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Conserved domains on  [gi|197387234|ref|NP_001128096|]
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leucine-rich repeat-containing protein 69 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-233 2.10e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 2.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234   8 TALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKN 87
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT-----------------------DLPEPLGNLTNLKS 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  88 LhlfgnricriaagvldglgdlvllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITR 167
Cdd:COG4886  164 L------------------------DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 197387234 168 IPEEIRFLQNLQQLSLVRNNIEELPeEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 233
Cdd:COG4886  220 LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-233 2.10e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 2.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234   8 TALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKN 87
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT-----------------------DLPEPLGNLTNLKS 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  88 LhlfgnricriaagvldglgdlvllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITR 167
Cdd:COG4886  164 L------------------------DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 197387234 168 IPEEIRFLQNLQQLSLVRNNIEELPeEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 233
Cdd:COG4886  220 LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 19-253 1.46e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.34  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  19 LTLNGKKMS-KMPSALEKLPNLRTLDLQNNQISKvcpelrtltkltllnlgnnllqEVPEEIKYLT-SLKNLHLFGNRIC 96
Cdd:PLN00113  74 IDLSGKNISgKISSAIFRLPYIQTINLSNNQLSG----------------------PIPDDIFTTSsSLRYLNLSNNNFT 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  97 riAAGVLDGLGDLVLLNLNDNQLS-SLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIPEEIR 173
Cdd:PLN00113 132 --GSIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELG 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 174 FLQNLQQLSLVRNNIE-ELPEEVCQLTKLGVLD-VAGNVIQIFPAGFQDLKLREFycegnpLFL-KNPIFAPQPKDLWTL 250
Cdd:PLN00113 210 QMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQY------LFLyQNKLSGPIPPSIFSL 283


                 ...
gi 197387234 251 REI 253
Cdd:PLN00113 284 QKL 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-209 1.10e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234   7 LTALKGGKSTKILTLNGKKMSKMPSaLEKLPNLRTLDLQNNQISKVcpelrtltkltllnlgnnllqevpEEIKYLTSLK 86
Cdd:cd21340   17 IDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI------------------------ENLENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  87 NLHLFGNRICRIAagvldglgdlvllNLNdnqlsslppeigRLQNLTFLSLNHNKLtviPKEICFL----------EHLS 156
Cdd:cd21340   72 KLYLGGNRISVVE-------------GLE------------NLTNLEELHIENQRL---PPGEKLTfdprslaalsNSLR 123

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 197387234 157 ELHINYNRITRIpEEIRFLQNLQQLSLVRNNIEELpEEVCQL----TKLGVLDVAGN 209
Cdd:cd21340  124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL-EELLDLlsswPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
130-188 9.96e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 9.96e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197387234  130 QNLTFLSLNHNKLTVIPKEiCF--LEHLSELHINYNRITRI-PEEIRFLQNLQQLSLVRNNI 188
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFkgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-233 2.10e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 2.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234   8 TALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKN 87
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT-----------------------DLPEPLGNLTNLKS 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  88 LhlfgnricriaagvldglgdlvllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITR 167
Cdd:COG4886  164 L------------------------DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 197387234 168 IPEEIRFLQNLQQLSLVRNNIEELPeEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 233
Cdd:COG4886  220 LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
14-233 3.22e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 3.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  14 KSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISKVCPELRTLTKLTLLNLGNNLLQEVPEEIKYLTSLKNLHLFGN 93
Cdd:COG4886   27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  94 RicriaagVLDGLGDLVLLNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITRIPEEIR 173
Cdd:COG4886  107 E-------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197387234 174 FLQNLQQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLK-LREFYCEGNPL 233
Cdd:COG4886  180 NLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTnLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-233 4.39e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.72  E-value: 4.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  30 PSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKNLhlfgnricriaagvldglgdl 109
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLT-----------------------DLPEELANLTNLKEL--------------------- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 110 vllNLNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITRIPEEIRFLQNLQQLSLVRNNIE 189
Cdd:COG4886  142 ---DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 197387234 190 ELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPL 233
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-233 8.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 8.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  36 LPNLRTLDLQNNQISKVCPELRTLTKLTLLNLGNNLLQEVPEEIKYLTSLKNLHLFGNRICRIAAGVLDGLGDLVLLNLN 115
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 116 DNQLSSLPPEIGRLQNLTF-----------------LSLNHNKLTVIPKEICFLEHLSELHINYNRITRIPEEIRFLQNL 178
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTEldlsgneelsnltnlesLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 197387234 179 QQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLK-LREFYCEGNPL 233
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTnLEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 19-253 1.46e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.34  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  19 LTLNGKKMS-KMPSALEKLPNLRTLDLQNNQISKvcpelrtltkltllnlgnnllqEVPEEIKYLT-SLKNLHLFGNRIC 96
Cdd:PLN00113  74 IDLSGKNISgKISSAIFRLPYIQTINLSNNQLSG----------------------PIPDDIFTTSsSLRYLNLSNNNFT 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  97 riAAGVLDGLGDLVLLNLNDNQLS-SLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIPEEIR 173
Cdd:PLN00113 132 --GSIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELG 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 174 FLQNLQQLSLVRNNIE-ELPEEVCQLTKLGVLD-VAGNVIQIFPAGFQDLKLREFycegnpLFL-KNPIFAPQPKDLWTL 250
Cdd:PLN00113 210 QMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQY------LFLyQNKLSGPIPPSIFSL 283


                 ...
gi 197387234 251 REI 253
Cdd:PLN00113 284 QKL 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
9-250 3.62e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 3.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234   9 ALKGGKSTKILTLNGKKMSKMPSALEKLPNLRTLDLQNNQISkvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKNL 88
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT-----------------------DLPEPLANLTNLETL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  89 HLFGNRICRIAAGVLDGLGDLVllNLNDNQLSSLPPEiGRLQNLTFLSLNHNKLTVIPKEICFLEHLSELHINYNRITRI 168
Cdd:COG4886  234 DLSNNQLTDLPELGNLTNLEEL--DLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 169 PEEIRFLQNLQQLSLVRNNIEELPEEVCQLTKLGVLDVAGNVIQIFPAGFQDLKLREFYCEGNPLFLKNPIFAPQPKDLW 248
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390


                 ..
gi 197387234 249 TL 250
Cdd:COG4886  391 LL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 15-209 6.66e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 6.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  15 STKILTLNGKK-MSKMPSALEKLPNLRTLDLQNNQISKVCPELRTLTKLTLLNLG--NNLLQEVPEEIKYLTSLKNLHLF 91
Cdd:PLN00113 165 SLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLgyNNLSGEIPYEIGGLTSLNHLDLV 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  92 GNricriaagvldglgdlvllnlndNQLSSLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIP 169
Cdd:PLN00113 245 YN-----------------------NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIP 301

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 197387234 170 EEIRFLQNLQQLSLVRNNIE-ELPEEVCQLTKLGVLDVAGN 209
Cdd:PLN00113 302 ELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSN 342
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-209 1.10e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234   7 LTALKGGKSTKILTLNGKKMSKMPSaLEKLPNLRTLDLQNNQISKVcpelrtltkltllnlgnnllqevpEEIKYLTSLK 86
Cdd:cd21340   17 IDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI------------------------ENLENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  87 NLHLFGNRICRIAagvldglgdlvllNLNdnqlsslppeigRLQNLTFLSLNHNKLtviPKEICFL----------EHLS 156
Cdd:cd21340   72 KLYLGGNRISVVE-------------GLE------------NLTNLEELHIENQRL---PPGEKLTfdprslaalsNSLR 123

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 197387234 157 ELHINYNRITRIpEEIRFLQNLQQLSLVRNNIEELpEEVCQL----TKLGVLDVAGN 209
Cdd:cd21340  124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL-EELLDLlsswPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-212 2.95e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 2.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  29 MPSALEKLPNLRTLDLQNNQISKvcpelrtltkltllnlgnnllqEVPEEIKYLTSLKNLHLFGNRICRIAAGVLDGLGD 108
Cdd:PLN00113 276 IPPSIFSLQKLISLDLSDNSLSG----------------------EIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPR 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 109 LVLLNLNDNQLS-SLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRI-TRIPEEIRFLQNLQQLSLVR 185
Cdd:PLN00113 334 LQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQD 413

                        170       180
                 ....*....|....*....|....*...
gi 197387234 186 NNIE-ELPEEVCQLTKLGVLDVAGNVIQ 212
Cdd:PLN00113 414 NSFSgELPSEFTKLPLVYFLDISNNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-220 7.35e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 7.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 119 LSSLPPEIGrlQNLTFLSLNHNKLTVIPKEIcfLEHLSELHINYNRITRIPEEIRflQNLQQLSLVRNNIEELPEEVCql 198
Cdd:PRK15370 190 LTTIPACIP--EQITTLILDNNELKSLPENL--QGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPERLP-- 261

                         90       100
                 ....*....|....*....|..
gi 197387234 199 TKLGVLDVAGNVIQIFPAGFQD 220
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPE 283
LRR_8 pfam13855
Leucine rich repeat;
130-188 9.96e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 9.96e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197387234  130 QNLTFLSLNHNKLTVIPKEiCF--LEHLSELHINYNRITRI-PEEIRFLQNLQQLSLVRNNI 188
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFkgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
114-216 1.27e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 114 LNDNQLSSLPPEIGrlQNLTFLSLNHNKLTVIPKEICflEHLSELHINYNRITRIPEEI-RFLQNL-------------- 178
Cdd:PRK15370 206 LDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPERLpSALQSLdlfhnkisclpenl 281

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 197387234 179 ----QQLSLVRNNIEELPEEVCqlTKLGVLDVAGNVIQIFPA 216
Cdd:PRK15370 282 peelRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPE 321
LRR_8 pfam13855
Leucine rich repeat;
113-165 1.33e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 197387234  113 NLNDNQLSSLPPEI-GRLQNLTFLSLNHNKLTVI-PKEICFLEHLSELHINYNRI 165
Cdd:pfam13855   7 DLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-229 1.38e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 129 LQNLTFLSLNHNKLTVIPkEICFLEHLSELHINYNRITRIpEEIRFLQNLQQLSLVRNNIEELpEEVCQLTKLGVLDVAG 208
Cdd:cd21340    1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGG 77

                         90       100
                 ....*....|....*....|..
gi 197387234 209 NVIQIFpAGFQDLK-LREFYCE 229
Cdd:cd21340   78 NRISVV-EGLENLTnLEELHIE 98
LRR_8 pfam13855
Leucine rich repeat;
154-211 8.53e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 8.53e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  154 HLSELHINYNRITRIPEEI-RFLQNLQQLSLVRNNIEELPEEVCQ-LTKLGVLDVAGNVI 211
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-209 3.51e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 3.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 113 NLNDNQLSSLPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIPEEIRFLQNLQQLSLVRNNIE- 189
Cdd:PLN00113 458 SLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSg 537

                         90       100
                 ....*....|....*....|
gi 197387234 190 ELPEEVCQLTKLGVLDVAGN 209
Cdd:PLN00113 538 QIPASFSEMPVLSQLDLSQN 557
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
116-209 3.92e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 116 DNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEicflehLSELHINYNRITRIPeeiRFLQNLQQLSLVRNNIEELPEEV 195
Cdd:PRK15387 371 NNRLTSLPALPSGLKELIVSGNRLTSLPVLPSE------LKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESL 441

                         90
                 ....*....|....
gi 197387234 196 CQLTKLGVLDVAGN 209
Cdd:PRK15387 442 IHLSSETTVNLEGN 455
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 28-186 1.52e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  28 KMPSALEKLPNLRTLDLQNNQISKVCPELR--TLTKLTLLNLGNNLLQEVPEEIKYlTSLKNLHLFGNRICRIAAGVLDG 105
Cdd:PLN00113 419 ELPSEFTKLPLVYFLDISNNNLQGRINSRKwdMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGS 497

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 106 LGDLVLLNLNDNQLSS-LPPEIGRLQNLTFLSLNHNKLT-VIPKEICFLEHLSELHINYNRIT-RIPEEIRFLQNLQQLS 182
Cdd:PLN00113 498 LSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVN 577


                 ....
gi 197387234 183 LVRN 186
Cdd:PLN00113 578 ISHN 581
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
117-247 4.70e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.60  E-value: 4.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 117 NQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICflehlsELHINYNRITRIPEeirFLQNLQQLSLVRNNIEELPEEVC 196
Cdd:PRK15387 292 NQLTSLPVLPPGLQELSVSDNQLASLPALPSELC------KLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPS 362

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 197387234 197 QLTKLGVLDVAGNVIQIFPAGfqdlkLREFYCEGNPLfLKNPIFAPQPKDL 247
Cdd:PRK15387 363 ELYKLWAYNNRLTSLPALPSG-----LKELIVSGNRL-TSLPVLPSELKEL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
114-225 7.79e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.22  E-value: 7.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234 114 LNDNQLSSLPPEIGRLQNLTFLSLNHNKLTVIPKEICflehlsELHINYNRITRIPEeirFLQNLQQLSLVRNNIEELPE 193
Cdd:PRK15387 249 VSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLC------KLWIFGNQLTSLPV---LPPGLQELSVSDNQLASLPA 319

                         90       100       110
                 ....*....|....*....|....*....|..
gi 197387234 194 EVCQLTKLGVLDVAGNVIQIFPAGFQDLKLRE 225
Cdd:PRK15387 320 LPSELCKLWAYNNQLTSLPTLPSGLQELSVSD 351
LRR_9 pfam14580
Leucine-rich repeat;
151-225 8.34e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 36.67  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197387234  151 FLEHLSELHINYNRITRIPEEI-RFLQNLQQLSLVRNNIEELPE-----EVCQLTKLGVLD------------VAGNVIQ 212
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIGEGLgEALPNLTELILTNNNLQELGDldplaSLKKLTFLSLLRnpvtnkphyrlyVIYKVPQ 141

                          90
                  ....*....|...
gi 197387234  213 IFPAGFQDLKLRE 225
Cdd:pfam14580 142 LRLLDFRKVKQKE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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