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Conserved domains on  [gi|1676319742|ref|NP_001138472|]
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integrin alpha-V isoform 3 precursor [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192668)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.60.40.1530|2.60.40.1510|2.60.40.1460|2.130.10.130
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4007553|4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 432-878 6.71e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 486.44  E-value: 6.71e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  432 RPVITVNAGLEVYPSILNQDNKTCSLPGTalKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSR 511
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGT--PVSCFTVRACFSYTGKPIPNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  512 SPSHSKNMTISRGGLMQCEELIAYLRDEseFRDKLTPITIFMEYRL--DYRTAADTTGLQPILNQFTPANISRQAHILLD 589
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  590 CGEDNVCKPKLEVSV----DSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVvRNNEALARLSCAFK 665
Cdd:pfam08441  157 CGEDNVCVPDLQLSAkfdsRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  666 TENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPD 745
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  746 HVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNT-LLYILHYDIDGPMNCTSDMEINP 824
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1676319742  825 LRIKISSLQTTEkndtvAGQGERDHLITKRDLALSEG----DIHTLGCG-VAQCLKIVC 878
Cdd:pfam08441  396 LNLTQSLESSKP-----LRTSRVHHVVKRRDVLKSEKatqtASVLLSCDsGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 331-385 4.44e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.70  E-value: 4.44e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1676319742   331 FARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKK-GIVYIFNGRSTGLNAVPSQIL 385
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 212-252 4.45e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 56.23  E-value: 4.45e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1676319742   212 DDSYLGYSVA-VGDFNGDGIDDFVSGVPRA--ARTLGMVYIYDG 252
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 266-319 1.87e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 1.87e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1676319742   266 MAAYFGFSVA-ATDINGDDYADVFIGAPLFMDRgsdgklQEVGQVSVSLQRASGD 319
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSGGG 49
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 398-440 1.02e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.02e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1676319742   398 FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAG 440
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 46-103 1.45e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.52  E-value: 1.45e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742    46 GSYFGFAVDFFVP-SASSRMFLLVGAPKANTTQpgivEGGQVLKCDWSS-TRRCQPIEFD 103
Cdd:smart00191    2 GSYFGYSVAGVGDvNGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSgGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 185-235 1.08e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 38.36  E-value: 1.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1676319742  185 IVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVS 235
Cdd:pfam13517   11 VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 432-878 6.71e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 486.44  E-value: 6.71e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  432 RPVITVNAGLEVYPSILNQDNKTCSLPGTalKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSR 511
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGT--PVSCFTVRACFSYTGKPIPNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  512 SPSHSKNMTISRGGLMQCEELIAYLRDEseFRDKLTPITIFMEYRL--DYRTAADTTGLQPILNQFTPANISRQAHILLD 589
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  590 CGEDNVCKPKLEVSV----DSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVvRNNEALARLSCAFK 665
Cdd:pfam08441  157 CGEDNVCVPDLQLSAkfdsRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  666 TENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPD 745
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  746 HVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNT-LLYILHYDIDGPMNCTSDMEINP 824
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1676319742  825 LRIKISSLQTTEkndtvAGQGERDHLITKRDLALSEG----DIHTLGCG-VAQCLKIVC 878
Cdd:pfam08441  396 LNLTQSLESSKP-----LRTSRVHHVVKRRDVLKSEKatqtASVLLSCDsGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 331-385 4.44e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.70  E-value: 4.44e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1676319742   331 FARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKK-GIVYIFNGRSTGLNAVPSQIL 385
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 212-252 4.45e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 56.23  E-value: 4.45e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1676319742   212 DDSYLGYSVA-VGDFNGDGIDDFVSGVPRA--ARTLGMVYIYDG 252
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 334-370 1.10e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 1.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1676319742  334 FGSAIApLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF 370
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 266-319 1.87e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 1.87e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1676319742   266 MAAYFGFSVA-ATDINGDDYADVFIGAPLFMDRgsdgklQEVGQVSVSLQRASGD 319
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 217-250 3.48e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.12  E-value: 3.48e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1676319742  217 GYSVAVGDFNGDGIDDFVSGVPRAART-LGMVYIY 250
Cdd:pfam01839    2 GYSVAVGDLNGDGYADLAVGAPGEGGAgAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 270-311 9.92e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.96  E-value: 9.92e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1676319742  270 FGFSVAATDINGDDYADVFIGAPLFMDRGSdgklqevGQVSV 311
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYV 35
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 398-440 1.02e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.02e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1676319742   398 FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAG 440
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 46-103 1.45e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.52  E-value: 1.45e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742    46 GSYFGFAVDFFVP-SASSRMFLLVGAPKANTTQpgivEGGQVLKCDWSS-TRRCQPIEFD 103
Cdd:smart00191    2 GSYFGYSVAGVGDvNGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSgGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 185-235 1.08e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 38.36  E-value: 1.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1676319742  185 IVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVS 235
Cdd:pfam13517   11 VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 432-878 6.71e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 486.44  E-value: 6.71e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  432 RPVITVNAGLEVYPSILNQDNKTCSLPGTalKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSR 511
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGT--PVSCFTVRACFSYTGKPIPNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  512 SPSHSKNMTISRGGLMQCEELIAYLRDEseFRDKLTPITIFMEYRL--DYRTAADTTGLQPILNQFTPANISRQAHILLD 589
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  590 CGEDNVCKPKLEVSV----DSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVvRNNEALARLSCAFK 665
Cdd:pfam08441  157 CGEDNVCVPDLQLSAkfdsRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  666 TENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPD 745
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742  746 HVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNT-LLYILHYDIDGPMNCTSDMEINP 824
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1676319742  825 LRIKISSLQTTEkndtvAGQGERDHLITKRDLALSEG----DIHTLGCG-VAQCLKIVC 878
Cdd:pfam08441  396 LNLTQSLESSKP-----LRTSRVHHVVKRRDVLKSEKatqtASVLLSCDsGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 331-385 4.44e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.70  E-value: 4.44e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1676319742   331 FARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKK-GIVYIFNGRSTGLNAVPSQIL 385
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 212-252 4.45e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 56.23  E-value: 4.45e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1676319742   212 DDSYLGYSVA-VGDFNGDGIDDFVSGVPRA--ARTLGMVYIYDG 252
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 334-370 1.10e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 1.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1676319742  334 FGSAIApLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF 370
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 266-319 1.87e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 1.87e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1676319742   266 MAAYFGFSVA-ATDINGDDYADVFIGAPLFMDRgsdgklQEVGQVSVSLQRASGD 319
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 217-250 3.48e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.12  E-value: 3.48e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1676319742  217 GYSVAVGDFNGDGIDDFVSGVPRAART-LGMVYIY 250
Cdd:pfam01839    2 GYSVAVGDLNGDGYADLAVGAPGEGGAgAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 270-311 9.92e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.96  E-value: 9.92e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1676319742  270 FGFSVAATDINGDDYADVFIGAPLFMDRGSdgklqevGQVSV 311
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYV 35
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 398-440 1.02e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.02e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1676319742   398 FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAG 440
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 224-289 2.57e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 45.68  E-value: 2.57e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1676319742  224 DFNGDGIDDFVSGVPRAARtlgmVYIYDGKNM---SSLYNFTGeqmaAYFGFSVAATDINGDDYADVFI 289
Cdd:pfam13517    1 DLDGDGKLDLVVANDGGLR----LYLNNGDGTftfITSVSLGG----GGGGLSVAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 46-103 1.45e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.52  E-value: 1.45e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319742    46 GSYFGFAVDFFVP-SASSRMFLLVGAPKANTTQpgivEGGQVLKCDWSS-TRRCQPIEFD 103
Cdd:smart00191    2 GSYFGYSVAGVGDvNGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSgGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 343-418 1.08e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 38.36  E-value: 1.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1676319742  343 DLDQDGFNDIAIAapyggEDKKGIVYIFNGRSTGLNAVPSQILEGQWAarsMPPSFGysmkgatDIDKNGYPDLIV 418
Cdd:pfam13517    1 DLDGDGKLDLVVA-----NDGGLRLYLNNGDGTFTFITSVSLGGGGGG---LSVAVG-------DLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 185-235 1.08e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 38.36  E-value: 1.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1676319742  185 IVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVS 235
Cdd:pfam13517   11 VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 278-354 1.21e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.98  E-value: 1.21e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1676319742  278 DINGDDYADVFIGAPlfmdrgsdgklqevGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAplGDLDQDGFNDIAI 354
Cdd:pfam13517    1 DLDGDGKLDLVVAND--------------GGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAV--GDLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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