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Conserved domains on  [gi|226423909|ref|NP_001139790|]
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2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 1 [Mus musculus]

Protein Classification

NUDIX hydrolase( domain architecture ID 13597307)

NUDIX hydrolase catalyzes the hydrolysis of nucleoside diphosphates linked to other moieties (X); it requires a divalent cation, such as Mg2+ or Mn2+ for its activity; contains an AAA domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNPase pfam05881
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the ...
 165-378 1.32e-147

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.


:

Pssm-ID: 461769  Cd Length: 214  Bit Score: 416.93  E-value: 1.32e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  165 LPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGA 244
Cdd:pfam05881   1 LPLYFGWFLTKKSSEALRKTGQVFLEELGNHKAFKKELRHFQSGDEPKEKIDLTSYFGKRPPGVLHCTTKFCDYGKAPGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  245 EEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTG 324
Cdd:pfam05881  81 EEYAQQDVVKKSYGKAFTLSISALFVTPKTVGARVELNEQQLALWPADVDKLSPSDSLPKGSRAHVTLGCASDVEAVQTG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226423909  325 LDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 378
Cdd:pfam05881 161 LDLLEIVKLEKGGSQGEEVGELGRGKLQSLGNGRWMLSLAKKIEVRAIFSGYYG 214
COG4639 super family cl44097
Predicted kinase [General function prediction only];
30-127 2.37e-13

Predicted kinase [General function prediction only];


The actual alignment was detected with superfamily member COG4639:

Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 66.78  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  30 KTLFILRGLPGSGKSTLARlileKYHDGTKMVSADAY----KIIPGSRADFSEAYKRLDEDLAGYCRRDiRVLVLDDTNH 105
Cdd:COG4639    2 LSLVVLIGLPGSGKSTFAR----RLFAPTEVVSSDDIrallGGDENDQSAWGDVFQLAHEIARARLRAG-RLTVVDATNL 76

                         90       100
                 ....*....|....*....|..
gi 226423909 106 ERERLDQLFEMADQYQYQVVLV 127
Cdd:COG4639   77 QREARRRLLALARAYGALVVAV 98
 
Name Accession Description Interval E-value
CNPase pfam05881
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the ...
 165-378 1.32e-147

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.


Pssm-ID: 461769  Cd Length: 214  Bit Score: 416.93  E-value: 1.32e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  165 LPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGA 244
Cdd:pfam05881   1 LPLYFGWFLTKKSSEALRKTGQVFLEELGNHKAFKKELRHFQSGDEPKEKIDLTSYFGKRPPGVLHCTTKFCDYGKAPGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  245 EEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTG 324
Cdd:pfam05881  81 EEYAQQDVVKKSYGKAFTLSISALFVTPKTVGARVELNEQQLALWPADVDKLSPSDSLPKGSRAHVTLGCASDVEAVQTG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226423909  325 LDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 378
Cdd:pfam05881 161 LDLLEIVKLEKGGSQGEEVGELGRGKLQSLGNGRWMLSLAKKIEVRAIFSGYYG 214
COG4639 COG4639
Predicted kinase [General function prediction only];
30-127 2.37e-13

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 66.78  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  30 KTLFILRGLPGSGKSTLARlileKYHDGTKMVSADAY----KIIPGSRADFSEAYKRLDEDLAGYCRRDiRVLVLDDTNH 105
Cdd:COG4639    2 LSLVVLIGLPGSGKSTFAR----RLFAPTEVVSSDDIrallGGDENDQSAWGDVFQLAHEIARARLRAG-RLTVVDATNL 76

                         90       100
                 ....*....|....*....|..
gi 226423909 106 ERERLDQLFEMADQYQYQVVLV 127
Cdd:COG4639   77 QREARRRLLALARAYGALVVAV 98
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 32-145 1.64e-09

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 55.78  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909   32 LFILRGLPGSGKSTLARLILEKYhdGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVlVLDD 102
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEEL--GAVRLSSDDErkrlfgegrPSISYYTDATDRTYERLHELARIALRAGRPV-ILDA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 226423909  103 TN---HERERLDQLFEmadQYQYQVVLVEPKTAWrldcAQLKEKNQ 145
Cdd:pfam13671  78 TNlrrDERARLLALAR---EYGVPVRIVVFEAPE----EVLRERLA 116
pseT PHA02530
polynucleotide kinase; Provisional
 30-127 1.16e-05

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 46.55  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  30 KTLFILRGLPGSGKSTLARLILEKyHDGTKMVSADAYKII---PGSRADFSeaYKRLDEDLAGYCRRDIRVL-------- 98
Cdd:PHA02530   2 MKIILTVGVPGSGKSTWAREFAAK-NPKAVNVNRDDLRQSlfgHGEWGEYK--FTKEKEDLVTKAQEAAALAalksgksv 78

                         90       100
                 ....*....|....*....|....*....
gi 226423909  99 VLDDTNHERERLDQLFEMADQYQYQVVLV 127
Cdd:PHA02530  79 IISDTNLNPERRRKWKELAKELGAEFEEK 107
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 34-102 2.78e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.82  E-value: 2.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909    34 ILRGLPGSGKSTLARLI---LEKYHDGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVLVLD 101
Cdd:smart00382   6 LIVGPPGSGKTTLARALareLGPPGGGVIYIDGEDIleevldqllLIIVGGKKASGSGELRLRLALALARKLKPDVLILD 85


                   .
gi 226423909   102 D 102
Cdd:smart00382  86 E 86
 
Name Accession Description Interval E-value
CNPase pfam05881
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the ...
 165-378 1.32e-147

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase); This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.


Pssm-ID: 461769  Cd Length: 214  Bit Score: 416.93  E-value: 1.32e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  165 LPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGA 244
Cdd:pfam05881   1 LPLYFGWFLTKKSSEALRKTGQVFLEELGNHKAFKKELRHFQSGDEPKEKIDLTSYFGKRPPGVLHCTTKFCDYGKAPGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  245 EEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTG 324
Cdd:pfam05881  81 EEYAQQDVVKKSYGKAFTLSISALFVTPKTVGARVELNEQQLALWPADVDKLSPSDSLPKGSRAHVTLGCASDVEAVQTG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226423909  325 LDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 378
Cdd:pfam05881 161 LDLLEIVKLEKGGSQGEEVGELGRGKLQSLGNGRWMLSLAKKIEVRAIFSGYYG 214
COG4639 COG4639
Predicted kinase [General function prediction only];
30-127 2.37e-13

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 66.78  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  30 KTLFILRGLPGSGKSTLARlileKYHDGTKMVSADAY----KIIPGSRADFSEAYKRLDEDLAGYCRRDiRVLVLDDTNH 105
Cdd:COG4639    2 LSLVVLIGLPGSGKSTFAR----RLFAPTEVVSSDDIrallGGDENDQSAWGDVFQLAHEIARARLRAG-RLTVVDATNL 76

                         90       100
                 ....*....|....*....|..
gi 226423909 106 ERERLDQLFEMADQYQYQVVLV 127
Cdd:COG4639   77 QREARRRLLALARAYGALVVAV 98
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 32-145 1.64e-09

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 55.78  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909   32 LFILRGLPGSGKSTLARLILEKYhdGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVlVLDD 102
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEEL--GAVRLSSDDErkrlfgegrPSISYYTDATDRTYERLHELARIALRAGRPV-ILDA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 226423909  103 TN---HERERLDQLFEmadQYQYQVVLVEPKTAWrldcAQLKEKNQ 145
Cdd:pfam13671  78 TNlrrDERARLLALAR---EYGVPVRIVVFEAPE----EVLRERLA 116
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 31-129 6.38e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 49.34  E-value: 6.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  31 TLFILRGLPGSGKSTLARLI---LEKYHDGTKMVSADAYKIIPGSRADFSEAYKRLDEDLAGYCRRDIR----VLVLDDT 103
Cdd:COG4088    5 MLLILTGPPGSGKTTFAKALaqrLYAEGIAVALLHSDDFRRFLVNESFPKETYEEVVEDVRTTTADNALdngySVIVDGT 84

                         90       100
                 ....*....|....*....|....*..
gi 226423909 104 NHERERLDQLFEMA-DQYQYQVVLVEP 129
Cdd:COG4088   85 FYYRSWQRDFRNLAkHKAPIHIIYLKA 111
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
32-128 1.09e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 48.37  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  32 LFILRGLPGSGKSTLARLILEKYhdGTKMVSADA-----YKIIPGSRADFSEA----YKRLDEDLAGYCRRDIRVlVLDD 102
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAERL--GAVRLRSDVvrkrlFGAGLAPLERSPEAtartYARLLALARELLAAGRSV-ILDA 77

                         90       100
                 ....*....|....*....|....*.
gi 226423909 103 TNHERERLDQLFEMADQYQYQVVLVE 128
Cdd:COG0645   78 TFLRRAQREAFRALAEEAGAPFVLIW 103
pseT PHA02530
polynucleotide kinase; Provisional
 30-127 1.16e-05

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 46.55  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909  30 KTLFILRGLPGSGKSTLARLILEKyHDGTKMVSADAYKII---PGSRADFSeaYKRLDEDLAGYCRRDIRVL-------- 98
Cdd:PHA02530   2 MKIILTVGVPGSGKSTWAREFAAK-NPKAVNVNRDDLRQSlfgHGEWGEYK--FTKEKEDLVTKAQEAAALAalksgksv 78

                         90       100
                 ....*....|....*....|....*....
gi 226423909  99 VLDDTNHERERLDQLFEMADQYQYQVVLV 127
Cdd:PHA02530  79 IISDTNLNPERRRKWKELAKELGAEFEEK 107
PRK04182 PRK04182
cytidylate kinase; Provisional
 37-63 2.64e-04

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 41.33  E-value: 2.64e-04
                         10        20
                 ....*....|....*....|....*..
gi 226423909  37 GLPGSGKSTLARLILEKYhdGTKMVSA 63
Cdd:PRK04182   7 GPPGSGKTTVARLLAEKL--GLKHVSA 31
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 34-102 2.78e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.82  E-value: 2.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909    34 ILRGLPGSGKSTLARLI---LEKYHDGTKMVSADAY---------KIIPGSRADFSEAYKRLDEDLAGYCRRDIRVLVLD 101
Cdd:smart00382   6 LIVGPPGSGKTTLARALareLGPPGGGVIYIDGEDIleevldqllLIIVGGKKASGSGELRLRLALALARKLKPDVLILD 85


                   .
gi 226423909   102 D 102
Cdd:smart00382  86 E 86
AAA_18 pfam13238
AAA domain;
34-134 4.00e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 40.10  E-value: 4.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226423909   34 ILRGLPGSGKSTLARLILEKYHDGTKMVSADAYKIIPGSRADFSEAYKRLDEDLAGYCRRDIR---------VLVLDDTn 104
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEenaaleeggNLIIDGH- 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 226423909  105 hereRLDQLFEMADQYQYQVVLVEPKTAWR 134
Cdd:pfam13238  81 ----LAELEPERAKDLVGIVLRASPEELLE 106
PRK06762 PRK06762
hypothetical protein; Provisional
 31-64 7.44e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 39.95  E-value: 7.44e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 226423909  31 TLFILRGLPGSGKSTLARLILEKYHDGTKMVSAD 64
Cdd:PRK06762   3 TLIIIRGNSGSGKTTIAKQLQERLGRGTLLVSQD 36
COG4185 COG4185
Predicted ABC-type ATPase or kinase [General function prediction only];
30-65 3.18e-03

Predicted ABC-type ATPase or kinase [General function prediction only];


Pssm-ID: 443339  Cd Length: 197  Bit Score: 38.33  E-value: 3.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 226423909  30 KTLFILRGLPGSGKSTLARLILEKYHDGTKMVSADA 65
Cdd:COG4185    4 PRLYIIAGPNGAGKSTFARTILPEELGGLEFVNADL 39
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 30-99 7.72e-03

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 37.34  E-value: 7.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226423909   30 KTLFILRGLPGSGKSTLARLILEK--YHDGTKMVSADAYK-IIPgsraDFSEAYKRLDEDLAGYCRRDIRVLV 99
Cdd:pfam06414  11 PKAILLGGQPGAGKTELARALLDElgRQGNVVRIDPDDFReLHP----HYRELQAADPKTASEYTQPDASRWV 79
AAA_17 pfam13207
AAA domain;
37-63 8.13e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 36.45  E-value: 8.13e-03
                          10        20
                  ....*....|....*....|....*..
gi 226423909   37 GLPGSGKSTLARLILEKYhdGTKMVSA 63
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKL--GFPHISA 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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