLT 137
Cdd:cd17974 36 QYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSE-KTVLKYMTDGMLLREFLTEPDLA 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 299829255 138 KYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQ 191
Cdd:cd17974 115 SYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAEKFSAFFDD 168
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
68-190 |
2.87e-55 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 186.47 E-value: 2.87e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 68 EGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEA 147
Cdd:cd17973 59 PKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFEDCSSA-KTILKYMTDGMLLREAMSDPLLSRYSVIILDEA 137
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 299829255 148 HERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFN 190
Cdd:cd17973 138 HERTLATDILMGLLKEVVRRRPDLKLIVMSATLDAGKFQKYFD 180
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
58-189 |
3.82e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 177.65 E-value: 3.82e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 58 KYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLT 137
Cdd:cd17983 36 QYLHEDGYTDYG-MIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGYAIRFEDCTSE-NTVIKYMTDGILLRESLRDPDLD 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 299829255 138 KYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFF 189
Cdd:cd17983 114 KYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADKFADFF 165
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
53-189 |
1.13e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 163.10 E-value: 1.13e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 53 KLPvfKYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMV 132
Cdd:cd17984 33 QLP--KYLYEAGFSQHGMI-GVTQPRRVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSK-ETAIKYMTDGCLLRHILA 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 299829255 133 DPLLTKYSVIMLDEAHERTLYTDIAIGLLKKI--QKKRG---DLRLIVASATLDADKFRDFF 189
Cdd:cd17984 109 DPNLTKYSVIILDEAHERSLTTDILFGLLKKLfqEKSPNrkeHLKVVVMSATLELAKLSAFF 170
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
53-187 |
1.96e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 160.21 E-value: 1.96e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 53 KLPVFKYlaEAGWTAE----GRVVGVTQPRRVAAVTVAGRVAEERGaVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVR 128
Cdd:cd17982 33 QVPQFLY--EAGFGSPesdnPGMIGITQPRRVAAVSMAKRVAEELN-VFGKEVSYQIRYDSTVSE-NTKIKFMTDGVLLK 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 299829255 129 EMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD----------LRLIVASATLDADKFRD 187
Cdd:cd17982 109 EIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvkpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
53-190 |
6.22e-36 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 132.96 E-value: 6.22e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 53 KLPvfKYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMV 132
Cdd:cd17989 33 QLP--KICLELGRGIRG-LIGHTQPRRLAARSVAERIAEELKTELGGAVGYKVRFTDQTSD-ETCVKLMTDGILLAETQT 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 299829255 133 DPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFN 190
Cdd:cd17989 109 DRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAERFSRHFN 166
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
56-191 |
4.69e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 124.86 E-value: 4.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 56 VFKYLAEAGWTAegrvVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDcTDQLATRIKFLTDGMLVREMMVDPL 135
Cdd:cd17979 34 VPQYLLAAGFRH----IACTQPRRIACISLAKRVAFESLNQYGSKVAYQIRFER-TRTLATKLLFLTEGLLLRQIQRDAS 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 299829255 136 LTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQ 191
Cdd:cd17979 109 LPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSGYFEG 164
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
60-185 |
4.86e-32 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 122.06 E-value: 4.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 60 LAEAGWTAEGRVVgVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKY 139
Cdd:cd17990 38 LLAELWIAGGKII-VLEPRRVAARAAARRLATLLGEAPGETVGYRVRGESRVGR-RTRVEVVTEGVLLRRLQRDPELSGV 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 299829255 140 SVIMLDEAHERTLYTDIAIGLLKKIQK-KRGDLRLIVASATLDADKF 185
Cdd:cd17990 116 GAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDGDGL 162
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
62-190 |
7.24e-30 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 116.10 E-value: 7.24e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 62 EAGWTAEGRVVgVTQPRRVAAVTVAGRVAEERG--AVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKY 139
Cdd:cd17981 44 ERGKGSSCRIV-CTQPRRISAISVAERVAAERAesCGLGNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNV 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 299829255 140 SVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFN 190
Cdd:cd17981 123 SHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMSATLNAEKFSDYFN 173
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
71-178 |
3.97e-28 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 111.07 E-value: 3.97e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 71 VVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHER 150
Cdd:cd17977 51 VVVCTQVHKQTAVWLALRVADEMDVNIGHEVGYVIPFENCCTN-ETILRYCTDDMLLREMMSDPLLESYGVIILDDAHER 129
|
90 100
....*....|....*....|....*...
gi 299829255 151 TLYTDIAIGLLKKIQKKRGDLRLIVASA 178
Cdd:cd17977 130 TVSTDVLLGLLKDVLLSRPELKLVIITC 157
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
75-190 |
2.33e-27 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 109.16 E-value: 2.33e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 75 TQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYT 154
Cdd:cd17985 56 TQPRRISAISVAERVAQERAERVGQSVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEES 134
|
90 100 110
....*....|....*....|....*....|....*.
gi 299829255 155 DIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFN 190
Cdd:cd17985 135 DFLLLVLKDLMVQRPDLKVILMSATLNAELFSDYFN 170
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
60-191 |
2.71e-27 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 108.85 E-value: 2.71e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 60 LAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLG-----HEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDP 134
Cdd:cd17975 42 LLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESGpggknSLCGYQIRMESRTGE-ATRLLYCTTGVLLRKLQEDG 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 299829255 135 LLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQ 191
Cdd:cd17975 121 LLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLILMSATVDCEKFSSYFTH 177
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
72-188 |
4.82e-27 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 108.06 E-value: 4.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 72 VGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERT 151
Cdd:cd17986 53 VTVTQPHPLAARSLALRVADEMDLNLGHEVGYSIPQEDCTGP-NTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERS 131
|
90 100 110
....*....|....*....|....*....|....*..
gi 299829255 152 LYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDF 188
Cdd:cd17986 132 VASDSLLGLLKDVRLQRPELRVVVVTSPALEPKLRAF 168
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
428-517 |
1.39e-26 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 104.24 E-value: 1.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 428 ALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVP----PNQKSHAIRV 503
Cdd:pfam04408 1 ALELLYYLGALDEDGELT-PLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldPRSAAKAARR 79
|
90 100
....*....|....*....|....*
gi 299829255 504 HRKFAVEE-----------GDHLTM 517
Cdd:pfam04408 80 RRRAADEKarakfarldleGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
434-518 |
1.14e-24 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 98.11 E-value: 1.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 434 ALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFvvPPNQKSHAIRVHRKFAVEEGD 513
Cdd:smart00847 1 ELGALDDDGRLT-PLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESD 77
|
....*
gi 299829255 514 HLTML 518
Cdd:smart00847 78 HLTLL 82
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
72-189 |
4.36e-23 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 96.79 E-value: 4.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 72 VGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERT 151
Cdd:cd17976 53 VVITQPRRISAVSVAQRVAHELGPNLRRNVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERD 132
|
90 100 110
....*....|....*....|....*....|....*...
gi 299829255 152 LYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFF 189
Cdd:cd17976 133 VNTDFLLILLKGVLQLNPELRVVLMSATGDNQRLSRYF 170
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
75-190 |
7.78e-23 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 96.05 E-value: 7.78e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 75 TQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMV-DPLLTKYSVIMLDEAHERTLY 153
Cdd:cd17987 54 TQPRRLAAIAVAERVAAERGEKIGQTVGYQIRLESRVSP-KTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRF 132
|
90 100 110
....*....|....*....|....*....|....*..
gi 299829255 154 TDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFN 190
Cdd:cd17987 133 SDFLLTKLRDILQKHPNLKLILSSAALDVNLFIRYFG 169
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
7-189 |
8.49e-23 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 97.60 E-value: 8.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 7 PVKFWRPGT-----EGPGVSISEERQSLA-ENSGTTVVYNPYAALSIEQQRQKLPVFKYLAEAGWT-AEGRVV------- 72
Cdd:cd17972 6 PQSNWNPWTssnidEGPLAFATPEQISMDlKNELMYQREQDHNLQQILQERELLPVKKFREEILEAiSNNPVViirgatg 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 73 --------------------------GVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGML 126
Cdd:cd17972 86 cgkttqvpqyilddfiqndraaecniVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGVL 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 299829255 127 VREMmvDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFF 189
Cdd:cd17972 166 LRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYF 226
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
575-652 |
1.42e-21 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 89.23 E-value: 1.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 575 VLRCIVSGFFANAARF-HSTGAYRTIRDDHELHIHPASVLY--AEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP 651
Cdd:pfam07717 1 LRAALAAGLYPNVARRdPKGKGYTTLSDNQRVFIHPSSVLFneKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
.
gi 299829255 652 H 652
Cdd:pfam07717 81 H 81
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
74-189 |
5.58e-18 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 82.16 E-value: 5.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 74 VTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDcTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLY 153
Cdd:cd17988 53 VTQPRRIAAISIARRVSQEREWTLGSLVGYQVGLER-PASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQE 131
|
90 100 110
....*....|....*....|....*....|....*..
gi 299829255 154 TDIAIGLLKK-IQKKRGDLRLIVASATLDADKFRDFF 189
Cdd:cd17988 132 LDFLLLVVRRlLRTNSRHVKIILMSATISCKEFADYF 168
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
270-365 |
6.35e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 67.24 E-value: 6.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 270 LARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFvklraynprtaieclvvv 349
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------ 64
|
90
....*....|....*.
gi 299829255 350 PVSQASANQRAGRGGR 365
Cdd:smart00490 65 PWSPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
231-365 |
1.17e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 64.54 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 231 VETVVKIHQTEGDGDVLAFLTGQEEVETvvSMLIEqaralartgmKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVA 310
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEA--ELLLE----------KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVA 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 299829255 311 TNVAETSITISGIVYVIDCGFVklraYNPRTAIeclvvvpvsqasanQRAGRGGR 365
Cdd:pfam00271 71 TDVAERGLDLPDVDLVINYDLP----WNPASYI--------------QRIGRAGR 107
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
59-193 |
8.78e-09 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 55.96 E-value: 8.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 59 YLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYcIRFDDCTDQLA------TRIKFLTDGMLVREMMV 132
Cdd:smart00487 44 PALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGL-YGGDSKREQLRklesgkTDILVTTPGRLLDLLEN 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 299829255 133 DPL-LTKYSVIMLDEAHERT--LYTDIAIGLLKKIQKKRgdlRLIVASATL--DADKFRDFFNQNE 193
Cdd:smart00487 123 DKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV---QLLLLSATPpeEIENLLELFLNDP 185
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
136-376 |
2.13e-08 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 57.29 E-value: 2.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 136 LTKYSVIMLDEAHERTLYTDIAIGLLKkiqKKRGDLR-LIVASATL--DADKFRDFFNqnetsDPArdtcvILTVEGRT- 211
Cdd:PHA02653 289 LFDYGTVIIDEVHEHDQIGDIIIAVAR---KHIDKIRsLFLMTATLedDRDRIKEFFP-----NPA-----FVHIPGGTl 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 212 FPVDIFYL---QSPvPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETvVSMLIEQARALArtgmKRH--LRVLPMYA 286
Cdd:PHA02653 356 FPISEVYVknkYNP-KNKRAYIEEEKKNIVTALKKYTPPKGSSGIVFVAS-VSQCEEYKKYLE----KRLpiYDFYIIHG 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 287 GLPSFEQM--KVF--ERVSrsvrkVIVATNVAETSITISGIVYVIDCGfvklRAYNPRtaieclvvvP-------VSQAS 355
Cdd:PHA02653 430 KVPNIDEIleKVYssKNPS-----IIISTPYLESSVTIRNATHVYDTG----RVYVPE---------PfggkemfISKSM 491
|
250 260
....*....|....*....|.
gi 299829255 356 ANQRAGRGGRSRSGKCYRLYT 376
Cdd:PHA02653 492 RTQRKGRVGRVSPGTYVYFYD 512
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
230-380 |
2.70e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 44.09 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 230 TVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIE----------QARALARTGMKRHlrvlpmyaglpsfEQMKVFER 299
Cdd:PRK13766 352 LREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKegikavrfvgQASKDGDKGMSQK-------------EQIEILDK 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 300 VSRSVRKVIVATNVAETSITISGIVYVIdcgFvklraYNPrtaieclvvVPvSQASANQRAGRGGRSRSGKCYRLYTE-- 377
Cdd:PRK13766 419 FRAGEFNVLVSTSVAEEGLDIPSVDLVI---F-----YEP---------VP-SEIRSIQRKGRTGRQEEGRVVVLIAKgt 480
|
....*
gi 299829255 378 --EAF 380
Cdd:PRK13766 481 rdEAY 485
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
298-375 |
9.18e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.45 E-value: 9.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299829255 298 ERVSRSVrKVIVATNVAETSITISGIVYVIDCGFVKlraynprtaieclvvvpvSQASANQRAGRGGR--SRSGKCYRLY 375
Cdd:cd18785 17 EEIASSL-EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRggKDEGEVILFV 77
|
|
| |
