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Conserved domains on  [gi|294345400|ref|NP_001170870|]
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ethanol induced 1 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.19e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.19e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294345400    3 LVTYDDVHVNFTQEEWALLDASQKSLYKGVMVETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-458 1.32e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400  75 SEFIQCGKAFAYQSHSQRHERIHNGEKHCECNQCGKD--FGTRSILQRLKRTHTGEKPYEC----------------NHC 136
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 137 GKAFVESCTLQIHKRKHTGEKPYECNQCGKAFAQSCHLRIHKRTHTGEK-------PYECKQCGKAFAVSSHLGIHKRTH 209
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 210 TGEKPYECKQCGKAFAVSSHLGIHKRTHTGEKPYECKQCdkAFVRRGKLQIHKRTHTGeKPYECKQCGKAFAHSGTLQIH 289
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLS-SSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 290 KRTH----------TGEKPYECYQCGKAFATSCHLRRHNRT--HSGE--KQYEC--NQCGKAFASSSDLQKHKRTHTGDK 353
Cdd:COG5048  271 QSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 354 PYECK--QCGKAFASSSD------LQKHKRTHTgEKPYEC--KQCGKAFAESSTLQRHKRTHTGEKPYECK--QCGKAFA 421
Cdd:COG5048  351 PAKEKllNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 294345400 422 RSCHLQIHKRTHTGEKPYECKQCGKAFARSSHLRIHK 458
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.19e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.19e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294345400    3 LVTYDDVHVNFTQEEWALLDASQKSLYKGVMVETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.65e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 72.63  E-value: 3.65e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 294345400     4 VTYDDVHVNFTQEEWALLDASQKSLYKGVMVETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 2.23e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 2.23e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 294345400   4 VTYDDVHVNFTQEEWALLDASQKSLYKGVMVETYRNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-458 1.32e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400  75 SEFIQCGKAFAYQSHSQRHERIHNGEKHCECNQCGKD--FGTRSILQRLKRTHTGEKPYEC----------------NHC 136
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 137 GKAFVESCTLQIHKRKHTGEKPYECNQCGKAFAQSCHLRIHKRTHTGEK-------PYECKQCGKAFAVSSHLGIHKRTH 209
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 210 TGEKPYECKQCGKAFAVSSHLGIHKRTHTGEKPYECKQCdkAFVRRGKLQIHKRTHTGeKPYECKQCGKAFAHSGTLQIH 289
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLS-SSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 290 KRTH----------TGEKPYECYQCGKAFATSCHLRRHNRT--HSGE--KQYEC--NQCGKAFASSSDLQKHKRTHTGDK 353
Cdd:COG5048  271 QSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 354 PYECK--QCGKAFASSSD------LQKHKRTHTgEKPYEC--KQCGKAFAESSTLQRHKRTHTGEKPYECK--QCGKAFA 421
Cdd:COG5048  351 PAKEKllNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 294345400 422 RSCHLQIHKRTHTGEKPYECKQCGKAFARSSHLRIHK 458
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-422 1.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.79e-04
                          10        20
                  ....*....|....*....|....*
gi 294345400  398 LQRHKRTHTGEKPYECKQCGKAFAR 422
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.19e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.19e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294345400    3 LVTYDDVHVNFTQEEWALLDASQKSLYKGVMVETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.65e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 72.63  E-value: 3.65e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 294345400     4 VTYDDVHVNFTQEEWALLDASQKSLYKGVMVETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 2.23e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 2.23e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 294345400   4 VTYDDVHVNFTQEEWALLDASQKSLYKGVMVETYRNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-458 1.32e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400  75 SEFIQCGKAFAYQSHSQRHERIHNGEKHCECNQCGKD--FGTRSILQRLKRTHTGEKPYEC----------------NHC 136
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 137 GKAFVESCTLQIHKRKHTGEKPYECNQCGKAFAQSCHLRIHKRTHTGEK-------PYECKQCGKAFAVSSHLGIHKRTH 209
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 210 TGEKPYECKQCGKAFAVSSHLGIHKRTHTGEKPYECKQCdkAFVRRGKLQIHKRTHTGeKPYECKQCGKAFAHSGTLQIH 289
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLS-SSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 290 KRTH----------TGEKPYECYQCGKAFATSCHLRRHNRT--HSGE--KQYEC--NQCGKAFASSSDLQKHKRTHTGDK 353
Cdd:COG5048  271 QSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 354 PYECK--QCGKAFASSSD------LQKHKRTHTgEKPYEC--KQCGKAFAESSTLQRHKRTHTGEKPYECK--QCGKAFA 421
Cdd:COG5048  351 PAKEKllNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 294345400 422 RSCHLQIHKRTHTGEKPYECKQCGKAFARSSHLRIHK 458
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-469 1.49e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 157 KPYECNQCGKAFAQSCHLRIHKRTHTGEKPYEC--KQCGKAFAVSSHLGIHKRTHTGEKPYEC-KQCGKAFAVSSHLGIH 233
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 234 KRTHTGEKPYECKQCDKAFVRRGKLQIHKRTHTGEKPYECKQC-GKAFAHSGTLQIHKRTHTGEKPYECYQCGkafatsc 312
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNL------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 313 HLRRHNRTHSGEKQYECNQCGKAFASSSDLQKHKRTHTGDKPYECKQCGKAFASSSDLQKHKRTHTGEKPYECKQCGKAF 392
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 393 AESSTLQRHKRTHTGE-------KPYECKQCGKAFARSCHLQIHKRT--HTGE--KPYEC--KQCGKAFARSSHLRIHKR 459
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 294345400 460 THTGERPYEC 469
Cdd:COG5048  345 LHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-422 1.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.79e-04
                          10        20
                  ....*....|....*....|....*
gi 294345400  398 LQRHKRTHTGEKPYECKQCGKAFAR 422
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
395-470 2.18e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 395 SSTLQRHKRTHTGE----KPYECKQCGKAFARSCHLQIHKRTHTGEKPYEC--KQCGKAFARSSHLRIHKRTHTGERPYE 468
Cdd:COG5048   14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL 93


                 ..
gi 294345400 469 CN 470
Cdd:COG5048   94 NS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 6.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 294345400  425 HLQIHKRTHTGEKPYECKQCGKAFAR 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-393 6.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.72e-04
                          10        20
                  ....*....|....*....|....*
gi 294345400  369 DLQKHKRTHTGEKPYECKQCGKAFA 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 6.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 294345400  341 DLQKHKRTHTGDKPYECKQCGKAFAS 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-418 7.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 338 SSSDLQKHKRTHTG----DKPYECKQCGKAFASSSDLQKHKRTHTGEKPYEC--KQCGKAFAESSTLQRHKRTHTGEKPY 411
Cdd:COG5048   13 NSVLSSTPKSTLKSlsnaPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD 92


                 ....*..
gi 294345400 412 ECKQCGK 418
Cdd:COG5048   93 LNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-197 9.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.76e-04
                          10        20
                  ....*....|....*....|....*
gi 294345400  173 HLRIHKRTHTGEKPYECKQCGKAFA 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*
gi 294345400  258 LQIHKRTHTGEKPYECKQCGKAFAH 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 268-378 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 268 EKPYECKQCGKAFAHSGTLQIH---KRTHT-GEKPYEC--YQCGKAFATSCHLRRHnRTHSgekqyecnQCGKAFASSSD 341
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCpvEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPS 385

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 294345400 342 LQKHKRTHTGDKPYECKQCGKAFASSSDLQKHkRTHT 378
Cdd:COG5189  386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-170 1.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.67e-03
                          10        20
                  ....*....|....*....|....*
gi 294345400  146 LQIHKRKHTGEKPYECNQCGKAFAQ 170
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|....*
gi 294345400  286 LQIHKRTHTGEKPYECYQCGKAFAT 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 294345400  313 HLRRHNRTHSGEKQYECNQCGKAFAS 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-254 4.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.17e-03
                          10        20
                  ....*....|....*....|..
gi 294345400  233 HKRTHTGEKPYECKQCDKAFVR 254
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
366-446 4.50e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 4.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294345400 366 SSSDLQKHKRTHTGE----KPYECKQCGKAFAESSTLQRHKRTHTGEKPYEC--KQCGKAFARSCHLQIHKRTHTGEKPY 439
Cdd:COG5048   13 NSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD 92


                 ....*..
gi 294345400 440 ECKQCGK 446
Cdd:COG5048   93 LNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-225 7.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.68e-03
                          10        20
                  ....*....|....*....|.
gi 294345400  205 HKRTHTGEKPYECKQCGKAFA 225
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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