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Conserved domains on  [gi|225543116|ref|NP_001139417|]
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solute carrier organic anion transporter family member 1C1 isoform 3 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
42-530 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17459:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 498  Bit Score: 795.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17459    1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKYER-YSPSSNSTLSISPCLLESSSQLPVsvMEKSKSKISN------------------------ 176
Cdd:cd17459   81 GTFLIALPHFFMGRYKYETaIQSSSNSTVSISPCSLEPSPQLHS--IESSDSKTGTgcekepgssmwiyvflgnllrgig 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 177 -------------------------GCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLI 231
Cdd:cd17459  159 etpvqplgisyiddfakeenaafyiGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 232 AGIISLLAAVPFWYLPKSLPRsqsredsnsssekskfiiddhtdyqtpqgenakimemarDFLPSLKNLFGNPVYFLYLC 311
Cdd:cd17459  239 AGVITLLSAVPFWFLPKSLPK---------------------------------------DFLPSLKNLLGNPVYFLYLC 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 312 TSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFL 391
Cdd:cd17459  280 TSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLL 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 392 SLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYN 471
Cdd:cd17459  360 SFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHN 439
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 225543116 472 CTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRC 530
Cdd:cd17459  440 CSCIGIPSSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
 
Name Accession Description Interval E-value
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
42-530 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 795.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17459    1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKYER-YSPSSNSTLSISPCLLESSSQLPVsvMEKSKSKISN------------------------ 176
Cdd:cd17459   81 GTFLIALPHFFMGRYKYETaIQSSSNSTVSISPCSLEPSPQLHS--IESSDSKTGTgcekepgssmwiyvflgnllrgig 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 177 -------------------------GCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLI 231
Cdd:cd17459  159 etpvqplgisyiddfakeenaafyiGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 232 AGIISLLAAVPFWYLPKSLPRsqsredsnsssekskfiiddhtdyqtpqgenakimemarDFLPSLKNLFGNPVYFLYLC 311
Cdd:cd17459  239 AGVITLLSAVPFWFLPKSLPK---------------------------------------DFLPSLKNLLGNPVYFLYLC 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 312 TSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFL 391
Cdd:cd17459  280 TSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLL 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 392 SLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYN 471
Cdd:cd17459  360 SFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHN 439
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 225543116 472 CTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRC 530
Cdd:cd17459  440 CSCIGIPSSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
44-589 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 595.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116   44 VFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGT 123
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  124 LLIAMPQFFMeqykyeryspssnstLSISPCLL---ESSSQ-LPVSVME----KSKSKISNGCVQTVAIIGPIFGFLLGS 195
Cdd:pfam03137  81 LLFALPHFLS---------------FFLGQLLLgigGTPIYtLGISYIDdnvkKKNSPLYLGILYAVRVLGPALGFLLGS 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  196 LCAKLYVDIGFVNldhITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTD 275
Cdd:pfam03137 146 LCLRIYVDIGKVS---ITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKT 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  276 YQtpqgeNAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVA 355
Cdd:pfam03137 223 KS-----LKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAA 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  356 LGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSyheRALFSDCNSRCKCSE 435
Cdd:pfam03137 298 LGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCST 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  436 TKWEPMCGENG-ITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCqkDNGCPQMFLYFLVISVITSY 514
Cdd:pfam03137 375 SAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCSCGSQDSGGNGSATPGKC--PSDCSNKLPPFLALLFLASF 452
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225543116  515 TLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGfKRCGSRGSCRLYDSNVF 589
Cdd:pfam03137 453 FSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALIDSTCLLWG-KTCGGRGNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
40-617 2.61e-174

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 510.81  E-value: 2.61e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116   40 GELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIM 119
Cdd:TIGR00805  29 SKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIM 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  120 GVGTLLIAMPQFFMEQYKYERySPSSNSTLSISPCLL--ESSSQ------------------------------------ 161
Cdd:TIGR00805 109 GLGSLLSSLPHFLMGRYSYST-TVSSTGNLSSANSFLcmENLTQtlrptqdpsecqkqhkslmwllflvsnilrgigatp 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  162 ---LPVSVME----KSKSKISNGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGI 234
Cdd:TIGR00805 188 ifpLGISYIDdfakSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGF 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  235 ISLLAAVPFWYLPKSLPRSQSRED--------SNSSSEKSKFIIDDHTdyqtpqgenakimemaRDFLPSLKNLFGNPVY 306
Cdd:TIGR00805 268 VALLTSIPLFFFPKTLPKEGKRVNvdvheaekLEKSRGEDRKKNSGIT----------------KDFPKFIKRLLCNKIY 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  307 FLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFG 386
Cdd:TIGR00805 332 MLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLE 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  387 YLLFLSLFALGCENSDVAGLTV-SYQGTKPVsyherALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGK 465
Cdd:TIGR00805 412 YLLYSPKFLITCESAPVAGVNNpSNDQPLYV-----ENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGS 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  466 NIIFYNCTCVgiaaSKSGNSSGIVGRCqkDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTL 545
Cdd:TIGR00805 487 NMVFTNCSCI----QTPGNSSAKKGLC--DPPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWF 560
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543116  546 AIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKK 617
Cdd:TIGR00805 561 CIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
46-397 5.54e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.69  E-value: 5.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  46 LCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLL 125
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 126 IAMpqffmeqykyerySPSSNSTL------SISPCLLESSSQ-LPVSVMEKSKSKISNGCVQTVAIIGPIFGFLLGSLCA 198
Cdd:COG2814   92 CAL-------------APSLWLLLaarflqGLGAGALFPAALaLIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 199 klyvdigfvnldhititpkdpQWVGaWWLGYLIAGIISLLAAVPFW-YLPKSLPRSQSRedsnsssekskfiiddhtdyq 277
Cdd:COG2814  159 ---------------------DLFG-WRWVFLVNAVLALLALLLLLrLLPESRPAARAR--------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 278 tpqgenakimemardFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALG 357
Cdd:COG2814  196 ---------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA 260
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 225543116 358 IFSGGIVMKKFR---------ISVCGAAKLYLGSSVFGYLLFLSLFALG 397
Cdd:COG2814  261 LLAGRLADRFGRrrllligllLLALGLLLLALAGSLWLLLLALFLLGFG 309
 
Name Accession Description Interval E-value
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
42-530 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 795.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17459    1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKYER-YSPSSNSTLSISPCLLESSSQLPVsvMEKSKSKISN------------------------ 176
Cdd:cd17459   81 GTFLIALPHFFMGRYKYETaIQSSSNSTVSISPCSLEPSPQLHS--IESSDSKTGTgcekepgssmwiyvflgnllrgig 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 177 -------------------------GCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLI 231
Cdd:cd17459  159 etpvqplgisyiddfakeenaafyiGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 232 AGIISLLAAVPFWYLPKSLPRsqsredsnsssekskfiiddhtdyqtpqgenakimemarDFLPSLKNLFGNPVYFLYLC 311
Cdd:cd17459  239 AGVITLLSAVPFWFLPKSLPK---------------------------------------DFLPSLKNLLGNPVYFLYLC 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 312 TSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFL 391
Cdd:cd17459  280 TSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLL 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 392 SLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYN 471
Cdd:cd17459  360 SFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHN 439
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 225543116 472 CTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRC 530
Cdd:cd17459  440 CSCIGIPSSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
42-529 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 651.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17400    1 LKMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKYeryspSSNSTLSISPCLLESSSQLPVSVM---------EKSKSKISNGCVQTVAIIGPIFGFL 192
Cdd:cd17400   81 GCFLKALPHFFMNQYEY-----SLMWIYVFVGNILRGIGETPILPLgisyiddfaKEENSPLYIGLVETGAIIGPIIGFL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 193 LGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPkslprsqsredsnsssekskfiidd 272
Cdd:cd17400  156 LGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVLTAIPFFFLP------------------------- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 273 htdyqtpqgenakimemardflpslknlfgnPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIP 352
Cdd:cd17400  211 -------------------------------PIYMLFILVSVIQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIP 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 353 AVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCK 432
Cdd:cd17400  260 PIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCN 339
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 433 CSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVIT 512
Cdd:cd17400  340 CPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSCIQTSGNSSANLSLCDGGCPRDPDCSLMFQYFLIISVMS 419
                        490
                 ....*....|....*..
gi 225543116 513 SYTLSLGGIPGYILLLR 529
Cdd:cd17400  420 SFIYSLGGIPGYMLLLR 436
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
44-589 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 595.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116   44 VFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGT 123
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  124 LLIAMPQFFMeqykyeryspssnstLSISPCLL---ESSSQ-LPVSVME----KSKSKISNGCVQTVAIIGPIFGFLLGS 195
Cdd:pfam03137  81 LLFALPHFLS---------------FFLGQLLLgigGTPIYtLGISYIDdnvkKKNSPLYLGILYAVRVLGPALGFLLGS 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  196 LCAKLYVDIGFVNldhITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTD 275
Cdd:pfam03137 146 LCLRIYVDIGKVS---ITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKT 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  276 YQtpqgeNAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVA 355
Cdd:pfam03137 223 KS-----LKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAA 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  356 LGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSyheRALFSDCNSRCKCSE 435
Cdd:pfam03137 298 LGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCST 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  436 TKWEPMCGENG-ITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCqkDNGCPQMFLYFLVISVITSY 514
Cdd:pfam03137 375 SAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCSCGSQDSGGNGSATPGKC--PSDCSNKLPPFLALLFLASF 452
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225543116  515 TLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGfKRCGSRGSCRLYDSNVF 589
Cdd:pfam03137 453 FSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALIDSTCLLWG-KTCGGRGNCWLYDNDKL 526
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
41-530 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 540.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  41 ELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMG 120
Cdd:cd17458    1 KLKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 121 VGTLLIAMPQFFMEQYKYER-YSPSSNSTLSISPC-----LLESSSQLPVSVMEKSKS---------------------- 172
Cdd:cd17458   81 LGCFLASLPHFLMGRYEYEStVSTTSNSSSRVPLClanqsLSHNVTQLPSECEKESMSlmwifvlvgnllrgigetpvmp 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 173 ----------KISN-----GCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISL 237
Cdd:cd17458  161 lgisyiddfsKKENspfyiGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 238 LAAVPFWYLPKSLPRsQSREDSNSSSEKSKFIIDDHtdyqtpQGENAK--IMEMARDFLPSLKNLFGNPVYFLYLCTSTV 315
Cdd:cd17458  241 LAGLPFWFLPKSLPK-EGEENETEPSKTLTVELEEN------KGQETKqeMYEIAKDFLPFLKSLFRNPIYMLFIIVTVL 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 316 QFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFA 395
Cdd:cd17458  314 QFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFW 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 396 LGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCV 475
Cdd:cd17458  394 MGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCV 473
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 225543116 476 gIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRC 530
Cdd:cd17458  474 -AASGFPSQNSSAVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
42-529 2.17e-179

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 517.47  E-value: 2.17e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17457    1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKY--ERYSPSSNSTLSISPCLLESSSQLPVSVM---------EKSKSKISNGCVQTVAIIGPIFG 190
Cdd:cd17457   81 GSVLTALPHFFMGYYKYgcLKESGSYMWVYVLMGNMLRGIGETPIVPLgisylddfaKEENSPLYLACLHTIAMIGPMIG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 191 FLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPkslprsqsredsnsssekskfii 270
Cdd:cd17457  161 FTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSIISAIPFFFLP----------------------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 271 ddhtdyqtpqgenakimemarDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLIN 350
Cdd:cd17457  218 ---------------------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVIT 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 351 IPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSR 430
Cdd:cd17457  277 LPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSD 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 431 CKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISV 510
Cdd:cd17457  357 CNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSCLEVTGSQNRNYSAHLGECPRDDDCSRMFYFYVVIQV 436
                        490
                 ....*....|....*....
gi 225543116 511 ITSYTLSLGGIPGYILLLR 529
Cdd:cd17457  437 LNLFFSALGGTSAYMLIVK 455
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
40-617 2.61e-174

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 510.81  E-value: 2.61e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116   40 GELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIM 119
Cdd:TIGR00805  29 SKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIM 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  120 GVGTLLIAMPQFFMEQYKYERySPSSNSTLSISPCLL--ESSSQ------------------------------------ 161
Cdd:TIGR00805 109 GLGSLLSSLPHFLMGRYSYST-TVSSTGNLSSANSFLcmENLTQtlrptqdpsecqkqhkslmwllflvsnilrgigatp 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  162 ---LPVSVME----KSKSKISNGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGI 234
Cdd:TIGR00805 188 ifpLGISYIDdfakSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGF 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  235 ISLLAAVPFWYLPKSLPRSQSRED--------SNSSSEKSKFIIDDHTdyqtpqgenakimemaRDFLPSLKNLFGNPVY 306
Cdd:TIGR00805 268 VALLTSIPLFFFPKTLPKEGKRVNvdvheaekLEKSRGEDRKKNSGIT----------------KDFPKFIKRLLCNKIY 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  307 FLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFG 386
Cdd:TIGR00805 332 MLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLE 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  387 YLLFLSLFALGCENSDVAGLTV-SYQGTKPVsyherALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGK 465
Cdd:TIGR00805 412 YLLYSPKFLITCESAPVAGVNNpSNDQPLYV-----ENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGS 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  466 NIIFYNCTCVgiaaSKSGNSSGIVGRCqkDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTL 545
Cdd:TIGR00805 487 NMVFTNCSCI----QTPGNSSAKKGLC--DPPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWF 560
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543116  546 AIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKK 617
Cdd:TIGR00805 561 CIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
42-529 1.18e-114

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 350.00  E-value: 1.18e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17336    1 PKVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMeqykyeryspSSNSTLSISPCLLESssqLPVSVME----KSKSKISNGCVQTVAIIGPIFGFLLGSLC 197
Cdd:cd17336   81 GCFLLALPHFLF----------VGQFLLGIGSSPLYT---LGITYIDdnvsKKNSPLYIGILYAMRVLGPALGFLLGSFL 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 198 AKLYVDIGFVNldhITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPkslprsqsredsnsssekskfiiddhtdyq 277
Cdd:cd17336  148 LRIYVDFSRVP---LGITPDDPRWIGAWWLGFLILGILLLIVSIPLFFFP------------------------------ 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 278 tpqgenakimemardflpslknlfgnPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALG 357
Cdd:cd17336  195 --------------------------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALG 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 358 IFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYheralfSDCNSRCKCSETK 437
Cdd:cd17336  249 ILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGVTTPYGSSSSPIT------SSCNSDCNCSDSS 322
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 438 WEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGiaaSKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLS 517
Cdd:cd17336  323 FSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSCIN---SGTATSSGCPPDCSVAPNCCSKLIPFLAVLFLSSFLLS 399
                        490
                 ....*....|..
gi 225543116 518 LGGIPGYILLLR 529
Cdd:cd17336  400 LSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
42-529 7.33e-93

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 295.56  E-value: 7.33e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17461    2 IKVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKYERYSpssnstLSISPCLLESSSQLPVS---------VMEKSKSKISNGCVQTVAIIGPIFGFL 192
Cdd:cd17461   82 GAFLLTLPHFLSEPYQYSMWV------LMVVAQLLAGIGTVPIQpfgisyvddFAEPSNSPLYIAILFAISVFGPAFGYL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 193 LGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNsssekskfiiDD 272
Cdd:cd17461  156 LGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPREMLVGKKPSPEG----------DM 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 273 HTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLyLCTSTVQFNSLF-GMVTYKPKYIEQQYGQSSSRANFVIGLINI 351
Cdd:cd17461  226 LRKKEDEKKEEGSLLDFIKRFPKMFVKLLLNPLFML-LVLAQCTFSSVIaGLSTFLNKFLEKQYGASASYANFLIGAVNL 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 352 PAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLtvsYQGTKPVSYHERAlfsDCNSRC 431
Cdd:cd17461  305 PAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCSTQDVAGV---YPKTSNSSDGPHL---SCSANC 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 432 KCSETKWEPMCGENGITYVSACLAGCQTSNRSG---KNIIFYNCTCVgiaASKSGNSSGIVGRCQkdNGCPQMFLYFLVI 508
Cdd:cd17461  379 SCPESAFNPVCGENGIEYISPCHAGCTNSNMDSstyRQQIYSNCSCI---PDLSGEKPAKTGSCP--NSCSHLLLPVMFL 453
                        490       500
                 ....*....|....*....|.
gi 225543116 509 SVITSYTLSLGGIPGYILLLR 529
Cdd:cd17461  454 ISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
42-529 7.97e-92

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 292.83  E-value: 7.97e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17460    1 IKFFVLCHGLLQLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKYeryspssnSTLSISPCLLESSSqLPVS---------VMEKSKSKISNGCVQTVAIIGPIFGFL 192
Cdd:cd17460   81 AGFLMALPHFISEPYEY--------GILFLGQLLLGIGG-VPIQpfgisyiddFASESNSPLYLGILFAVTVLGPGFGFM 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 193 LGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRsQSREDSNSSSEKSKFIIDD 272
Cdd:cd17460  152 LGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPREMPK-EVVELQPREKKLAKTMLKK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 273 hTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIP 352
Cdd:cd17460  231 -LKSLSDILQNLSLLQFIKKFPRILLRTLRNPIYLLVVLAQVNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIP 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 353 AVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQgtkpvSYHERALFSDCNSRCK 432
Cdd:cd17460  310 SAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLFIGCSTQKIAGITHRTS-----SSPGLELSSQCSEACS 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 433 CSETKWEPMCGENGITYVSACLAGCQTSN---RSGKNIIFYNCTCVGiaaskSGNSSGIVGRCQKDNGCPQMFLYFLVIS 509
Cdd:cd17460  385 CPPEAFNPVCGSDGVEYISPCHAGCKSVNvqaLDNSVVNYTDCSCVS-----EGGPVGAASPGTCGSGCSHLLVPFMLLV 459
                        490       500
                 ....*....|....*....|
gi 225543116 510 VITSYTLSLGGIPGYILLLR 529
Cdd:cd17460  460 SLGGFLASLSHTPSFMLILR 479
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
44-529 7.15e-90

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 286.17  E-value: 7.15e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  44 VFLCALSFvyFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGT 123
Cdd:cd17404    5 VCMCLLIF--IQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIALGS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 124 LLIAMPQFFMeqykyeryspSSNSTLSI--SPCLLESSSQLPVSVmEKSKSKISNGCVQTVAIIGPIFGFLLGSLCAKLY 201
Cdd:cd17404   83 FLFSLPHFFI----------LAQILIGMggTPIFTLGTTYLDDHV-KKESSSLYLAIMYVMGALGPAAGFLLGGLLINFY 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 202 VDIGFVNLDhitITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKslprsqsredsnsssekskfiiddhtdyqtpqg 281
Cdd:cd17404  152 VDPLSTPPD---ISPGDPRWIGAWWGGFLLCGIALLLVAFPFFTFPK--------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 282 enakimemardflpslknlfgnPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSG 361
Cdd:cd17404  196 ----------------------MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLG 253
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 362 GIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQ-GTKPVSYHERALFSDCNSRCKCSETKWEP 440
Cdd:cd17404  254 GYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGITIPYTtGPSLSSTHGRNLTSECNVNCGCSINEYEP 333
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 441 MCGENGITYVSACLAGCQT-SNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQ--KDNGCPQMFLYFLVISVITSYTLS 517
Cdd:cd17404  334 VCGSDGITYFSPCLAGCTSvGNTSTGIRNYTNCACLQSRSSISPPTVGQGSQLQagPCSRTCNTLIPFLILLFIVTLITA 413
                        490
                 ....*....|..
gi 225543116 518 LGGIPGYILLLR 529
Cdd:cd17404  414 CAQMPALMITLR 425
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
42-529 9.82e-88

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 281.05  E-value: 9.82e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17402    1 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKyerysPSSNSTLSISPCLLESSSQLPVSVM---------EKSKSKISNGCVQTVAIIGPIFGFL 192
Cdd:cd17402   81 GALLSALPEFLTHQYK-----TNMMYLLLIGAQVLLGIGATPVQPLgvsyiddhvRRKDSSLYIGILFTMLVFGPACGFI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 193 LGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLprsqsredsnsssekskfiidd 272
Cdd:cd17402  156 LGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSL---------------------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 273 htdyqtpqgenakimEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIP 352
Cdd:cd17402  214 ---------------QQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIP 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 353 AVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYqGTKPVSYHERALFSDCNSRCK 432
Cdd:cd17402  279 CACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPY-GNDTAPGSSLDPYAPCNSNCE 357
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 433 CSETKWEPMCGENGITYVSACLAGCQTSNRSGkniifynCTCVGIAASKsgNSSGIVGRCQKDnGCPQMFLYFLVISVIT 512
Cdd:cd17402  358 CQTDSFSPVCGADGITYLSACFAGCSSTNLSG-------CACLSSVPAE--NATVVPGKCPSP-GCQEAFLTFLCVMCVC 427
                        490
                 ....*....|....*..
gi 225543116 513 SYTLSLGGIPGYILLLR 529
Cdd:cd17402  428 SMIGAMAQTPSVIILIR 444
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
42-529 1.93e-82

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 267.10  E-value: 1.93e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  42 LKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGV 121
Cdd:cd17401    1 IKVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 122 GTLLIAMPQFFMEQYKYeryspssnsTLSISPCLLESSSQLPVS---------VMEKSKSKISNGCVQTVAIIGPIFGFL 192
Cdd:cd17401   81 GAFLLTLPHFISEPYQY---------GIMVVAQLLLGIGGVPIQpfgisyiddFAEPSNSPLYLGILFAVTVFGPAFGYL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 193 LGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRsqsredsnsssekskfiidd 272
Cdd:cd17401  152 LGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPRFIKR-------------------- 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 273 htdyqtpqgenakimeMARDFLPSLKNlfgnPVYFLyLCTSTVQFNSLF-GMVTYKPKYIEQQYGQSSSRANFVIGLINI 351
Cdd:cd17401  212 ----------------FPCIFLRTLRN----PIFLL-VVLAQVTLSSMIaGLATFLNKFLEKQFGTTASYANFLIGAVNL 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 352 PAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTvsYQGTkpvSYHERALFSDCNSRC 431
Cdd:cd17401  271 PSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGVY--PPSS---SSSIHPQSPACRRDC 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 432 KCSETKWEPMCGENGITYVSACLAGCQTSNRSG----KNIIFYNCTCVgiaasKSGNSSGIVGRCqkDNGCPQMFLYFLV 507
Cdd:cd17401  346 SCPDSIFNPVCGDNGVEYLSPCHAGCSNINMSTsatsKQVIYTNCSCV-----TGGSASAKTGSC--PSPCSHLLLPFIF 418
                        490       500
                 ....*....|....*....|..
gi 225543116 508 ISVITSYTLSLGGIPGYILLLR 529
Cdd:cd17401  419 LISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
44-529 2.72e-82

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 266.04  E-value: 2.72e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  44 VFLCALSFVyfAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGT 123
Cdd:cd17403    6 FFLCIFAFL--QGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGIGS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 124 LLIAMPQFFM-------------EQYkyeryspssnsTLSISpCLLESSSqlpvsvmeKSKSKISNGCVQTVAIIGPIFG 190
Cdd:cd17403   84 LVFALPHFTVfilaqllhgagatPLY-----------TLGVT-YLDENVS--------TKMSPLYIGIFYAMAILGPAIG 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 191 FLLGSLCAKLYVDIGFVNLDhITITPKDPQWVGAWWLGYLIAGIISLLAAVPfwylpkslprsqsredsnsssekskfii 270
Cdd:cd17403  144 YVLGGFLLNLYTDIDQVDSE-LGLTPDDPRWVGAWWLGFLISGALALIIAFP---------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 271 ddhtdyqtpqgenakimemardflpslknLFGNPVYFLYLCTSTVqFNSLF--GMVTYKPKYIEQQYGQSSSRANFVIGL 348
Cdd:cd17403  195 -----------------------------LLGFPPTFMFLNLAGA-SEGMLlaGFATFLPKLIESQFSLSASLAALLVGV 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 349 INIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFaLGCENSDVAGLTVSYQGTKpvSYHERALFSDCN 428
Cdd:cd17403  245 VVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILL-IYCPNAPFAGVTVPYGNSP--LEGTSNLTSTCN 321
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 429 SRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIvGRCQKDNGCPQMFLYFLVI 508
Cdd:cd17403  322 ADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCIQSNSSKTSTAATG-KACPCETCCQKLYLFLAVF 400
                        490       500
                 ....*....|....*....|.
gi 225543116 509 SVITSYTLsLGGIPGYILLLR 529
Cdd:cd17403  401 FLLIVFTF-MSSTPALSATLR 420
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
44-529 1.03e-70

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 235.88  E-value: 1.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  44 VFLCALSFVyfAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGT 123
Cdd:cd17462    6 FFLCAASFL--QGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 124 LLIAMPQF--FMEQYKYERYSPSSNSTLSISpCLLES--SSQLPVSVmekskskisnGCVQTVAIIGPIFGFLLGSLCAK 199
Cdd:cd17462   84 LVFALPHFtvFMLGQFLHGIGATPLYTLGVT-YLDENvkSNYSPVYI----------GIFYTAAIVGPAAGYLLGGFFLN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 200 LYVDIGfvnlDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPrsqsredsnsssekskfiiddhtdyqtp 279
Cdd:cd17462  153 IYTEIG----RQTELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQLP---------------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 280 qgenakimemardflpslkNLFGNPVyFLYLCTSTVQFNSLF-GMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGI 358
Cdd:cd17462  201 -------------------GLLKNPT-FIFLCLAGATEATLIaGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGT 260
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 359 FSGGIVMKKFRISVCGAAKLYLGSSVFGyLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERaLFSDCNSRCKCSETKW 438
Cdd:cd17462  261 FLGGFIVNKLKLRCSGIIKFCLICTVVS-LLAIFIFSLHCPNVPMAGVTASYRGSVLPEGSLN-LTALCNADCRCLEEIY 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 439 EPMCGENGITYVSACLAGCQ---TSNRSGKNiIFYNCTCVGIAASKSGNSSgivGRCQKDNGCPQMFLYFLVISVITSYT 515
Cdd:cd17462  339 SPVCGADGLMYYSPCHAGCSeaySDIRNGQK-VYQDCSCVAGNLSVGFGEA---SAGKCTSNCNHMPLLLAFVFLVILFT 414
                        490
                 ....*....|....
gi 225543116 516 LsLGGIPGYILLLR 529
Cdd:cd17462  415 F-LCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
44-529 1.22e-58

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 203.44  E-value: 1.22e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  44 VFLCALSFVyfAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGT 123
Cdd:cd17463    6 LFYSLLAVV--QGIVVNGLVNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 124 LLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSsqlpvsvMEKSKSKISNGCVQTVAIIGPIFGFLLGSLCAKLYVD 203
Cdd:cd17463   84 LVFSLPHFFVFILGQLLLGVGGTPLYTLGTAYIDDS-------VPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYID 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 204 IGFVnlDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPrsqsredsnsssekskfiiddhtdyqtpqgen 283
Cdd:cd17463  157 VNKG--QSVDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPKHLP-------------------------------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 284 akimemardflpslkNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGI 363
Cdd:cd17463  203 ---------------GLLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGI 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 364 VMKKFRISVCGAAKLYLGSSVFGyLLFLSLFALG-CENSDVAGLTVSYQGTKPVSyherALFSDCNSRCKCSETKWEPMC 442
Cdd:cd17463  268 IVSKFKLKCKNMIKFAIITTTVS-LLLLSVFIFAkCGNDPFAGVSETYNGTGKIG----NLTAPCNANCSCLSSFYYPVC 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 443 GENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGiaaSKSGNSSGIVGRCQKDNGCPQ------MFLYFLVISVITSYtl 516
Cdd:cd17463  343 GADGVQYFSPCFAGCTNENLHDKKKVYYNCSCIG---NFTEEFSANTTKCEEGKKCETtcknlpIFLCFFFFVVIFTF-- 417
                        490
                 ....*....|...
gi 225543116 517 sLGGIPGYILLLR 529
Cdd:cd17463  418 -MTSTPITVAILR 429
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
44-529 1.29e-31

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 128.04  E-value: 1.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  44 VFLCALSFvyfAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGT 123
Cdd:cd17405    6 ILYCILVL---IQGAVFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 124 LLIAMPQFfmeqykyeryspssnsTLSISPCLLESSSQLPVSVM---------EKSKSKISNGCVQTVAIIGPIFGFLLG 194
Cdd:cd17405   83 MLFAFPFF----------------TFHIAGQCIQGIAGMPIYILgitfifdniPTSSAGIYLGIAHSAYLIGYLLGYVGG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 195 SLCAKLYVDIGFVNldhITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPrsqsredsnsssekskfiiddht 274
Cdd:cd17405  147 LPNFQPPPNEKSVE---IEVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLP----------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 275 dyqtpqgenakimemardflpslkNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAV 354
Cdd:cd17405  201 ------------------------GLLKNPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGG 256
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 355 ALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSyherALFSDCNSRCKCS 434
Cdd:cd17405  257 AIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQLG----NLTAPCNEYCDCT 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 435 ETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCV--GIAASKSGNS--SGIVGRCQKDNGCPQMFLYFLVISV 510
Cdd:cd17405  333 SSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCIkeGLAAADDEGDfiDAIAGKCDSKCYKLPLFFAFYFSAT 412
                        490
                 ....*....|....*....
gi 225543116 511 ITSytlSLGGIPGYILLLR 529
Cdd:cd17405  413 VFS---NMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
423-476 3.19e-24

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 95.83  E-value: 3.19e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 225543116 423 LFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVG 476
Cdd:cd01330    1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
428-474 4.19e-13

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 64.05  E-value: 4.19e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 225543116  428 NSRCKCSETKWEPMCGENGITYVSAC---LAGCQTSNRSGKNIIFYNCTC 474
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
49-397 1.62e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.38  E-value: 1.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  49 LSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAM 128
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 129 PQFFmeqykyeryspssnSTLSISPCLLESSSQLPVSVMEKSKSKISN--------GCVQTVAIIGPIFGFLLGSLCAKL 200
Cdd:cd06174   81 APSF--------------WLLLLGRFLLGLGSGLIDPAVLALIADLFPerergralGLLQAFGSVGGILGPLLGGILASS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 201 YVdigfvnldhititpkdpqwvGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSekskfiiddhtdyqtpq 280
Cdd:cd06174  147 LG--------------------FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS----------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 281 genakimemaRDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFS 360
Cdd:cd06174  190 ----------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLL 259
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 225543116 361 GGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALG 397
Cdd:cd06174  260 GLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL 296
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
46-397 5.54e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.69  E-value: 5.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  46 LCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLL 125
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 126 IAMpqffmeqykyerySPSSNSTL------SISPCLLESSSQ-LPVSVMEKSKSKISNGCVQTVAIIGPIFGFLLGSLCA 198
Cdd:COG2814   92 CAL-------------APSLWLLLaarflqGLGAGALFPAALaLIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 199 klyvdigfvnldhititpkdpQWVGaWWLGYLIAGIISLLAAVPFW-YLPKSLPRSQSRedsnsssekskfiiddhtdyq 277
Cdd:COG2814  159 ---------------------DLFG-WRWVFLVNAVLALLALLLLLrLLPESRPAARAR--------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 278 tpqgenakimemardFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALG 357
Cdd:COG2814  196 ---------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA 260
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 225543116 358 IFSGGIVMKKFR---------ISVCGAAKLYLGSSVFGYLLFLSLFALG 397
Cdd:COG2814  261 LLAGRLADRFGRrrllligllLLALGLLLLALAGSLWLLLLALFLLGFG 309
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
433-474 2.29e-08

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 50.35  E-value: 2.29e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 225543116 433 CSETkWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTC 474
Cdd:cd00104    1 CPKE-YDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_1 pfam07690
Major Facilitator Superfamily;
45-397 8.05e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.73  E-value: 8.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116   45 FLCALSFVYFAKALAEGYLKSTITQIerrFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTL 124
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAED---LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  125 LIAMPqffmeqykyeryspSSNSTLSISPCL--LESSSQLPVS------VMEKSKSKISNGCVQTVAIIGPIFGFLLGSL 196
Cdd:pfam07690  78 LLLFA--------------SSLWLLLVLRVLqgLGAGALFPAAlaliadWFPPEERGRALGLVSAGFGLGAALGPLLGGL 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  197 CAKLYvdigfvnldhititpkDPQWVgawwlgYLIAGIISLLAAVPFWYLPKSlprsqsredsnsssekskfiiddhtdy 276
Cdd:pfam07690 144 LASLF----------------GWRAA------FLILAILSLLAAVLLLLPRPP--------------------------- 174
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  277 qtPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQqYGQSSSRANFVIGLINIPAVAL 356
Cdd:pfam07690 175 --PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIG 251
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 225543116  357 GIFSGGIVMKKFR----------ISVCGAAKLYLGSSVFGYLLFLSLFALG 397
Cdd:pfam07690 252 RLLLGRLSDRLGRrrrlllalllLILAALGLLLLSLTLSSLWLLLALLLLG 302
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
48-397 2.41e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 53.32  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  48 ALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIA 127
Cdd:COG0738   12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 128 M----PQFFMeqykyeryspsSNSTLSISPCLLESSSQLPVSVMEKSKSK----ISNGCVQTVAIIGPifgfLLGSLCAK 199
Cdd:COG0738   92 LapsyPLLLL-----------ALFLLGLGLGLLDVAANPYVAALGPETAAsrlnLLHAFFSLGALLGP----LLGGLLIL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 200 LYVDIgfvnldhititpkdpqwvgAWWLGYLIAGIISLLAAVPFWYLPksLPRSQSREDSNSSSEKskfiiddhtdyqtp 279
Cdd:COG0738  157 LGLSL-------------------SWHLPYLILAVLLLLLALLFLRSK--LPEIEEEEEEAAGSAA-------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 280 qgenakimemardflpSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIpAVALGIF 359
Cdd:COG0738  202 ----------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRF 264
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 225543116 360 SGGIVMKKFrisvcGAAKLYLGSSVFGyLLFLSLFALG 397
Cdd:COG0738  265 LGGFLLKRF-----GPVRLLRLSALLA-AVGLLLALLA 296
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
224-394 1.32e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 51.20  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  224 AWWLGYLIAGIISLLAAVPFW-YLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQT---PQGENAKIMEMARDFLPSLKN 299
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLLMrFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSalpEQKSTQGTKRSVFKALFQGKT 248
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  300 LFGNPvyFLYLCTSTVQFnSLFGMVTYKPKYIEQQyGQSSSRANFVIGLINIpAVALGIFSGGIVMKKFRISVCGAakLY 379
Cdd:TIGR00895 249 ARITV--LLWLLYFMLLV-GVYFLTNWLPKLMVEL-GFSLSLAATGGALFNF-GGVIGSIIFGWLADRLGPRVTAL--LL 321
                         170
                  ....*....|....*
gi 225543116  380 LGSSVFGYLLFLSLF 394
Cdd:TIGR00895 322 LLGAVFAVLVGSTLF 336
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
49-271 4.32e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.00  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116  49 LSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAM 128
Cdd:cd17333    1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 129 PQFFMeqykyerYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKIS----NGCVQTVAIIGP-IFGFLLgslcaklyvd 203
Cdd:cd17333   81 TPSIY-------LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRlnvlHGFFGLGALIGPlIATSLL---------- 143
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543116 204 igfvnldhititpkdpQWVGAWWLGYLIAGIISLLAAVpFWYLPKSLPRSQSREDSNSSSEKSKFIID 271
Cdd:cd17333  144 ----------------TSELSWSWAYLIIGLIYLLLAI-LILLTLFPELPSARNPQQSVGAFSASASR 194
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
293-397 5.26e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543116 293 FLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVaLGIFSGGIVMKKFrisv 372
Cdd:COG2211  217 LKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAAL-LGAPLWPRLAKRF---- 291
                         90       100
                 ....*....|....*....|....*
gi 225543116 373 cGAAKLYLGSSVFGYLLFLSLFALG 397
Cdd:COG2211  292 -GKKKAFIIGLLLAALGLLLLFFLG 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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