BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 135 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 213
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 281362037 214 LQVRG 218
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 135 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 213
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 281362037 214 LQVRG 218
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037   137 DVTLACEGETVKAHQTILSACSPYFETIFLQNQ--HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESL 214
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 281362037   215 QVRGLTD 221
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 135 LCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 213
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 281362037 214 LQVRG 218
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037   137 DVTLACEGETVKAHQTILSACSPYFETIFLQNQ--HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESL 214
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 281362037   215 QVRGLTD 221
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKG 195
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNlsEKENSEVEFQCIDETALQAIVEYAYTG 80

                         90       100
                 ....*....|....*....|..
gi 281362037 196 EVNVGQSSLPMFLKTAESLQVR 217
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 130 LQRE----ALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHP---IIYLKDVRYSEMRSLLDFMYKGEVNVGQS 202
Cdd:cd18293    6 LHRQqnsgVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGqkvVLELQGLKAHTLLKLVDFLYTSELEVSSE 85

                         90
                 ....*....|....*..
gi 281362037 203 SLPMFLKTAESLQVRGL 219
Cdd:cd18293   86 EAQDVLAAARRLQISEL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 114 RWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPiIYLKDVRYSEMRSLLD 190
Cdd:cd18266    4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigMREAHQKE-VELVGASYIGLKAVID 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 281362037 191 FMYKGEVNVGQSSLPMFLKTAESLQVRGLTD 221
Cdd:cd18266   83 FLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 125 VLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQS 202
Cdd:cd18238    5 VLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmaESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVD 84

                         90
                 ....*....|....
gi 281362037 203 SLPMFLKTAESLQV 216
Cdd:cd18238   85 NVQSLLYAASLLQV 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL-QNQHPHPIIYLKDVRYSE-MRSLLDFMYKG 195
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTdQLKNNVSVINLDPEIEPEgFRILLDFMYTS 81

                         90       100
                 ....*....|....*....|....*.
gi 281362037 196 EVNVGQSSLPMFLKTAESLQVRGLTD 221
Cdd:cd18215   82 RLNLREGNIMAVMATAMYLQMEHVVD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPIIyLKDVRYSEMRSLLDFMYK 194
Cdd:cd18249    6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgeLAESRQTEVT-IRDIDERAMELLIDFAYT 84

                         90       100
                 ....*....|....*....|....*..
gi 281362037 195 GEVNVGQSSLPMFLKTAESLQVRGLTD 221
Cdd:cd18249   85 SQITVEEGNVQTLLPAACLLQLAEIQE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 117 NHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHpHPIIYLKDVRYSEMRSLLDFMY 193
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFaggMSESS-KDVVQIHGVEPDIFHILLDFIY 80

                         90       100
                 ....*....|....*....|..
gi 281362037 194 KGEVNVGQSSLPMFLKTAESLQ 215
Cdd:cd18256   81 TGVVEVTVSNVQELLVAADMLQ 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 125 VLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL--QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQS 202
Cdd:cd18338   11 VMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTgeMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEE 90

                         90
                 ....*....|....*
gi 281362037 203 SLPMFLKTAESLQVR 217
Cdd:cd18338   91 NVQVLLPAAGLLQLQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQ-----NQHphpIIYLKDVRYSEMRSLLDFM 192
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmresSQD---EIELKGVSAKGLKHILDFA 77

                         90       100
                 ....*....|....*....|....
gi 281362037 193 YKGEVNVGQSSLPMFLKTAESLQV 216
Cdd:cd18255   78 YTSELTLDLDCIQDVLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 126 LTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF----LQNQHPHpiIYLKDVRYSEMRSLLDFMYKGEVNVGQ 201
Cdd:cd18246   30 MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFtnemSESRQTH--VTLHDIDPQALEQLVQYAYTAEIVVGE 107

                         90       100
                 ....*....|....*....|
gi 281362037 202 SSLPMFLKTAESLQVRGLTD 221
Cdd:cd18246  108 GNVQTLLPAASLLQLNGVRD 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 117 NHPTNLTGVLTSLLQREALCDVTLACEGETVK----AHQTILSACSPYFETIF---LQNQHPHpIIYLKDVRYSEMRSLL 189
Cdd:cd18248    3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQDPKeefmAHKVVLASSSPYFKAMFtsgLRECGME-VVPIEGVHPCVMSRLI 81

                         90       100
                 ....*....|....*....|....*..
gi 281362037 190 DFMYKGEVNVGQSSLPMFLKTAESLQV 216
Cdd:cd18248   82 EFAYTASISVGEKCVLHVLPGAVMYQM 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 125 VLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHP-HPIIY-LKDVRYSEMRSLLDFMYKGEVNVGQS 202
Cdd:cd18240    7 VFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNEtEKKVYkIPGVSPEMMELIIEYAYTRTVPITAE 86

                         90
                 ....*....|....*..
gi 281362037 203 SLPMFLKTAESLQVRGL 219
Cdd:cd18240   87 NVEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF---LQNQHPHPIIyLKDVRYSEMRSLLDFMYK 194
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFageLRESRADRVV-LHGVSAEILGLLLDFSYT 82

                         90       100
                 ....*....|....*....|.
gi 281362037 195 GEVNVGQSSLPMFLKTAESLQ 215
Cdd:cd18250   83 GRVTVTQDNVEALLRAADLFQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQnQHPHPIIYLKDVRYSEMRS---LLDFMYK 194
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSG-RVGEGVSVLTLPSGLEARGfqlLLDFMYT 80

                         90       100
                 ....*....|....*....|....*..
gi 281362037 195 GEVNVGQSSLPMFLKTAESLQVRGLTD 221
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYF-ETIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGE 196
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFlQALVGQTENDLVVSLPEEVTARGFGPLLQFAYTAK 93

                         90       100
                 ....*....|....*....|....*.
gi 281362037 197 VNVGQSSLPMFLKTAESLQVRGLTDN 222
Cdd:cd18278   94 LLLSRENIQEVIRCAEFLRMHNLEDS 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 131 QREALCDVTLACEGETVKAHQTILSACSPYFETiFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNV-GQSSLPMFLK 209
Cdd:cd18221   14 ELDQFTDITLIVDGHQFKAHKAVLAACSQFFYK-FFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVqGEEEANDVWK 92

                         90       100
                 ....*....|....*....|.
gi 281362037 210 TAESLQ----VRGLTDNNNLN 226
Cdd:cd18221   93 AAEYLQmqeaIKALEFRNKES 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLqNQHPHP---IIYLKDVRYSEMRSLLDFMYK 194
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC-NDHRESremLVEINGILAEAMDCFLQYVYT 79

                         90       100
                 ....*....|....*....|....*..
gi 281362037 195 GEVNVGQSSLPMFLKTAESLQVRGLTD 221
Cdd:cd18253   80 GKVKITTENVQYLFETSSLFQISPLRD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 120 TNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETI---FLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGE 196
Cdd:cd18330    3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALlihYIQDSGRHSTASLDIVTSEAFSIILDFLYSGK 82

                         90       100
                 ....*....|....*....|
gi 281362037 197 VNVGQSSLPMFLKTAESLQV 216
Cdd:cd18330   83 LDLCSENVIEVMSAASYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 118 HPTNLTGVLTSLLQ-------REALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKDVRysEMRSLLD 190
Cdd:cd18208    1 HSINLHNFSNSVLEtlneqrnRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQ--SVQKLID 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 281362037 191 FMYKGEVNVGQSSLPMFLKTAESLQVRGLTD 221
Cdd:cd18208   79 FMYSGVLRVSQSEALQILTAASILQIKTVID 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 130 LQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHpIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLK 209
Cdd:cd18226   17 QKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTD-AVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLE 95

                 ....*..
gi 281362037 210 TAESLQV 216
Cdd:cd18226   96 AAKFLDI 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 117 NHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPH---PIIYLKDVRYSEMRSLLDFMY 193
Cdd:cd18230    3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSdqaTVTHLDIVTAQGFKAIIDFMY 82

                         90       100
                 ....*....|....*....|...
gi 281362037 194 KGEVNVGQSSLPMFLKTAESLQV 216
Cdd:cd18230   83 SAHLALTSKNVIEVMSAASYLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 114 RWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIF------LQNQHphpiIYLKDVRYSEMRS 187
Cdd:cd18251    2 RSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFagglreMQQTE----VLIHGVSYNAMCK 77

                         90       100
                 ....*....|....*....|....*....
gi 281362037 188 LLDFMYKGEVNVGQSSLPMFLKTAESLQV 216
Cdd:cd18251   78 ILDFIYTSELELSLDNVQETLTAACQLQI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 136 CDVTLACEGETVKAHQTILSACSPYFETIFlQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEV--NVGQSSLPMFlkTAES 213
Cdd:cd18290   28 CDVSVVVKGHAFKAHRAVLAASSSYFRDLF-NSSRSAVVELPAAVQPQSFQQILSFCYTGRLsmNVGDQFLLMY--TAGF 104

                 ....*...
gi 281362037 214 LQVRGLTD 221
Cdd:cd18290  105 LQIQEIME 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 135 LCDVTLACEGETVKAHQTILSACSPYFETIFLQN--QHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAE 212
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDvrEATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                 ...
gi 281362037 213 SLQ 215
Cdd:cd18234   81 LLQ 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 136 CDVTLACEGETVKAHQTILSACSPYFETIFLQNqhpHPIIYLKDVRYSE-MRSLLDFMYKGEVNVGQSSLPMFLKTAESL 214
Cdd:cd18229   19 CDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLG---HSEIEVPPVVPAQtVRQLVEFMYSGSLVVAQSEALQILTAASIL 95

                 ....*..
gi 281362037 215 QVRGLTD 221
Cdd:cd18229   96 QIKTVID 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 135 LCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYL-KDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAES 213
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                 ....*...
gi 281362037 214 LQVRGLTD 221
Cdd:cd18955   81 LGVHNIEK 88

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362037 129 LLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL-------QNQHPHPIIYLKDvryseMRSLLDFMYKGEVNVGQ 201
Cdd:cd18263    7 LWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTsgmkestQSVVQLPTIPAKD-----LRLLISFAYSGILHLSW 81

                         90
                 ....*....|....*...
gi 281362037 202 SSLPMFLKTAESLQVRGL 219
Cdd:cd18263   82 ENLFEATCTALQLQISGA 99