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Conserved domains on  [gi|226958478|ref|NP_001152994|]
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putative zinc finger protein 727 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.70e-34

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 123.47  E-value: 1.70e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958478     4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLGLAIFKPDLITYLEQRKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 392-477 8.55e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 8.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 392 GEKPYKCE--ECGKSFTcSSNLIKHKRIHMEVRPYKCEEcgktfkwfPDLTNHKRIHTGEKPYKCEECGKTFTCSSSLiK 469
Cdd:COG5189  346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHGHQNQKLHEN--------PSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                 ....*...
gi 226958478 470 HKRSHTGD 477
Cdd:COG5189  416 YHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-465 1.07e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 296 CSDLTKHKRIHTgekPYKCNECGKAFMWISALSQHNR--IHTGE--KPYICEE--CGKAFTYSSTLISHKRIHMELRPYK 369
Cdd:COG5048  277 ESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 370 C--EECGKTF-----KWFSDLTNHKRIHTGEKPYKCE--ECGKSFTCSSNLIKHKRIHMEVRP--YKCEECGKTFKWFPD 438
Cdd:COG5048  354 EklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        170       180
                 ....*....|....*....|....*..
gi 226958478 439 LTNHKRIHTGEKPYKCEECGKTFTCSS 465
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 2.47e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 226958478  270 DLTKHKRIHTGEKPYKCKECHKAFRC 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-267 1.30e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958478  242 ALTKHKRNHTGDRPYKCEECHKAFRC 267
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-239 1.43e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958478  214 NLTEHNRVHTGKKPYKCEECGKTFTC 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.70e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 123.47  E-value: 1.70e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958478     4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLGLAIFKPDLITYLEQRKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.06e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.06e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 226958478    3 VLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.59e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.21  E-value: 8.59e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 226958478   4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 392-477 8.55e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 8.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 392 GEKPYKCE--ECGKSFTcSSNLIKHKRIHMEVRPYKCEEcgktfkwfPDLTNHKRIHTGEKPYKCEECGKTFTCSSSLiK 469
Cdd:COG5189  346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHGHQNQKLHEN--------PSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                 ....*...
gi 226958478 470 HKRSHTGD 477
Cdd:COG5189  416 YHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-465 1.07e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 296 CSDLTKHKRIHTgekPYKCNECGKAFMWISALSQHNR--IHTGE--KPYICEE--CGKAFTYSSTLISHKRIHMELRPYK 369
Cdd:COG5048  277 ESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 370 C--EECGKTF-----KWFSDLTNHKRIHTGEKPYKCE--ECGKSFTCSSNLIKHKRIHMEVRP--YKCEECGKTFKWFPD 438
Cdd:COG5048  354 EklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        170       180
                 ....*....|....*....|....*..
gi 226958478 439 LTNHKRIHTGEKPYKCEECGKTFTCSS 465
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-407 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 226958478  382 DLTNHKRIHTGEKPYKCEECGKSFTC 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 2.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 226958478  270 DLTKHKRIHTGEKPYKCKECHKAFRC 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-321 5.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.26e-04
                          10        20
                  ....*....|....*....|....
gi 226958478  298 DLTKHKRIHTGEKPYKCNECGKAF 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-267 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958478  242 ALTKHKRNHTGDRPYKCEECHKAFRC 267
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-239 1.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958478  214 NLTEHNRVHTGKKPYKCEECGKTFTC 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.70e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 123.47  E-value: 1.70e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958478     4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLGLAIFKPDLITYLEQRKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.06e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.06e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 226958478    3 VLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.59e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.21  E-value: 8.59e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 226958478   4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 392-477 8.55e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 8.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 392 GEKPYKCE--ECGKSFTcSSNLIKHKRIHMEVRPYKCEEcgktfkwfPDLTNHKRIHTGEKPYKCEECGKTFTCSSSLiK 469
Cdd:COG5189  346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHGHQNQKLHEN--------PSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                 ....*...
gi 226958478 470 HKRSHTGD 477
Cdd:COG5189  416 YHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
296-465 1.07e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 296 CSDLTKHKRIHTgekPYKCNECGKAFMWISALSQHNR--IHTGE--KPYICEE--CGKAFTYSSTLISHKRIHMELRPYK 369
Cdd:COG5048  277 ESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 370 C--EECGKTF-----KWFSDLTNHKRIHTGEKPYKCE--ECGKSFTCSSNLIKHKRIHMEVRP--YKCEECGKTFKWFPD 438
Cdd:COG5048  354 EklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        170       180
                 ....*....|....*....|....*..
gi 226958478 439 LTNHKRIHTGEKPYKCEECGKTFTCSS 465
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-475 1.13e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 338 KPYICEECGKAFTYSSTLISHKR--IH--MELRPYKCEE--CGKTFKWFSDLTNHKRIHTGEKPYKC--EECGKSFTCSS 409
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226958478 410 NLIKHKRIHMEVRP----YKCEECGKTFKWFPD---LTNHKRIHTGEKP--YKCEECGKTFTCSSSLIKHKRSHT 475
Cdd:COG5048  368 NNEPPQSLQQYKDLkndkKSETLSNSCIRNFKRdsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-409 1.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 226 KPYKCEECGKTFTCSSALTKHKR--NHTG--DRPYKCEE--CHKAFRCCSDLTKHKRIHTGEKPYKCKECHkafrccsDL 299
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLN-------SS 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 300 TKHKRIHTGEKPykcnecgkafmwisALSQHNRIHTGEKPYICE--ECGKAFTYSSTLISHKRIHMELRP--YKCEECGK 375
Cdd:COG5048  361 SKFSPLLNNEPP--------------QSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                        170       180       190
                 ....*....|....*....|....*....|....
gi 226958478 376 TFKWFSDLTNHKRIHTGEKPYKCEECGKSFTCSS 409
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-433 1.85e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 268 CSDLTKHKRIHTgekPYKCKECHKAFRCCSDLTKHKR--IHTGE--KPYKCNE--CGKAFMWISALSQHNRIHTGEKPYI 341
Cdd:COG5048  277 ESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 342 CEEC------GKAFTYSSTLISHKRIHMELRPYKCEECGKTFKWFSD---LTNHKRIHTGEKP--YKCEECGKSFTCSSN 410
Cdd:COG5048  354 EKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdsnLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                        170       180
                 ....*....|....*....|...
gi 226958478 411 LIKHKRIHMEVRPYKCEECGKTF 433
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
196-466 4.11e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 196 ADRSYKCEECGKACKKFSNLTEHNRVHTGKKPYKC--EECGKTFTCSSALTKHKRNHTGD----------------RPYK 257
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskaSSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 258 CEECHKAFR----CCSDLTKHKRIHTGEKPY---------KCKECHKAFR----------------------CCSDLTKH 302
Cdd:COG5048  110 LSSSSSNSNdnnlLSSHSLPPSSRDPQLPDLlsisnlrnnPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 303 KRIHTGEKPYKCNECGKAFMWISALSQHNRIHTGEKPYICEECGKAFTYSSTLISHKRIHMELRPYKCEECGKTFK--WF 380
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 381 SDLTNHKRIHTGE-----KPYKCEECGKSFTCSSNLIKHKR--IH--MEVRPYKCEE--CGKTFKWFPDLTNHKRIHTGE 449
Cdd:COG5048  270 SQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330
                 ....*....|....*..
gi 226958478 450 KPYKCeecgKTFTCSSS 466
Cdd:COG5048  350 SPAKE----KLLNSSSK 362
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-407 2.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 226958478  382 DLTNHKRIHTGEKPYKCEECGKSFTC 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 2.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 226958478  270 DLTKHKRIHTGEKPYKCKECHKAFRC 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-463 3.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 226958478  438 DLTNHKRIHTGEKPYKCEECGKTFTC 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-321 5.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.26e-04
                          10        20
                  ....*....|....*....|....
gi 226958478  298 DLTKHKRIHTGEKPYKCNECGKAF 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 363-443 9.13e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958478 363 MELRPYKCE--ECGKTFKWFSDLTNHKrihtgekpyKCEECGKSFTCSSNLIKHKRIHMEVRPYKCEECGKTFKWFPDLT 440
Cdd:COG5189  345 KDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ...
gi 226958478 441 NHK 443
Cdd:COG5189  416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-267 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958478  242 ALTKHKRNHTGDRPYKCEECHKAFRC 267
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-239 1.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958478  214 NLTEHNRVHTGKKPYKCEECGKTFTC 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
422-477 2.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 226958478 422 RPYKCEECGKTFKWFPDLTNHKRIHTGEKPYKC--EECGKTFTCSSSLIKHKRSHTGD 477
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNN 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-434 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 226958478  410 NLIKHKRIHMEVRPYKCEECGKTFK 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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