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Conserved domains on  [gi|221330082|ref|NP_001137623|]
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uncharacterized protein Dmel_CG8008, isoform B [Drosophila melanogaster]

Protein Classification

solute carrier 46 family transporter( domain architecture ID 13024389)

solute carrier 46 (SLC46) family transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 25-551 4.74e-124

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 368.91  E-value: 4.74e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  25 MFYIEPVVFMLLFSHTLSGTIQRNQViyqtctvifhynesdckqldvknasaeinaietelqpYVANLFLARTLLESIVP 104
Cdd:cd17386    1 MLNVEPIVFLYMFASVLSGPVTQNFV-------------------------------------YAANFYLYMNLMGSIPP 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICELssYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITD 184
Cdd:cd17386   44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYF--TTVPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISS 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 185 CKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVpeslhfhkeqetknaitanveke 264
Cdd:cd17386  122 EKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL----------------------- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 265 cidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyverlpqkaeerkrqeaeeqakk 344
Cdd:cd17386      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 345 aglfsmvhirdmistcfkrrdhharAIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGAL 424
Cdd:cd17386  179 -------------------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGML 233

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 425 IGFLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNV 504
Cdd:cd17386  234 GGVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSV 313

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 221330082 505 LQSFAPFVAAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFVFIGYVL 551
Cdd:cd17386  314 LESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 25-551 4.74e-124

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 368.91  E-value: 4.74e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  25 MFYIEPVVFMLLFSHTLSGTIQRNQViyqtctvifhynesdckqldvknasaeinaietelqpYVANLFLARTLLESIVP 104
Cdd:cd17386    1 MLNVEPIVFLYMFASVLSGPVTQNFV-------------------------------------YAANFYLYMNLMGSIPP 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICELssYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITD 184
Cdd:cd17386   44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYF--TTVPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISS 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 185 CKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVpeslhfhkeqetknaitanveke 264
Cdd:cd17386  122 EKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL----------------------- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 265 cidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyverlpqkaeerkrqeaeeqakk 344
Cdd:cd17386      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 345 aglfsmvhirdmistcfkrrdhharAIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGAL 424
Cdd:cd17386  179 -------------------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGML 233

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 425 IGFLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNV 504
Cdd:cd17386  234 GGVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSV 313

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 221330082 505 LQSFAPFVAAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFVFIGYVL 551
Cdd:cd17386  314 LESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
105-509 1.52e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.85  E-value: 1.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAicelssyyVVNPWWYIMAAVphsLLG-GNCVFSVAAFCFISDIT 183
Cdd:COG2814   59 ALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL--------APSLWLLLAARF---LQGlGAGALFPAALALIADLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 184 DCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNaitanvek 263
Cdd:COG2814  128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS-------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 264 ecidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyverlpqkaeerkrqeaeeqak 343
Cdd:COG2814      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 344 kaglfsmvhirdmISTCFKRRdhharaIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGA 423
Cdd:COG2814  200 -------------LRELLRRP------RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA 260

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 424 LIGFLILRKVFRLSVVTLALLAFfseILNNLAKGFATMPWHMYLSVTL-GVFRSISGPMCRTIVSNIVPPSDLGKIFSIK 502
Cdd:COG2814  261 LLAGRLADRFGRRRLLLIGLLLL---ALGLLLLALAGSLWLLLLALFLlGFGFGLLFPLLQALVAELAPPEARGRASGLY 337


                 ....*..
gi 221330082 503 NVLQSFA 509
Cdd:COG2814  338 NSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
101-246 1.99e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.44  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVPHSLLGGncVFSVAAFCFIS 180
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL--------FASSLWLLLVLRVLQGLGAG--ALFPAALALIA 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330082  181 DITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLH 246
Cdd:pfam07690 112 DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES 177
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 105-258 5.91e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.89  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSasflmmaaICELSSYYVVNPWWYIMAAVPHSL-LGGncvFSVAAFCFISDIT 183
Cdd:TIGR00895  66 AFGALFFGPLADRIGRRRVLLWSILLFS--------VFTLLCALATNVTQLLILRFLAGLgLGG---LMPNLNALVSEYA 134

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330082  184 DCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAIT 258
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRR 209
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 25-551 4.74e-124

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 368.91  E-value: 4.74e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  25 MFYIEPVVFMLLFSHTLSGTIQRNQViyqtctvifhynesdckqldvknasaeinaietelqpYVANLFLARTLLESIVP 104
Cdd:cd17386    1 MLNVEPIVFLYMFASVLSGPVTQNFV-------------------------------------YAANFYLYMNLMGSIPP 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICELssYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITD 184
Cdd:cd17386   44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYF--TTVPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISS 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 185 CKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVpeslhfhkeqetknaitanveke 264
Cdd:cd17386  122 EKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL----------------------- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 265 cidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyverlpqkaeerkrqeaeeqakk 344
Cdd:cd17386      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 345 aglfsmvhirdmistcfkrrdhharAIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGAL 424
Cdd:cd17386  179 -------------------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGML 233

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 425 IGFLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNV 504
Cdd:cd17386  234 GGVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSV 313

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 221330082 505 LQSFAPFVAAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFVFIGYVL 551
Cdd:cd17386  314 LESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILIGVVY 360
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 101-546 8.54e-18

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 84.94  E-value: 8.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVPHSLLGGNcvfSVAAFCFIS 180
Cdd:cd17330   44 SLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG--------LSRNLWLLFLARFLDGLTGGN---VSVAQAYIA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 181 DITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPeslhfhkeqetknaitan 260
Cdd:cd17330  113 DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP------------------ 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 261 vekecidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyverlpqkaeerkrqeaee 340
Cdd:cd17330      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 341 qakkaglfsmvhirdmistcfkrrdhharaIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRdytFFETVSHLVPM 420
Cdd:cd17330  175 ------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPS---QIGLLLALVGI 221

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 421 IGALI-GFLILRKVFRLSVVTLALLAFFSEILNNLAKGFAT-MPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKI 498
Cdd:cd17330  222 AGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKA 301

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 221330082 499 FSIKNVLQSFAPFVAAPLYTLIYKRSlttYPGLFNFVSSFLYLLSFVF 546
Cdd:cd17330  302 QGIIQSLQSLARIIGPLLAGPLYSFL---GPGVPFLLAAGLLLIALFL 346
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 101-252 2.76e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 77.62  E-value: 2.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVPHSLLGGncVFSVAAFCFIS 180
Cdd:cd17325   41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA--------FATSYWQLLLARFLQGLASA--AVWPAAMALIA 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221330082 181 DITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQE 252
Cdd:cd17325  111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA 182
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 106-545 4.89e-13

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 70.74  E-value: 4.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 106 FCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICELssyyvvnpWWYIMAAVPHSLLGGncVFSVAAFCfISDITDC 185
Cdd:cd17388   53 IFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTL--------WWLYLGRIIAGITGA--TGAVAAAY-IADVTPP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 186 KSRPYRMIFMESLFFIGLTSGSLLSSFVyAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAiTANvekec 265
Cdd:cd17388  122 EQRARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWR-RAN----- 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 266 idskvPITAcdLQLDRvaidcppnfmndeepgkdkrmelptpATPAMSFdddLLAKYVerlpqkaeerkrqeaeeqakka 345
Cdd:cd17388  195 -----PFGS--LRWLT--------------------------GFPGLLG---LLAVFF---------------------- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 346 gLFSMVhirdmistcfkrrdHHARAIIWLvtlamflsifvfdgvmtvmyLFVREKFHWTVRDYTFFETVSHLvpMIGALI 425
Cdd:cd17388  217 -LIQLI--------------GQVPATTWV--------------------LFTEDRFDWSPTMVGLSLAVFGL--LHALFQ 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 426 GFLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVL 505
Cdd:cd17388  260 AFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSL 339

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 221330082 506 QSFAPFVAAPLYTLIYKRSLTTYPGLFNFVSSFLYLLSFV 545
Cdd:cd17388  340 TSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLV 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
105-509 1.52e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.85  E-value: 1.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAicelssyyVVNPWWYIMAAVphsLLG-GNCVFSVAAFCFISDIT 183
Cdd:COG2814   59 ALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL--------APSLWLLLAARF---LQGlGAGALFPAALALIADLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 184 DCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNaitanvek 263
Cdd:COG2814  128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS-------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 264 ecidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyverlpqkaeerkrqeaeeqak 343
Cdd:COG2814      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 344 kaglfsmvhirdmISTCFKRRdhharaIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGA 423
Cdd:COG2814  200 -------------LRELLRRP------RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA 260

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 424 LIGFLILRKVFRLSVVTLALLAFfseILNNLAKGFATMPWHMYLSVTL-GVFRSISGPMCRTIVSNIVPPSDLGKIFSIK 502
Cdd:COG2814  261 LLAGRLADRFGRRRLLLIGLLLL---ALGLLLLALAGSLWLLLLALFLlGFGFGLLFPLLQALVAELAPPEARGRASGLY 337


                 ....*..
gi 221330082 503 NVLQSFA 509
Cdd:COG2814  338 NSAFFLG 344
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 28-542 1.70e-12

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 69.45  E-value: 1.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  28 IEPVVFMLLFSHTLSGTIQrNQVIYQTCTVIFHYN---ESDCKQldvkNASAEINAIETELQPYVANLFLARTLLESIVP 104
Cdd:cd17449    4 VEPVLFLAMFALVLQGPLT-TQYLWDRLSADLGYNgtrTRGCAS----NASTSADPLQQEVETLTAHWNLYINLGGFLVG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGfsasFLMMAAICELSSYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITD 184
Cdd:cd17449   79 LFSVTLLGPWSDSVGRRPVLILPSLG----LALQAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAGCFAYVADVSD 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 185 CKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLhfhkeqetknaitanveke 264
Cdd:cd17449  155 RRSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESV------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 265 cidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyverlpqkaeerkrqeaeEQAKK 344
Cdd:cd17449  216 ---------------------------------------------------------------------------KEPKS 220

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 345 AGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFDGVMTVMYLF-VREKFHWTVRDYTFFETVSHLvPMIGA 423
Cdd:cd17449  221 ARLFTTRHHQSVVRLYVAPAPNGSRRKLALYSLALFVVVTVHFGAKDLLVLYeLSSPLCWDSDLIGYGSAAEHL-TYLSS 299

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 424 LIGFLILRKVFRLSVVtlALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKN 503
Cdd:cd17449  300 LLGLRLLQLCLEDTWV--AEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVA 377

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 221330082 504 VLQSFAPFVAAPLYTliykrslTTYPGLFNFVSSFLYLL 542
Cdd:cd17449  378 CVEGLCSLVATGIFN-------SLYPATLHFMKGFPFLF 409
MFS_1 pfam07690
Major Facilitator Superfamily;
101-246 1.99e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.44  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVPHSLLGGncVFSVAAFCFIS 180
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL--------FASSLWLLLVLRVLQGLGAG--ALFPAALALIA 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330082  181 DITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLH 246
Cdd:pfam07690 112 DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 101-241 3.33e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.82  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyyVVNPWWYIMAAVphSLLG-GNCVFSVAAFCFI 179
Cdd:cd17325  245 GLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP---------LATSFWLLLLLL--ALLGlGLGLVFPATLALL 313

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221330082 180 SDITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFV 241
Cdd:cd17325  314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 97-520 5.24e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 61.48  E-value: 5.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  97 TLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAiceLSSYYVVNPWW-YIMAAVphsLLGGNCVFSVAA 175
Cdd:cd06173   40 LAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAL---LALLGSLSLWLlLVLAFL---LGIASAFFGPAR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 176 FCFISDITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGcIVTFATLFIIFFVpeslhfhkeqetkn 255
Cdd:cd06173  114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSALLLLFI-------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 256 aitanvekecidskvpitacdlqldrvaidcppnfmndeepgkdkrmelptpatpamsfdddllakyveRLPQKAEERKR 335
Cdd:cd06173  179 ---------------------------------------------------------------------RRPPPAAPGES 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 336 QEAEEQAKKAGLFSMVHIRdmistcfkrrdhharaIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVs 415
Cdd:cd06173  190 SSLLLRDLREGLRYLRRSP----------------LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA- 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 416 hlvPMIGALIG-FLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVTL-GVFRSISGPMCRTIVSNIVPPS 493
Cdd:cd06173  253 ---FGVGALLGaLLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLlGLAGGLFNVPLNTLLQLRVPDE 329

                        410       420
                 ....*....|....*....|....*..
gi 221330082 494 DLGKIFSIKNVLQSFAPFVAAPLYTLI 520
Cdd:cd06173  330 LRGRVFSVYNALNSGAMPLGALLAGLL 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
367-552 1.58e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.60  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 367 HARAIIWLVTLAMFLSIFVFDGVMTVMYLFVREkFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAF 446
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 447 fseILNNLAKGFATMPWHMYLSVTL-GVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYkrSL 525
Cdd:COG2814   86 ---ALGSLLCALAPSLWLLLAARFLqGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA--DL 160

                        170       180
                 ....*....|....*....|....*..
gi 221330082 526 TTYPGLFnFVSSFLYLLSFVFIGYVLR 552
Cdd:COG2814  161 FGWRWVF-LVNAVLALLALLLLLRLLP 186
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 25-240 3.93e-09

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 58.59  E-value: 3.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  25 MFYIEPVVFMLLFSHTLSGTIQRnQVIYQ-------TCTVIFHYNESDCKQldvkNASAEINAIETELQPyVANLFLART 97
Cdd:cd17448    1 LYLVEPVVALYAFASFMTYPLIQ-QYVYRrlweetsNSTYISSSNISHCEK----NKSSPAFVFQEEVQK-KTSLFNMQM 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  98 LLESIVPAFCGLFI-GSWSDHYGRKPLLIVSMIGFSASFLMMAAICelssYYVVNPWWYIMAAVPHSLLGGNCVFSVAAF 176
Cdd:cd17448   75 DLSGLIPSLIVTLIlVSYSDRHGRKFSIILPSIGALLTSLSYCLVS----YFSFPLNLLIASSFISGLFGGFTTFIGGCF 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330082 177 CFISDI-TDCKSRPYRMIFMEslFFIGLTSG--SLLSSFVYAAVGSAATIGISGCIVTFATLFIIFF 240
Cdd:cd17448  151 AYVADLcKDHKQKTIRMAVVD--MILGVLTGlaGLSSGYFIRALGFNWPFLTIALLHVVNLLYILFF 215
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 101-243 1.52e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 56.67  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAicelssyyVVNPWWYIMAAVphsLLG-GNCVFSVAAFCFI 179
Cdd:cd06174   41 SLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF--------APSFWLLLLGRF---LLGlGSGLIDPAVLALI 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330082 180 SDITDCKSRPYRMIFMESLFFIGLTSGSLLSSFV--YAAVGSAATIGISGCIVTFATLFIIFFVPE 243
Cdd:cd06174  110 ADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLAAILLLLVVPD 175
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 99-255 5.76e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 54.93  E-value: 5.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  99 LESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICelssyyvvNPWWYIMAAVphsLLG-GNCVFSVAAFC 177
Cdd:cd17329   43 LSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH--------SPWLFAIALV---LTGfGGGLFEPASEA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 178 FISDITDCKSRpyRMIFMESLFF--IGLTSGSLLSSFVYAAVGSAATIgISGCIVTFATLFIIFFVPESLHFHKEQETKN 255
Cdd:cd17329  112 MIADVTTPENR--TRAFSLLYWAinLGVAIGPLLGGLLLLYSFRLLFL-AAAVLFLLAALVLLFLLPETRPKRRAAEKTE 188
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 111-245 8.13e-08

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 54.73  E-value: 8.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 111 IGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyyvVNPWWYIMAAVPHSLLGgnCVFSVAaFCFISDITDCKSRPY 190
Cdd:cd17387   56 IGALSDVWGRKSFLLLTVFFTCAPIPLMR----------ISPWWYFAMISVSGIFS--VTFSVI-FAYVADITTEEERST 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 221330082 191 RMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESL 245
Cdd:cd17387  123 AYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESL 177
MFS_1 pfam07690
Major Facilitator Superfamily;
375-546 2.04e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.19  E-value: 2.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  375 VTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFFseILNNL 454
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFA--LGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  455 AKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSLTTYPGLFNF 534
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158

                         170
                  ....*....|..
gi 221330082  535 VSSFLYLLSFVF 546
Cdd:pfam07690 159 ILSLLAAVLLLL 170
MFS_SLC46A2_TSCOT cd17450
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ...
 375-550 2.76e-07

Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341008  Cd Length: 383  Bit Score: 52.83  E-value: 2.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 375 VTLAM-FLSIFVFD----GVMTVMYLFV-REKFHWTVRDYTFFETVSHLVpMIGALIGFLILRKVFR-LSVVTLALLAFF 447
Cdd:cd17450  204 ITIALlFVGAILYDlavaGGMDVLSVFVlKEPLSWGAVEVGYGNAAGYMI-FITSFLGVFVFSRCLRdTTMIMIGMVSFS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 448 SEILnnlAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSLTT 527
Cdd:cd17450  283 SGIL---IMAFVKWTFMFYIARAVMLFALIPLPTIRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIYQATLDW 359

                        170       180
                 ....*....|....*....|...
gi 221330082 528 YPGLFNFVSSFLYLLSFVFIGYV 550
Cdd:cd17450  360 FPGFCFILSSILGFLSIIPISIV 382
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 106-246 8.33e-07

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 51.51  E-value: 8.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 106 FCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAicelSSYYVVnpwwYIMAAVPHSLLGGNCVFSVAafcFISDITDC 185
Cdd:cd17389   79 LSSPITGAASDVYGRKPVLLLTMIGLAISYALWAV----SRSFTI----FLLSRIVGGISKGNVSLSTA---IVADVTSP 147

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221330082 186 KSRPYRMIFMESLFFIGLTSGSLL-------------SSFVYAAVgsaatigISGCIVTFATLFIIFFVPESLH 246
Cdd:cd17389  148 KKRSKGMALIGVAFSLGFIIGPMIgayfasftrslgeVFFSMPAL-------FALVLALADLLFIFFFLPETLP 214
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
372-552 1.26e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 372 IWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFFSeIL 451
Cdd:COG2271  182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA-AL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 452 NNLAKGFATMPWHMYLSVTL-GVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYkrSLTTYPG 530
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLaGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL--DATGYQA 338

                        170       180
                 ....*....|....*....|..
gi 221330082 531 LFnFVSSFLYLLSFVFIGYVLR 552
Cdd:COG2271  339 AF-LLLAALALLAALLALLLLR 359
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 372-552 2.03e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 372 IWLVTLAMFLSIFVFDGVMTVMYLFvrekFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFfseIL 451
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQS----FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLF---AL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 452 NNLAKGFATMPWHMYLSVTL-GVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSLTTYPG 530
Cdd:cd06174   74 GALLFAFAPSFWLLLLGRFLlGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRA 153

                        170       180
                 ....*....|....*....|..
gi 221330082 531 LFnFVSSFLYLLSFVFIGYVLR 552
Cdd:cd06174  154 VF-LIAAALALLAAILLLLVVP 174
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 105-244 2.73e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.42  E-value: 2.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVphsLLG-GNCVFSVAAFCFISDIT 183
Cdd:COG0477   63 AIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG--------LAPSPELLIAARA---LQGiGAGGLMPGALALIAELF 131

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330082 184 DCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFAtLFIIFFVPES 244
Cdd:COG0477  132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLA-LVLRLRLPES 191
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
101-240 3.95e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVphsLLG-GNCVFSVAAFCFI 179
Cdd:COG2271   55 FLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG--------FATSFWQLLLLRF---LLGlGEAGFFPAALKLI 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330082 180 SDITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVG------SAATIGISGCIVTFATLFIIFF 240
Cdd:COG2271  124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwraaflILGLPGLLLALLRFWLLALAYF 190
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 105-258 5.91e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.89  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSasflmmaaICELSSYYVVNPWWYIMAAVPHSL-LGGncvFSVAAFCFISDIT 183
Cdd:TIGR00895  66 AFGALFFGPLADRIGRRRVLLWSILLFS--------VFTLLCALATNVTQLLILRFLAGLgLGG---LMPNLNALVSEYA 134

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330082  184 DCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAIT 258
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRR 209
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 105-249 1.04e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.93  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyyVVNPWWYIMAAvpHSLLGGNC-VFSVAAFCFISDIT 183
Cdd:cd17324   48 ALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA---------LAPSFALLLLA--RALAGLAHgGFWAIAAAYAADLV 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330082 184 DCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHK 249
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
362-551 1.56e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 362 KRRDHHARAIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGALI-GFLI----LRKVFRL 436
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPaGLLAdrfgRRRVLAI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 437 SVVTLALLAFFSeilnnlakGFATMPWHMYLS-VTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAP 515
Cdd:COG2271   81 GLLLWGLATLLF--------GFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 221330082 516 LYTLIYK----RSLTTYPGLFNFVSSFLYLLsFVFIGYVL 551
Cdd:COG2271  153 LLGWLLAafgwRAAFLILGLPGLLLALLRFW-LLALAYFL 191
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 112-264 1.81e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.21  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 112 GSWSDHYGRKPLLIVSMIGFSASFLMmaaicelsSYYVVNPWWYIMAavphSLLGGNCVFSVAAFCFISDITDCKSRPYR 191
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLL--------AAYATSIYGLILG----RALQGSGAISSVVMALLADLTREENRTKA 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221330082 192 MIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITANVEKE 264
Cdd:cd17472  121 MALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKN 193
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 372-544 5.41e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.66  E-value: 5.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 372 IWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWtvrDYTFFETVSHLVPMI-GALIGFLILRKVFRLsVVTLALLAFFSEI 450
Cdd:cd17489  196 VLPPALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTVYAIALLLsRPFSGKLSDRKGPKT-VIIPGLLLLALGL 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 451 lnnLAKGFATMPWHMYLSVTL-GVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQ----SFAPFVAAPLYTLIYKRSL 525
Cdd:cd17489  272 ---LLLSFAGSPWMLLLAAVLyGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFdlgiGLGGLLLGLVAELFGYRAM 348

                        170
                 ....*....|....*....
gi 221330082 526 TTYPGLFNFVSSFLYLLSF 544
Cdd:cd17489  349 FLLAAVVVLLALVLYIFLL 367
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 109-254 7.89e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.28  E-value: 7.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 109 LFIGSWSDHYGRKPLLIVSMIGFSASFLMMaaicelssYYVVNPWWYIMAAVPHSLlgGNCVFSVAAFCFISDITDcKSR 188
Cdd:cd17489   49 PFAGRLLDRFGRKRLLLIGLLIFALATLLY--------LLATSVALLLVLRLIHGI--GWGAFTTAAATLVADIIP-PSR 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330082 189 PYRMIFMESLFF-IGLTSGSLLSSFVYAAVGsAATIGISGCIVTFATLFIIFFVPESLHFHKEQETK 254
Cdd:cd17489  118 RGEGIGYYGLATtLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEA 183
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 109-241 3.08e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 109 LFIGSWSDH-YGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVPHSLLGGNCVFSVAAFcfisdITDCKS 187
Cdd:cd17474  252 LFVGRLLKKrFGARRILVIGLLLYALSLLLLG--------FVPSLALLLIAIVLFGLGLGLNLPLLTTL-----VTELAP 318

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221330082 188 RPYRMIFM---ESLFFIGLTSGSLLSSFVYAAVGSAATIgISGCIVTFATLFIIFFV 241
Cdd:cd17474  319 EEERGTASslyNFVRFLGQAVGPLLFGLLLEIFGLSAPF-LVGAAIALAAAVLLALL 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
101-250 3.52e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSW-SDHYGRKPLLIVSMIGFSASFLMMaaicelssyYVVNPWWYIMAAVPHSLLG-GNCVFSVAAFCF 178
Cdd:COG2211  273 YFLAALLGAPLWPRlAKRFGKKKAFIIGLLLAALGLLLL---------FFLGPGNLWLLLVLAALAGiGLGAILVLPWAM 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 179 ISDITDcKSRPYRMIFMESLFF--------IGLTSGSLLSSFVYAAVG-------SAATI-------GISGCIVTFATLF 236
Cdd:COG2211  344 LADVVD-YDEWKTGRRREGLYFgiftfaikLGQALAGALAGLLLALFGyvagaaqSPSALtgirllfFLLPAVLLLLAAL 422

                        170
                 ....*....|....
gi 221330082 237 IIFFVPESLHFHKE 250
Cdd:COG2211  423 LLLFYPLTRERHAE 436
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 326-547 3.61e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 42.98  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 326 LPQKAEERKRQEAEEQAKKAGLFSMVHIRDMIStcfkrrdHHARAIIWLVTLAMFLSIFVFDGVMTvmyLFVREKFHWTV 405
Cdd:cd17331  173 IPSNTKSKREKEAKESASPPSVFNLKEILRLLR-------LPGVAFLLLVKLLSGLPIGMFQSMFS---LVAMDFFGLTP 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 406 RDYTFFETVSHLVPMI--GALIGFLILRkvfrLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVT-LGVFRSISGPMC 482
Cdd:cd17331  243 EENGYLMSYAGVLGMVvqGLLVGPLTKR----FGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLpLVIGGSVLYTVI 318

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221330082 483 RTIVSNIVPPSDLGKIFSIKNVLQSF----APFVAAPLYTLIYKRSLTtypglfnFVSSFLYLLSFVFI 547
Cdd:cd17331  319 TSLLTKAVPPEDTGTALGLSHALFSLvrtvSPTIGGALLQAYGFPSFG-------LLGAAINGLLTVYL 380
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 106-243 4.40e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.56  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 106 FCGLFIGSW-SDHYGRKPLLIVSMIGFSASFLMMAAICELSSYYVVNPWWyimaavphSLLGgnCVFSVAAFCF------ 178
Cdd:cd17315  228 LLATLVAIRlVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWL--------ALLG--ILLYIAAFAMgagpvp 297

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221330082 179 ---ISDITDCKSRPYRMIFMESL-----FFIGLTSGSLLSSFvyaavGSAATIGISGCIVTFATLFIIFFVPE 243
Cdd:cd17315  298 wllLSEIFPLRIRGKGMAIATLVnwifnFIVGLTFLIMVSTI-----GLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 109-256 5.69e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 5.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 109 LFIGSWSD-HYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCF-ISDITDCK 186
Cdd:cd17471   50 QWLGRLSDrGGDRKPLILLALLAGALGYLLFA--------FLRNYWVLLLVGVVLLSLGAAAFPQLFALAReYADRSSGR 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 187 SRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIvTFATLFIIFFVPESLHFHKEQETKNA 256
Cdd:cd17471  122 DATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALL-YLVVALLVLFLLPSVKPPAQKATPAS 190
Sugar_tr pfam00083
Sugar (and other) transporter;
101-247 1.14e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.49  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAICELSSYYVvnpwwYIMAAVphsLLGGNC-VFSVAAFCFI 179
Cdd:pfam00083  56 SVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQ-----LIVGRV---LVGIGVgGASVLAPMYI 127

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330082  180 SDITDCKSRPyrmiFMESLFFIGLTSGSLLSSFVYAAV--GSAAT---IGISGCIVtFATLFII--FFVPESLHF 247
Cdd:pfam00083 128 SEIAPKKLRG----ALGSLYQLAITFGILLAYIFGLGLnkTSNSDgwrIPLGLQLV-PALLLIIglLFLPESPRW 197
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 105-264 1.15e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 41.41  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 105 AFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMaaicelssYYVVNPWWYIMAavphSLLGGNCV--FSVAAFCFISDI 182
Cdd:cd17358   55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLI--------AFAKDVWMLYLG----RFLAGFGGgaASVVVPVYIAEI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 183 TDCKSRPyRMIFMESLFF-IGLTSGSLLSSFVyaavgSAATIGISGCIVTFATLFIIFFVPESLHFH----KEQETKNA- 256
Cdd:cd17358  123 APKNVRG-ALGSLNQLLVnIGILLGYVLGSFL-----PWRTLALIGAIPPVVFLILLFFIPESPRWLakkgREEEAEKSl 196

                        170
                 ....*....|...
gi 221330082 257 -----ITANVEKE 264
Cdd:cd17358  197 qflrgKDADISKE 209
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
98-243 2.07e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.66  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082  98 LLESIVPAFCGLFIGSWSDHYG-----RKPLLIVSMIGFSASFLMMAAICELSsyYVVNPWWYIMAAVphsLLG-GNCVF 171
Cdd:COG2211   53 LVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLS--PTGKLIYALVTYL---LLGlAYTLV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 172 SVAAFCFISDIT-DCKSRP----YRMIFMeslfFIGLTSGSLLSSFVYAAVGSAATIG------ISGCIVTFATLFIIFF 240
Cdd:COG2211  128 NIPYSALGAELTpDYEERTrlssWRFAFA----GLGGLLASVLPPPLVAAFGGDAALGyrltalIFAVLGLLAFLLTFFG 203


                 ...
gi 221330082 241 VPE 243
Cdd:COG2211  204 TKE 206
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
108-256 2.49e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 108 GLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVphsLLG-GNCVFSVAAFCFISDITDcK 186
Cdd:COG0738   60 SLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA--------LAPSYPLLLLALF---LLGlGLGLLDVAANPYVAALGP-E 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 187 SRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNA 256
Cdd:COG0738  128 TAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAA 197
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 101-264 2.81e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASflmmAAICELSSYYvvnpWWYIMAAVPHSLlgGNCVFSVAAFCFIS 180
Cdd:cd17474   44 TLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG----GLLCGLSDSF----ALLLAGRALQGI--GAAGLGPLALTLIG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 181 DITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVyAAVGSAATIGISGCIVTFATLFIIFFVPESlhfHKEQETKNAITAN 260
Cdd:cd17474  114 DLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLLPEP---KEKAKSSSATKLR 189


                 ....
gi 221330082 261 VEKE 264
Cdd:cd17474  190 DLKK 193
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
368-520 3.02e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 368 ARAIIWLVTLAMFLSIFVFDgVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGALI-GFLI----LRKVFRLSVVTLA 442
Cdd:COG2223    3 RWRVLLLATLAFFLAFGVWY-LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPlGFLVdrfgPRRVLLIGLLLLG 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221330082 443 LLAFFSeilnnlakGFATMPWHMYL-SVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLI 520
Cdd:COG2223   82 IGLLLL--------ALAVSYWLLLLlGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL 152
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 101-244 3.17e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 39.95  E-value: 3.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 101 SIVPAFCGLFIGSW-SDHYGRKPLLIVSMIGFSASFLMMAAicelssyyVVNPWWYIMAAVphsLLG-GNCVFSVAAFCF 178
Cdd:cd17360   44 TVAGAAVGAAIGGWlNDRFGRRPCILLADALFTIGAIVMAA--------APNKEVLIVGRV---LVGlGVGIASMTVPLY 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330082 179 ISDITDCKSRPyRMIFMESLFfigLTSGSLLSS-----FVYAAVGSAATIGISGcIVTFATLFIIFFVPES 244
Cdd:cd17360  113 IAEAAPPRIRG-RLVTINVLF---ITGGQFVAYvingaFSYLPGGWRWMLGLAA-VPAVLQFIGLLFLPES 178
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 106-245 3.19e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.90  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 106 FCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAIcelSSYYVVnpwwyIMAAVPHSLLGGNCVFSVAafcFISDITDC 185
Cdd:cd17390   46 FSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS---TSLALL-----FLSRIPLGIFKHTQSLCKA---YLSDLVSE 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 186 KSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESL 245
Cdd:cd17390  115 QERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLLSKL 174
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 108-214 3.99e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.51  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 108 GLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYIMAAVPHSL-LGGNCvfsVAAFCFISDITDCK 186
Cdd:cd17316   53 ALLFGYLGDRIGRKKALILTLLLFGLATLLIG--------LLPTPILLLVLRFLQGIgIGGEY---PGASTYVAEFAPSK 121

                         90       100
                 ....*....|....*....|....*...
gi 221330082 187 SRPYRMIFMESLFFIGLTSGSLLSSFVY 214
Cdd:cd17316  122 RRGFALGLLQSGWALGALLAALVASLLI 149
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 439-551 5.04e-03

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 39.33  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 439 VTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYT 518
Cdd:cd17448  284 IYIVFIGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFN 363

                         90       100       110
                 ....*....|....*....|....*....|...
gi 221330082 519 LIYKRSLTTYPGLFNFVSSFLYLLSFVFIGYVL 551
Cdd:cd17448  364 SIYAATVAWFPGFSFLLSAGLCLIPASLLCVLL 396
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 108-240 5.85e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 5.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082 108 GLFIGSWSDHYGRKPLLIVSMIGFSASFLMMAAicelssyyVVNPWWYIMAAVPHSLLGGncVFSVAAFCFISDITDCKS 187
Cdd:cd06173  261 ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGG--LFNVPLNTLLQLRVPDEL 330

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221330082 188 RPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFF 240
Cdd:cd06173  331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 98-244 7.13e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 39.23  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330082   98 LLESIVpaFCGLFIGSW-----SDHYGRKPLLIVSMIGFSASFLMMAaicelssyYVVNPWWYimaAVPHSLLG-GNCVF 171
Cdd:TIGR00898 131 LTQSCF--FVGVLLGSFvfgylSDRFGRKKVLLLSTLVTAVSGVLTA--------FSPNYTVF---LVFRLLVGmGIGGI 197

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221330082  172 SVAAFCFISDITDCKSRPYRMIFMESLFFIGLTSGSLLSSFVYAAVGSAATIGISgcivTFATLFIIFFVPES 244
Cdd:TIGR00898 198 WVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLP----TFLFFLLSWFVPES 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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