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Conserved domains on  [gi|254692894|ref|NP_001157097|]
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sulfotransferase 6B1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
56-289 1.05e-65

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 206.43  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894   56 DDVLLASYPKCGSNWILHIVSELIFAVSKKKYACPEF-------PVLEC-------GDAEKYQRMKLFPSPRILTTHLHY 121
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnhnrsPFLEWypgdtyfDVAEGPVRLNALPSPRIIKTHLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  122 DKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINWNKHIDDENVKFI 201
Cdd:pfam00685  82 HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  202 LYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAI----GPFlFRKGEVGDWKRLFNETQNQE 277
Cdd:pfam00685 162 RYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLpkevSPF-FRKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|..
gi 254692894  278 MDERFKECLAGT 289
Cdd:pfam00685 241 FDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
56-289 1.05e-65

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 206.43  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894   56 DDVLLASYPKCGSNWILHIVSELIFAVSKKKYACPEF-------PVLEC-------GDAEKYQRMKLFPSPRILTTHLHY 121
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnhnrsPFLEWypgdtyfDVAEGPVRLNALPSPRIIKTHLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  122 DKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINWNKHIDDENVKFI 201
Cdd:pfam00685  82 HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  202 LYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAI----GPFlFRKGEVGDWKRLFNETQNQE 277
Cdd:pfam00685 162 RYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLpkevSPF-FRKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|..
gi 254692894  278 MDERFKECLAGT 289
Cdd:pfam00685 241 FDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 45-291 5.30e-25

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 102.69  E-value: 5.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  45 FRALDAFEARSDDVLLASYPKCGSNWIlhivSELIFA-VSKKKYACPEFPVLECGDAEKYQRMKL----FPSPRIL---- 115
Cdd:PLN02164  69 LHAQEFFQARPNDFLVCSYPKTGTTWL----KALTFAiANRSRFDDSSNPLLKRNPHEFVPYIEIdfpfFPSVDVLkdkg 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894 116 ----TTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHF-HNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAIN-W 189
Cdd:PLN02164 145 ntlfSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyW 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894 190 NKHIDDEN-VKFILYEDLKENLVVGIKQISEFLGFSLTDEQIE--------TISTQSTFLAMRANSQETHGAIGPFL--- 257
Cdd:PLN02164 225 KAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEkgvvekvvKLCSFETLKNLEANKGEKDREDRPAVyan 304

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 254692894 258 ---FRKGEVGDWKRLFNETQNQEMDERFKECLAGTSL 291
Cdd:PLN02164 305 sayFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
56-289 1.05e-65

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 206.43  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894   56 DDVLLASYPKCGSNWILHIVSELIFAVSKKKYACPEF-------PVLEC-------GDAEKYQRMKLFPSPRILTTHLHY 121
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnhnrsPFLEWypgdtyfDVAEGPVRLNALPSPRIIKTHLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  122 DKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINWNKHIDDENVKFI 201
Cdd:pfam00685  82 HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  202 LYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAI----GPFlFRKGEVGDWKRLFNETQNQE 277
Cdd:pfam00685 162 RYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLpkevSPF-FRKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|..
gi 254692894  278 MDERFKECLAGT 289
Cdd:pfam00685 241 FDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 45-291 5.30e-25

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 102.69  E-value: 5.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  45 FRALDAFEARSDDVLLASYPKCGSNWIlhivSELIFA-VSKKKYACPEFPVLECGDAEKYQRMKL----FPSPRIL---- 115
Cdd:PLN02164  69 LHAQEFFQARPNDFLVCSYPKTGTTWL----KALTFAiANRSRFDDSSNPLLKRNPHEFVPYIEIdfpfFPSVDVLkdkg 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894 116 ----TTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHF-HNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAIN-W 189
Cdd:PLN02164 145 ntlfSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyW 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894 190 NKHIDDEN-VKFILYEDLKENLVVGIKQISEFLGFSLTDEQIE--------TISTQSTFLAMRANSQETHGAIGPFL--- 257
Cdd:PLN02164 225 KAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEkgvvekvvKLCSFETLKNLEANKGEKDREDRPAVyan 304

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 254692894 258 ---FRKGEVGDWKRLFNETQNQEMDERFKECLAGTSL 291
Cdd:PLN02164 305 sayFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
133-227 3.98e-05

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 43.43  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692894  133 AKILVIFRNPKDTAVS----FFHFHNdvpdipsyASWDEFFRQFIKGQVS-W-GSYFDFAINWNKhIDDENVKFILYEDL 206
Cdd:pfam13469  82 AKFIHLHRDPVDTVISsycsLFGFTL--------SSYSTAFLRDIGLALArWsRAYERLMAARAR-VPPGRFLDVRYEDL 152

                          90       100
                  ....*....|....*....|.
gi 254692894  207 KENLVVGIKQISEFLGFSLTD 227
Cdd:pfam13469 153 VADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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